Detailed information for compound 1126102

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 188.183 | Formula: C10H8N2O2
  • H donors: 1 H acceptors: 1 LogP: 1.24 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc(n[nH]1)Oc1ccccc1
  • InChi: 1S/C10H8N2O2/c13-9-6-7-10(12-11-9)14-8-4-2-1-3-5-8/h1-7H,(H,11,13)
  • InChiKey: KHTZJZTUOROSFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii flavodoxin domain-containing protein 0.0025 0.0023 0.0519
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0266 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0266 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0146 0.0146
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.005 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.005 0.0131 0.0131
Onchocerca volvulus 0.0109 0.0388 0.9692
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0131 0.0131
Brugia malayi hypothetical protein 0.0025 0.0025 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0012 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.001 0.0763
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0146 0.0146
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0012 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.001 0.0763
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0151 0.0151
Toxoplasma gondii flavodoxin domain-containing protein 0.0025 0.0023 0.0519
Loa Loa (eye worm) hypothetical protein 0.0112 0.04 0.04
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0012 0.0012
Toxoplasma gondii hypothetical protein 0.0028 0.0037 0.1063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0012 0.0012
Trichomonas vaginalis sulfite reductase, putative 0.005 0.0131 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0012 0.0012
Brugia malayi bHLH-PAS transcription factor 0.004 0.009 0.009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.001 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0182 0.0703 0.0703
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0012 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0012 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0012 0.0012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0146 0.4744
Brugia malayi Cytochrome P450 family protein 0.0036 0.0071 0.0071
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0012 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0012 0.0012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0266 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0012 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0025 0.0025 0.1169
Echinococcus granulosus methionine synthase reductase 0.0031 0.0049 0.0049
Trypanosoma cruzi cytochrome P450 reductase, putative 0.005 0.0131 1
Schistosoma mansoni cellular tumor antigen P53 0.0112 0.04 0.04
Plasmodium vivax flavodoxin domain containing protein 0.0044 0.0107 0.3784
Schistosoma mansoni NADPH flavin oxidoreductase 0.0025 0.0025 0.0025
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0266 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.001 0.0937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0012 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0025 0.1936
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0266 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0217 0.8171
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0012 0.0012
Brugia malayi steroid hormone receptor 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0045 0.011 0.011
Brugia malayi hypothetical protein 0.0182 0.0703 0.0703
Echinococcus multilocularis microtubule associated protein 2 0.0792 0.3331 0.3331
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0201 0.9237
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0131 0.0131
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.005 0.0131 0.4735
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0025 0.1936
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0217 1
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.005 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Echinococcus multilocularis transfer RNA-Lys 0.004 0.009 0.009
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0266 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0031 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0109 0.0388 0.0388
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.011 0.835
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0037 0.1063
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0071 0.0071
Schistosoma mansoni coup transcription factor 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0003
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0201 0.0201
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0025 0.0601
Brugia malayi nuclear receptor NHR-88 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.2338 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0217 0.0217
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0012 0.0012
Echinococcus multilocularis tumor protein p63 0.0765 0.3216 0.3216
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0071 0.2675
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.001 0.0461
Leishmania major DNA polymerase eta, putative 0.0031 0.0052 0.2407
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0031 0.0049 0.0049
Echinococcus multilocularis methionine synthase reductase 0.0031 0.0049 0.0049
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.005 0.0131 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3536 0.3536
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0012 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.2338 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0012 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Brugia malayi FAD binding domain containing protein 0.005 0.0131 0.0131
Schistosoma mansoni microtubule-associated protein tau 0.0792 0.3331 0.3331
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0012 0.0012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0266 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0012 0.0012
Brugia malayi Probable ClpP-like protease 0.0081 0.0266 0.0266
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0037 0.1063
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0266 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0052 0.1653
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0201 0.0201
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.0642 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0012 0.0012
Schistosoma mansoni DNA polymerase eta 0.0045 0.011 0.011
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0044 0.0107 0.8144
Brugia malayi ecdysteroid receptor 0.0022 0.0012 0.0012
Onchocerca volvulus 0.0112 0.04 1
Mycobacterium ulcerans putative regulatory protein 0.004 0.009 0.3398
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0012 0.0012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0146 0.6706
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0025 0.1936
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.001 0.0461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.001 0.0763
Giardia lamblia Nitric oxide synthase, inducible 0.0044 0.0107 1
Schistosoma mansoni survival motor neuron protein 0.0109 0.0388 0.0388
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0012 0.0012
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0012 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0217 0.8171
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0535 0.2226 0.2226
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0025 0.0601
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0201 0.0201
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0266 0.0266
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0012 0.0012
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.2338 1 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0266 0.0266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0012 0.0012
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.005 0.0131 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.005 0.0131 0.0131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0763
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0012 0.0012
Leishmania major cytochrome p450-like protein 0.0036 0.0071 0.3274
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0012
Plasmodium falciparum nitric oxide synthase, putative 0.005 0.0131 0.4735
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.2338 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0012 0.0012
Echinococcus granulosus NADPH cytochrome P450 reductase 0.005 0.0131 0.0131
Echinococcus granulosus dna polymerase eta 0.0045 0.011 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0064 0.0064
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.001 0.0377
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Schistosoma mansoni single-minded 0.0054 0.0151 0.0151
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0266 0.0266
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0064 0.0064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0012 0.0012
Echinococcus granulosus single minded 2 0.004 0.009 0.009
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.005 0.0131 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.005 0.0131 1
Schistosoma mansoni diflavin oxidoreductase 0.0025 0.0023 0.0023
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0025 0.0601
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0201 0.0201
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0217 0.8099
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0266 1
Echinococcus granulosus tumor protein p63 0.0765 0.3216 0.3216
Brugia malayi PAS domain containing protein 0.0054 0.0151 0.0151
Echinococcus multilocularis dna polymerase eta 0.0045 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0146 0.6706
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0012 0.0012
Leishmania major p450 reductase, putative 0.005 0.0131 0.6038
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0071 0.0071
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0012 0.0012
Echinococcus granulosus microtubule associated protein 2 0.0792 0.3331 0.3331
Trypanosoma cruzi p450 reductase, putative 0.005 0.0131 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0217 0.8171
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.005 0.0131 0.6038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0012 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0535 0.2226 0.2226
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.001 0.001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0012 0.0012
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.005 0.0131 0.4933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0012 0.0012
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0025 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0012 0.0012
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0217 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0071 0.0071
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.005 0.0131 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0131 0.0131
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.005 0.0131 1
Echinococcus multilocularis survival motor neuron protein 1 0.0535 0.2226 0.2226
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0266 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0201 0.7547
Brugia malayi Cytochrome P450 family protein 0.0036 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.2338 1 1
Schistosoma mansoni cytochrome P450 reductase 0.005 0.0131 0.0131
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0109 0.0388 0.0388
Schistosoma mansoni hypothetical protein 0.0034 0.0064 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0217 0.0217
Brugia malayi nuclear hormone receptor 0.0022 0.0012 0.0012
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0071 0.5423
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0081 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.005 0.0131 0.0131
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.011 0.835
Brugia malayi flavodoxin family protein 0.005 0.0131 0.0131
Brugia malayi FAD binding domain containing protein 0.0031 0.0049 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.011 0.011
Onchocerca volvulus 0.004 0.009 0.202
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0071 0.5423
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0052 0.3987
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0012 0.0012
Giardia lamblia Hypothetical protein 0.0044 0.0107 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0012
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0182 0.0182
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Loa Loa (eye worm) FAD binding domain-containing protein 0.005 0.0131 0.0131
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0763
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0201 0.7547
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0201 0.9237
Leishmania major cytochrome P450 reductase, putative 0.0044 0.0107 0.4917
Brugia malayi hypoxia-induced factor 1 0.0168 0.0642 0.0642
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.001 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0012 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0071 0.5423
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.001 0.001
Leishmania major DNA polymerase eta, putative 0.0045 0.011 0.5041
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0217 0.0217
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0012 0.0012
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0037 0.1063
Brugia malayi hypothetical protein 0.0535 0.2226 0.2226

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 109.6 mg kg-1 Anticonvulsant in ip dosed mouse assessed as protection against maximum electric stimulus-induced seizures ChEMBL. 20116141
TD50 (ADMET) = 273.9 mg kg-1 Neurotoxicity against ip dosed mouse by rotarod ataxia test ChEMBL. 20116141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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