Detailed information for compound 1136795

Basic information

Technical information
  • TDR Targets ID: 1136795
  • Name: 4-methyl-N-[5-[(4-methylphenyl)sulfonylamino] naphthalen-1-yl]benzenesulfonamide
  • MW: 466.572 | Formula: C24H22N2O4S2
  • H donors: 2 H acceptors: 4 LogP: 4.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1cccc2c1cccc2NS(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C24H22N2O4S2/c1-17-9-13-19(14-10-17)31(27,28)25-23-7-3-6-22-21(23)5-4-8-24(22)26-32(29,30)20-15-11-18(2)12-16-20/h3-16,25-26H,1-2H3
  • InChiKey: MIVPUXMNDCDKFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methyl-N-[5-[(4-methylphenyl)sulfonylamino]-1-naphthyl]benzenesulfonamide
  • 57159-76-9
  • NSC144469

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nocturnin 0.0004 0.0167 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.3986 0.3986
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.2171 1
Echinococcus granulosus neutral sphingomyelinase 0.0004 0.0167 0.0167
Echinococcus multilocularis traf and tnf receptor associated protein 0.0004 0.0167 0.0167
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0004 0.0167 0.0452
Onchocerca volvulus Putative neutral sphingomyelinase 0.0004 0.0167 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.2171 1
Leishmania major hypothetical protein, conserved 0.0026 0.2171 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0004 0.0167 0.0167
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0004 0.0167 0.0167
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.3986 1
Schistosoma mansoni neutral sphingomyelinase 0.0004 0.0167 0.0167
Schistosoma mansoni cript-related 0.0004 0.0167 0.0167
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0004 0.0167 0.0418
Loa Loa (eye worm) hypothetical protein 0.0004 0.0167 0.0418
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.2171 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0004 0.0167 0.0452
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0004 0.0167 0.0452
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0167 0.0452
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0004 0.0167 0.0418
Brugia malayi hypothetical protein 0.0017 0.1338 0.3358
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0004 0.0167 0.0418
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.1533 0.6817
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1533 0.6817
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0004 0.0167 0.0167
Entamoeba histolytica hypothetical protein 0.0043 0.3688 1
Schistosoma mansoni ap endonuclease 0.0019 0.1533 0.1533
Entamoeba histolytica hypothetical protein 0.0043 0.3688 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0167 0.1088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.3986 0.3986
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0004 0.0167 0.0418
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0167 0.0452
Loa Loa (eye worm) hypothetical protein 0.0004 0.0167 0.0418
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.1533 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.3688 1
Entamoeba histolytica hypothetical protein 0.0043 0.3688 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.2171 0.5448
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.1533 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1533 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0167 0.1088
Onchocerca volvulus 0.0004 0.0167 1
Echinococcus granulosus traf and tnf receptor associated protein 0.0004 0.0167 0.0167
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.1533 0.1538
Schistosoma mansoni hypothetical protein 0.0114 1 1
Schistosoma mansoni hypothetical protein 0.0012 0.0875 0.0875
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0004 0.0167 0.0167
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.9972 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0167 0.0452
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0875 0.0878
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.1533 0.5
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0004 0.0167 0.1088
Echinococcus multilocularis deoxyribonuclease 1 2 0.0004 0.0167 0.0167
Onchocerca volvulus 0.0004 0.0167 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.3986 0.3986
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0004 0.0167 0.0167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.1533 0.1533
Schistosoma mansoni synaptojanin 0.0004 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0004 0.0167 0.0167
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.2171 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.3986 0.3997
Schistosoma mansoni hypothetical protein 0.0043 0.3688 0.3688
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.1533 0.6817
Brugia malayi CCR4 0.0004 0.0167 0.0418
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0004 0.0167 0.0452
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1533 0.6817
Loa Loa (eye worm) hypothetical protein 0.0004 0.0167 0.0418
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1533 1
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0004 0.0167 0.1088
Brugia malayi hypothetical protein 0.0026 0.2171 0.5448
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0004 0.0167 0.0167
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.1533 1
Echinococcus multilocularis neutral sphingomyelinase 0.0004 0.0167 0.0167
Toxoplasma gondii exonuclease III APE 0.0019 0.1533 0.6817
Loa Loa (eye worm) hypothetical protein 0.0004 0.0167 0.0418
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0004 0.0167 0.0167
Brugia malayi hypothetical protein 0.0043 0.3688 0.9253
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.3688 0.3698
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0004 0.0167 0.0418
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.2171 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.3986 1
Schistosoma mansoni carbon catabolite repressor protein 0.0004 0.0167 0.0167
Schistosoma mansoni ap endonuclease 0.0019 0.1533 0.1533
Trichomonas vaginalis Phospholipase C precursor, putative 0.0004 0.0167 0.1088
Echinococcus granulosus synaptojanin 1 0.0004 0.0167 0.0167
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.1533 0.3847
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.9972 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.1533 0.6817
Echinococcus multilocularis synaptojanin 1 0.0004 0.0167 0.0167
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.1533 1
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0004 0.0167 0.1088
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.9972 0.9972
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0004 0.0167 0.0418
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.3688 0.3688
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.1533 0.4158
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.2171 1
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0004 0.0167 0.1088
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0875 0.0875
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0004 0.0167 0.1088
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0004 0.0167 0.0418
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0167 0.0452
Echinococcus granulosus kelch ECH associated protein 1 0.0114 0.9972 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0167 0.1088
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.1533 0.6817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.3986 0.3986
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.9972 0.9972
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.2171 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.3688 0.3688
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0167 0.0452
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.1533 0.3847
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0167 0.0452
Schistosoma mansoni synaptojanin 0.0004 0.0167 0.0167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.3986 0.3997
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.3986 0.3986
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0004 0.0167 0.0452

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibition of CETP in rabbit serum at 10 uM after 1 hr by fluorescent cholesteryl esters transfer assay ChEMBL. 20116902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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