TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.486 | Formula: C19H26N2O4S
H donors: 4 H acceptors: 4 LogP: 1.83 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O[C@H](c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C
InChi: 1S/C19H26N2O4S/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25/h4-11,18,20-23H,12-13H2,1-3H3/t18-/m0/s1
InChiKey: XJBCFFLVLOPYBV-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Plasmodium falciparum	phd finger protein, putative	0.0031	0.0245	1
Brugia malayi	Bromodomain containing protein	0.0031	0.0245	0.0687
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0016	0.0074	0.0067
Schistosoma mansoni	hypothetical protein	0.0038	0.033	0.0926
Entamoeba histolytica	hypothetical protein	0.0038	0.033	0.1641
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0177	0.1548
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0016	0.0074	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Onchocerca volvulus		0.0016	0.0074	0.0507
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0102	0.4171
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0016	0.0074	0.0067
Schistosoma mansoni	nAChR subunit	0.0016	0.0074	0.0207
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0016	0.0074	0.0207
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0016	0.0074	0.0207
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0177	0.0496
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0016	0.0074	0.0187
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0101	0.1073	0.2995
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0016	0.0074	0.0067
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0016	0.0074	0.0207
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0007	0.002
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0408	0.1128
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0105	0.1129	0.3167
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0007	0.002
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.1371	0.3846
Schistosoma mansoni	nAChR subunit	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Echinococcus multilocularis	protein patched	0.0045	0.0408	0.0401
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.111	0.1103
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.111	0.3113
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0007	0.002
Brugia malayi	Hyaluronidase family protein	0.0311	0.3564	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0074	0.0207
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0007	0.002
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.111	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0408	0.1146
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0321	0.0902
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0007	0.002
Loa Loa (eye worm)	ACC-1 protein	0.0016	0.0074	0.0207
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.033	0.0926
Schistosoma mansoni	nAChR subunit	0.0016	0.0074	0.0207
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0016	0.0074	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0016	0.0074	0.0207
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0016	0.0074	0.0207
Loa Loa (eye worm)	LGC-31 protein	0.0016	0.0074	0.0207
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0016	0.0074	0.0207
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0321	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Echinococcus granulosus	peregrin	0.0031	0.0245	0.0668
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0016	0.0074	0.0187
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0245	0.0668
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0483	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0245	0.0687
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0102	0.4171
Schistosoma mansoni	coup transcription factor	0.0011	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0287
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0177	0.1754
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0007	0.002
Schistosoma mansoni	hypothetical protein	0.0031	0.0245	0.0687
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0016	0.0074	0.0187
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0016	0.0074	0.0207
Schistosoma mansoni	jumonji domain containing protein	0.008	0.0828	0.2322
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0016	0.0074	0.0207
Onchocerca volvulus		0.0016	0.0074	0.0507
Onchocerca volvulus		0.0025	0.0177	0.1294
Schistosoma mansoni	patched 1	0.0045	0.0408	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0287
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0321	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0074	0.0207
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.1092
Schistosoma mansoni	nAChR subunit	0.0016	0.0074	0.0207
Schistosoma mansoni	nAChR subunit	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0408	0.1146
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0007	0.002
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.0245	0.0687
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0007	0.002
Onchocerca volvulus	Putative nachr subunit	0.0016	0.0074	0.0507
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0016	0.0074	0.0067
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0177	0.1548
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0177	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0074	0.0207
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0016	0.0074	0.0067
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0016	0.0074	0.0187
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0321	0.0883
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0016	0.0074	0.0067
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0074	0.0207
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0585	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0287
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0016	0.0074	0.0207
Onchocerca volvulus		0.0016	0.0074	0.0507
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0007	0.002
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.1371	0.3846
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0016	0.0074	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0527	0.1478
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0016	0.0074	0.0067
Echinococcus granulosus	nAChR subunit	0.0016	0.0074	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Brugia malayi	hypothetical protein	0.0122	0.1319	0.37
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0016	0.0074	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0287
Brugia malayi	nuclear hormone receptor	0.0011	0.0007	0.002
Brugia malayi	hypothetical protein	0.0038	0.033	0.0926
Brugia malayi	MH2 domain containing protein	0.0126	0.1371	0.3846
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0016	0.0074	0.0207
Echinococcus granulosus	glycine receptor subunit beta	0.0016	0.0074	0.0187
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0177	0.1548
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0101	0.1073	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0177	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1319	0.37
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0585	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0102	0.5
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0016	0.0074	0.0207
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0016	0.0074	0.0207
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0007	0.002
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0016	0.0074	0.0207
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0102	0.0244
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0408	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0585	1
Brugia malayi	jmjC domain containing protein	0.0101	0.1073	0.301
Echinococcus granulosus	bifunctional protein NCOAT	0.0311	0.3564	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0585	0.1626
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0016	0.0074	0.0207
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0007	0.002
Brugia malayi	PHD-finger family protein	0.0031	0.0245	0.0687
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0585	0.1643
Echinococcus multilocularis	bifunctional protein NCOAT	0.0311	0.3564	0.3559
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0408	0.1128
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0016	0.0074	0.0187
Onchocerca volvulus	Huntingtin homolog	0.0122	0.1319	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0007	0.002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0177	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1446	0.4056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Brugia malayi	Cation transporter family protein	0.0016	0.0074	0.0207
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0311	0.3564	1
Entamoeba histolytica	hypothetical protein	0.0038	0.033	0.1641
Schistosoma mansoni	Hyaluronidase	0.0311	0.3564	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0148	0.1637	0.1631
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0007	0.002
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0007	0.002
Brugia malayi	Cation transporter family protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Echinococcus granulosus	glycine receptor subunit beta	0.0016	0.0074	0.0187
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0007	0.002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0007	0.002
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Echinococcus granulosus	expressed conserved protein	0.0098	0.1035	0.289
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0007	0.002
Echinococcus multilocularis	peregrin	0.0031	0.0245	0.0238
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0177	0.0496
Brugia malayi	Cation transporter family protein	0.0016	0.0074	0.0207
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0007	0.002
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.111	0.31
Brugia malayi	excitatory GABA receptor EXP-1A	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0505	0.1416
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.033	0.0323
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0585	1
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.0387	0.038
Onchocerca volvulus		0.0016	0.0074	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0104	0.111	0.3113
Brugia malayi	ecdysteroid receptor	0.0011	0.0007	0.002
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0016	0.0074	0.0067
Brugia malayi	CHE-14 protein	0.0045	0.0408	0.1146
Entamoeba histolytica	hypothetical protein	0.0038	0.033	0.1641
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.1092
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.033	0.0908
Entamoeba histolytica	hypothetical protein	0.0038	0.033	0.1641
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0007	0.002
Loa Loa (eye worm)	hyaluronidase	0.0311	0.3564	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0007	0.002
Brugia malayi	steroid hormone receptor	0.0011	0.0007	0.002
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0585	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0177	0.1548
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0007	0.002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0007	0.002
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0016	0.0074	0.0187
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0177	0.1548
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0016	0.0074	0.0207
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0632	0.1774
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0007	0.002
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0016	0.0074	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0007	0.002
Loa Loa (eye worm)	ACC-1 protein	0.0016	0.0074	0.0207
Brugia malayi	jmjC domain containing protein	0.0037	0.0321	0.0902
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0585	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0177	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0016	0.0074	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Onchocerca volvulus	Huntingtin homolog	0.0122	0.1319	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0016	0.0074	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0007	0.002
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.1092
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0321	0.0902
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0177	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0585	0.1643
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0007	0.002
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0007	0.002
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0408	0.0401
Schistosoma mansoni	nAChR subunit	0.0016	0.0074	0.0207
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0007	0.002
Echinococcus granulosus	Niemann Pick C1 protein	0.0148	0.1637	0.4582
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1319	0.37
Onchocerca volvulus		0.0016	0.0074	0.0507
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0177	0.0496
Onchocerca volvulus	Alhambra homolog	0.0031	0.0245	0.1813
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0177	0.0496
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0585	1
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0	0.5
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0245	0.0238
Echinococcus multilocularis	expressed conserved protein	0.0098	0.1035	0.1029
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.0387	0.1069
Schistosoma mansoni	nAChR subunit	0.0016	0.0074	0.0207
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.0245	0.0687
Echinococcus multilocularis	glycine receptor subunit beta	0.0016	0.0074	0.0067
Onchocerca volvulus		0.0016	0.0074	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0177	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0207
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0177	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0007	0.002
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0245	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0177	0.0496
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0007	0.002
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0245	0.4183
Giardia lamblia	PHD finger protein 15	0.0031	0.0245	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.0074	0.0207
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0016	0.0074	0.0207
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0016	0.0074	0.0067
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0245	0.4183
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0016	0.0074	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0007	0.002
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0016	0.0074	0.0207
Echinococcus multilocularis	nAChR subunit	0.0016	0.0074	0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1160740

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1137619