Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0102 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0102 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0602 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0602 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0602 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0602 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0602 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0602 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0602 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0102 | 0 | 0.5 |
Onchocerca volvulus | 0.0102 | 0 | 0.5 | |
Onchocerca volvulus | 0.0102 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0602 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0102 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.45 uM | Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 | ChEMBL. | 8667363 |
IC50 (binding) | = 0.45 uM | Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 | ChEMBL. | 8667363 |
Inhibition (functional) | = 61.7 % | In vivo inhibitory percentage of pressor response induced by exogenous submaxilmal dose of angiotensin-II (3 ug/kg) administered iv to pithed rats | ChEMBL. | 8667363 |
Inhibition (functional) | = 61.7 % | In vivo inhibitory percentage of pressor response induced by exogenous submaxilmal dose of angiotensin-II (3 ug/kg) administered iv to pithed rats | ChEMBL. | 8667363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.