Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.2562 | 0.289 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.2296 | 0.2296 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | nuclear receptor RXR | 0.0012 | 0.0041 | 0.0041 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0.2562 | 0.289 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.8864 | 0.8864 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0021 | 0.2296 | 0.2296 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.2562 | 0.2562 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.8864 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.2562 | 0.289 |
Brugia malayi | steroid hormone receptor | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | ecdysteroid receptor | 0.0022 | 0.2562 | 0.2562 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.8864 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0041 | 0.0041 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0.2296 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.2562 | 0.289 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.2562 | 0.289 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.2562 | 0.2562 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.2562 | 0.289 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.2562 | 0.2562 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.8864 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0012 | 0.0041 | 0.0046 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.2562 | 0.2562 |
Trypanosoma brucei | cytochrome P450, putative | 0.0021 | 0.2296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.8864 | 0.8864 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.8864 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0021 | 0.2296 | 0.2296 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0012 | 0.0041 | 0.0046 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0012 | 0.0041 | 0.0046 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0021 | 0.2296 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0012 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0022 | 0.2562 | 0.2562 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.2562 | 0.289 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0.2562 | 0.289 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0041 | 0.0041 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0021 | 0.2296 | 0.2296 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0041 | 0.0041 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0022 | 0.2562 | 0.2562 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.2562 | 0.289 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0011 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0041 | 0.0041 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.2562 | 0.289 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.2562 | 0.2562 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.8864 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.2562 | 0.289 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0.2296 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.2562 | 0.289 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.2562 | 0.289 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0022 | 0.2562 | 0.5 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0041 | 0.0041 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0022 | 0.2562 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0041 | 0.0041 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0041 | 0.0046 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.8864 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0022 | 0.2562 | 0.2562 |
Onchocerca volvulus | 0.0022 | 0.2562 | 0.5 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.2562 | 0.289 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.2296 | 0.2296 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.2562 | 0.2562 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.2562 | 0.289 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.2562 | 0.289 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0022 | 0.2562 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.2562 | 0.289 |
Mycobacterium leprae | putative cytochrome p450 | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.2562 | 0.289 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.8864 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0.2562 | 0.289 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0022 | 0.2562 | 0.2562 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.2562 | 0.2562 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.2562 | 0.289 |
Leishmania major | cytochrome p450-like protein | 0.0021 | 0.2296 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2562 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0053 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0.2562 | 0.289 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.2562 | 0.289 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.2562 | 0.2562 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0.2562 | 0.289 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.2562 | 0.2562 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0011 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.2562 | 0.289 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.