TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.512 | Formula: C26H27N3O
H donors: 0 H acceptors: 1 LogP: 4.44 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(C(C1)Cn1cc(c2c1cccc2)C(=O)c1cccc2c1cccc2)C
InChi: 1S/C26H27N3O/c1-27-14-15-28(2)20(16-27)17-29-18-24(22-11-5-6-13-25(22)29)26(30)23-12-7-9-19-8-3-4-10-21(19)23/h3-13,18,20H,14-17H2,1-2H3
InChiKey: CPHORMQWXVSQFN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Cannabinoid receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	ctsf protein	0.0211	0.1041	0.1041
Brugia malayi	Papain family cysteine protease containing protein	0.0109	0.0239	0.0239
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0118	0.0306	0.0069
Trichomonas vaginalis	alpha-amylase, putative	0.0492	0.3235	1
Trypanosoma brucei	glucosidase, putative	0.0198	0.0936	0.1232
Schistosoma mansoni	cathepsin F (C01 family)	0.0211	0.1041	0.1091
Trichomonas vaginalis	alpha-glucosidase, putative	0.0198	0.0936	0.2892
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0447	0.0447
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.023	0.1183	0.3152
Onchocerca volvulus	Cathepsin L homolog	0.0211	0.1041	0.0902
Mycobacterium tuberculosis	1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme)	0.023	0.1183	0.7318
Loa Loa (eye worm)	alpha amylase	0.0136	0.0449	0.0449
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Loa Loa (eye worm)	trehalase	0.0136	0.0447	0.0447
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Onchocerca volvulus		0.0975	0.702	1
Echinococcus multilocularis	cysteine protease	0.0211	0.1041	0.0822
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0447	0.1383
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0109	0.0239	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0109	0.0239	0.0738
Trichomonas vaginalis	alpha-glucosidase, putative	0.0198	0.0936	0.2892
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0139	0.0477	0.0046
Loa Loa (eye worm)	hypothetical protein	0.023	0.1183	0.1183
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0211	0.1041	0.0822
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0211	0.1041	0.0822
Leishmania major	alpha glucosidase II subunit, putative	0.0198	0.0936	0.0833
Brugia malayi	Cathepsin L-like precursor	0.0141	0.0494	0.0494
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Schistosoma mansoni	alpha-amylase	0.0136	0.0449	0.0471
Onchocerca volvulus		0.0211	0.1041	0.0902
Brugia malayi	1,4-alpha-glucan branching enzyme	0.023	0.1183	0.1183
Echinococcus granulosus	neutral alpha glucosidase AB	0.0198	0.0936	0.0714
Onchocerca volvulus		0.0211	0.1041	0.0902
Entamoeba histolytica	cysteine proteinase, putative	0.0211	0.1041	0.2676
Trichomonas vaginalis	alpha-glucosidase, putative	0.0198	0.0936	0.2892
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0306	0.0321
Brugia malayi	Papain family cysteine protease containing protein	0.0211	0.1041	0.1041
Schistosoma mansoni	alpha-amylase	0.0136	0.0449	0.0471
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0198	0.0936	0.2892
Onchocerca volvulus		0.0211	0.1041	0.0902
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0494	0.0494
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0139	0.0477	0.1476
Trichomonas vaginalis	amylase, putative	0.0492	0.3235	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0805	0.5688	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0198	0.0936	0.2326
Brugia malayi	Cathepsin L-like precursor	0.0211	0.1041	0.1041
Echinococcus granulosus	glucan 14 alpha branching enzyme 1	0.023	0.1183	0.0968
Leishmania major	cathepsin L-like protease	0.0211	0.1041	0.1023
Schistosoma mansoni	alpha-amylase	0.0136	0.0449	0.0471
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0136	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0477	0.0477
Trypanosoma cruzi	major cysteine proteinase, putative	0.0633	0.4339	0.7525
Echinococcus multilocularis	glucan (1,4 alpha), branching enzyme 1	0.023	0.1183	0.0968
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0198	0.0936	0.0714
Trichomonas vaginalis	alpha-glucosidase, putative	0.0139	0.0477	0.1476
Entamoeba histolytica	cysteine proteinase, putative	0.0211	0.1041	0.2676
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0211	0.1041	0.1041
Mycobacterium leprae	Putative uncharacterized protein ML2045	0.0136	0.0449	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0139	0.0477	0.1476
Echinococcus multilocularis	cathepsin L cysteine protease	0.0211	0.1041	0.0822
Trypanosoma cruzi	cysteine peptidase, putative	0.0805	0.5688	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Trichomonas vaginalis	alpha-amylase, putative	0.0492	0.3235	1
Brugia malayi	Cathepsin L-like precursor	0.0211	0.1041	0.1041
Entamoeba histolytica	oligo-1,6-glucosidase, putative	0.0136	0.0449	0.0703
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Trypanosoma cruzi	cruzipain precursor, putative	0.0805	0.5688	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Echinococcus multilocularis	cysteine protease	0.0211	0.1041	0.0822
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0211	0.1041	1
Onchocerca volvulus	Cathepsin L homolog	0.0211	0.1041	0.0902
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0198	0.0936	0.2892
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0139	0.0477	0.0438
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0139	0.0477	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0447	0.0447
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Trichomonas vaginalis	alpha-glucosidase, putative	0.0198	0.0936	0.2892
Schistosoma mansoni	cathepsin F (C01 family)	0.0211	0.1041	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0447	0.0447
Loa Loa (eye worm)	trehalase	0.0136	0.0447	0.0447
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0139	0.0477	0.0422
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0198	0.0936	0.0936
Trichomonas vaginalis	alpha-amylase, putative	0.042	0.2674	0.8265
Trypanosoma cruzi	hypothetical protein, conserved	0.0198	0.0936	0.1279
Trypanosoma cruzi	cysteine peptidase, putative	0.0211	0.1041	0.1472
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0211	0.1041	0.0822
Mycobacterium ulcerans	glycogen branching protein	0.023	0.1183	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0447	0.0447
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Trichomonas vaginalis	alpha-glucosidase, putative	0.0198	0.0936	0.2892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.0494	0.1526
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0211	0.1041	1
Trichomonas vaginalis	trehalase, putative	0.0136	0.0447	0.1383
Loa Loa (eye worm)	TRE-1 protein	0.0136	0.0447	0.0447
Loa Loa (eye worm)	cysteine protease	0.0211	0.1041	0.1041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0198	0.0936	0.2326
Brugia malayi	Cathepsin L-like precursor	0.0211	0.1041	0.1041
Schistosoma mansoni	hypothetical protein	0.0194	0.0908	0.0952
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0136	0.0449	0.0449
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0139	0.0477	0.0797
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0211	0.1041	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0805	0.5688	1
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.0494	0.0851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0211	0.1041	0.3216
Chlamydia trachomatis	1,4-alpha-glucan branching enzyme	0.023	0.1183	0.5
Brugia malayi	Cathepsin L-like precursor	0.0211	0.1041	0.1041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Brugia malayi	hypothetical protein	0.0136	0.0447	0.0447
Brugia malayi	Trehalase family protein	0.0136	0.0447	0.0447
Leishmania major	cathepsin L-like protease	0.0211	0.1041	0.1023
Brugia malayi	Cathepsin L-like precursor	0.0211	0.1041	0.1041
Trichomonas vaginalis	alpha-glucosidase, putative	0.0139	0.0477	0.1476
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0306	0.0321
Trichomonas vaginalis	alpha-glucosidase, putative	0.0139	0.0477	0.1476
Brugia malayi	Cathepsin L-like precursor	0.0141	0.0494	0.0494
Brugia malayi	cathepsin L-like precursor	0.0141	0.0494	0.0494
Giardia lamblia	1,4-alpha-glucan branching enzyme	0.023	0.1183	0.5
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0118	0.0306	0.0069
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Loa Loa (eye worm)	trehalase	0.0136	0.0447	0.0447
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Brugia malayi	Trehalase family protein	0.0136	0.0447	0.0447
Echinococcus multilocularis	alpha glucosidase	0.0136	0.0449	0.0216
Brugia malayi	Trehalase family protein	0.0136	0.0447	0.0447
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0198	0.0936	0.7178
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0735	0.5141	0.8997
Leishmania major	cathepsin L-like protease	0.0805	0.5688	0.9466
Echinococcus granulosus	cathepsin l1	0.0141	0.0494	0.0261
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Leishmania major	cathepsin L-like protease	0.0805	0.5688	0.9466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0141	0.0494	0.0494
Schistosoma mansoni	alpha glucosidase	0.0198	0.0936	0.0981
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Trichomonas vaginalis	amylase, putative	0.023	0.1183	0.3657
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0494	0.0494
Onchocerca volvulus		0.0211	0.1041	0.0902
Loa Loa (eye worm)	fibroinase	0.0211	0.1041	0.1041
Entamoeba histolytica	alpha-amylase family protein	0.0492	0.3235	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0139	0.0477	0.1476
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0211	0.1041	0.1041
Trichomonas vaginalis	alpha-amylase, putative	0.0492	0.3235	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.1356	1	1
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.023	0.1183	0.3152
Trichomonas vaginalis	amylase, putative	0.0492	0.3235	1
Schistosoma mansoni	alpha-glucosidase	0.1297	0.9542	1
Toxoplasma gondii	glycosyltransferase	0.023	0.1183	1
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1041	0.1041
Schistosoma mansoni	alpha-amylase	0.0136	0.0449	0.0471
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Toxoplasma gondii	cathepsin CPL	0.0211	0.1041	0.8373
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0198	0.0936	0.0936
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Trypanosoma brucei	pteridine reductase 1	0.0832	0.5896	1
Leishmania major	cathepsin L-like protease	0.0805	0.5688	0.9466
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0306	0.0321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.0494	0.1526
Echinococcus granulosus	lysosomal alpha glucosidase	0.1356	1	1
Leishmania major	pteridine reductase 1	0.0843	0.5982	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0447	0.0447
Schistosoma mansoni	cathepsin F (C01 family)	0.0141	0.0494	0.0518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Echinococcus multilocularis	lysosomal alpha glucosidase	0.1356	1	1
Brugia malayi	Trehalase family protein	0.0136	0.0447	0.0447
Echinococcus multilocularis	geminin	0.0194	0.0908	0.0686
Plasmodium vivax	vivapain-2	0.0211	0.1041	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0211	0.1041	0.3216
Leishmania major	cathepsin L-like protease	0.0211	0.1041	0.1023
Trichomonas vaginalis	alpha-amylase, putative	0.0492	0.3235	1
Entamoeba histolytica	cysteine protease, putative	0.0211	0.1041	0.2676
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0109	0.0239	0.025
Onchocerca volvulus		0.0211	0.1041	0.0902
Onchocerca volvulus		0.0141	0.0494	0.007
Leishmania major	cysteine peptidase A (CPA)	0.0211	0.1041	0.1023
Leishmania major	cathepsin L-like protease	0.0211	0.1041	0.1023
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0109	0.0239	0.025
Schistosoma mansoni	alpha-amylase	0.0136	0.0449	0.0471
Toxoplasma gondii	1,4-alpha-glucan-branching enzyme	0.023	0.1183	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Loa Loa (eye worm)	alpha amylase	0.0136	0.0449	0.0449
Echinococcus granulosus	alpha glucosidase	0.0136	0.0449	0.0216
Leishmania major	cathepsin L-like protease	0.0211	0.1041	0.1023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0109	0.0239	0.0738
Plasmodium vivax	vivapain-2	0.0211	0.1041	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.008	0.008
Entamoeba histolytica	alpha-amylase family protein	0.0492	0.3235	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0139	0.0477	0.0438
Brugia malayi	Cathepsin L-like precursor	0.0211	0.1041	0.1041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.1041	0.3216
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.1356	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0494	0.0494
Onchocerca volvulus		0.0211	0.1041	0.0902
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0264	0.1452	1
Brugia malayi	Papain family cysteine protease containing protein	0.0109	0.0239	0.0239
Trichomonas vaginalis	starch branching enzyme II, putative	0.023	0.1183	0.3657
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0306	0.0321
Trypanosoma cruzi	hypothetical protein, conserved	0.0198	0.0936	0.1279
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Schistosoma mansoni	starch branching enzyme II	0.023	0.1183	0.124
Onchocerca volvulus	Cathepsin F homolog	0.0211	0.1041	0.0902
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0118	0.0306	0.0069
Echinococcus granulosus	geminin	0.0194	0.0908	0.0686
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0805	0.5688	0.9633
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0139	0.0477	0.1476
Toxoplasma gondii	alpha amylase, catalytic domain-containing protein	0.023	0.1183	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0211	0.1041	0.0822
Onchocerca volvulus		0.0211	0.1041	0.0902
Loa Loa (eye worm)	TRE-2 protein	0.0136	0.0447	0.0447
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Echinococcus multilocularis	cathepsin L cysteine protease	0.0211	0.1041	0.0822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.1041	0.3216
Echinococcus granulosus	cathepsin l1	0.0211	0.1041	0.0822
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0198	0.0936	0.2892
Schistosoma mansoni	alpha-glucosidase	0.1297	0.9542	1
Schistosoma mansoni	hypothetical protein	0.0194	0.0908	0.0952
Trichomonas vaginalis	alpha-glucosidase, putative	0.0139	0.0477	0.1476
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0198	0.0936	0.2892

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 15 nM	Compound was evaluated in vitro for the inhibition of electrically induced contractions in isolated mouse vas deferens (MVD) preparations.	ChEMBL.	No reference
IC50 (functional)	= 15 nM	Compound was evaluated in vitro for the inhibition of electrically induced contractions in isolated mouse vas deferens (MVD) preparations.	ChEMBL.	No reference
IC50 (binding)	= 51 nM	Compound was evaluated for the inhibition of [3H]-WIN- 55212-2 binding in rat cerebellum membranes	ChEMBL.	No reference
IC50 (binding)	= 51 nM	Compound was evaluated for the inhibition of [3H]-WIN- 55212-2 binding in rat cerebellum membranes	ChEMBL.	No reference
Ki (binding)	= -1.96	Displacement of [3H]-CP-55,940 from Cannabinoid receptor 1 of rat forebrain membranes	ChEMBL.	9804691
Ki (binding)	= -1.61	Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]-WIN-55,212-2 in rat forebrain membranes	ChEMBL.	9804691
Ki (binding)	= -1.61	Binding affinity at cannabinoid receptor 1 using rat brain membranes	ChEMBL.	11448223
Log Ki (binding)	= -1.96	Displacement of [3H]-CP-55,940 from Cannabinoid receptor 1 of rat forebrain membranes	ChEMBL.	9804691
Log Ki (binding)	= -1.61	Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]-WIN-55,212-2 in rat forebrain membranes	ChEMBL.	9804691
Log Ki (binding)	= -1.61	Binding affinity at cannabinoid receptor 1 using rat brain membranes	ChEMBL.	11448223

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL302948

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 115055