Detailed information for compound 1151419

Basic information

Technical information
  • TDR Targets ID: 1151419
  • Name: [3-[[4-(carboxymethyl)phenyl]amino]-3-oxoprop yl]-dimethylsulfanium
  • MW: 268.352 | Formula: C13H18NO3S+
  • H donors: 2 H acceptors: 3 LogP: 1.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[S+](CCC(=O)Nc1ccc(cc1)CC(=O)O)C
  • InChi: 1S/C13H17NO3S/c1-18(2)8-7-12(15)14-11-5-3-10(4-6-11)9-13(16)17/h3-6H,7-9H2,1-2H3,(H-,14,15,16,17)/p+1
  • InChiKey: KHMKABURAVDNFD-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • [3-[[4-(carboxymethyl)phenyl]amino]-3-oxo-propyl]-dimethyl-sulfonium
  • [3-[[4-(carboxymethyl)phenyl]amino]-3-oxopropyl]-dimethylsulfonium
  • [3-[[4-(carboxymethyl)phenyl]amino]-3-keto-propyl]-dimethyl-sulfonium
  • [3-[[4-(carboxymethyl)phenyl]amino]-3-oxo-propyl]-dimethyl-sulfanium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0684 0.0569
Brugia malayi Cathepsin L-like precursor 0.0018 0.0145 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.005 0.2082 0.389
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.6025 0.8837
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.516 1
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0684 0.0569
Plasmodium vivax vivapain-2 0.0018 0.0145 0.0116
Schistosoma mansoni hypothetical protein 0.0031 0.0946 0.0946
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.3181 0.6072
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.031 0.0211
Schistosoma mansoni hypothetical protein 0.0182 1 1
Brugia malayi PHD-finger family protein 0.0031 0.0946 0.0926
Brugia malayi glutathione reductase 0.0051 0.2116 0.224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0145 0.0023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.516 0.5101
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.031 0.0373
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0122 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.031 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.23 0.4323
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0145 0.0023
Loa Loa (eye worm) hypothetical protein 0.0074 0.3472 0.6634
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0145 0.0023
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0946 0.1667
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.2116 0.393
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.011 0.5675 0.5621
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0145 0.0116
Loa Loa (eye worm) glutathione reductase 0.0051 0.2116 0.393
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.031 0.0329
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.5675 0.5675
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0946 0.1597
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0122 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.031 0.0373
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0684 0.1205
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.031 0.0281
Plasmodium vivax JmjC domain containing protein 0.0027 0.0684 0.2818
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.031 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0684 0.1115
Schistosoma mansoni jumonji domain containing protein 0.0145 0.7756 0.7756
Schistosoma mansoni DNA polymerase eta 0.0021 0.031 0.031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.031 0.0373
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.516 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.6802 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Brugia malayi Bromodomain containing protein 0.0031 0.0946 0.0926
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.3472 0.3472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Leishmania major cathepsin L-like protease 0.0069 0.3181 0.6072
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.2949 0.5591
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0684 0.0684
Mycobacterium tuberculosis Probable reductase 0.0116 0.6025 0.8837
Leishmania major cathepsin L-like protease 0.0018 0.0145 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.5675 0.5675
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.031 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.031 0.0211
Leishmania major DNA polymerase kappa, putative 0.0021 0.031 0.0373
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0122 0.5
Brugia malayi jmjC domain containing protein 0.0027 0.0684 0.0631
Trypanosoma brucei unspecified product 0.0021 0.031 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.2824 0.5363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.031 0.0373
Plasmodium vivax vivapain-2 0.0018 0.0145 0.0116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.6802 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.031 0.0373
Brugia malayi Melibiase family protein 0.0074 0.3472 0.3764
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.516 0.5101
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.031 0.0373
Loa Loa (eye worm) hypothetical protein 0.0027 0.0684 0.1074
Echinococcus multilocularis Glycoside hydrolase, family 27 0.011 0.5675 0.5621
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.6025 0.8837
Echinococcus multilocularis peregrin 0.0031 0.0946 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0145 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.031 0.019
Toxoplasma gondii melibiase subfamily protein 0.011 0.5675 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Leishmania major cathepsin L-like protease 0.0018 0.0145 0.0046
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0684 0.0684
Trichomonas vaginalis CAMK family protein kinase 0.005 0.2082 0.389
Trypanosoma brucei polo-like protein kinase 0.0102 0.516 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0145 0.0046
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0684 0.2818
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0946 0.1667
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.2116 0.2019
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.3181 0.6072
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.5675 0.5675
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Brugia malayi jmjC domain containing protein 0.0027 0.0684 0.0631
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0145 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0145 0.0046
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0684 0.0684
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0145 0.0023
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.516 1
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0684 0.0569
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.031 0.031
Echinococcus multilocularis lysine specific demethylase 5A 0.0101 0.5137 0.5077
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0684 0.1115
Loa Loa (eye worm) hypothetical protein 0.0027 0.0684 0.1074
Plasmodium vivax glutathione reductase, putative 0.0051 0.2116 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.4394 0.8472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Echinococcus granulosus lysine specific demethylase 5A 0.0101 0.5137 0.5077
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0145 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.1683 0.158
Leishmania major cathepsin L-like protease 0.0018 0.0145 0.0046
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0684 0.0569
Echinococcus multilocularis cysteine protease 0.0018 0.0145 0.0023
Echinococcus granulosus dna polymerase eta 0.0021 0.031 0.019
Giardia lamblia PHD finger protein 15 0.0031 0.0946 0.1635
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0946 0.0834
Brugia malayi Thioredoxin reductase 0.0051 0.2116 0.224
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.031 0.031
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.516 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0145 0.0116
Echinococcus multilocularis cysteine protease 0.0018 0.0145 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Leishmania major hypothetical protein, conserved 0.0027 0.0684 0.1115
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.516 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.031 0.0373
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.4394 0.8472
Trypanosoma brucei trypanothione reductase 0.0051 0.2116 0.3958
Treponema pallidum NADH oxidase 0.0018 0.0122 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.0329
Brugia malayi Cathepsin L-like precursor 0.0018 0.0145 0.0026
Loa Loa (eye worm) hypothetical protein 0.0089 0.4394 0.8472
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.3181 0.6072
Leishmania major trypanothione reductase 0.0051 0.2116 0.3958
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.516 0.516
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Echinococcus multilocularis dna polymerase eta 0.0021 0.031 0.019
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.516 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Plasmodium falciparum thioredoxin reductase 0.0051 0.2116 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.516 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0101 0.5137 0.9954
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.6802 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.3472 0.3472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Echinococcus granulosus phd:f box containing protein 0.0027 0.0684 0.0569
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0684 0.1074
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.3181 0.6072
Brugia malayi Cathepsin L-like precursor 0.0018 0.0145 0.0026
Echinococcus multilocularis geminin 0.0182 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.6802 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.6025 0.8837
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0166 0.9022 0.901
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Echinococcus granulosus dna polymerase kappa 0.0021 0.031 0.019
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0684 0.0569
Giardia lamblia Kinase, PLK 0.0102 0.516 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Brugia malayi jmjC domain containing protein 0.0027 0.0684 0.0631
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.5137 0.5137
Onchocerca volvulus Alhambra homolog 0.0031 0.0946 0.1597
Toxoplasma gondii cathepsin CPL 0.0018 0.0145 0.0255
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.516 1
Echinococcus granulosus cathepsin l1 0.0018 0.0145 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Brugia malayi jmjC domain containing protein 0.0101 0.5137 0.5635
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0074 0.3472 0.665
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0166 0.9022 0.901
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.6025 0.8837
Loa Loa (eye worm) hypothetical protein 0.0071 0.3302 0.6295
Echinococcus granulosus peregrin 0.0031 0.0946 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0684 0.0569
Brugia malayi Cathepsin L-like precursor 0.0018 0.0145 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0946 0.1597
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.031 0.0373
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.2116 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0145 0.0026
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0684 0.1115
Brugia malayi Cathepsin L-like precursor 0.0018 0.0145 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.5675 0.5675
Brugia malayi jmjC domain containing protein 0.0166 0.9022 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0122 0.0122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.5137 0.5137
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.031 1
Echinococcus granulosus jumonji domain containing protein 0.0044 0.1683 0.158
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.031 0.019
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0145 0.0116
Leishmania major cathepsin L-like protease 0.0069 0.3181 0.6072
Leishmania major cathepsin L-like protease 0.0018 0.0145 0.0046
Plasmodium falciparum phd finger protein, putative 0.0031 0.0946 0.4132
Giardia lamblia DINP protein human, muc B family 0.0021 0.031 0.0373
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.031 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.516 1
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0684 0.0569
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0684 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Brugia malayi jmjC domain containing protein 0.0027 0.0684 0.0631
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0684 0.0684
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0684 0.0684
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.2116 0.2985
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.2116 0.3958
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0946 0.0834
Plasmodium falciparum glutathione reductase 0.0051 0.2116 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0946 0.4132
Schistosoma mansoni hypothetical protein 0.0182 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0145 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.031 0.0373
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0684 0.1074
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.011 0.5675 0.5621
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0122 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.031 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.516 1
Leishmania major cathepsin L-like protease 0.0018 0.0145 0.0046
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0684 0.0569
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0946 0.0946
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0122 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.031 0.0329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072
Schistosoma mansoni kinase 0.0052 0.2163 0.2163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.031 0.0281
Leishmania major cathepsin L-like protease 0.0069 0.3181 0.6072
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0684 0.1074
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0684 0.1205
Echinococcus multilocularis dna polymerase kappa 0.0021 0.031 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.516 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0145 0.0145
Toxoplasma gondii thioredoxin reductase 0.0051 0.2116 0.3729
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0145 0.0046
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.2116 0.2019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0145 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0145 0.0046
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.6025 0.8837
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.516 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.516 0.5661
Leishmania major DNA polymerase eta, putative 0.0021 0.031 0.0373
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.516 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.3181 0.6072

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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