Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.4735 | 0.7343 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0419 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0182 | 0.6297 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.1445 | 0.1745 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.1205 | 0.1205 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.1205 | 0.1822 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0099 | 0.3192 | 0.4717 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0066 | 0.1953 | 0.1953 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0419 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.3192 | 0.3192 |
Onchocerca volvulus | 0.0046 | 0.1205 | 0.5 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.1021 | 0.1024 |
Toxoplasma gondii | melibiase subfamily protein | 0.0099 | 0.3192 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.1205 | 0.1338 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.1021 | 0.3924 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.4588 | 0.7092 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.1445 | 0.2377 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0419 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.1205 | 0.1822 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.1205 | 0.1338 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0182 | 0.6297 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.3192 | 0.3192 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0099 | 0.3192 | 0.4717 |
Brugia malayi | Melibiase family protein | 0.0066 | 0.1953 | 0.3554 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.1445 | 0.1745 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.1445 | 0.1445 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.1445 | 0.1745 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.4735 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.1205 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.1205 | 0.1205 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.4735 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0892 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.3192 | 0.3192 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.1205 | 0.1338 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1953 | 0.3554 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.1021 | 0.3199 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.1205 | 0.1822 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.1021 | 0.3199 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.1021 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0066 | 0.1953 | 0.1953 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.1445 | 0.2377 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0066 | 0.1953 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.1021 | 0.3924 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1205 | 0.1822 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1445 | 0.2377 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0892 | 1 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.0419 | 0.1313 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.1205 | 0.1338 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.1445 | 0.1745 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.3192 | 0.3192 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0099 | 0.3192 | 0.4717 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.1205 | 0.1205 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.4735 | 0.4735 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 99 % | Inhibition of COX-2-mediated PGE2 production in LPS-induced mouse RAW 264.7 cells at 10 uM after 24 hrs by EIA | ChEMBL. | 20554444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.