Detailed information for compound 1159887

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 302.285 | Formula: C14H14N4O4
  • H donors: 2 H acceptors: 2 LogP: 1.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(nc2c1cc1OCOc1c2)C(=O)N=C(N)N
  • InChi: 1S/C14H14N4O4/c1-2-20-10-5-9(13(19)18-14(15)16)17-8-4-12-11(3-7(8)10)21-6-22-12/h3-5H,2,6H2,1H3,(H4,15,16,18,19)
  • InChiKey: MPWIZPFPGBVNAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.008 0.0556 0.0883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0238 0.2376 0.5371
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0308 0.0696
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0302 0.1943
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0132 0.1156 0.1156
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Echinococcus multilocularis jun protein 0.0262 0.2651 0.4205
Loa Loa (eye worm) hypothetical protein 0.0089 0.0667 0.0667
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0096 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1559 0.5923
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.008 0.0556 0.0883
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0302 1
Loa Loa (eye worm) DR-78 0.008 0.0556 0.0556
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2565 1
Schistosoma mansoni importin beta-1 0.0033 0.0017 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.1586 0.1586
Brugia malayi nuclear hormone receptor 0.0169 0.1586 0.1586
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0556 0.0883
Onchocerca volvulus 0.008 0.0556 0.0556
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0436 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1037 1
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0436 0.0692
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0401 0.0401
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0017 0.0027
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0089 0.0667 0.1507
Loa Loa (eye worm) hypothetical protein 0.0089 0.0667 0.0667
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0409 0.4355 0.6909
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.2565 0.2565
Brugia malayi RNA, U transporter 1 0.0094 0.0716 0.0716
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0667 0.0667
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1662 0.6342
Brugia malayi hypothetical protein 0.0037 0.0066 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0401 0.0637
Brugia malayi nuclear receptor NHR-88 0.008 0.0556 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0169 0.1586 0.1586
Brugia malayi Steroid receptor seven-up type 2 0.0169 0.1586 0.1586
Echinococcus multilocularis ecdysone induced protein 78C 0.0169 0.1586 0.2516
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.1586 0.2516
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2565 1
Echinococcus granulosus snurportin 1 0.0351 0.3687 0.8333
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0189 0.0883
Echinococcus multilocularis serotonin receptor 0.0415 0.4424 0.7018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0169 0.1586 0.3584
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0169 0.1586 0.2516
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0896 0.8507
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0238 0.2376 0.3769
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Echinococcus granulosus nuclear factor of activated T cells 5 0.0161 0.1494 0.3378
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0401 0.0637
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0308 0.2
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0774 0.1228
Echinococcus multilocularis Protein lozenge 0.0113 0.0937 0.1487
Echinococcus multilocularis thyroid hormone receptor alpha 0.0579 0.6304 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0169 0.1586 0.2516
Schistosoma mansoni lozenge 0.0113 0.0937 0.1487
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0089 0.0667 0.1058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0293 0.0293
Loa Loa (eye worm) nuclear receptor nhr-7B 0.008 0.0556 0.0556
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0071 0.0113
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.008 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0308 0.2
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0774 0.1228
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0293 0.0293
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1662 0.6342
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Onchocerca volvulus 0.0099 0.0774 0.0774
Schistosoma mansoni zinc finger protein 0.008 0.0556 0.0883
Loa Loa (eye worm) nuclear receptor NHR-67 0.008 0.0556 0.0556
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0302 1
Onchocerca volvulus 0.0899 1 1
Brugia malayi nuclear receptor RXR 0.0089 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0415 0.4424 0.4424
Loa Loa (eye worm) glutathione reductase 0.0048 0.0189 0.0189
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0169 0.1586 0.2516
Onchocerca volvulus 0.0092 0.07 0.07
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0436 1
Brugia malayi MAP kinase sur-1 0.0058 0.0308 0.0308
Schistosoma mansoni hypothetical protein 0.0353 0.3709 0.5885
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.0667 0.1058
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Echinococcus granulosus tumor protein p63 0.0372 0.3926 0.8875
Echinococcus granulosus FTZ F1 alpha 0.0169 0.1586 0.3584
Loa Loa (eye worm) hypothetical protein 0.0099 0.0774 0.0774
Schistosoma mansoni nuclear hormone receptor 0.008 0.0556 0.0883
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.1586 0.1586
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1037 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0401 0.0637
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2565 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0169 0.1586 0.3584
Loa Loa (eye worm) hypothetical protein 0.0099 0.0774 0.0774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.2376 0.3769
Loa Loa (eye worm) hypothetical protein 0.0254 0.2568 0.2568
Plasmodium falciparum thioredoxin reductase 0.0048 0.0189 0.6053
Brugia malayi Thioredoxin reductase 0.0048 0.0189 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0415 0.4424 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.000000021017 0.000000047506
Brugia malayi nuclear receptor NHR-67 0.008 0.0556 0.0556
Echinococcus granulosus thyroid hormone receptor alpha 0.008 0.0556 0.1258
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.1586 0.1586
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0238 0.2376 0.5371
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0071 0.0113
Schistosoma mansoni hypothetical protein 0.0353 0.3709 0.5885
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1559 0.5923
Plasmodium vivax glutathione reductase, putative 0.0048 0.0189 0.6053
Loa Loa (eye worm) CYP4Cod1 0.0064 0.0371 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0401 0.0637
Loa Loa (eye worm) hypothetical protein 0.0899 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0169 0.1586 0.1586
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Brugia malayi nuclear receptor NHR-88 0.0169 0.1586 0.1586
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0132 0.1156 0.1156
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0132 0.1156 0.1834
Brugia malayi ecdysteroid receptor 0.0169 0.1586 0.1586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0556 0.1258
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0086
Onchocerca volvulus Bile acid receptor homolog 0.0169 0.1586 0.1586
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0302 0.2501
Brugia malayi Cytochrome P450 family protein 0.0065 0.0382 0.0382
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0169 0.1586 0.3584
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0556 0.0883
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0308 0.2
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0371 0.0371
Brugia malayi Nuclear hormone receptor E75 0.008 0.0556 0.0556
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0293 0.0293
Schistosoma mansoni hypothetical protein 0.0038 0.0071 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.2376 0.3769
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0169 0.1586 0.1586
Schistosoma mansoni hypothetical protein 0.0351 0.3687 0.5849
Leishmania major trypanothione reductase 0.0048 0.0189 0.0883
Onchocerca volvulus 0.008 0.0556 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0308 0.0859
Brugia malayi Trypsin family protein 0.0099 0.0774 0.0774
Trypanosoma cruzi cytochrome P450, putative 0.0064 0.0371 0.2598
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0189 0.0428
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0136
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0169 0.1586 0.2516
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0308 0.0859
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0308 0.2
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.1586 0.3584
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0401 0.0637
Echinococcus multilocularis serotonin receptor 0.0415 0.4424 0.7018
Loa Loa (eye worm) hypothetical protein 0.0089 0.0667 0.0667
Brugia malayi hypothetical protein 0.008 0.0556 0.0556
Brugia malayi TAR-binding protein 0.0066 0.0401 0.0401
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2565 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0169 0.1586 0.2516
Loa Loa (eye worm) hypothetical protein 0.0089 0.0667 0.0667
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0089 0.0667 0.1058
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2565 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0096 0.0152
Schistosoma mansoni hypothetical protein 0.0213 0.2086 0.331
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.008 0.0556 0.0883
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0189 0.0189
Brugia malayi hypothetical protein 0.0089 0.0667 0.0667
Brugia malayi ecdysone receptor 0.008 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.0517 0.082
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0302 1
Loa Loa (eye worm) hypothetical protein 0.0415 0.4424 0.4424
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.0556 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0308 0.0859
Loa Loa (eye worm) hypothetical protein 0.0899 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0169 0.1586 0.1586
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1559 0.5923
Brugia malayi Nuclear hormone receptor-like 1 0.0169 0.1586 0.1586
Echinococcus granulosus tar DNA binding protein 0.0066 0.0401 0.0907
Schistosoma mansoni coup transcription factor 0.0169 0.1586 0.2516
Schistosoma mansoni jun-related protein 0.0213 0.2086 0.331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0169 0.1586 0.1586
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1559 0.5923
Loa Loa (eye worm) hypothetical protein 0.0058 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0057 0.0293 0.0293
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0238 0.2376 0.2376
Onchocerca volvulus Protein ultraspiracle homolog 0.0169 0.1586 0.1586
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.1156 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0262 0.2651 0.4205
Schistosoma mansoni nuclear receptor 0.008 0.0556 0.0883
Brugia malayi glutathione reductase 0.0048 0.0189 0.0189
Onchocerca volvulus 0.0205 0.2004 0.2004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0169 0.1586 0.2516
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0308 0.0488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0169 0.1586 0.1586
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0382 0.0382
Brugia malayi Importin beta-1 subunit 0.0033 0.0017 0.0017
Toxoplasma gondii exonuclease III APE 0.004 0.0096 0.188
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0169 0.1586 0.1586
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0265 0.0421
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0096 0.0216
Brugia malayi hypothetical protein 0.0038 0.0071 0.0071
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.1156 1
Echinococcus multilocularis FTZ F1 alpha 0.0169 0.1586 0.2516
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0436 1
Brugia malayi Protein kinase domain containing protein 0.0032 0.0006 0.0006
Brugia malayi hypothetical protein 0.0058 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0096 0.2768
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.3687 0.3687
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0436 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0169 0.1586 0.2516
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0096 0.5
Echinococcus granulosus geminin 0.0353 0.3709 0.8385
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1559 0.5923
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0896 0.8507
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0096 0.0224
Toxoplasma gondii thioredoxin reductase 0.0048 0.0189 0.4112
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0308 0.0859
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0189 0.03
Schistosoma mansoni ap endonuclease 0.004 0.0096 0.0152
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.1559 0.1559
Brugia malayi Death domain containing protein 0.0031 0.000000021017 0.000000021017
Brugia malayi nuclear hormone receptor family member nhr-6 0.008 0.0556 0.0556
Echinococcus multilocularis geminin 0.0353 0.3709 0.5885
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1559 0.5923
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0436 0.0692
Echinococcus granulosus importin subunit beta 1 0.0033 0.0017 0.0038
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0308 0.0488
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0401 0.0401
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1037 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0189 0.0995
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0169 0.1586 0.3584
Echinococcus granulosus transcription factor Dp 1 0.0076 0.0517 0.1168
Loa Loa (eye worm) RNA binding protein 0.0066 0.0401 0.0401
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0169 0.1586 0.1586
Schistosoma mansoni nuclear hormone receptor 0.0169 0.1586 0.2516
Schistosoma mansoni biogenic amine (5HT) receptor 0.0415 0.4424 0.7018
Mycobacterium tuberculosis Probable reductase 0.0109 0.0896 0.8507
Schistosoma mansoni thyroid hormone receptor 0.0579 0.6304 1
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0086 0.0086
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.1156 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0132 0.1156 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.008 0.0556 0.0883
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0308 0.0696
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0302 0.1943
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0096 0.0692
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0896 0.8507
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0556 0.1258
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.000000021017 0.000000033342
Leishmania major hypothetical protein, conserved 0.0058 0.0302 0.1943
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0132 0.1156 0.1834
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0436 0.3619
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0308 0.2554
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0308 0.6937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.1586 0.2516
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.008 0.0556 0.0883
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0169 0.1586 0.3584
Loa Loa (eye worm) nuclear hormone receptor 0.008 0.0556 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.2376 0.3769
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0096 0.2768
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0169 0.1586 0.2516
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.0556 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.1586 0.1586
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0169 0.1586 0.1586
Echinococcus granulosus jun protein 0.0262 0.2651 0.5992
Trypanosoma cruzi cytochrome P450, putative 0.0064 0.0371 0.2598
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0132 0.1156 0.2613
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0096 0.0096
Schistosoma mansoni ap endonuclease 0.004 0.0096 0.0152
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.1586 0.1586
Echinococcus multilocularis Ankyrin 0.0032 0.0003 0.0005
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.000000021017 0.000000033342
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0308 0.2
Schistosoma mansoni retinoic acid receptor RXR 0.0169 0.1586 0.2516
Brugia malayi Cytochrome P450 family protein 0.0064 0.0371 0.0371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.1586 0.3584
Brugia malayi hypothetical protein 0.0089 0.0667 0.0667
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1037 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0161 0.1494 0.237
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0896 0.8507
Brugia malayi Nuclear hormone receptor E75 0.008 0.0556 0.0556
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0169 0.1586 0.2516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0169 0.1586 0.1586
Brugia malayi tailless protein 0.008 0.0556 0.0556
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0436 0.3211
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2565 1
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0302 0.6793
Brugia malayi nuclear hormone receptor 0.008 0.0556 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0169 0.1586 0.1586
Echinococcus granulosus ecdysone induced protein 78C 0.0169 0.1586 0.3584
Echinococcus multilocularis nuclear receptor nhr 48 0.008 0.0556 0.0883
Brugia malayi bZIP transcription factor family protein 0.0262 0.2651 0.2651
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.0017
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0189 0.6053
Brugia malayi nuclear hormone receptor family member odr-7 0.008 0.0556 0.0556
Brugia malayi follicle stimulating hormone receptor 0.0799 0.8842 0.8842
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0401 0.0637
Brugia malayi Uncoordinated protein 44 0.0031 0.000000021017 0.000000021017
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Schistosoma mansoni RAR-like nuclear receptor 0.0169 0.1586 0.2516
Brugia malayi photoreceptor-specific nuclear receptor 0.0169 0.1586 0.1586
Loa Loa (eye worm) hypothetical protein 0.0089 0.0667 0.0667
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0371 0.0371
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0003 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1559 0.5923
Loa Loa (eye worm) runx1 0.0113 0.0937 0.0937
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0308 0.0308
Echinococcus multilocularis tumor protein p63 0.0372 0.3926 0.6229
Loa Loa (eye worm) hypothetical protein 0.0169 0.1586 0.1586
Loa Loa (eye worm) steroid hormone receptor 0.0169 0.1586 0.1586
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0308 0.0488
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0896 0.8507
Brugia malayi steroid hormone receptor 0.0169 0.1586 0.1586
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.2565 0.2565
Trypanosoma brucei cytochrome P450, putative 0.0064 0.0371 0.311
Schistosoma mansoni nuclear receptor 0.008 0.0556 0.0883
Brugia malayi orphan nuclear receptor NR2E1 0.008 0.0556 0.0556
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0064 0.0371 0.809
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0308 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0308 0.2
Loa Loa (eye worm) hypothetical protein 0.008 0.0556 0.0556
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0556 0.0883
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.1586 0.1586
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0262 0.2651 0.5992
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0169 0.1586 0.1586
Trypanosoma brucei protein kinase, putative 0.0058 0.0308 0.2554
Trypanosoma brucei trypanothione reductase 0.0048 0.0189 0.1514
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0436 0.0692
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0401 0.0401
Onchocerca volvulus 0.0169 0.1586 0.1586
Brugia malayi Cytochrome P450 family protein 0.0064 0.0371 0.0371
Schistosoma mansoni nuclear receptor nhr-48 0.008 0.0556 0.0883
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0436 0.0986
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0132 0.1156 1
Echinococcus granulosus nuclear receptor nhr 48 0.008 0.0556 0.1258
Plasmodium falciparum glutathione reductase 0.0048 0.0189 0.6053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0169 0.1586 0.1586
Schistosoma mansoni hypothetical protein 0.0409 0.4355 0.6909
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0799 0.8842 0.8842
Brugia malayi hypothetical protein 0.0205 0.2004 0.2004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0169 0.1586 0.2516
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0556 0.1258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0238 0.2376 0.2376
Brugia malayi conserved hypotetical protein 0.008 0.0556 0.0556
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.008 0.0556 0.1258
Schistosoma mansoni steroid hormone receptor ad4bp 0.0169 0.1586 0.2516
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0071 0.0161
Brugia malayi hypothetical protein 0.008 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0054 0.0265 0.0265
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0238 0.2376 0.3769
Brugia malayi nuclear receptor RXR 0.008 0.0556 0.0556
Echinococcus multilocularis snurportin 1 0.0351 0.3687 0.5849
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0089 0.0667 0.0667
Brugia malayi RNA binding protein 0.0066 0.0401 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0169 0.1586 0.1586
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0169 0.1586 0.1586
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0096 0.0096
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0409 0.4355 0.9845
Schistosoma mansoni thyroid hormone receptor 0.0579 0.6304 1
Echinococcus granulosus Ankyrin 0.0032 0.0003 0.0007
Onchocerca volvulus 0.0054 0.0265 0.0265
Leishmania major cytochrome p450-like protein 0.0064 0.0371 0.2598

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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