Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1699 | 0.1699 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.1699 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0855 | 0.0985 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0062 | 0.637 | 0.7344 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.1699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1699 | 0.1699 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0855 | 0.0855 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0718 | 0.4226 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.1699 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.1699 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.008 | 0.8674 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0013 | 0 | 0.5 |
Brugia malayi | glycyl-tRNA synthetase | 0.0062 | 0.637 | 0.7344 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.008 | 0.8674 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.1699 | 0.1959 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.009 | 1 | 1 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0062 | 0.637 | 0.637 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0067 | 0.7031 | 0.7031 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1699 | 0.1699 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.1699 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.1699 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.008 | 0.8674 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.1699 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.1699 | 0.1959 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0013 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.1699 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.008 | 0.8674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0855 | 0.0855 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0855 | 0.5028 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.008 | 0.8674 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0855 | 0.5028 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0062 | 0.637 | 0.7344 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0855 | 0.0855 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.1699 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0855 | 0.0855 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0855 | 0.0855 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0062 | 0.637 | 0.637 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.1699 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0855 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.008 | 0.8674 | 0.8402 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.1699 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0718 | 0.4226 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.1699 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.1699 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0718 | 0.4226 |
Treponema pallidum | methionyl-tRNA synthetase | 0.008 | 0.8674 | 1 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.1699 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.1699 | 0.1959 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.1699 | 0.5 | |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0062 | 0.637 | 0.7344 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0062 | 0.637 | 0.7344 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0718 | 0.4226 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.8674 | 0.8674 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0013 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.1699 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.63 uM | Inhibitory activity against Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS) | ChEMBL. | 12798340 |
IC50 (binding) | = 0.63 uM | Inhibitory activity against Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS) | ChEMBL. | 12798340 |
IC50 (binding) | = 1.93 uM | Inhibitory activity against Enterococci faecalis methionyl-tRNA synthetase (EfMetRS) | ChEMBL. | 12798340 |
IC50 (binding) | = 1.93 uM | Inhibitory activity against Enterococci faecalis methionyl-tRNA synthetase (EfMetRS) | ChEMBL. | 12798340 |
IC50 (binding) | > 100 uM | Inhibitory activity against human methionyl-tRNA synthetase (hMetRS). | ChEMBL. | 12798340 |
IC50 (binding) | > 100 uM | Inhibitory activity against human methionyl-tRNA synthetase (hMetRS). | ChEMBL. | 12798340 |
Ratio (binding) | > 159 | Selectivity ratio for inhibition of human Methionyl-tRNA synthetase to that of Staphylococcus aureus Methionyl-tRNA synthetase. | ChEMBL. | 12798340 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.