Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.4553 | 0.4553 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0189 | 0.0189 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.035 | 0.9901 | 0.9901 |
Brugia malayi | hypothetical protein | 0.0161 | 0.3814 | 0.3814 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.005 | 0.0215 | 0.0221 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0345 | 0.9757 | 0.9757 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.005 | 0.0215 | 0.0221 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0353 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0264 | 0.7138 | 0.7315 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.005 | 0.0215 | 0.0221 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.005 | 0.0215 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.005 | 0.0215 | 0.0221 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0215 | 0.0221 |
Trypanosoma cruzi | oligopeptidase b | 0.005 | 0.0215 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.3814 | 0.3814 |
Brugia malayi | prolyl oligopeptidase family protein | 0.005 | 0.0215 | 0.0215 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.005 | 0.0215 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0353 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.035 | 0.9901 | 0.9901 |
Plasmodium vivax | topoisomerase I, putative | 0.0353 | 1 | 1 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0264 | 0.7138 | 0.7315 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.005 | 0.0215 | 0.0215 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0089 | 0.1472 | 0.1508 |
Echinococcus multilocularis | prolyl endopeptidase | 0.005 | 0.0215 | 0.0215 |
Trypanosoma brucei | oligopeptidase b | 0.005 | 0.0215 | 0.0221 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.005 | 0.0215 | 0.0221 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.005 | 0.0215 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0345 | 0.9757 | 0.9757 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.005 | 0.0215 | 1 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0353 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0264 | 0.7138 | 0.7138 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0215 | 0.0221 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0345 | 0.9757 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0189 | 0.0189 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.005 | 0.0215 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.005 | 0.0215 | 0.0215 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0353 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.005 | 0.0215 | 0.0221 |
Plasmodium falciparum | topoisomerase I | 0.0353 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.005 | 0.0215 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0189 | 0.0189 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.005 | 0.0215 | 0.0215 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.005 | 0.0215 | 0.0221 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0345 | 0.9757 | 0.9757 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.005 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0215 | 0.0215 |
Leishmania major | oligopeptidase b | 0.005 | 0.0215 | 0.0221 |
Echinococcus granulosus | prolyl endopeptidase | 0.005 | 0.0215 | 0.0215 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.0215 | 0.0215 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.035 | 0.9901 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0211 | 0.542 | 0.542 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.005 | 0.0215 | 1 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0089 | 0.1472 | 0.1508 |
Trypanosoma brucei | prolyl endopeptidase | 0.005 | 0.0215 | 0.0221 |
Brugia malayi | prolyl oligopeptidase family protein | 0.005 | 0.0215 | 0.0215 |
Brugia malayi | prolyl oligopeptidase family protein | 0.005 | 0.0215 | 0.0215 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.005 | 0.0215 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0345 | 0.9757 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.035 | 0.9901 | 0.9901 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0264 | 0.7138 | 0.7315 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0353 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.7267 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.005 | 0.0215 | 0.0215 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.005 | 0.0215 | 0.0221 |
Entamoeba histolytica | hypothetical protein, conserved | 0.005 | 0.0215 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.035 | 0.9901 | 0.9901 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.005 | 0.0215 | 0.0215 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0345 | 0.9757 | 0.9757 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.005 | 0.0215 | 0.0215 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0089 | 0.1472 | 0.1508 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0189 | 0.0189 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0345 | 0.9757 | 1 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.005 | 0.0215 | 0.0215 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0345 | 0.9757 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.005 | 0.0215 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0264 | 0.7138 | 0.7138 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0345 | 0.9757 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.005 | 0.0215 | 0.0215 |
Trypanosoma cruzi | prolyl endopeptidase | 0.005 | 0.0215 | 0.0221 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.005 | 0.0215 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.005 | 0.0215 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.035 | 0.9901 | 0.9901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.