Detailed information for compound 1168795

Basic information

Technical information
  • TDR Targets ID: 1168795
  • Name: 5-chloro-6-[4-(2-hydroxyethyl)piperidin-1-yl] -1H-pyrimidine-2,4-dione
  • MW: 273.716 | Formula: C11H16ClN3O3
  • H donors: 3 H acceptors: 5 LogP: 1.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CCN(CC1)c1nc(O)nc(c1Cl)O
  • InChi: 1S/C11H16ClN3O3/c12-8-9(13-11(18)14-10(8)17)15-4-1-7(2-5-15)3-6-16/h7,16H,1-6H2,(H2,13,14,17,18)
  • InChiKey: RWWZYORFHGIOOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-6-[4-(2-hydroxyethyl)-1-piperidyl]-1H-pyrimidine-2,4-dione
  • 5-chloro-6-[4-(2-hydroxyethyl)-1-piperidinyl]-1H-pyrimidine-2,4-dione
  • 5-chloro-6-[4-(2-hydroxyethyl)-1-piperidyl]uracil

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2688 0.226
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Onchocerca volvulus Protein cycle homolog 0.0056 0.0184 0.0197
Onchocerca volvulus 0.0144 0.077 0.2066
Schistosoma mansoni hypothetical protein 0.0144 0.077 0.1663
Schistosoma mansoni microtubule-associated protein tau 0.0724 0.4631 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.0553 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.0651 0.048
Onchocerca volvulus 0.0144 0.077 0.2066
Brugia malayi RNA, U transporter 1 0.008 0.0346 0.1062
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0144 0.077 0.1663
Brugia malayi AKH receptor 0.0144 0.077 0.2365
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0166 0.0166
Echinococcus granulosus neuropeptide receptor A26 0.153 0.9993 0.9993
Loa Loa (eye worm) neuropeptide F receptor 0.0144 0.077 0.2365
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0144 0.077 0.077
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.5085 0.5085
Echinococcus granulosus tachykinin peptides receptor 99D 0.0144 0.077 0.077
Echinococcus multilocularis thymidine phosphorylase 0.1531 1 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0255 0.055
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0166 0.0358
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 1 1
Schistosoma mansoni hypothetical protein 0.0288 0.1728 0.3731
Brugia malayi Muscleblind-like protein 0.0147 0.0793 0.2435
Loa Loa (eye worm) hypothetical protein 0.0147 0.0793 0.2435
Loa Loa (eye worm) TYRA-2 protein 0.0144 0.077 0.2365
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.018 0.0553
Brugia malayi G protein-coupled receptor F59B2.13 0.0144 0.077 0.2365
Echinococcus multilocularis Protein lozenge 0.0065 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0047 0.0126 0.0272
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus neuropeptide s receptor 0.153 0.9993 0.9993
Echinococcus granulosus muscleblind protein 0.0147 0.0793 0.0793
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0107 0.0524 0.161
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0144 0.077 0.077
Brugia malayi Dopamine receptor protein 2 0.0144 0.077 0.2365
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.135 0.135
Schistosoma mansoni histamine h1 receptor 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.0561
Echinococcus granulosus g protein coupled receptor 0.0144 0.077 0.077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.0651 0.048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0524 0.161
Brugia malayi putative neuropeptide receptor 0.0144 0.077 0.2365
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0111 0.0553 1
Echinococcus multilocularis neuropeptide Y receptor 0.0144 0.077 0.077
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0144 0.077 0.077
Onchocerca volvulus 0.0144 0.077 0.2066
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0144 0.077 0.1663
Echinococcus granulosus g protein coupled receptor 0.0144 0.077 0.077
Echinococcus granulosus sex peptide receptor 0.0144 0.077 0.077
Schistosoma mansoni amine GPCR 0.0144 0.077 0.1663
Schistosoma mansoni biogenic amine (5HT) receptor 0.0144 0.077 0.1663
Schistosoma mansoni amine GPCR 0.0144 0.077 0.1663
Brugia malayi hypothetical protein 0.0056 0.0183 0.0561
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0144 0.077 0.2365
Echinococcus multilocularis aryl hydrocarbon receptor 0.008 0.0343 0.0343
Echinococcus granulosus peptide allatostatin:somatostatin 0.0144 0.077 0.077
Echinococcus granulosus biogenic amine 5HT receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Onchocerca volvulus 0.0144 0.077 0.2066
Onchocerca volvulus 0.0144 0.077 0.2066
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Brugia malayi GnHR receptor homolog 0.0144 0.077 0.2365
Echinococcus multilocularis neuropeptide s receptor 0.153 0.9993 0.9993
Schistosoma mansoni hypothetical protein 0.0073 0.0299 0.0646
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.0745 0.0575
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Echinococcus multilocularis G protein coupled receptor 139 0.0144 0.077 0.077
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.1814 0.5572
Echinococcus granulosus biogenic amine 5HT receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0111 0.0553 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0144 0.077 0.077
Schistosoma mansoni amine GPCR 0.0144 0.077 0.1663
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0144 0.077 0.077
Echinococcus multilocularis neuropeptides capa receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi neuropeptide F receptor 0.0144 0.077 0.2365
Schistosoma mansoni amine GPCR 0.0317 0.1924 0.4155
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi RNA binding protein 0.0066 0.0255 0.0783
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0524 0.161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0144 0.077 0.077
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.1064 0.1064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0038 0.0038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0038 0.0116
Brugia malayi G-protein coupled receptor 0.0144 0.077 0.2365
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0123 0.0377
Echinococcus granulosus fmrfamide receptor 0.0144 0.077 0.077
Echinococcus multilocularis muscleblind protein 0.0147 0.0793 0.0793
Schistosoma mansoni hypothetical protein 0.0034 0.0038 0.0081
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0038 0.0116
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0144 0.077 0.1663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0123 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0144 0.077 0.2365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Plasmodium falciparum thioredoxin reductase 0.0055 0.018 1
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.018 1
Onchocerca volvulus 0.0144 0.077 0.2066
Loa Loa (eye worm) hypothetical protein 0.0517 0.3256 1
Schistosoma mansoni opsin-like receptor 0.0144 0.077 0.1663
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.008 0.0343 0.1054
Echinococcus multilocularis GPCR, family 2 0.0034 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi mbt repeat family protein 0.0047 0.0123 0.0377
Schistosoma mansoni neuropeptide receptor 0.0144 0.077 0.1663
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0144 0.077 0.077
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.018 0.018
Echinococcus granulosus tm gpcr rhodopsin 0.0144 0.077 0.077
Onchocerca volvulus 0.0144 0.077 0.2066
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0255 0.0783
Onchocerca volvulus 0.0047 0.0126 0.0011
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) melatonin receptor type 1A 0.0144 0.077 0.2365
Loa Loa (eye worm) runx1 0.0065 0.0244 0.0751
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus rhodopsin orphan GPCR 0.0144 0.077 0.077
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0553 1
Echinococcus multilocularis neuropeptide Y receptor 0.0144 0.077 0.077
Loa Loa (eye worm) MBCTL1 0.0053 0.0166 0.0509
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.0745 0.0575
Loa Loa (eye worm) G-protein coupled receptor 0.0144 0.077 0.2365
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0255 0.055
Schistosoma mansoni survival motor neuron protein 0.0047 0.0126 0.0272
Echinococcus granulosus 7TM GPCR rhodopsin 0.0144 0.077 0.077
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0553 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Onchocerca volvulus 0.0144 0.077 0.2066
Echinococcus granulosus neuropeptide receptor 0.0144 0.077 0.077
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0144 0.077 0.077
Brugia malayi neuropeptide F receptor 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0147 0.0793 0.2435
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus GPCR family 2 0.0034 0.0038 0.0038
Brugia malayi ORL1-like opioid receptor 0.0144 0.077 0.2365
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0166 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Echinococcus multilocularis neuropeptide receptor A26 0.153 0.9993 0.9993
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2688 1
Schistosoma mansoni neuropeptide receptor 0.0144 0.077 0.1663
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0056 0.0184 0.0566
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0144 0.077 0.2365
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0166 0.0509
Echinococcus granulosus neuropeptide Y receptor 0.0144 0.077 0.077
Brugia malayi hypothetical protein 0.0231 0.135 0.4147
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0144 0.077 0.077
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0056 0.0184 0.0398
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni neuropeptide f receptor 76f 0.0144 0.077 0.1663
Echinococcus granulosus neuropeptides capa receptor 0.0144 0.077 0.077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.0561
Echinococcus multilocularis neuropeptide FF receptor 2 0.0144 0.077 0.077
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0126 0.0387
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0111 0.0553 0.5
Echinococcus multilocularis orexin receptor type 2 0.0144 0.077 0.077
Schistosoma mansoni lozenge 0.0065 0.0244 0.0528
Brugia malayi putative neuropeptide receptor NPR1 0.0144 0.077 0.2365
Trypanosoma brucei trypanothione reductase 0.0055 0.018 0.3256
Plasmodium vivax glutathione reductase, putative 0.0055 0.018 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus allatostatin A receptor 0.0144 0.077 0.077
Schistosoma mansoni inositol monophosphatase 0.0111 0.0553 0.1194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0524 0.161
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni opsin-like receptor 0.0144 0.077 0.1663
Echinococcus granulosus rhodopsin orphan GPCR 0.0144 0.077 0.077
Schistosoma mansoni neuropeptide F-like receptor 0.0144 0.077 0.1663
Echinococcus multilocularis fmrfamide receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0073 0.0299 0.0918
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0123 0.0265
Brugia malayi sulfakinin receptor protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi mbt repeat family protein 0.0047 0.0123 0.0377
Echinococcus granulosus hypothetical protein 0.0144 0.077 0.077
Echinococcus granulosus inositol monophosphatase 1 0.0111 0.0553 0.0553
Onchocerca volvulus 0.0144 0.077 0.2066
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0255 0.055
Schistosoma mansoni hypothetical protein 0.0034 0.0038 0.0081
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0144 0.077 0.1663
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.0745 0.1216
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni neuropeptide receptor 0.0144 0.077 0.1663
Brugia malayi hypothetical protein 0.0056 0.0184 0.0566
Loa Loa (eye worm) hypothetical protein 0.0053 0.0166 0.0509
Echinococcus granulosus serotonin receptor 0.0144 0.077 0.077
Echinococcus multilocularis G-protein coupled receptor, putative 0.0144 0.077 0.077
Echinococcus multilocularis g protein coupled receptor 0.0144 0.077 0.077
Loa Loa (eye worm) G-protein coupled receptor 0.0144 0.077 0.2365
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.0651 0.048
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0553 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0144 0.077 0.077
Schistosoma mansoni biogenic amine receptor 0.0144 0.077 0.1663
Brugia malayi glutathione reductase 0.0055 0.018 0.0553
Brugia malayi TAR-binding protein 0.0066 0.0255 0.0783
Echinococcus granulosus g protein coupled receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus multilocularis neuropeptide receptor 0.0144 0.077 0.077
Brugia malayi Thioredoxin reductase 0.0055 0.018 0.0553
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Loa Loa (eye worm) glutathione reductase 0.0055 0.018 0.0553
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0056 0.0183 0.0561
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2688 0.2554
Echinococcus multilocularis microtubule associated protein 2 0.0724 0.4631 0.4631
Brugia malayi Dopamine receptor protein 1 0.0144 0.077 0.2365
Onchocerca volvulus 0.0144 0.077 0.2066
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus aryl hydrocarbon receptor 0.008 0.0343 0.0343
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0038 0.0038
Onchocerca volvulus 0.0144 0.077 0.2066
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0255 0.0783
Echinococcus granulosus rhodopsin orphan GPCR 0.0144 0.077 0.077
Echinococcus multilocularis snurportin 1 0.0301 0.1814 0.1814
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0144 0.077 0.1663
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0144 0.077 0.1663
Schistosoma mansoni alpha-1 adrenergic receptor 0.0144 0.077 0.1663
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0144 0.077 0.1663
Schistosoma mansoni opsin-like receptor 0.0144 0.077 0.1663
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0255 0.055
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.135 0.135
Echinococcus granulosus dro:myosuppressin receptor 0.0144 0.077 0.077
Brugia malayi Melatonin receptor type 1A 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0034 0.0038 0.0116
Echinococcus multilocularis allatostatin A receptor 0.0144 0.077 0.077
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0144 0.077 0.077
Schistosoma mansoni myosin xvIII 0.0144 0.077 0.1663
Trichomonas vaginalis inositol monophosphatase, putative 0.0111 0.0553 0.5
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni hypothetical protein 0.0144 0.077 0.1663
Schistosoma mansoni biogenic amine (5HT) receptor 0.0144 0.077 0.1663
Echinococcus multilocularis serotonin receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0123 0.0123
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0123 0.0123
Onchocerca volvulus 0.0144 0.077 0.2066
Onchocerca volvulus 0.0144 0.077 0.2066
Echinococcus granulosus snurportin 1 0.0301 0.1814 0.1814
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0553 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0144 0.077 0.2365
Echinococcus granulosus g-protein coupled receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Mycobacterium ulcerans thymidine phosphorylase 0.1531 1 1
Schistosoma mansoni adenoreceptor 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.0561
Echinococcus granulosus somatostatin receptor 0.0144 0.077 0.077
Schistosoma mansoni hypothetical protein 0.0301 0.1814 0.3918
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus multilocularis inositol monophosphatase 1 0.0111 0.0553 0.0553
Brugia malayi Serotonin receptor 0.0144 0.077 0.2365
Schistosoma mansoni hypothetical protein 0.0034 0.0038 0.0081
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.0651 0.048
Echinococcus granulosus rhodopsin orphan GPCR 0.0144 0.077 0.077
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.01 0.0475 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0144 0.077 0.077
Echinococcus multilocularis serotonin receptor 0.0144 0.077 0.077
Brugia malayi G-protein coupled receptor 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0047 0.0123 0.0377
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0144 0.077 0.077
Echinococcus multilocularis neuropeptide receptor 0.0144 0.077 0.077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Schistosoma mansoni neuropeptide receptor 0.0144 0.077 0.1663
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0144 0.077 0.2365
Onchocerca volvulus 0.0144 0.077 0.2066
Toxoplasma gondii thioredoxin reductase 0.0055 0.018 0.3256
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0123 0.0123
Onchocerca volvulus Neuropeptide F receptor homolog 0.0144 0.077 0.2066
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus G protein coupled receptor 139 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi G protein-coupled receptor 0.0144 0.077 0.2365
Brugia malayi Dopamine receptor 0.0144 0.077 0.2365
Schistosoma mansoni hypothetical protein 0.0034 0.0038 0.0081
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0144 0.077 0.1663
Echinococcus multilocularis dro:myosuppressin receptor 0.0144 0.077 0.077
Schistosoma mansoni inositol monophosphatase 0.0111 0.0553 0.1194
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.1064 0.1064
Echinococcus multilocularis sex peptide receptor 0.0144 0.077 0.077
Echinococcus multilocularis neuropeptides capa receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Loa Loa (eye worm) RNA binding protein 0.0066 0.0255 0.0783
Echinococcus granulosus tm gpcr rhodopsin 0.0144 0.077 0.077
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0144 0.077 0.077
Echinococcus multilocularis somatostatin receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus rhodopsin orphan GPCR 0.0144 0.077 0.077
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0144 0.077 0.1663
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0123 0.0265
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0144 0.077 0.077
Brugia malayi RE15519p 0.0144 0.077 0.2365
Onchocerca volvulus 0.0144 0.077 0.2066
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0299 0.0918
Onchocerca volvulus 0.008 0.0342 0.0699
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0144 0.077 0.077
Echinococcus granulosus rhodopsin orphan GPCR 0.0144 0.077 0.077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0144 0.077 0.077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0056 0.0184 0.0566
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0144 0.077 0.2365
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.018 0.018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Schistosoma mansoni biogenic amine receptor 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Brugia malayi hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus alpha 1A adrenergic receptor 0.0144 0.077 0.077
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0255 0.0783
Loa Loa (eye worm) neuropeptide F receptor 0.0144 0.077 0.2365
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0255 0.055
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0144 0.077 0.077
Echinococcus granulosus neuropeptides capa receptor 0.0144 0.077 0.077
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0144 0.077 0.2365
Brugia malayi follicle stimulating hormone receptor 0.0144 0.077 0.2365
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0144 0.077 0.2365
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0038 0.0116
Echinococcus multilocularis g protein coupled receptor 0.0144 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0517 0.3256 1
Onchocerca volvulus 0.0144 0.077 0.2066
Echinococcus multilocularis fmrfamide receptor 0.0144 0.077 0.077
Brugia malayi Inositol-1 0.0111 0.0553 0.1698
Schistosoma mansoni growth hormone secretagogue receptor 0.0144 0.077 0.1663
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.0561
Plasmodium falciparum glutathione reductase 0.0055 0.018 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0255 0.0255
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0144 0.077 0.077
Echinococcus multilocularis g protein coupled receptor 0.0144 0.077 0.077
Mycobacterium tuberculosis Probable reductase 0.0126 0.0651 0.048
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0144 0.077 0.2365
Onchocerca volvulus 0.0144 0.077 0.2066
Echinococcus granulosus neuropeptide Y receptor 0.0144 0.077 0.077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Brugia malayi larval opioid receptor 0.0144 0.077 0.2365
Loa Loa (eye worm) hypothetical protein 0.0144 0.077 0.2365
Echinococcus granulosus microtubule associated protein 2 0.0724 0.4631 0.4631
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0144 0.077 0.2066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0144 0.077 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0144 0.077 0.1663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.0745 0.0575
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.0553 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0144 0.077 0.077
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0144 0.077 0.077
Schistosoma mansoni hypothetical protein 0.0144 0.077 0.1663
Schistosoma mansoni biogenic amine receptor 0.0144 0.077 0.1663
Echinococcus granulosus 7tm_1 domain containing protein 0.0144 0.077 0.077
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.0651 0.0794
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0056 0.0184 0.0566
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0038 0.0038
Schistosoma mansoni neuropeptide F-like receptor 0.0144 0.077 0.1663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0144 0.077 0.077
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0166 0.0166
Brugia malayi hypothetical protein 0.008 0.0342 0.1049
Loa Loa (eye worm) hypothetical protein 0.008 0.0342 0.1049
Schistosoma mansoni amine GPCR 0.0144 0.077 0.1663
Echinococcus granulosus orexin receptor type 2 0.0144 0.077 0.077
Onchocerca volvulus 0.0517 0.3256 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0144 0.077 0.077
Brugia malayi Serotonin receptor 0.0144 0.077 0.2365
Echinococcus granulosus neuropeptide receptor 0.0144 0.077 0.077
Loa Loa (eye worm) inositol-1 0.0111 0.0553 0.1698
Echinococcus granulosus neuropeptide FF receptor 2 0.0144 0.077 0.077
Brugia malayi hypothetical protein 0.0517 0.3256 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.0651 0.048
Loa Loa (eye worm) hypothetical protein 0.0231 0.135 0.4147
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0123 0.0123
Echinococcus multilocularis g-protein coupled receptor 0.0144 0.077 0.077
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0793 0.0793

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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