Detailed information for compound 1169180

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.511 | Formula: C25H27F2N5O2
  • H donors: 3 H acceptors: 3 LogP: 2.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(F)c2c(c1)c(ccn2)[C@H](CN1CCC(CC1)NCc1nc2c([nH]1)c(F)ccc2)O
  • InChi: 1S/C25H27F2N5O2/c1-34-16-11-18-17(5-8-28-24(18)20(27)12-16)22(33)14-32-9-6-15(7-10-32)29-13-23-30-21-4-2-3-19(26)25(21)31-23/h2-5,8,11-12,15,22,29,33H,6-7,9-10,13-14H2,1H3,(H,30,31)/t22-/m0/s1
  • InChiKey: KNVNPHYNKYIWDZ-QFIPXVFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0034 0.0567 0.0569
Schistosoma mansoni pyruvate kinase 0.0037 0.0624 0.0828
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0388 0.0795
Echinococcus granulosus pyruvate kinase 0.0019 0.0239 0.0286
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0671 0.1829
Echinococcus granulosus pyruvate kinase 0.0019 0.0239 0.0286
Schistosoma mansoni glucose transport protein 0.0111 0.2229 0.3089
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0339 0.7132 0.7165
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0552 0.0726
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0143 0.2908 1
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0368 0.4357
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0368 0.0467
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0337 0.0338
Plasmodium falciparum mitogen-activated protein kinase 2 0.018 0.3704 0.3595
Echinococcus multilocularis RUN 0.002 0.0263 0.0318
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0656 0.0873
Plasmodium vivax hexose transporter 0.0111 0.2229 0.2094
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0624 0.9141
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0302 0.0641
Loa Loa (eye worm) hypothetical protein 0.0038 0.0656 0.0659
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0656 0.0873
Schistosoma mansoni sugar transporter 0.0016 0.017 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0567 0.0747
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0624 0.2124
Schistosoma mansoni loxhd1 0.002 0.0263 0.0318
Echinococcus multilocularis solute carrier family 22 0.0016 0.017 0.0188
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0521 0.0683
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.017 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2891 0.4023
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0567 0.0747
Echinococcus granulosus RUN 0.002 0.0263 0.0318
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0368 0.0201
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0624 0.0706
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0567 0.0404
Giardia lamblia Pyruvate kinase 0.0019 0.0239 0.1523
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.017 0.0188
Onchocerca volvulus 0.0038 0.0656 0.0624
Brugia malayi Sugar transporter family protein 0.0016 0.017 0.0171
Schistosoma mansoni hypothetical protein 0.0017 0.0207 0.0241
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0143 0.2908 1
Echinococcus granulosus tar DNA binding protein 0.007 0.1335 0.183
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0263 0.0318
Brugia malayi hypothetical protein 0.002 0.0263 0.0264
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.017 0.0171
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.1035 0.1407
Echinococcus multilocularis solute carrier family 22 0.0016 0.017 0.0188
Echinococcus multilocularis Protein lozenge 0.0059 0.1103 0.1503
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0671 0.1829
Onchocerca volvulus 0.0016 0.017 0.0135
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0656 0.236
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0671 0.051
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0143 0.2908 0.2922
Echinococcus granulosus transcription factor Dp 1 0.0083 0.1613 0.2222
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.1145 0.3562
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0671 0.1829
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0009 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.0656 0.0659
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0337 0.0338
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.017 0.0171
Echinococcus multilocularis pyruvate kinase 0.0019 0.0239 0.0286
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0263 0.0318
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0517 0.1754
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2891 0.4023
Schistosoma mansoni importin beta-1 0.0032 0.0517 0.0677
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Schistosoma mansoni ran 0.0023 0.0337 0.0423
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.018 0.3704 0.3595
Schistosoma mansoni hypothetical protein 0.0339 0.7132 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0337 0.0423
Schistosoma mansoni glucose transport protein 0.0111 0.2229 0.3089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.1335 0.1342
Brugia malayi hypothetical protein 0.002 0.0263 0.0264
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0576 0.1973
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0576 0.1483
Onchocerca volvulus 0.002 0.0263 0.0228
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.2229 0.3089
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Loa Loa (eye worm) sugar transporter 0.0111 0.2229 0.2239
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.2229 0.3089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Echinococcus granulosus snurportin 1 0.0339 0.7132 1
Onchocerca volvulus 0.047 0.9954 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0552 0.0838
Onchocerca volvulus Putative transporter 0.0016 0.017 0.0135
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0656 0.0873
Echinococcus multilocularis geminin 0.0332 0.6982 0.9788
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0009 0.0037 0.0037
Echinococcus multilocularis tar DNA binding protein 0.007 0.1335 0.183
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0239 0.0108
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0624 0.1659
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0263 0.0318
Plasmodium vivax importin-beta 2, putative 0.0032 0.0517 0.0353
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0388 0.1057
Entamoeba histolytica protein kinase, putative 0.0034 0.0567 0.0895
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0207 0.0241
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2891 0.4023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0656 0.1774
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Onchocerca volvulus 0.0038 0.0656 0.0624
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.017 0.0188
Toxoplasma gondii protein kinase, putative 0.0315 0.6601 1
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Schistosoma mansoni tar DNA-binding protein 0.007 0.1335 0.183
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0567 0.0747
Brugia malayi beta-lactamase 0.0038 0.0656 0.0659
Onchocerca volvulus 0.0016 0.017 0.0135
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0671 0.2285
Echinococcus multilocularis transcription factor Dp 1 0.0083 0.1613 0.2222
Echinococcus multilocularis solute carrier family 22 0.0016 0.017 0.0188
Schistosoma mansoni pyruvate kinase 0.0037 0.0624 0.0828
Onchocerca volvulus 0.0016 0.017 0.0135
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0552 0.1855
Brugia malayi major facilitator superfamily protein 0.0016 0.017 0.0171
Plasmodium falciparum protein kinase 7 0.0315 0.6601 0.6542
Schistosoma mansoni tar DNA-binding protein 0.007 0.1335 0.183
Brugia malayi TAR-binding protein 0.007 0.1335 0.1342
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0263 0.0318
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0009 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0656 0.5375
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0567 0.0569
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0368 0.037
Schistosoma mansoni tar DNA-binding protein 0.007 0.1335 0.183
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0656 0.236
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0567 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0567 0.0747
Leishmania major pyruvate kinase 0.0037 0.0624 0.1659
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.0263 0.0264
Brugia malayi major facilitator superfamily protein 0.0016 0.017 0.0171
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Mycobacterium leprae Probable lipase LipE 0.0038 0.0656 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0641 0.0644
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0207 0.0208
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0337 0.3664
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0337 0.0259
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0656 0.0988
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0567 0.0747
Loa Loa (eye worm) hypothetical protein 0.0038 0.0656 0.0659
Loa Loa (eye worm) hypothetical protein 0.0033 0.0552 0.0555
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0656 0.0659
Loa Loa (eye worm) beta-lactamase 0.0038 0.0656 0.0659
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Schistosoma mansoni sugar transporter 0.0016 0.017 0.0188
Echinococcus multilocularis pyruvate kinase 0.0037 0.0624 0.0828
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0671 0.051
Onchocerca volvulus 0.0016 0.017 0.0135
Loa Loa (eye worm) hypothetical protein 0.0038 0.0656 0.0659
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0073 0.0073
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0368 0.0723
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0368 0.2654
Loa Loa (eye worm) hypothetical protein 0.0038 0.0656 0.0659
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0576 0.1973
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0656 0.0988
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0656 0.0988
Entamoeba histolytica protein kinase, putative 0.0034 0.0567 0.0895
Echinococcus granulosus solute carrier family 22 0.0016 0.017 0.0188
Trypanosoma brucei glucose transporter 1E 0.0035 0.0576 0.1958
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1145 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.4926 0.4949
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Loa Loa (eye worm) runx1 0.0059 0.1103 0.1108
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0624 0.0593
Schistosoma mansoni protein kinase 0.0034 0.0567 0.0747
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0368 0.0961
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.017 0.0188
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0656 1
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0263 0.0094
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0287 0.0238
Loa Loa (eye worm) RNA binding protein 0.007 0.1335 0.1342
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0552 0.0555
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0624 0.2206
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.2229 0.3201
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0552 0.0726
Onchocerca volvulus 0.0016 0.017 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0576 0.1973
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0567 0.0404
Brugia malayi Importin beta-1 subunit 0.0032 0.0517 0.0519
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.017 0.0784
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0671 0.0779
Mycobacterium tuberculosis Conserved protein 0.0038 0.0656 0.0988
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Onchocerca volvulus 0.0016 0.017 0.0135
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0337 0.0169
Loa Loa (eye worm) hypothetical protein 0.0025 0.0368 0.037
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0656 0.0988
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0263 0.0094
Loa Loa (eye worm) hypothetical protein 0.0032 0.0517 0.0519
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.2891 0.2905
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0567 0.0404
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0517 0.1754
Leishmania major glucose transporter, lmgt2 0.0035 0.0576 0.1483
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0576 0.1973
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0656 0.236
Schistosoma mansoni glucose transport protein 0.0111 0.2229 0.3089
Loa Loa (eye worm) hypothetical protein 0.0033 0.0552 0.0555
Loa Loa (eye worm) hypothetical protein 0.002 0.0263 0.0264
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Echinococcus granulosus solute carrier family 22 0.0016 0.017 0.0188
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0567 0.1926
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0385 0.0188
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0656 0.236
Brugia malayi RNA binding protein 0.007 0.1335 0.1342
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0576 0.1958
Brugia malayi RNA, U transporter 1 0.009 0.1778 0.1786
Leishmania major glucose transporter, lmgt1 0.0035 0.0576 0.1483
Brugia malayi basement membrane proteoglycan precursor 0.0009 0.0037 0.0037
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0567 0.0617
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1145 0.1563
Leishmania major hypothetical protein, conserved 0.0038 0.0656 0.1774
Mycobacterium tuberculosis Conserved protein 0.0038 0.0656 0.0988
Plasmodium falciparum importin beta, putative 0.0032 0.0517 0.0353
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0263 0.0318
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0624 0.0593
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0624 0.2206
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0143 0.2908 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0207 0.0241
Brugia malayi Sugar transporter family protein 0.0111 0.2229 0.2239
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.2229 0.3089
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0656 0.0494
Leishmania major GTP-binding protein, putative 0.0023 0.0337 0.0608
Plasmodium falciparum hexose transporter 0.0111 0.2229 0.2094
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Loa Loa (eye worm) hypothetical protein 0.0037 0.0624 0.0627
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0567 0.0617
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.2229 0.3089
Brugia malayi enteropeptidase precursor 0.0009 0.0037 0.0037
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0368 0.2187
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0576 0.1973
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0337 0.0608
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0388 0.1057
Schistosoma mansoni sugar transporter 0.0016 0.017 0.0188
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0026 0.0388 0.0199
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0624 0.0627
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0656 0.0988
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0552 0.8407
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0552 0.0726
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.2229 0.3089
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0552 0.0555
Schistosoma mansoni hypothetical protein 0.002 0.0263 0.0318
Loa Loa (eye worm) hypothetical protein 0.0026 0.0385 0.0387
Mycobacterium ulcerans sugar transporter 0.0016 0.017 0.0784
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0385 0.0387
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1145 0.1563
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0037 0.0037
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0567 0.0404
Brugia malayi follicle stimulating hormone receptor 0.0237 0.4926 0.4949
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0207 0.0241
Leishmania major importin beta-1 subunit, putative 0.0026 0.0388 0.0795
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0656 0.0988
Echinococcus multilocularis pyruvate kinase 0.0019 0.0239 0.0286
Loa Loa (eye worm) hypothetical protein 0.047 0.9954 1
Schistosoma mansoni lipoxygenase 0.002 0.0263 0.0318
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0576 0.1973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2891 0.4023
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.2229 0.3089
Schistosoma mansoni lozenge 0.0059 0.1103 0.1503
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0552 0.7178
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0656 0.0873
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0624 0.0627
Loa Loa (eye worm) TAR-binding protein 0.007 0.1335 0.1342
Onchocerca volvulus 0.0016 0.017 0.0135
Echinococcus multilocularis solute carrier family 22 0.0016 0.017 0.0188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1015 0.102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0207 0.0208
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0368 0.5228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.2891 0.2905
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0517 0.0677
Loa Loa (eye worm) sugar transporter 0.0016 0.017 0.0171
Plasmodium falciparum pyruvate kinase 0.0037 0.0624 0.0462
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Onchocerca volvulus 0.0016 0.017 0.0135
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0624 0.0593
Echinococcus granulosus General substrate transporter 0.0096 0.1892 0.2615
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2891 0.4023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2891 0.4023
Mycobacterium tuberculosis Conserved protein 0.0038 0.0656 0.0988
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0368 0.0308
Toxoplasma gondii ABC1 family protein 0.0038 0.0656 0.0755
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0656 0.2233
Echinococcus granulosus solute carrier family 22 0.0016 0.017 0.0188
Schistosoma mansoni hypothetical protein 0.0017 0.0207 0.0241
Schistosoma mansoni polycystin 1-related 0.002 0.0263 0.0318
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0143 0.2908 1
Schistosoma mansoni rab6-interacting 0.002 0.0263 0.0318
Mycobacterium ulcerans lipase LipD 0.0038 0.0656 0.5375
Echinococcus granulosus pyruvate kinase 0.0037 0.0624 0.0828
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0624 0.0627
Schistosoma mansoni hypothetical protein 0.0332 0.6982 0.9788
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0671 0.1829
Schistosoma mansoni tar DNA-binding protein 0.007 0.1335 0.183
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0143 0.2908 0.4047
Loa Loa (eye worm) hypothetical protein 0.047 0.9954 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0368 0.0467
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0517 0.0539
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Leishmania major glucose transporter, lmgt3 0.0035 0.0576 0.1483
Echinococcus granulosus GPCR family 2 0.0017 0.0207 0.0241
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.018 0.3704 0.5495
Brugia malayi hypothetical protein 0.0016 0.017 0.0171
Onchocerca volvulus 0.0038 0.0656 0.0624
Schistosoma mansoni hypothetical protein 0.0017 0.0207 0.0241
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.017 0.0171
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0567 0.0404
Onchocerca volvulus 0.0016 0.017 0.0135
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0368 0.2654
Leishmania major pyruvate kinase 0.0037 0.0624 0.1659
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Brugia malayi beta-lactamase family protein 0.0038 0.0656 0.0659
Onchocerca volvulus 0.0016 0.017 0.0135
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.017 0.0188
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0576 0.1483
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0656 0.1774
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0337 0.0608
Echinococcus multilocularis pyruvate kinase 0.0037 0.0624 0.0828
Echinococcus multilocularis pyruvate kinase 0.0029 0.0458 0.0593
Onchocerca volvulus 0.0016 0.017 0.0135
Schistosoma mansoni rab6-interacting 0.002 0.0263 0.0318
Schistosoma mansoni tar DNA-binding protein 0.007 0.1335 0.183
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Schistosoma mansoni ran 0.0023 0.0337 0.0423
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0239 0.007
Brugia malayi Doublecortin family protein 0.002 0.0263 0.0264
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1145 0.1983
Brugia malayi hypothetical protein 0.047 0.9954 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0239 0.007
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0009 0.0037 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2891 0.4023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0128 0.0129
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0576 0.1973
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0552 0.0726
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.017 0.0784
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0656 0.0659
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0656 0.0988
Trypanosoma brucei sugar transporter, putative 0.0016 0.017 0.0558
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0143 0.2908 1
Brugia malayi hypothetical protein 0.0016 0.017 0.0171
Echinococcus granulosus solute carrier family 22 0.0016 0.017 0.0188
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1015 0.102
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Schistosoma mansoni hypothetical protein 0.0017 0.0207 0.0241
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0368 0.0723
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0143 0.2908 0.4047
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0567 0.1927
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0567 0.0404
Loa Loa (eye worm) hypothetical protein 0.0027 0.0417 0.0419
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Giardia lamblia Pyruvate kinase 0.0037 0.0624 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.1145 0.1563
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0624 0.1659
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0368 0.0201
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0624 0.5076
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.1057 0.1062
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.1035 0.1407
Schistosoma mansoni hypothetical protein 0.0038 0.0641 0.0852
Schistosoma mansoni protein kinase 0.0034 0.0567 0.0747
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1015 0.102
Trypanosoma brucei glucose transporter 2A 0.0035 0.0576 0.1958
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0624 0.0627
Schistosoma mansoni protein kinase 0.0034 0.0567 0.0747
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Brugia malayi Sugar transporter family protein 0.0016 0.017 0.0171
Brugia malayi RNA recognition motif domain containing protein 0.007 0.1335 0.1342
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.017 0.0784
Mycobacterium ulcerans beta-lactamase 0.0038 0.0656 0.5375
Schistosoma mansoni sugar transporter 0.0016 0.017 0.0188
Trichomonas vaginalis esterase, putative 0.0038 0.0656 0.236
Schistosoma mansoni lipoxygenase 0.0056 0.1035 0.1407
Entamoeba histolytica hypothetical protein 0.0025 0.0368 0.0122
Brugia malayi hypothetical protein 0.0016 0.017 0.0171
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0207 0.0241
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0239 0.0253
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Onchocerca volvulus 0.0016 0.017 0.0135
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0656 0.5375
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0087 0.5
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0263 0.0318
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0567 0.0747
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0656 0.236
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0576 0.1958
Loa Loa (eye worm) doublecortin family protein 0.002 0.0263 0.0264
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0368 0.0467
Loa Loa (eye worm) hypothetical protein 0.0038 0.0641 0.0644
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0576 0.1958
Echinococcus multilocularis General substrate transporter 0.0096 0.1892 0.2615
Onchocerca volvulus 0.0016 0.017 0.0135
Schistosoma mansoni hypothetical protein 0.0111 0.2229 0.3089
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0368 0.0467
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.2229 0.3089
Chlamydia trachomatis pyruvate kinase 0.0037 0.0624 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0656 0.5375
Loa Loa (eye worm) hypothetical protein 0.0038 0.0656 0.0659
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.017 0.0558
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Trypanosoma cruzi hexose transporter 0.0035 0.0576 0.1483
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0521 0.0683
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0567 0.0569
Echinococcus granulosus importin subunit beta 1 0.0032 0.0517 0.0677
Brugia malayi CUB domain containing protein 0.0009 0.0037 0.0037
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0567 0.0404
Echinococcus multilocularis pyruvate kinase 0.0019 0.0239 0.0286
Echinococcus granulosus geminin 0.0332 0.6982 0.9788
Onchocerca volvulus 0.0016 0.017 0.0135
Echinococcus granulosus pyruvate kinase 0.0019 0.0239 0.0286
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.2229 0.3089
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0143 0.2908 0.4047
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.017 0.5
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0576 0.1483
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Plasmodium vivax CDK-related protein kinase 6, putative 0.0473 1 1
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0624 0.0462
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0567 0.0747
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0143 0.2908 0.2922
Onchocerca volvulus 0.0016 0.017 0.0135
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0576 0.1483
Schistosoma mansoni hypothetical protein 0.0332 0.6982 0.9788
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0567 0.0747
Leishmania major protein kinase, putative 0.0034 0.0567 0.1449
Schistosoma mansoni glucose transporter 0.0016 0.017 0.0188
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0368 0.124
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0567 0.0747
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0337 0.0423
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.5089 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0624 0.0627
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0287 0.0238
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0567 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.2229 1
Onchocerca volvulus 0.0016 0.017 0.0135
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0171
Schistosoma mansoni pyruvate kinase 0.0019 0.0239 0.0286
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1145 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1015 0.102
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0388 0.1057
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.1145 0.1151
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0337 0.1131
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0337 0.0169
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0624 0.2124
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Brugia malayi beta-lactamase family protein 0.0038 0.0656 0.0659
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.0037
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0567 0.0404
Echinococcus multilocularis snurportin 1 0.0339 0.7132 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0207 0.0208
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0037 0.0037
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.017 0.0171
Trypanosoma brucei glucose transporter, putative 0.0035 0.0576 0.1958
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0624 0.0923
Echinococcus granulosus pyruvate kinase 0.0037 0.0624 0.0828
Trichomonas vaginalis ran, putative 0.0023 0.0337 0.0808
Onchocerca volvulus 0.002 0.0263 0.0228
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0207 0.0241
Brugia malayi Cam kinase protein 1 0.0034 0.0567 0.0569
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0207 0.0208
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.017 0.0188
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0567 0.0617

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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