TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 570.757 | Formula: C34H50O7
H donors: 1 H acceptors: 4 LogP: 6.1 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COC(/C(=C/C=C/C(=C\1/C(=O)C[C@H]2[C@]1(C)CC[C@@H]1[C@]2(C)CC[C@H]([C@]1(C)C(=O)OC)OC(=O)C)/C)/C)/C=C/C(O)(C)C
InChi: 1S/C34H50O7/c1-21(25(39-9)14-17-31(4,5)38)12-11-13-22(2)29-24(36)20-27-32(6)19-16-28(41-23(3)35)34(8,30(37)40-10)26(32)15-18-33(27,29)7/h11-14,17,25-28,38H,15-16,18-20H2,1-10H3/b13-11+,17-14+,21-12+,29-22-/t25?,26-,27-,28-,32+,33+,34-/m1/s1
InChiKey: QIHQIMPZPQVOJO-ZQZPQVQISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0033	0.0278	0.0997
Toxoplasma gondii	ion channel protein	0.0033	0.0278	0.4032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0127
Echinococcus multilocularis	lamin	0.0028	0.0217	0.0217
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0065	0.0065
Echinococcus multilocularis	musashi	0.0028	0.0217	0.0217
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0177	0.0634
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0092	0.3317
Echinococcus granulosus	calcium activated potassium channel variant	0.0033	0.0278	0.0346
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Schistosoma mansoni	patched 1	0.0044	0.0408	0.0509
Trypanosoma cruzi	ion transport protein, putative	0.0033	0.0278	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0208	0.6029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Plasmodium falciparum	potassium channel	0.0033	0.0278	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0177	0.1592
Schistosoma mansoni	lamin	0.0028	0.0217	0.0271
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0033	0.0278	0.0997
Echinococcus multilocularis	potassium channel subfamily K 8	0.0033	0.0278	0.0278
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0033	0.0278	0.0997
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0177	0.1319
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0177	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0621	0.0774
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0753	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0308	0.3544	0.4417
Brugia malayi	hypothetical protein	0.0018	0.0092	0.033
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.0408	0.0509
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0419	0.0522
Echinococcus granulosus	potassium channel subfamily K	0.0033	0.0278	0.0346
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0419	0.0419
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0753	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0029	0.023	0.0286
Echinococcus granulosus	potassium channel subfamily K 8	0.0033	0.0278	0.0346
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0092	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0279	0.0348
Echinococcus granulosus	Niemann Pick C1 protein	0.0103	0.1109	0.1383
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0408	0.154
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0408	0.0509
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0669	0.0834
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.0092	0.3317
Brugia malayi	CHE-14 protein	0.0044	0.0408	0.1465
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0217	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0163
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0102	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0065	0.0065
Leishmania major	ion transport protein-like protein	0.0033	0.0278	0.3219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Brugia malayi	hypothetical protein	0.0027	0.0208	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0621	0.0774
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0092	0.2973
Giardia lamblia	Hypothetical protein	0.0033	0.0278	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.0485
Echinococcus granulosus	lamin dm0	0.0028	0.0217	0.0271
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0033	0.0278	0.0997
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.0092	0.2973
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0065	0.0234
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0033	0.0278	0.0997
Onchocerca volvulus		0.0033	0.0278	0.0409
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0483	0.0483
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0278	0.1049
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0621	0.0774
Loa Loa (eye worm)	TWK-7 protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Mycobacterium ulcerans	ion transport protein	0.0033	0.0278	0.3103
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0092	0.3317
Schistosoma mansoni	hypothetical protein	0.0015	0.0065	0.0081
Entamoeba histolytica	hypothetical protein	0.0073	0.0753	0.6787
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0279	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.0171	0.0614
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0014	0.0051
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0217	0.027
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0033	0.0278	0.0997
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0033	0.0278	0.0997
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0043	0.0054
Entamoeba histolytica	hypothetical protein	0.0073	0.0753	0.6787
Schistosoma mansoni	hypothetical protein	0.0684	0.8024	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.0408	0.0509
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0033	0.0278	0.0997
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0092	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0177	0.022
Onchocerca volvulus		0.0033	0.0278	0.0409
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0177	0.1466
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0033	0.0278	0.0997
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0217	0.0271
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0033	0.0278	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0244	0.2785	0.3471
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.0092	0.0831
Loa Loa (eye worm)	uncoordinated protein 58	0.0033	0.0278	0.0346
Echinococcus multilocularis	Niemann Pick C1 protein	0.0147	0.1637	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0127
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0208	0.7485
Schistosoma mansoni	hypothetical protein	0.0012	0.0028	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0621	0.0774
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0061	0.0219
Plasmodium falciparum	potassium channel	0.0033	0.0278	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0103	0.1109	0.3983
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0033	0.0278	1
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0033	0.0278	0.0346
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0419	0.0522
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0033	0.0278	0.0346
Onchocerca volvulus		0.0033	0.0278	0.0409
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0033	0.0278	0.0278
Echinococcus granulosus	serine protein kinase ATM	0.0024	0.0171	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1109	0.1383
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.0092	0.3317
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Plasmodium vivax	potassium channel, putative	0.0033	0.0278	1
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0033	0.0278	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0208	0.2966
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.0092	0.2973
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0092	0.0331
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0669	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0092	0.2973
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Schistosoma mansoni	hypothetical protein	0.0362	0.4195	0.5228
Echinococcus granulosus	small conductance calcium activated potassium	0.0684	0.8024	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.023	0.023
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.0092	0.2973
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.0046
Schistosoma mansoni	calcium-activated potassium channel	0.0651	0.7627	0.9505
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0092	0.0115
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0753	0.0938
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0177	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0621	0.0774
Schistosoma mansoni	hypothetical protein	0.0015	0.0065	0.0081
Onchocerca volvulus		0.0033	0.0278	0.0409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0621	0.0774
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0177	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0621	0.0621
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0065	0.0065
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0669	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0092	0.0092
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0177	0.1466
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Entamoeba histolytica	hypothetical protein	0.0073	0.0753	0.6787
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.023	0.0286
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0177	0.1466
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0278	0.1049
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0419	0.1504
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0065	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Schistosoma mansoni	hypothetical protein	0.0033	0.0278	0.0346
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0033	0.0278	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0177	0.1592
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0033	0.0278	0.0997
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0043	0.0043
Leishmania major	potassium channel subunit-like protein	0.0033	0.0278	0.3219
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.0485
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.0408	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Onchocerca volvulus		0.0233	0.2649	1
Leishmania major	hypothetical protein, conserved	0.0033	0.0278	0.3219
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0208	0.7355
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0024	0.0171	0.5961
Echinococcus multilocularis	Niemann Pick C1 protein	0.0103	0.1109	0.1109
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0024	0.0171	0.0213
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0419	0.0522
Echinococcus granulosus	expressed conserved protein	0.0097	0.1035	0.129
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0177	0.15
Echinococcus granulosus	intermediate filament protein	0.0028	0.0217	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0278	0.1049
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0463	0.0577
Onchocerca volvulus		0.0033	0.0278	0.0409
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2313	0.2883
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Echinococcus granulosus	GPCR family 2	0.0015	0.0065	0.0081
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0177	0.1319
Brugia malayi	TAR-binding protein	0.0062	0.0621	0.223
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0621	0.0774
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0033	0.0278	0.0997
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0093	0.3332
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.2649	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0208	0.6029
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0669	0.0669
Echinococcus granulosus	twik family of potassium channels	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Echinococcus granulosus	twik family of potassium channels	0.0033	0.0278	0.0346
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.013	0.4695
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0527	0.0656
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Schistosoma mansoni	hypothetical protein	0.0015	0.0065	0.0081
Echinococcus multilocularis	serine protein kinase ATM	0.0024	0.0171	0.0171
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0208	0.7485
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0177	0.0634
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0419	0.0522
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0419	0.0419
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0033	0.0278	0.0997
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0033	0.0278	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0065	0.0081
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0621	0.223
Loa Loa (eye worm)	hypothetical protein	0.0684	0.8024	1
Echinococcus multilocularis	geminin	0.0362	0.4195	0.4195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0217	0.0271
Echinococcus multilocularis	potassium channel subfamily K 8	0.0033	0.0278	0.0278
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0102	0.0209
Plasmodium vivax	potassium channel, putative	0.0033	0.0278	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Plasmodium vivax	SET domain protein, putative	0.0029	0.023	0.7263
Trypanosoma cruzi	ion transport protein, putative	0.0033	0.0278	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0171	0.1542
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0217	0.078
Brugia malayi	follicle stimulating hormone receptor	0.0244	0.2785	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0278	0.1049
Echinococcus granulosus	potassium channel subfamily K 8	0.0033	0.0278	0.0346
Onchocerca volvulus		0.0033	0.0278	0.0409
Onchocerca volvulus		0.0033	0.0278	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0463	0.1664
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.023	0.3297
Loa Loa (eye worm)	hypothetical protein	0.0343	0.3963	0.4939
Schistosoma mansoni	hypothetical protein	0.0073	0.0753	0.0938
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0669	0.0834
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0061	0.0076
Mycobacterium ulcerans	transmembrane cation transporter	0.0033	0.0278	0.3103
Schistosoma mansoni	calcium-activated potassium channel	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0463	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0033	0.0278	0.2504
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.023	0.0286
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0092	0.0115
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.0092	0.0831
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Onchocerca volvulus		0.0029	0.023	0.0214
Echinococcus multilocularis	twik family of potassium channels	0.0033	0.0278	0.0278
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0024	0.0171	0.6159
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0177	0.15
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0177	0.1319
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0028	0.0034
Brugia malayi	hypothetical protein	0.0073	0.0753	0.2703
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0621	0.0774
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.023	0.0286
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0092	0.0115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0177	0.0634
Echinococcus multilocularis	small conductance calcium activated potassium	0.0684	0.8024	0.8024
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Entamoeba histolytica	hypothetical protein	0.0073	0.0753	0.6787
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0621	0.0774
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0177	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0177	0.022
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0014	0.0051
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Toxoplasma gondii	FATC domain-containing protein	0.0024	0.0171	0.2403
Echinococcus multilocularis	calcium activated potassium channel variant	0.0033	0.0278	0.0278
Schistosoma mansoni	calcium-activated potassium channel	0.0033	0.0278	0.0346
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0177	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.0092	0.3317
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0033	0.0278	1
Brugia malayi	intermediate filament protein	0.0028	0.0217	0.078
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0177	0.022
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0177	0.1319
Echinococcus granulosus	geminin	0.0362	0.4195	0.5228
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0669	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.0485
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.023	0.0286
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Echinococcus multilocularis	expressed conserved protein	0.0097	0.1035	0.1035
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0127
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0093	0.0007
Echinococcus multilocularis	protein patched	0.0044	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0033	0.0278	0.0997
Brugia malayi	RNA binding protein	0.0062	0.0621	0.223
Schistosoma mansoni	calcium-activated potassium channel	0.0684	0.8024	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.023	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Leishmania major	calcium/potassium channel (CAKC), putative	0.0033	0.0278	0.3219
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0669	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0065	0.0081
Echinococcus multilocularis	twik family of potassium channels	0.0033	0.0278	0.0278
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0177	0.1592
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0033	0.0278	0.0346
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0103	0.1109	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0208	0.2008
Onchocerca volvulus		0.0033	0.0278	0.0409
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0177	0.1319
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0092	0.0115
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0278	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0211	0.0263
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0208	0.0259
Brugia malayi	Pre-SET motif family protein	0.0029	0.023	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.0046
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0033	0.0278	0.0346
Schistosoma mansoni	hypothetical protein	0.0043	0.0389	0.0485
Schistosoma mansoni	hypothetical protein	0.0362	0.4195	0.5228
Brugia malayi	Pre-SET motif family protein	0.0204	0.2313	0.8305
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0033	0.0278	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Schistosoma mansoni	hypothetical protein	0.0033	0.0279	0.0348
Brugia malayi	hypothetical protein	0.0033	0.0278	0.0997
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.0408	0.0408
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0669	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0033	0.0278	0.0997
Onchocerca volvulus		0.0028	0.0217	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0102	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0171	0.0646
Brugia malayi	hypothetical protein	0.0033	0.0278	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Toxoplasma gondii	ion channel protein	0.0033	0.0278	0.4032
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0033	0.0278	0.0997
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.0092	0.1199
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0669	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0147	0.1637	0.204
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0033	0.0278	0.3247
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0043	0.0054
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0065	0.0234
Loa Loa (eye worm)	TWK-28 protein	0.0033	0.0278	0.0346
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0065	0.0081
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0278	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0033	0.0278	0.0997
Onchocerca volvulus		0.0028	0.0217	0.0165
Echinococcus multilocularis	lamin dm0	0.0028	0.0217	0.0217
Echinococcus multilocularis	potassium channel subfamily K	0.0033	0.0278	0.0278
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0419	0.0522
Echinococcus granulosus	lamin	0.0028	0.0217	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0419	0.0522
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0669	0.0834
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0033	0.0278	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0463	0.1664
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0105	0.1128	0.1406
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0065	0.0081
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0278	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0208	0.6029
Schistosoma mansoni	twik family of potassium channels-related	0.0033	0.0278	0.0346
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0217	0.0271
Leishmania major	hypothetical protein, conserved	0.0033	0.0278	0.3219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0092	0.0348
Schistosoma mansoni	lamin	0.0028	0.0217	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0346
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0092	0.0115
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0033	0.0278	0.0278

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL507276

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1181266