Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Torpedo californica | Vesicular acetylcholine transporter | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | abnormal catecholamine distribution protein 1 | Vesicular acetylcholine transporter | 515 aa | 427 aa | 38.6 % |
Onchocerca volvulus | Vesicular acetylcholine transporter | 515 aa | 456 aa | 53.1 % | |
Brugia malayi | Abnormal catecholamine distribution protein 1 | Vesicular acetylcholine transporter | 515 aa | 431 aa | 37.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.0339 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.4594 | 0.4594 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.5007 | 0.5007 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 0.5007 | 0.5007 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Echinococcus multilocularis | geminin | 0.0186 | 0.6777 | 0.6777 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.0339 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 0.5007 | 0.5007 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.0339 | 0.0339 |
Schistosoma mansoni | gliotactin | 0.0024 | 0.0339 | 0.0339 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.0339 | 0.0339 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1317 | 0.1317 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.0339 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0339 | 0.0339 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.0339 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0339 | 0.0339 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.5007 | 0.5007 |
Echinococcus multilocularis | neuroligin | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.5007 | 0.5007 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0707 | 0.0707 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0339 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0339 | 0.0339 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 0.5007 | 0.5007 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.0339 | 0.0339 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.5007 | 0.5007 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.0339 | 0.0339 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0339 | 0.0339 |
Echinococcus granulosus | neuroligin | 0.0024 | 0.0339 | 0.0339 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0339 | 0.0339 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1317 | 0.1317 |
Echinococcus granulosus | geminin | 0.0186 | 0.6777 | 0.6777 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0707 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.4594 | 0.4594 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.5007 | 0.5007 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.5007 | 0.5007 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.6777 | 0.6777 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.0339 | 0.0339 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.5007 | 0.5007 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0339 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0339 | 0.0339 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.5007 | 0.5007 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.0339 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0707 | 0.0707 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.5007 | 0.5007 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.0339 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.6777 | 0.6777 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1317 | 0.1317 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.5007 | 0.5007 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.4594 | 0.4594 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1317 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0339 | 0.0339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 310 nM | Inhibition of [3H]- vesamicol binding to synaptic vesicles preparation from the electric organ of T. californica | ChEMBL. | 8478910 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.