Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0151 | 0.0253 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0422 | 0.5483 | 0.5475 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0072 | 0.0789 | 0.0879 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0789 | 0.9462 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0285 | 0.0477 |
Brugia malayi | hypothetical protein | 0.0459 | 0.5975 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0285 | 0.0269 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0187 | 0.017 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0789 | 0.1321 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0462 | 0.6018 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0285 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1074 | 0.1935 |
Echinococcus multilocularis | lamin dm0 | 0.0025 | 0.0157 | 0.0141 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0789 | 0.1413 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0058 | 0.0069 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0025 | 0.0157 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0144 | 0.0241 |
Schistosoma mansoni | pyruvate kinase | 0.0018 | 0.0058 | 0.0075 |
Onchocerca volvulus | 0.0072 | 0.0789 | 0.689 | |
Schistosoma mansoni | intermediate filament proteins | 0.0025 | 0.0157 | 0.0257 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0017 | 0.0028 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0789 | 0.9462 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0285 | 0.0477 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0789 | 0.9462 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0047 | 0.0445 | 0.0744 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.1649 | 0.2739 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0075 | 0.0818 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0075 | 0.0818 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0025 | 0.0157 | 0.0236 |
Mycobacterium ulcerans | beta-lactamase | 0.0072 | 0.0789 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0025 | 0.0157 | 0.0263 |
Onchocerca volvulus | 0.0072 | 0.0789 | 0.689 | |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0035 | 0.0285 | 0.3104 |
Onchocerca volvulus | 0.0072 | 0.0789 | 0.689 | |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0285 | 0.0477 |
Onchocerca volvulus | 0.0094 | 0.1074 | 1 | |
Echinococcus granulosus | lamin | 0.0025 | 0.0157 | 0.0236 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0169 | 0.2084 | 0.3489 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0789 | 0.1321 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.0789 | 0.0774 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0789 | 0.9462 |
Brugia malayi | intermediate filament protein | 0.0025 | 0.0157 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.1649 | 0.1635 |
Schistosoma mansoni | survival motor neuron protein | 0.0094 | 0.1074 | 0.1935 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0422 | 0.5483 | 0.9177 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.0285 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.0144 | 0.0241 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0789 | 0.1321 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0017 | 0.0028 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0058 | 0.0069 |
Toxoplasma gondii | ABC1 family protein | 0.0072 | 0.0789 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0094 | 0.1074 | 0.1798 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.1649 | 0.2986 |
Echinococcus multilocularis | lamin | 0.0025 | 0.0157 | 0.0141 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0058 | 0.0041 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0422 | 0.5483 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0058 | 0.0041 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0035 | 0.0285 | 0.0477 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0157 | 0.0263 |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.0789 | 1 |
Echinococcus multilocularis | musashi | 0.0025 | 0.0157 | 0.0141 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0285 | 0.045 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0789 | 0.1321 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0246 | 0.0413 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0047 | 0.0445 | 0.0744 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.1649 | 0.2739 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0157 | 0.0263 |
Echinococcus granulosus | sodium calcium exchanger | 0.0422 | 0.5483 | 0.9175 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0789 | 0.0879 |
Schistosoma mansoni | lamin | 0.0025 | 0.0157 | 0.0257 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0072 | 0.0789 | 0.0879 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0035 | 0.0285 | 0.0477 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0017 | 0.0028 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0072 | 0.0789 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.1649 | 0.2986 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0072 | 0.0789 | 0.0879 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0285 | 0.0491 |
Schistosoma mansoni | lamin | 0.0025 | 0.0157 | 0.0257 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0246 | 0.042 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0789 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0445 | 0.0744 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.0789 | 0.1296 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0285 | 0.0491 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0058 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0285 | 0.0269 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0789 | 0.1321 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0072 | 0.0789 | 0.0879 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0047 | 0.0445 | 0.0744 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.0789 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0285 | 0.0477 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.1649 | 0.1635 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0058 | 0.0041 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.5975 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0072 | 0.0789 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.1649 | 0.2986 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.0285 | 0.3104 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0285 | 0.1391 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0789 | 0.9462 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0459 | 0.5975 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0072 | 0.0789 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0032 | 0.0246 | 0.0413 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0789 | 0.9462 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0285 | 0.1391 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0789 | 0.1413 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0285 | 0.1391 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0136 | 0.1649 | 0.2759 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0017 | 0.0028 |
Giardia lamblia | Pyruvate kinase | 0.0035 | 0.0285 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0072 | 0.0789 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0024 | 0.0144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0157 | 0.0263 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.0285 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2084 | 0.3489 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0136 | 0.1649 | 0.2759 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0072 | 0.0789 | 0.0879 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0459 | 0.5975 | 0.5968 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 75.8 % | Cytotoxicity against human K562 cells assessed as cell viability at 30 uM | ChEMBL. | 20196571 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.