Detailed information for compound 1191256

Basic information

Technical information
  • TDR Targets ID: 1191256
  • Name: 2-[[4-chloro-2-(trifluoromethyl)phenyl]sulfon yl-ethylamino]-N-(1,1-dioxothiolan-3-yl)aceta mide
  • MW: 462.892 | Formula: C15H18ClF3N2O5S2
  • H donors: 1 H acceptors: 5 LogP: 1.87 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1C(F)(F)F)Cl)CC(=O)NC1CCS(=O)(=O)C1
  • InChi: 1S/C15H18ClF3N2O5S2/c1-2-21(8-14(22)20-11-5-6-27(23,24)9-11)28(25,26)13-4-3-10(16)7-12(13)15(17,18)19/h3-4,7,11H,2,5-6,8-9H2,1H3,(H,20,22)
  • InChiKey: JOZPEJTXXGVDOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-chloro-2-(trifluoromethyl)phenyl]sulfonyl-ethyl-amino]-N-(1,1-dioxothiolan-3-yl)acetamide
  • 2-[[4-chloro-2-(trifluoromethyl)phenyl]sulfonyl-ethylamino]-N-(1,1-dioxo-3-thiolanyl)acetamide
  • 2-[[4-chloro-2-(trifluoromethyl)phenyl]sulfonyl-ethyl-amino]-N-(1,1-diketothiolan-3-yl)acetamide
  • 2-[[4-chloro-2-(trifluoromethyl)phenyl]sulfonyl-ethyl-amino]-N-(1,1-dioxothiolan-3-yl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0855 1
Echinococcus multilocularis musashi 0.0027 0.014 0.0208
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0219 0.0382
Entamoeba histolytica hypothetical protein 0.0036 0.0219 0.1522
Loa Loa (eye worm) hypothetical protein 0.012 0.0952 0.19
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0165 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0291 0.0507
Echinococcus granulosus lamin dm0 0.0027 0.014 0.0244
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0161 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0165 0.0288
Schistosoma mansoni o-methyltransferase 0.012 0.0952 0.166
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0855 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0285 0.0268
Leishmania major hypothetical protein, conserved 0.0043 0.0285 0.24
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0161 0.0752
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1975 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0105 0.015
Brugia malayi O-methyltransferase family protein 0.012 0.0952 0.1872
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0165 0.0288
Trichomonas vaginalis esterase, putative 0.0043 0.0285 0.0681
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0086 0.0659 0.7386
Entamoeba histolytica protein kinase, putative 0.0086 0.0659 0.7386
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0194 0.1198
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0426 0.4192
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0369 0.3527
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0081
Schistosoma mansoni lamin 0.0027 0.014 0.0244
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0194 0.0365
Mycobacterium ulcerans hypothetical protein 0.0043 0.0285 0.0232
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.0431
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0285 0.0496
Brugia malayi intermediate filament protein 0.0027 0.014 0.0222
Loa Loa (eye worm) hypothetical protein 0.0023 0.0105 0.0184
Echinococcus multilocularis dna polymerase kappa 0.006 0.0426 0.0631
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0426 0.4295
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0105 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0285 0.2269
Entamoeba histolytica hypothetical protein 0.0036 0.0219 0.1522
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0161 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0117 0.2745
Mycobacterium tuberculosis Conserved protein 0.0043 0.0285 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0285 0.2269
Loa Loa (eye worm) hypothetical protein 0.0043 0.0285 0.0548
Brugia malayi hypothetical protein 0.0024 0.0117 0.0176
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0285 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0855 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0161 1
Leishmania major hypothetical protein, conserved 0.0024 0.0117 0.0169
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0855 1
Schistosoma mansoni o-methyltransferase 0.012 0.0952 0.166
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Brugia malayi hypothetical protein 0.0016 0.0042 0.0023
Brugia malayi polk-prov protein 0.0037 0.0227 0.0398
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.1034 0.8952 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.014 0.0222
Mycobacterium ulcerans methyltransferase 0.012 0.0952 0.0903
Onchocerca volvulus 0.0043 0.0285 0.0962
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0285 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0227 0.1634
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0194 0.0287
Loa Loa (eye worm) hypothetical protein 0.0086 0.0655 0.1297
Echinococcus granulosus intermediate filament protein 0.0027 0.014 0.0244
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0117 0.5916
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0291 0.0431
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0285 0.0681
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0285 0.0268
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0252 0.196
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.014 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0426 0.4192
Loa Loa (eye worm) intermediate filament protein 0.0027 0.014 0.0256
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0161 0.469
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0855 0.149
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0162 0.0768
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Onchocerca volvulus 0.003 0.0165 0.0324
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0285 0.0268
Entamoeba histolytica hypothetical protein 0.0036 0.0219 0.1522
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0382
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0194 0.0166
Onchocerca volvulus 0.0043 0.0285 0.0962
Onchocerca volvulus 0.0027 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0285 0.0681
Echinococcus granulosus dual specificity 0.0086 0.0659 0.1148
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0054 0.0009
Schistosoma mansoni DNA polymerase eta 0.0033 0.0194 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0855 0.1265
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0285 0.0548
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0285 0.0232
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0194 0.0338
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0855 0.8847
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0161 0.469
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0855 0.3823
Loa Loa (eye worm) hypothetical protein 0.0043 0.0285 0.0548
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0291 0.0529
Schistosoma mansoni o-methyltransferase 0.012 0.0952 0.166
Brugia malayi O-methyltransferase 0.012 0.0952 0.1872
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0291 0.0561
Echinococcus multilocularis dna polymerase eta 0.0033 0.0194 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0162 0.0768
Brugia malayi Pre-SET motif family protein 0.0208 0.1724 0.3439
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.0659 0.7341
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0285 0.0548
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0165 0.0245
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0105 0.0051
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0161 0.464
Brugia malayi Pre-SET motif family protein 0.003 0.0165 0.0274
Echinococcus granulosus dna polymerase eta 0.0033 0.0194 0.0338
Entamoeba histolytica protein kinase, putative 0.0086 0.0659 0.7386
Loa Loa (eye worm) hypothetical protein 0.0043 0.0285 0.0548
Plasmodium vivax SET domain protein, putative 0.003 0.0165 0.4824
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0285 0.0516
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1724 0.3461
Mycobacterium ulcerans hypothetical protein 0.0023 0.0105 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0227 0.1634
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0285 0.0268
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0285 0.0681
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0855 0.3823
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0285 0.2406
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0219 0.0324
Mycobacterium ulcerans beta-lactamase 0.0043 0.0285 0.0232
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0165 0.0288
Mycobacterium leprae Probable lipase LipE 0.0043 0.0285 0.2123
Brugia malayi O-methyltransferase family protein 0.012 0.0952 0.1872
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0194 0.0338
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0194 0.119
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0855 0.149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0105 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0307
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0161 0.469
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0031 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0105 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0285 0.0681
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0194 0.0332
Toxoplasma gondii ABC1 family protein 0.0043 0.0285 1
Onchocerca volvulus 0.0027 0.014 0.0189
Trypanosoma brucei unspecified product 0.0053 0.0369 0.3527
Brugia malayi hypothetical protein 0.0036 0.0219 0.0382
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0426 0.4192
Onchocerca volvulus 0.012 0.0952 0.4532
Loa Loa (eye worm) hypothetical protein 0.0023 0.0105 0.0184
Leishmania major DNA polymerase eta, putative 0.0033 0.0194 0.119
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0855 1
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.5735 0.8489
Brugia malayi 6-phosphofructokinase 0.0109 0.0855 0.1674
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0426 0.1463
Loa Loa (eye worm) hypothetical protein 0.0024 0.0117 0.021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0219 0.0382
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0855 0.3823
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.5735 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0855 0.0805
Mycobacterium tuberculosis Probable methyltransferase 0.012 0.0952 0.1018
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0855 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2334 0.2569
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.6756 1
Echinococcus granulosus microtubule associated protein 2 0.0667 0.5735 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0086 0.0659 0.1305
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0161 1
Brugia malayi beta-lactamase family protein 0.0043 0.0285 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0105 0.0051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0285 0.0548
Onchocerca volvulus 0.0237 0.1975 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0105 0.0051
Brugia malayi O-methyltransferase family protein 0.012 0.0952 0.1872
Entamoeba histolytica hypothetical protein 0.0036 0.0219 0.1522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0136 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0285 0.0681
Brugia malayi 6-phosphofructokinase 0.0109 0.0855 0.1674
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0018 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0117 0.5916
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0194 0.0332
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0855 0.3823
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0291 0.0431
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0165 0.4872
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0086 0.0659 0.7388
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0194 0.0338
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0855 0.149
Loa Loa (eye worm) O-methyltransferase 0.012 0.0952 0.19
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0252 0.1966
Echinococcus granulosus lamin 0.0027 0.014 0.0244
Entamoeba histolytica hypothetical protein 0.0086 0.0659 0.7386
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0855 0.1702
Brugia malayi Protein kinase domain containing protein 0.0086 0.0659 0.1275
Mycobacterium tuberculosis Conserved protein 0.0043 0.0285 0.0268
Schistosoma mansoni o-methyltransferase 0.012 0.0952 0.166
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0855 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.014 0.0244
Loa Loa (eye worm) hypothetical protein 0.0023 0.0105 0.0184
Brugia malayi small heat shock protein 0.0577 0.4953 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0105 0.0051
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0285 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0285 1
Echinococcus multilocularis dual specificity 0.0086 0.0659 0.0975
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.0659 0.7341
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.0659 0.7386
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.012 0.0952 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0161 0.464
Schistosoma mansoni lamin 0.0027 0.014 0.0244
Loa Loa (eye worm) hypothetical protein 0.0577 0.4953 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0117 0.2812
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0855 0.1702
Loa Loa (eye worm) hypothetical protein 0.0033 0.0194 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0256
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0105 0.015
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0855 1
Onchocerca volvulus 0.0043 0.0285 0.0962
Mycobacterium ulcerans lipase LipD 0.0043 0.0285 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0659 0.1148
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0426 0.0374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0105 0.0066
Brugia malayi phosphofructokinase 0.0109 0.0855 0.1674
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0426 0.4192
Loa Loa (eye worm) beta-lactamase 0.0043 0.0285 0.0548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0291 0.0507
Leishmania major DNA polymerase kappa, putative 0.004 0.0252 0.196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0291 0.0507
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0855 0.1702
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0426 0.0374
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0285 0.2123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0081
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0165 0.0245
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0285 0.0268
Mycobacterium tuberculosis Conserved protein 0.0043 0.0285 0.0268
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0285 0.0496
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.012 0.0952 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0165 0.0288
Echinococcus multilocularis lamin 0.0027 0.014 0.0208
Brugia malayi beta-lactamase 0.0043 0.0285 0.0516
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0426 0.4295
Echinococcus granulosus dna polymerase kappa 0.006 0.0426 0.0744
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0105 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0291 0.0507
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0285 0.0496
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0156 0.0272
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0105 0.0066
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0194 0.1039
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Giardia lamblia DINP protein human, muc B family 0.004 0.0252 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0162 0.0768
Loa Loa (eye worm) hypothetical protein 0.0043 0.0285 0.0548
Brugia malayi beta-lactamase family protein 0.0043 0.0285 0.0516
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0252 0.0231
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0285 0.0268
Echinococcus multilocularis lamin dm0 0.0027 0.014 0.0208
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0426 0.1463
Loa Loa (eye worm) hypothetical protein 0.0086 0.0655 0.1297
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Onchocerca volvulus 0.012 0.0952 0.4532
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0426 0.4295
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0117 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0291 0.0507

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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