TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.236 | Formula: C19H12BrN5
H donors: 0 H acceptors: 3 LogP: 4.52 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1)c1cc2c(n1c1ccccc1)ncn1c2ncn1
InChi: 1S/C19H12BrN5/c20-14-8-6-13(7-9-14)17-10-16-18-21-11-23-24(18)12-22-19(16)25(17)15-4-2-1-3-5-15/h1-12H
InChiKey: ANGDAYYSHOEIPO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0323	0.0531
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.005	0.0025
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0175	0.1937	0.7865
Entamoeba histolytica	cysteine proteinase 2	0.0117	0.119	0.3206
Echinococcus multilocularis	cathepsin L cysteine protease	0.0215	0.2462	0.2424
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0142	0.1517	0.2672
Loa Loa (eye worm)	hypothetical protein	0.005	0.0323	0.0582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0137	0.0087
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0323	0.0496
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0323	0.0582
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0117	0.119	0.2076
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0323	0.0531
Echinococcus multilocularis	geminin	0.0184	0.2055	0.2015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0323	0.0582
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0323	0.0531
Plasmodium falciparum	serine repeat antigen 7	0.005	0.0323	0.131
Onchocerca volvulus		0.0215	0.2462	0.9318
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0149	0.0604
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Echinococcus granulosus	biogenic amine 5HT receptor	0.0142	0.1517	0.269
Brugia malayi	Pre-SET motif family protein	0.0029	0.005	0.0091
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.005	0.0323	0.0496
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0117	0.119	0.2148
Brugia malayi	Papain family cysteine protease containing protein	0.0117	0.119	0.2148
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0215	0.2462	0.4407
Echinococcus granulosus	cathepsin L	0.0117	0.119	0.2095
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Loa Loa (eye worm)	cysteine protease	0.0215	0.2462	0.4443
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0497	0.0897
Entamoeba histolytica	cysteine protease, putative	0.005	0.0323	0.0566
Entamoeba histolytica	cysteine proteinase 1, putative	0.0117	0.119	0.3206
Echinococcus multilocularis	cysteine protease	0.0215	0.2462	0.2424
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.005	0.0323	0.131
Plasmodium vivax	vivapain-2	0.0215	0.2462	1
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.2639	0.7605
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.005	0.0323	0.0496
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Entamoeba histolytica	cysteine protease, putative	0.005	0.0323	0.0566
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Brugia malayi	Cathepsin L-like precursor	0.0215	0.2462	0.4443
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0453	0.5542	1
Echinococcus granulosus	cathepsin l1	0.0148	0.1595	0.2831
Plasmodium falciparum	serine repeat antigen 9	0.005	0.0323	0.131
Echinococcus granulosus	cathepsin b	0.0453	0.5542	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.005	0.0323	0.0531
Entamoeba histolytica	cysteine proteinase, putative	0.0148	0.1595	0.4437
Echinococcus multilocularis	cathepsin L	0.0117	0.119	0.1146
Toxoplasma gondii	cathepsin CPC1	0.005	0.0323	0.131
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0497	0.0814
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.0544	0.0982
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Schistosoma mansoni	hypothetical protein	0.0184	0.2055	0.365
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0544	0.0982
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0117	0.119	0.4833
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1517	0.2738
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0141	0.1507	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.005	0.0323	0.0582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Plasmodium vivax	unspecified product	0.005	0.0323	0.131
Loa Loa (eye worm)	ctsf protein	0.0215	0.2462	0.4443
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.005	0.0323	0.131
Onchocerca volvulus		0.0215	0.2462	0.9318
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0323	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1585	0.2861
Onchocerca volvulus	Cathepsin F homolog	0.0215	0.2462	0.9318
Brugia malayi	cathepsin Z-like cysteine proteinase	0.005	0.0323	0.0582
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.005	0.0323	0.131
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.2279	0.4113
Entamoeba histolytica	cysteine proteinase, putative	0.0215	0.2462	0.7077
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0149	0.0204
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0323	0.0582
Onchocerca volvulus		0.0215	0.2462	0.9318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0117	0.119	0.2076
Giardia lamblia	Fructose-bisphosphate aldolase	0.0289	0.3423	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1595	0.2878
Giardia lamblia	Cathepsin B precursor	0.0175	0.1937	0.5206
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0497	0.0814
Trypanosoma cruzi	cysteine peptidase, putative	0.0215	0.2462	0.4443
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.005	0.0323	0.0582
Plasmodium vivax	vivapain-3	0.0117	0.119	0.4833
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Onchocerca volvulus	Cathepsin L homolog	0.005	0.0323	0.1052
Trypanosoma cruzi	cysteine peptidase, putative	0.0117	0.119	0.2148
Plasmodium vivax	vivapain-1	0.0117	0.119	0.4833
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.0323	0.0531
Echinococcus granulosus	muscleblind protein	0.0147	0.1585	0.2813
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.005	0.0323	0.131
Echinococcus multilocularis	cathepsin L cysteine protease	0.0215	0.2462	0.2424
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0141	0.1507	1
Loa Loa (eye worm)	inositol-1	0.0036	0.0149	0.0268
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0215	0.2462	1
Plasmodium vivax	unspecified product	0.0117	0.119	0.4833
Schistosoma mansoni	cathepsin F (C01 family)	0.0215	0.2462	0.4393
Brugia malayi	Muscleblind-like protein	0.0147	0.1585	0.2861
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1595	0.2878
Plasmodium vivax	serine-repeat antigen (SERA)	0.005	0.0323	0.131
Treponema pallidum	fructose-bisphosphate aldolase	0.0289	0.3423	0.5
Brugia malayi	cathepsin L-like cysteine proteinase	0.005	0.0323	0.0582
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.005	0.0204
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0544	0.0982
Plasmodium falciparum	serine repeat antigen 5	0.005	0.0323	0.131
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1585	0.2861
Echinococcus multilocularis	cathepsin L	0.005	0.0323	0.0274
Loa Loa (eye worm)	cathepsin B	0.0175	0.1937	0.3495
Onchocerca volvulus		0.0229	0.2639	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.005	0.0323	0.0582
Onchocerca volvulus		0.0215	0.2462	0.9318
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0453	0.5542	1
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0215	0.2462	0.4407
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0215	0.2462	0.7066
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0149	0.018
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.1585	0.1543
Trypanosoma cruzi	cysteine peptidase, putative	0.0215	0.2462	0.4443
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0137	0.0182
Brugia malayi	cathepsin B-like cysteine proteinase	0.0453	0.5542	1
Brugia malayi	Inositol-1	0.0036	0.0149	0.0268
Plasmodium vivax	SET domain protein, putative	0.0029	0.005	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.005	0.0323	0.0531
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Brugia malayi	fibroinase precursor	0.005	0.0323	0.0582
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Entamoeba histolytica	cysteine protease, putative	0.005	0.0323	0.0566
Trypanosoma cruzi	cysteine protease, putative	0.0117	0.119	0.2148
Plasmodium falciparum	serine repeat antigen 4	0.005	0.0323	0.131
Entamoeba histolytica	cysteine protease, putative	0.005	0.0323	0.0566
Schistosoma mansoni	cathepsin S (C01 family)	0.005	0.0323	0.0496
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.005	0.0323	0.131
Schistosoma mansoni	cathepsin B (C01 family)	0.005	0.0323	0.0496
Schistosoma mansoni	cathepsin F (C01 family)	0.0215	0.2462	0.4393
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.005	0.0323	0.131
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.005	0.0323	0.0582
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0117	0.119	0.2076
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.005	0.0323	0.131
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0215	0.2462	0.4443
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.005	0.0323	0.131
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Brugia malayi	Cathepsin L-like precursor	0.0215	0.2462	0.4443
Brugia malayi	Cathepsin L-like precursor	0.0215	0.2462	0.4443
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0148	0.1595	0.4417
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0323	0.0531
Echinococcus granulosus	cathepsin l1	0.0215	0.2462	0.4407
Echinococcus granulosus	cathepsin L cysteine protease	0.0117	0.119	0.2095
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Plasmodium falciparum	serine repeat antigen 6	0.005	0.0323	0.131
Brugia malayi	Cathepsin L-like precursor	0.0215	0.2462	0.4443
Onchocerca volvulus		0.0215	0.2462	0.9318
Entamoeba histolytica	cysteine proteinase, putative	0.0117	0.119	0.3206
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0215	0.2462	0.4443
Onchocerca volvulus	Cathepsin L homolog	0.0215	0.2462	0.9318
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0323	0.0582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Schistosoma mansoni	cathepsin s	0.0067	0.0544	0.09
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.005	0.0323	0.0496
Loa Loa (eye worm)	fibroinase	0.0215	0.2462	0.4443
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0323	0.0496
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0497	0.0897
Brugia malayi	Pre-SET motif family protein	0.0201	0.2279	0.4113
Echinococcus granulosus	geminin	0.0184	0.2055	0.3666
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.005	0.0323	0.131
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0323	0.0496
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.005	0.0323	0.0531
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0117	0.119	0.318
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0323	0.0496
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0067	0.0544	0.0982
Loa Loa (eye worm)	hypothetical protein	0.005	0.0323	0.0582
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0323	0.0531
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0215	0.2462	0.2424
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0215	0.2462	0.7066
Onchocerca volvulus		0.005	0.0323	0.1052
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0117	0.119	0.4833
Brugia malayi	cathepsin L precursor	0.005	0.0323	0.0582
Giardia lamblia	Cathepsin B precursor	0.0175	0.1937	0.5206
Schistosoma mansoni	hypothetical protein	0.0184	0.2055	0.365
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0497	0.0897
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0215	0.2462	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0215	0.2462	0.4443
Brugia malayi	Papain family cysteine protease containing protein	0.0117	0.119	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1517	0.2738
Onchocerca volvulus		0.0215	0.2462	0.9318
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0149	0.0037
Brugia malayi	RNA binding protein	0.0063	0.0497	0.0897
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0497	0.0449
Toxoplasma gondii	preprocathepsin c precursor, putative	0.005	0.0323	0.131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.005	0.0323	0.0531
Brugia malayi	Cathepsin L-like precursor	0.0148	0.1595	0.2878
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0175	0.1937	0.5461
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0141	0.1507	1
Brugia malayi	cathepsin L-like precursor	0.0148	0.1595	0.2878
Entamoeba histolytica	hypothetical protein	0.005	0.0323	0.0566
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.005	0.0323	0.131
Schistosoma mansoni	hypothetical protein	0.0036	0.0137	0.0157
Plasmodium falciparum	serine repeat antigen 3	0.005	0.0323	0.131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0148	0.1595	0.4417
Leishmania major	cysteine peptidase A (CPA)	0.0215	0.2462	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0215	0.2462	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0453	0.5542	1
Brugia malayi	TAR-binding protein	0.0063	0.0497	0.0897
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0323	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0453	0.5542	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0149	0.0268
Loa Loa (eye worm)	hypothetical protein	0.005	0.0323	0.0582
Entamoeba histolytica	cysteine proteinase, putative	0.0117	0.119	0.3206
Entamoeba histolytica	cysteine proteinase, putative	0.0117	0.119	0.3206
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0323	0.0582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0149	0.0604
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0497	0.0897
Trypanosoma cruzi	cysteine proteinase, putative	0.0117	0.119	0.2148
Brugia malayi	Cathepsin L-like precursor	0.0148	0.1595	0.2878
Schistosoma mansoni	cathepsin F (C01 family)	0.0148	0.1595	0.2813
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0175	0.1937	0.7865
Toxoplasma gondii	cathepsin CPC2	0.005	0.0323	0.131
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0175	0.1937	0.3495
Loa Loa (eye worm)	hypothetical protein	0.0215	0.2462	0.4443
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0323	0.0531
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0544	0.0982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0323	0.0531
Trypanosoma cruzi	cysteine peptidase, putative	0.0215	0.2462	0.4443
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0117	0.119	0.318
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0497	0.0814
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Schistosoma mansoni	cathepsin C	0.005	0.0323	0.0496
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.005	0.0323	0.0566
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.005	0.0323	0.131
Schistosoma mansoni	amine GPCR	0.0347	0.4165	0.7492
Onchocerca volvulus	Cathepsin L homolog	0.0215	0.2462	0.9318
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Plasmodium vivax	serine-repeat antigen (SERA)	0.005	0.0323	0.131
Brugia malayi	cathepsin F-like cysteine proteinase	0.0067	0.0544	0.0982
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0289	0.3423	1
Plasmodium falciparum	serine repeat antigen 2	0.005	0.0323	0.131
Entamoeba histolytica	cysteine proteinase, putative	0.0215	0.2462	0.7077
Trypanosoma cruzi	cysteine proteinase, putative	0.0117	0.119	0.2148
Entamoeba histolytica	cysteine protease, putative	0.0215	0.2462	0.7077
Loa Loa (eye worm)	hypothetical protein	0.0029	0.005	0.0091
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Onchocerca volvulus		0.0215	0.2462	0.9318
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.005	0.0323	0.0566
Toxoplasma gondii	cathepsin CPL	0.0215	0.2462	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0323	0.0582
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0215	0.2462	0.4443
Brugia malayi	Cathepsin L-like precursor	0.0067	0.0544	0.0982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Plasmodium falciparum	serine repeat antigen 8	0.005	0.0323	0.131
Brugia malayi	Cathepsin L-like precursor	0.0215	0.2462	0.4443
Echinococcus granulosus	cathepsin L	0.005	0.0323	0.052
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0453	0.5542	1
Toxoplasma gondii	cathepsin B	0.0175	0.1937	0.7865
Plasmodium vivax	vivapain-2	0.0215	0.2462	1
Echinococcus multilocularis	muscleblind protein	0.0147	0.1585	0.1543
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0544	0.0982
Echinococcus multilocularis	cysteine protease	0.0215	0.2462	0.2424
Entamoeba histolytica	cysteine protease, putative	0.005	0.0323	0.0566
Echinococcus multilocularis	serotonin receptor	0.0142	0.1517	0.1475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0323	0.0531
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Loa Loa (eye worm)	hypothetical protein	0.005	0.0323	0.0582
Brugia malayi	hypothetical protein	0.0036	0.0137	0.0246
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.005	0.0323	0.0496
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0137	0.0157
Echinococcus granulosus	cysteine protease	0.0117	0.119	0.2095
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0497	0.0814
Entamoeba histolytica	cysteine proteinase, putative	0.0117	0.119	0.3206
Echinococcus multilocularis	cathepsin b	0.0453	0.5542	0.5519
Brugia malayi	Papain family cysteine protease containing protein	0.0215	0.2462	0.4443
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0453	0.5542	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0175	0.1937	0.3435
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.0323	0.0531
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.0323	0.0531
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0149	0.0268
Echinococcus multilocularis	serotonin receptor	0.0142	0.1517	0.1475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0323	0.0531
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0148	0.1595	0.2878
Giardia lamblia	Cathepsin B precursor	0.0175	0.1937	0.5206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0497	0.0814
Echinococcus granulosus	cathepsin b	0.0453	0.5542	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0117	0.119	0.4833
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0149	0.018
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0215	0.2462	0.2424
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.005	0.0323	0.131
Loa Loa (eye worm)	hypothetical protein	0.005	0.0323	0.0582
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.3423	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Entamoeba histolytica	cysteine protease, putative	0.005	0.0323	0.0566
Onchocerca volvulus		0.0148	0.1595	0.5967
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0149	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.0323	0.0531
Brugia malayi	Cathepsin L-like precursor	0.0215	0.2462	0.4443
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Echinococcus multilocularis	cathepsin b	0.0453	0.5542	0.5519
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.005	0.0323	0.131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0215	0.2462	0.7066
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0148	0.1595	0.2878
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0149	0.0604
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0149	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0067	0.0544	0.0982
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.005	0.0323	0.0582
Leishmania major	cathepsin L-like protease	0.0215	0.2462	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0215	0.2462	1
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Brugia malayi	cathepsin Z-like cysteine proteinase	0.005	0.0323	0.0582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0215	0.2462	0.7066
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0323	0.0496
Plasmodium falciparum	serine repeat antigen 1	0.005	0.0323	0.131
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1595	0.2878
Entamoeba histolytica	cysteine protease, putative	0.0117	0.119	0.3206
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0497	0.0837
Plasmodium vivax	unspecified product	0.0067	0.0544	0.2211
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0289	0.3423	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 14 mm	Antimicrobial activity against Escherichia coli NCTC 10416 at 5 mg/ml after 24 hrs by agar well diffusion assay	ChEMBL.	20828885
IZ (functional)	= 19 mm	Antimicrobial activity against Candida albicans ATCC 10145 at 5 mg/ml after 48 hrs by agar well diffusion assay	ChEMBL.	20828885

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1276993

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1191348