Detailed information for compound 1197647

Basic information

Technical information
  • TDR Targets ID: 1197647
  • Name: (2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-6-[[(2R, 3R,4R,5S)-4,5-dihydroxy-6-(hydroxyamino)-2-(h ydroxymethyl)-2,3,4,5-tetrahydropyridin-3-yl] oxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl ]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
  • MW: 516.451 | Formula: C18H32N2O15
  • H donors: 12 H acceptors: 11 LogP: -6.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)N/C(=N/O)/[C@@H]([C@H]2O)O)[C@@H]([C@H]([C@@H]1O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O)O)O
  • InChi: 1S/C18H32N2O15/c21-1-4-14(9(26)11(28)16(19-4)20-31)34-18-13(30)10(27)15(6(3-23)33-18)35-17-12(29)8(25)7(24)5(2-22)32-17/h4-15,17-18,21-31H,1-3H2,(H,19,20)/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,17-,18-/m1/s1
  • InChiKey: AHRWQUNEPBVNOT-IVJVVCOPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-6-[[(2R,3R,4R,5S)-4,5-dihydroxy-6-(hydroxyamino)-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-3-yl]oxy]-4,5-dihydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • (2R,3R,4S,5S,6R)-2-[[(2R,3S,4R,5R,6S)-6-[[(2R,3R,4R,5S)-4,5-dihydroxy-6-(hydroxyamino)-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-3-yl]oxy]-4,5-dihydroxy-2-(hydroxymethyl)-3-tetrahydropyranyl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • (2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-6-[[(2R,3R,4R,5S)-4,5-dihydroxy-6-(hydroxyamino)-2-methylol-2,3,4,5-tetrahydropyridin-3-yl]oxy]-4,5-dihydroxy-2-methylol-tetrahydropyran-3-yl]oxy-6-methylol-tetrahydropyran-3,4,5-triol
  • LAG
  • MALTOSYL-ALPHA (1,4)-(Z,3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-PIPERIDIN-2-ONE OXIME
  • MALTOSYL-ALPHA (1,4)-D-GLUCONHYDROXIMO-1,5-LACTAM

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) 0.0022 0.0106 0.0083
Loa Loa (eye worm) hypothetical protein 0.0037 0.0777 0.0895
Chlamydia trachomatis two component regulatory system response regulator/ATPase 0.0022 0.0106 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0777 0.0777
Mycobacterium leprae conserved hypothetical protein 0.0109 0.408 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0777 0.079
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.1419 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0777 0.5473
Echinococcus granulosus GPCR family 2 0.0063 0.1993 0.9443
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0071 0.0335
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.408 0.4149
Brugia malayi beta-lactamase family protein 0.0037 0.0777 0.0895
Schistosoma mansoni hypothetical protein 0.0063 0.1993 0.3722
Leishmania major hypothetical protein, conserved 0.0037 0.0777 0.3679
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.047 0.2226
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0777 0.079
Treponema pallidum protein-glutamate methylesterase (cheB) 0.0022 0.0106 1
Treponema pallidum chemotaxis response regulator (cheY) 0.0022 0.0106 1
Mycobacterium ulcerans two component sensory transduction transcriptional regulatory protein MtrA 0.0022 0.0106 0.0501
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0023 0.0139 0.0142
Loa Loa (eye worm) hypothetical protein 0.0051 0.1419 0.1636
Brugia malayi beta-lactamase family protein 0.0037 0.0777 0.0895
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0139 0.0661
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0022 0.0106 0.0106
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0022 0.0106 0.0106
Treponema pallidum response regulatory protein (atoC) 0.0022 0.0106 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0139 0.0142
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.047 0.2226
Echinococcus multilocularis disco interacting protein 2 0.0023 0.0139 0.0661
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0777 0.079
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1993 0.9443
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0073 0.0074
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.1419 0.6723
Loa Loa (eye worm) hypothetical protein 0.0037 0.0777 0.0895
Mycobacterium tuberculosis Possible two component system response transcriptional positive regulator PhoP 0.0022 0.0106 0.0107
Schistosoma mansoni hypothetical protein 0.0063 0.1993 0.3722
Loa Loa (eye worm) hypothetical protein 0.0037 0.0777 0.0895
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0139 0.0661
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0691 0.1291
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0022 0.0106 0.0106
Wolbachia endosymbiont of Brugia malayi response regulator 0.0022 0.0106 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.047 0.0877
Schistosoma mansoni hypothetical protein 0.0136 0.5356 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0777 0.0895
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0139 0.0167
Entamoeba histolytica hypothetical protein 0.0035 0.0691 1
Mycobacterium ulcerans two component transcriptional regulatory protein TcrX 0.0022 0.0106 0.0501
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.408 0.4149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.047 0.0877
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0022 0.0106 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0022 0.0106 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0777 0.5473
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.1854 0.1885
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0777 0.5473
Mycobacterium ulcerans beta-lactamase 0.0037 0.0777 0.3679
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0139 0.0142
Schistosoma mansoni hypothetical protein 0.0063 0.1993 0.3722
Loa Loa (eye worm) beta-lactamase 0.0037 0.0777 0.0895
Brugia malayi Cytochrome P450 family protein 0.0021 0.0071 0.0081
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0777 0.145
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0777 0.3679
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.1419 1
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0022 0.0106 0.0501
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.1854 0.3462
Mycobacterium ulcerans two component system response phosphate regulon transcriptional regulator, PhoP 0.0022 0.0106 0.0501
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.2111 0.2146
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0777 0.1757
Mycobacterium tuberculosis Probable two component transcriptional regulatory protein TcrX 0.0022 0.0106 0.0107
Mycobacterium tuberculosis Conserved protein 0.0037 0.0777 0.079
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0071 0.0498
Loa Loa (eye worm) hypothetical protein 0.0199 0.8254 0.9513
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.1419 1
Mycobacterium tuberculosis Two component DNA binding transcriptional regulatory protein TcrA 0.0022 0.0106 0.0107
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0023 0.0139 0.0142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0777 0.079
Mycobacterium ulcerans lipase LipD 0.0037 0.0777 0.3679
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0022 0.0106 0.0107
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0777 0.3679
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0139 0.0661
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0777 0.079
Mycobacterium ulcerans two-component system transcriptional regulator 0.0022 0.0106 0.0501
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0063 0.1974 0.1578
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0139 0.0142
Onchocerca volvulus 0.0037 0.0777 0.0322
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0139 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.047 0.0877
Brugia malayi Cytochrome P450 family protein 0.0021 0.0071 0.0081
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0777 0.079
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0139 0.0142
Mycobacterium tuberculosis Two component sensory transduction transcriptional regulatory protein MtrA 0.0022 0.0106 0.0107
Mycobacterium tuberculosis Conserved protein 0.0037 0.0777 0.079
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0777 0.0777
Mycobacterium ulcerans hypothetical protein 0.0022 0.0106 0.0501
Schistosoma mansoni hypothetical protein 0.0023 0.0138 0.0257
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1993 0.2297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0691 0.3276
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.1599 0.1843
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0161
Mycobacterium leprae conserved hypothetical protein 0.0109 0.408 1
Mycobacterium ulcerans two component transcriptional regulator 0.0022 0.0106 0.0501
Brugia malayi beta-lactamase 0.0037 0.0777 0.0895
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1993 0.2297
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0106 0.0106
Mycobacterium ulcerans two component transcriptional regulator 0.0022 0.0106 0.0501
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0139 0.0661
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.1419 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0022 0.0106 0.0106
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0777 0.3679
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0777 0.079
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0691 0.3276
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1993 0.9443
Onchocerca volvulus 0.0037 0.0777 0.0322
Loa Loa (eye worm) hypothetical protein 0.0037 0.0777 0.0895
Brugia malayi hypothetical protein 0.0033 0.0596 0.0687
Echinococcus granulosus disco interacting protein 2 0.0023 0.0139 0.0661
Mycobacterium ulcerans two component transcriptional regulator TrcR 0.0022 0.0106 0.0501
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.047 0.0877
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1854 0.2137
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0777 0.5473
Onchocerca volvulus 0.0037 0.0777 0.0322
Mycobacterium ulcerans two component regulator receiver domain-containing protein 0.0022 0.0106 0.0501
Mycobacterium ulcerans two component sensory transduction protein RegX3 0.0022 0.0106 0.0501
Schistosoma mansoni hypothetical protein 0.0035 0.0691 0.1291
Mycobacterium tuberculosis Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) 0.0022 0.0106 0.0107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1993 0.9443
Brugia malayi hypothetical protein 0.0035 0.0691 0.0797
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0777 0.3679
Brugia malayi hypothetical protein 0.0051 0.1419 0.1636
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0139 0.0167
Trichomonas vaginalis set domain proteins, putative 0.0238 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1993 0.9443
Trichomonas vaginalis esterase, putative 0.0037 0.0777 0.0777
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.2111 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.2111 0.3941
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1854 0.8783
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0071 0.0081
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0138 0.0653
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0777 0.0777
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0777 0.0895
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.2111 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1854 0.8783
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0022 0.0106 0.0501
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1854 0.8783
Leishmania major cytochrome p450-like protein 0.0021 0.0071 0.0335
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0023 0.0139 0.0661
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.2111 0.3941
Loa Loa (eye worm) hypothetical protein 0.003 0.047 0.0542
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0777 0.145
Brugia malayi Telomerase reverse transcriptase 0.0046 0.1188 0.1369
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.1419 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0071 0.0081
Leishmania major hypothetical protein, conserved 0.0051 0.1419 0.6723
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0419 0.1987
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.047 0.2226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.8254 0.9513
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0139 0.0167
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0139 0.0142
Mycobacterium tuberculosis Probable transcriptional regulatory protein KdpE 0.0022 0.0106 0.0107
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0071 0.0081
Mycobacterium tuberculosis Two component transcriptional regulator TrcR 0.0022 0.0106 0.0107
Mycobacterium leprae Probable two-component system transcriptional regulator 0.0022 0.0106 0.0083
Entamoeba histolytica hypothetical protein 0.0035 0.0691 1
Brugia malayi Pre-SET motif family protein 0.003 0.047 0.0542
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0073 0.0074
Trichomonas vaginalis receptor histidine kinase, putative 0.0022 0.0106 0.0106
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0071 0.0498
Brugia malayi Cytochrome P450 family protein 0.0055 0.1599 0.1843
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0139 0.0167
Mycobacterium tuberculosis Probable two-component system transcriptional regulator 0.0022 0.0106 0.0107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.2111 1
Schistosoma mansoni sensor histidine kinase/response regulator 0.0022 0.0106 0.0197
Toxoplasma gondii ABC1 family protein 0.0037 0.0777 0.3679
Mycobacterium ulcerans two component response transcriptional regulatory protein PrrA 0.0022 0.0106 0.0501
Mycobacterium leprae TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA 0.0022 0.0106 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0139 0.0661
Wolbachia endosymbiont of Brugia malayi response regulator PleD 0.0022 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.5356 0.6173
Schistosoma mansoni hypothetical protein 0.0063 0.1993 0.3722
Mycobacterium tuberculosis Two component response transcriptional regulatory protein PrrA 0.0022 0.0106 0.0107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.2111 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0777 0.0895
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0138 0.0653
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.2111 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0777 0.0895
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1668 0.1923
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.047 0.2226
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.1419 1
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0023 0.0139 0.026
Trichomonas vaginalis sensor histidine kinase, putative 0.0022 0.0106 0.0106
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1993 0.2297
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0777 0.0777
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.8676 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1993 0.2297
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.2111 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0777 0.0777
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1854 0.8783
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.8254 0.9513
Echinococcus multilocularis GPCR, family 2 0.0063 0.1993 0.9443
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.1854 0.8783
Mycobacterium ulcerans hypothetical protein 0.0037 0.0777 0.3679
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0022 0.0106 0.0501
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0777 0.079
Trypanosoma brucei RNA helicase, putative 0.0048 0.1322 0.9316
Plasmodium vivax SET domain protein, putative 0.003 0.047 0.3311
Entamoeba histolytica hypothetical protein 0.0035 0.0691 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0777 0.1757
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.5356 0.6173
Mycobacterium ulcerans two component response transcriptional regulatory protein MprA 0.0022 0.0106 0.0501
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.2111 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.8254 0.9513
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.9835 1
Brugia malayi Pre-SET motif family protein 0.0209 0.8676 1
Schistosoma mansoni hypothetical protein 0.0048 0.1322 0.2468
Mycobacterium tuberculosis Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) 0.0022 0.0106 0.0107
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0071 0.0498
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0022 0.0106 0.0106
Entamoeba histolytica hypothetical protein 0.0035 0.0691 1
Brugia malayi Disco-interacting protein 2 homolog 0.0023 0.0139 0.0161

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.8 mM Inhibition of human pancreatic alpha-amylase assessed as hydrolysis of G3F by Dixon plot analysis ChEMBL. 26395057

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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