Detailed information for compound 1199056

Basic information

Technical information
  • TDR Targets ID: 1199056
  • Name: 5-chloro-2-fluoro-N-naphthalen-2-ylbenzenesul fonamide
  • MW: 335.78 | Formula: C16H11ClFNO2S
  • H donors: 1 H acceptors: 2 LogP: 4.42 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)S(=O)(=O)Nc1ccc2c(c1)cccc2)F
  • InChi: 1S/C16H11ClFNO2S/c17-13-6-8-15(18)16(10-13)22(20,21)19-14-7-5-11-3-1-2-4-12(11)9-14/h1-10,19H
  • InChiKey: KEKZRBCKVZUAJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-chloro-2-fluoro-N-(2-naphthyl)benzenesulfonamide
  • 5-chloro-2-fluoro-N-naphthalen-2-yl-benzenesulfonamide
  • MLS-0146282.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alkaline phosphatase, liver/bone/kidney Starlite/ChEMBL No references
Homo sapiens glyceraldehyde-3-phosphate dehydrogenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Babesia bovis glyceraldehyde-3-phosphate dehydrogenase protein Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium hominis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium berghei glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium knowlesi glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania braziliensis glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium parvum glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative glyceraldehyde-3-phosphate dehydrogenase 293 aa 259 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0671 0.0772
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0642 0.0236
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.3083 1
Echinococcus granulosus alkaline phosphatase 0.0196 0.8472 1
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0028 0.0558 0.5
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.3083 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0642 0.0833
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1753 0.1482
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.1349 0.2894
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.1888 0.2172
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.3083 0.3547
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 0.2676
Loa Loa (eye worm) hypothetical protein 0.003 0.0642 0.0739
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.6879 0.7994
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0028 0.0556 0.0639
Echinococcus granulosus lamin 0.0031 0.0671 0.0173
Schistosoma mansoni hypothetical protein 0.0102 0.403 0.4369
Loa Loa (eye worm) hypothetical protein 0.0029 0.0584 0.0671
Loa Loa (eye worm) hypothetical protein 0.003 0.0645 0.0742
Echinococcus granulosus intermediate filament protein 0.0031 0.0671 0.0173
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 0.2676
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0082 0.3083 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1751 0.4996
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 0.2676
Brugia malayi hypothetical protein 0.003 0.0642 0.0739
Loa Loa (eye worm) acetyltransferase 0.0167 0.71 0.8169
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0584 0.0063
Echinococcus multilocularis lamin 0.0031 0.0671 0.0111
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.3083 0.3168
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.3083 0.3168
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0862 0.0414
Schistosoma mansoni alkaline phosphatase 0.0196 0.8472 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0642 0.0236
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0862 0.0353
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.71 0.8169
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0025 0.0421 0.0484
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.1888 0.2172
Brugia malayi hypothetical protein 0.0035 0.0862 0.0992
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.3083 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.1542 0.3833
Trichomonas vaginalis set domain proteins, putative 0.0229 1 1
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1751 0.4541
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.3083 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1542 0.1044
Schistosoma mansoni alkaline phosphatase 0.0196 0.8472 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Echinococcus multilocularis alkaline phosphatase 0.0196 0.8472 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0082 0.3083 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.1542 0.1044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.8692 1
Schistosoma mansoni hypothetical protein 0.0035 0.0862 0.0353
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 0.8472 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 0.2676
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.3083 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.3083 1
Brugia malayi hypothetical protein 0.0019 0.014 0.0162
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.3083 1
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 0.8472 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.1676 0.1928
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.1542 0.127
Echinococcus granulosus lamin dm0 0.0031 0.0671 0.0173
Schistosoma mansoni lamin 0.0031 0.0671 0.0111
Schistosoma mansoni intermediate filament proteins 0.0031 0.0671 0.0111
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1753 0.1536
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0671 0.0772
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.3083 0.3168
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1753 0.1267
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0642 0.0833
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.3083 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.3083 1
Schistosoma mansoni lamin 0.0031 0.0671 0.0111
Echinococcus multilocularis lamin dm0 0.0031 0.0671 0.0111
Brugia malayi Pre-SET motif family protein 0.0029 0.0584 0.0671
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.71 0.8261
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 0.8472 1
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0082 0.3083 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0862 0.0353
Echinococcus multilocularis musashi 0.0031 0.0671 0.0111
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.3083 0.3168
Brugia malayi intermediate filament protein 0.0031 0.0671 0.0772
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0082 0.3083 0.5
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.3083 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.1542 0.3833
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.3083 0.3168
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 0.8472 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0671 0.0772
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1753 0.2017
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1753 0.1267
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0054 0.1751 0.4541
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.3083 0.3211
Loa Loa (eye worm) hypothetical protein 0.0054 0.1753 0.2017
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.3083 0.3168
Brugia malayi Cytochrome P450 family protein 0.0052 0.1676 0.1928
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0082 0.3083 1
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0082 0.3083 0.5
Onchocerca volvulus 0.0031 0.0671 0.0093
Echinococcus granulosus intestinal type alkaline phosphatase 0.0196 0.8472 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1753 0.2017
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1751 0.4996
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.3083 1
Brugia malayi Pre-SET motif family protein 0.0201 0.8692 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.3083 0.2676
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1751 0.2319
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.3083 0.3211
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0671 0.0772
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.1542 0.3833
Onchocerca volvulus 0.0031 0.0671 0.0093
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0028 0.0558 0.5
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.1349 0.219
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 0.8472 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.71 0.8261

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 10 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.