Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0122 | 0.1941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0261 | 0.0773 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.0049 | 0.0049 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0031 | 0.0083 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0093 | 0.0276 |
Brugia malayi | Muscleblind-like protein | 0.0153 | 0.0616 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.022 | 0.0908 | 0.2678 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0003 | 0.0008 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.0561 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.1548 | 0.4576 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.049 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0002 | 0.0002 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0003 | 0.0008 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0067 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0003 | 0.0008 |
Brugia malayi | hypothetical protein | 0.014 | 0.0561 | 0.9104 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0261 | 0.0773 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0031 | 0.0459 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0031 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0003 | 0.0008 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0022 | 0.0049 | 0.7317 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.0049 | 0.0756 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.0002 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0031 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0049 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.2317 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.02 | 0.3219 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0003 | 0.0001 |
Echinococcus multilocularis | geminin | 0.0368 | 0.1548 | 0.4572 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2317 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0003 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.034 | 0.1426 | 0.4216 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.1548 | 0.4576 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0024 | 0.0056 | 0.0056 |
Echinococcus granulosus | bloom syndrome protein | 0.0022 | 0.0049 | 0.0137 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0049 | 0.2709 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0024 | 0.0056 | 0.6018 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.02 | 0.3219 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0003 | 0.0008 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0093 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0139 | 0.0557 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0261 | 0.0773 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0791 | 0.3382 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.0261 | 0.0765 |
Loa Loa (eye worm) | hypothetical protein | 0.2317 | 1 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0093 | 0.0093 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 0.0616 | 0.1816 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0139 | 0.0557 | 0.164 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0003 | 0.0008 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0139 | 0.0557 | 0.1647 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0093 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0064 | 0.0229 | 0.0668 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0031 | 0.0459 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0093 | 0.1472 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0139 | 0.0557 | 0.164 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | RecQ helicase | 0.0022 | 0.0049 | 0.0047 |
Brugia malayi | mbt repeat family protein | 0.0056 | 0.0195 | 0.3131 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0002 | 0.0201 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0067 | 1 |
Brugia malayi | RNA binding protein | 0.0071 | 0.0261 | 0.4214 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0022 | 0.0049 | 0.0137 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0022 | 0.0049 | 0.2709 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0031 | 0.0083 |
Brugia malayi | mbt repeat family protein | 0.0056 | 0.0195 | 0.3131 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0056 | 0.0195 | 0.0569 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0139 | 0.0557 | 0.1647 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0022 | 0.0049 | 0.2709 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0024 | 0.0056 | 0.0157 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0003 | 0.0008 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.049 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0031 | 0.0083 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0791 | 0.3382 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0022 | 0.0049 | 0.0146 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0022 | 0.0049 | 0.0756 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0064 | 0.0229 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.02 | 0.0199 |
Loa Loa (eye worm) | MBCTL1 | 0.0064 | 0.0229 | 0.0227 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0056 | 0.0195 | 0.3439 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.0049 | 0.0756 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.0261 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0616 | 0.0615 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0031 | 0.0092 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0261 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0616 | 0.0615 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0056 | 0.0195 | 0.0569 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.02 | 0.0199 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.0261 | 0.0765 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0033 | 0.4794 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 0.0616 | 0.1816 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 0.0616 | 0.1816 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0139 | 0.0557 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0056 | 0.0195 | 0.0577 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0031 | 0.0092 |
Toxoplasma gondii | hypothetical protein | 0.2317 | 1 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0064 | 0.0229 | 0.3678 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0089 |
Brugia malayi | RNA, U transporter 1 | 0.0092 | 0.0352 | 0.5695 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0056 | 0.0195 | 0.0193 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0003 | 0.0008 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0067 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0031 | 0.0083 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0033 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0122 | 0.0361 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0056 | 0.3844 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.0261 | 0.026 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0097 |
Entamoeba histolytica | Ran family GTPase | 0.0024 | 0.0056 | 0.842 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0791 | 0.3382 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.022 | 0.0908 | 0.2678 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0056 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0056 | 0.0195 | 0.0569 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0064 | 0.0229 | 0.0676 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.0261 | 0.4214 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.0002 | 0.0006 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.0033 | 0.3531 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0056 | 0.3844 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0139 | 0.0557 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0089 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0093 | 0.0267 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0056 | 0.0195 | 0.0577 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0003 | 0.0008 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0033 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0064 | 0.0229 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0561 | 0.056 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Schistosoma mansoni | ran | 0.0024 | 0.0056 | 0.0166 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0056 | 0.0867 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0261 | 0.0773 |
Entamoeba histolytica | recQ family helicase, putative | 0.0022 | 0.0049 | 0.7393 |
Echinococcus multilocularis | snurportin 1 | 0.0346 | 0.1453 | 0.4292 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0139 | 0.0557 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0031 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0093 | 0.0091 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0056 | 0.0195 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0031 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0024 | 0.0056 | 0.0157 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0089 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0022 | 0.0049 | 0.0137 |
Onchocerca volvulus | 0.0056 | 0.0195 | 0.3439 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0003 | 0.0001 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0003 | 0.0008 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0056 | 0.0054 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.0033 | 0.4794 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0064 | 0.0229 | 0.0668 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0003 | 0.0008 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0003 | 0.0008 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0089 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0056 | 0.0195 | 0.0569 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0022 | 0.0049 | 0.0137 |
Trichomonas vaginalis | ran, putative | 0.0024 | 0.0056 | 0.3938 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0346 | 0.1453 | 0.1451 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0067 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0561 | 0.056 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0056 | 0.8374 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0139 | 0.0557 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0229 | 0.0227 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0093 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 0.1453 | 0.4296 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0003 | 0.0001 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0011 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0122 | 0.012 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0093 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0056 | 0.8374 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.0261 | 0.4214 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0067 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0003 | 0.0008 |
Echinococcus granulosus | snurportin 1 | 0.0346 | 0.1453 | 0.4292 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0022 | 0.0049 | 0.0312 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0003 | 0.0001 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0022 | 0.0049 | 0.0137 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0031 | 0.0092 |
Schistosoma mansoni | DNA helicase recq5 | 0.0022 | 0.0049 | 0.0146 |
Echinococcus granulosus | geminin | 0.0368 | 0.1548 | 0.4572 |
Schistosoma mansoni | ran | 0.0024 | 0.0056 | 0.0166 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0002 | 0.00000000003984 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0022 | 0.0049 | 0.0047 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0031 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0195 | 0.0193 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0089 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.0561 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0093 | 0.0267 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.0261 | 0.026 |
Echinococcus multilocularis | bloom syndrome protein | 0.0022 | 0.0049 | 0.0137 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0139 | 0.0557 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0033 | 0.0033 |
Leishmania major | GTP-binding protein, putative | 0.0024 | 0.0056 | 0.0442 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0031 | 0.0083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.