Detailed information for compound 1239221

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.444 | Formula: C19H21FN2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)S(=O)(=O)N(CC1CCCO1)C)Nc1ccccc1F
  • InChi: 1S/C19H21FN2O4S/c1-22(13-15-5-4-12-26-15)27(24,25)16-10-8-14(9-11-16)19(23)21-18-7-3-2-6-17(18)20/h2-3,6-11,15H,4-5,12-13H2,1H3,(H,21,23)
  • InChiKey: WREQFIYKTSZNCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0019 0.0027
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1002 0.1462
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0381 0.4612 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1002 0.1438
Echinococcus granulosus chromobox protein 1 0.0083 0.0852 0.1326
Loa Loa (eye worm) hypothetical protein 0.0111 0.1206 0.1738
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0216 0.0288
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0386 0.4676 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0063 0.007
Echinococcus multilocularis apoptotic protease activating factor 1 0.0037 0.027 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1002 0.1438
Echinococcus multilocularis caspase 2 0.0037 0.027 0.0251
Brugia malayi glutaminase DH11.1 0.0558 0.6852 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0066 0.0674
Schistosoma mansoni inhibitor of apoptosis protein 0.0114 0.1245 0.1795
Echinococcus granulosus jumonji domain containing protein 0.009 0.0941 0.1468
Onchocerca volvulus Deterin homolog 0.0114 0.1245 0.1951
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0394 0.0548
Schistosoma mansoni FFA transport protein 0.0386 0.4676 0.6815
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0063 0.007
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0386 0.4676 0.4666
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0587 0.0904
Brugia malayi Bromodomain containing protein 0.0065 0.0619 0.0904
Trichomonas vaginalis glutaminase, putative 0.0558 0.6852 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0037 0.027 0.0399
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0119 0.1015
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0388 0.0541
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0617 0.0876
Echinococcus multilocularis jumonji domain containing protein 0.009 0.0941 0.0924
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1002 0.2111
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1002 0.2111
Plasmodium vivax JmjC domain containing protein 0.0021 0.0063 0.0728
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1002 0.1438
Schistosoma mansoni chromobox protein 0.0083 0.0852 0.1219
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0021 0.0063 0.0626
Echinococcus multilocularis chromobox protein 1 0.0083 0.0852 0.0835
Schistosoma mansoni hypothetical protein 0.0065 0.0619 0.0879
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0354
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0019 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0066 0.0783
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0617 0.0952
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0716 0.1021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0617 0.06
Loa Loa (eye worm) hypothetical protein 0.0114 0.1245 0.1795
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0018 0.0019 0.0027
Onchocerca volvulus Alhambra homolog 0.0065 0.0619 0.0955
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0065 0.0617 0.0876
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0213 0.2489 0.2475
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0119 0.0214
Echinococcus granulosus lysine specific demethylase 5A 0.0079 0.0792 0.1231
Onchocerca volvulus 0.0114 0.1245 0.1951
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0765 0.1092
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0852 0.1219
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0063 0.0064
Brugia malayi PHD-finger family protein 0.0021 0.0066 0.0096
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0114 0.1245 0.1952
Schistosoma mansoni glutaminase 0.0558 0.6852 1
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0114 0.1245 0.1795
Brugia malayi RNA binding protein 0.0076 0.0765 0.1116
Brugia malayi jmjC domain containing protein 0.0021 0.0063 0.0091
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0716 0.1519
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0019 0.0027
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1002 0.1564
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0367
Trypanosoma brucei polo-like protein kinase 0.0095 0.1002 1
Schistosoma mansoni jumonji domain containing protein 0.0169 0.1936 0.2806
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0216 0.0288
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0765 0.0748
Mycobacterium ulcerans glutaminase 0.0558 0.6852 1
Leishmania major fatty acid transporter protein-like protein 0.0381 0.4612 1
Schistosoma mansoni hypothetical protein 0.0114 0.1245 0.1795
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0765 0.1092
Echinococcus granulosus inhibitor of apoptosis protein 0.0114 0.1245 0.1952
Onchocerca volvulus 0.0514 0.6305 1
Loa Loa (eye worm) glutaminase 2 0.0558 0.6852 1
Loa Loa (eye worm) glutaminase 0.0558 0.6852 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1002 0.0985
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0063 0.0064
Entamoeba histolytica hypothetical protein 0.0036 0.025 0.235
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0066 0.0478
Echinococcus granulosus PHD finger protein rhinoceros 0.0065 0.0619 0.0955
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0367
Plasmodium falciparum phd finger protein, putative 0.0065 0.0619 1
Echinococcus granulosus peregrin 0.0065 0.0619 0.0955
Trichomonas vaginalis set domain proteins, putative 0.0514 0.6305 0.9199
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0716 0.0699
Schistosoma mansoni hypothetical protein 0.0036 0.025 0.0338
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0398 0.4834 0.7046
Brugia malayi jmjC domain containing protein 0.0021 0.0063 0.0091
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0021 0.0063 0.0626
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1002 0.1438
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.025 0.0231
Entamoeba histolytica hypothetical protein 0.0036 0.025 0.235
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0063 0.0444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0381 0.4612 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0765 0.1116
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0063 0.0044
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0063 0.0094
Brugia malayi hypothetical protein 0.0016 0.0005 0.0007
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0063 0.007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0063 0.0044
Brugia malayi PHD-finger family protein 0.0065 0.0619 0.0904
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0119 0.1663
Echinococcus multilocularis PHD finger protein rhinoceros 0.0065 0.0619 0.0602
Brugia malayi jmjC domain containing protein 0.0021 0.0063 0.0091
Plasmodium falciparum JmjC domain-containing protein, putative 0.0021 0.0063 0.0728
Onchocerca volvulus 0.0037 0.0261 0.0385
Echinococcus granulosus tar DNA binding protein 0.0076 0.0765 0.1187
Echinococcus granulosus long chain fatty acid transport protein 4 0.0386 0.4676 0.7412
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1002 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0792 0.1132
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0065 0.0619 0.0879
Trichomonas vaginalis chromobox protein, putative 0.005 0.0433 0.0607
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0063 0.0064
Brugia malayi jmjC domain containing protein 0.0213 0.2489 0.3633
Echinococcus granulosus geminin 0.0514 0.6303 1
Entamoeba histolytica hypothetical protein 0.0036 0.025 0.235
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0386 0.4676 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0617 0.8579
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0063 0.0044
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0063 0.0044
Schistosoma mansoni hypothetical protein 0.0514 0.6303 0.9195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0619 0.0879
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0716 0.1021
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0619 0.8606
Brugia malayi Cell death protein 3 precursor 0.0037 0.027 0.0393
Schistosoma mansoni caspase-7 (C14 family) 0.0037 0.027 0.0367
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.0619 0.0879
Brugia malayi Pre-SET motif family protein 0.0065 0.0617 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0394 0.0548
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0114 0.1245 0.1817
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1002 0.1564
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0063 0.007
Onchocerca volvulus 0.0078 0.079 0.1227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0792 0.1132
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.025 0.0338
Loa Loa (eye worm) hypothetical protein 0.0245 0.2895 0.4208
Onchocerca volvulus Cell death protein 3 homolog 0.0037 0.027 0.0399
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0617 0.0876
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0078 0.079 0.1128
Leishmania major hypothetical protein, conserved 0.0021 0.0063 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0019 0.0027
Brugia malayi Pre-SET motif family protein 0.0452 0.5515 0.8049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0617 0.06
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0119 0.1663
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.025 0.0368
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0114 0.1245 0.1229
Loa Loa (eye worm) RNA binding protein 0.0076 0.0765 0.1092
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0619 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0134 0.1494 0.2159
Echinococcus granulosus phd:f box containing protein 0.0021 0.0063 0.007
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0765 0.1092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0452 0.5515 0.8043
Brugia malayi photoreceptor-specific nuclear receptor 0.0245 0.2895 0.4224
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0765 0.1092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0617 0.0876
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0119 0.1431
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0792 0.1132
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0063 0.0044
Brugia malayi TAR-binding protein 0.0076 0.0765 0.1116
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0765 0.1092
Schistosoma mansoni hypothetical protein 0.0514 0.6303 0.9195
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1002 0.214
Plasmodium vivax SET domain protein, putative 0.0065 0.0617 0.9969
Brugia malayi chromobox protein homolog 3 0.0047 0.0388 0.0567
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0064
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0063 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0096 0.0113
Schistosoma mansoni chromobox protein 0.0083 0.0852 0.1219
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0096 0.014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0064
Leishmania major hypothetical protein, conserved 0.0025 0.0119 0.0217
Onchocerca volvulus 0.0037 0.027 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1002 0.1438
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0765 0.1092
Brugia malayi hypothetical protein 0.0025 0.0119 0.0173
Brugia malayi hypothetical protein 0.0036 0.025 0.0365
Echinococcus multilocularis inhibitor of apoptosis protein 0.0114 0.1245 0.1229
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0852 0.1219
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0433 0.0659
Echinococcus multilocularis peregrin 0.0065 0.0619 0.0602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.0069
Echinococcus granulosus chromobox protein 1 0.0083 0.0852 0.1326
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0388 0.0588
Brugia malayi AF-10 protein 0.0021 0.0066 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0716 0.1021
Schistosoma mansoni hypothetical protein 0.0037 0.027 0.0367
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1002 0.1438
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0146
Brugia malayi Heterochromatin protein 1 0.0083 0.0852 0.1243
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1002 0.1438
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0619 0.8606
Trichomonas vaginalis chromobox protein, putative 0.005 0.0433 0.0607
Brugia malayi AMP-binding enzyme family protein 0.0398 0.4834 0.7054
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0066 0.0783
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0716 0.1021
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0063 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0119 0.0214
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0213 0.2489 0.3932
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0398 0.4834 0.7046
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0019 0.0027
Schistosoma mansoni hypothetical protein 0.0021 0.0066 0.0069
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0716 0.1519
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0063 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0716 0.111
Echinococcus multilocularis geminin 0.0514 0.6303 0.6296
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0019 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1002 0.1438
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0119 0.1663
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0063 0.0064
Loa Loa (eye worm) hypothetical protein 0.0047 0.0388 0.0541
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0114 0.1245 0.1817
Echinococcus granulosus caspase 2 0.0037 0.027 0.0399
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0066 0.0674
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0792 0.0775
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0063 0.0064
Schistosoma mansoni kinase 0.0048 0.0409 0.0572
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0716 0.1021
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1002 0.1438
Echinococcus multilocularis chromobox protein 1 0.0083 0.0852 0.0835
Brugia malayi jmjC domain containing protein 0.0021 0.0063 0.0091
Giardia lamblia Kinase, PLK 0.0095 0.1002 1
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0063 0.0064
Loa Loa (eye worm) heterochromatin protein 1 0.0083 0.0852 0.1219
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0066 0.0478
Loa Loa (eye worm) hypothetical protein 0.0114 0.1245 0.1795
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0388 0.0541
Brugia malayi jmjC domain containing protein 0.0079 0.0792 0.1156
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0716 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0765 0.1092
Entamoeba histolytica hypothetical protein 0.0036 0.025 0.235
Brugia malayi hypothetical protein 0.0037 0.027 0.0393

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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