Detailed information for compound 1248395

Basic information

Technical information
  • TDR Targets ID: 1248395
  • Name: 5-ethyl-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymeth yl)oxolan-2-yl]pyrimidine-2,4-dione
  • MW: 258.246 | Formula: C11H15FN2O4
  • H donors: 2 H acceptors: 3 LogP: -0.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1F)n1cc(CC)c(=O)[nH]c1=O
  • InChi: 1S/C11H15FN2O4/c1-2-6-4-14(11(17)13-10(6)16)9-3-7(12)8(5-15)18-9/h4,7-9,15H,2-3,5H2,1H3,(H,13,16,17)/t7-,8+,9+/m0/s1
  • InChiKey: SSFQGWVTTOGGKN-DJLDLDEBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-ethyl-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
  • 5-ethyl-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)-2-tetrahydrofuranyl]pyrimidine-2,4-dione
  • 5-ethyl-1-[(2R,4S,5R)-4-fluoro-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone
  • 108895-53-0
  • 3'-F-5-Et-ddU
  • 3'-FddEtU
  • 3'-Fluoro-2',3'-dideoxy-5-ethyluridine
  • AIDS-000116
  • AIDS000116
  • FLEU
  • FddEtUrd

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutathione reductase 0.0099 0.0065 0.0715
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0183 0.015 0.3851
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Onchocerca volvulus 0.0263 0.023 0.6016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0009 0.0077
Plasmodium falciparum pyruvate kinase 0.0039 0.0005 0.0005
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0063 0.0977
Trypanosoma cruzi Peptide deformylase 2, putative 0.3809 0.3794 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.001 0.0264
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0058 0.1501
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.3809 0.3794 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.0135 0.0101 0.1141
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0005 0.0005
Plasmodium vivax glutathione reductase, putative 0.0099 0.0065 0.0065
Echinococcus granulosus adam 0.0073 0.0039 0.0604
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.0065 0.0065
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0042 0.0008 0.0117
Mycobacterium ulcerans hydrolase 0.0226 0.0193 0.0193
Schistosoma mansoni alpha glucosidase 0.0042 0.0008 0.0201
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0183 0.015 0.015
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0183 0.015 0.3588
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Echinococcus granulosus adam 17 protease 0.0463 0.043 0.6684
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0057 0.0057
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Onchocerca volvulus 0.0097 0.0063 0.1558
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0066 0.0718
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0264 0.0231 0.3583
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0057 0.0053
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0005 0.004
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0009 0.0095
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0066 0.1022
Brugia malayi Probable ClpP-like protease 0.0091 0.0057 0.1371
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0009 0.0077
Echinococcus granulosus disintegrin and metalloproteinase 0.0042 0.0008 0.0117
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0008 0.0069
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0045 0.001 0.0264
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0057 0.0057
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0226 0.0193 0.0193
Leishmania major pyruvate kinase 0.0039 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0186 0.0152 0.1736
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Trypanosoma cruzi Peptide deformylase 2, putative 0.3809 0.3794 1
Echinococcus multilocularis neuropeptide receptor A26 0.0542 0.051 0.5561
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0063 0.1511
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Plasmodium falciparum glutathione reductase 0.0099 0.0065 0.0065
Loa Loa (eye worm) matrixin family protein 0.0412 0.0379 0.4412
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0008 0.0121
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0199 0.0165 0.1801
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.001 0.0264
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0009 0.0008
Mycobacterium ulcerans zinc metalloprotease 0.0183 0.015 0.015
Toxoplasma gondii peptidase family M13 protein 0.0183 0.015 0.015
Schistosoma mansoni pyruvate kinase 0.0039 0.0005 0.0117
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.3809 0.3794 1
Brugia malayi peptidase family M13 containing protein 0.0045 0.001 0.0246
Onchocerca volvulus 0.0186 0.0152 0.3935
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0226 0.0193 0.4625
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0057 0.1472
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0009 0.0009
Onchocerca volvulus 0.011 0.0076 0.1905
Schistosoma mansoni endothelin-converting enzyme-related 0.0045 0.001 0.0264
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0008 0.0069
Loa Loa (eye worm) matrixin family protein 0.0449 0.0417 0.4852
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.0065 0.0715
Mycobacterium tuberculosis Probable dehydrogenase 0.0227 0.0193 0.0193
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0092 0.0058 0.1501
Trypanosoma brucei Peptide deformylase 2 0.3809 0.3794 1
Loa Loa (eye worm) zinc metallopeptidase 4 0.0045 0.001 0.0067
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0026 0.0279
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0264 0.0231 0.2517
Schistosoma mansoni alpha-glucosidase 0.0164 0.013 0.3346
Loa Loa (eye worm) reprolysin 0.0042 0.0008 0.0036
Onchocerca volvulus Matrilysin homolog 0.0186 0.0152 0.3935
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Loa Loa (eye worm) matrix metalloproteinase 0.0186 0.0152 0.1736
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0057 0.0057
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0063 0.1621
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0009 0.0136
Brugia malayi Hemopexin family protein 0.0263 0.023 0.5521
Loa Loa (eye worm) peptidase family M13 containing protein 0.0135 0.0101 0.1141
Loa Loa (eye worm) hypothetical protein 0.0183 0.015 0.1707
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0144 0.011 0.2825
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0623
Echinococcus granulosus pyruvate kinase 0.0039 0.0005 0.007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0227 0.0193 0.0193
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0613
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0008 0.0187
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.1161 0.1133 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0008 0.0085
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0005 0.0012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0138 0.0104 0.1132
Echinococcus multilocularis disintegrin and metalloproteinase 0.0042 0.0008 0.0082
Schistosoma mansoni lipoxygenase 0.0138 0.0104 0.2672
Treponema pallidum polypeptide deformylase (def) 0.9982 1 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0226 0.0193 0.0189
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0008 0.0021
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0227 0.0193 0.0193
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Echinococcus multilocularis pyruvate kinase 0.0039 0.0005 0.0049
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0887
Chlamydia trachomatis pyruvate kinase 0.0039 0.0005 0.0005
Onchocerca volvulus Matrilysin homolog 0.0412 0.0379 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Schistosoma mansoni dihydroceramide desaturase 0.0042 0.0008 0.0195
Loa Loa (eye worm) hypothetical protein 0.0183 0.015 0.1707
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Brugia malayi hypothetical protein 0.0073 0.0039 0.0934
Echinococcus multilocularis pyruvate kinase 0.0039 0.0005 0.0049
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0092 0.0058 0.1501
Loa Loa (eye worm) hypothetical protein 0.0097 0.0063 0.0688
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0005 0.0012
Plasmodium falciparum peptide deformylase 0.9982 1 1
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0199 0.0165 0.2564
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.0157 0.1708
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0042 0.0008 0.0195
Loa Loa (eye worm) hypothetical protein 0.0226 0.0193 0.2215
Plasmodium falciparum thioredoxin reductase 0.0099 0.0065 0.0065
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.0157 0.3757
Echinococcus granulosus neuropeptide s receptor 0.0542 0.051 0.7916
Loa Loa (eye worm) hypothetical protein 0.0186 0.0152 0.1736
Mycobacterium tuberculosis Probable reductase 0.0227 0.0193 0.0193
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0227 0.0193 0.0193
Schistosoma mansoni neprilysin 0.0048 0.0013 0.0346
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0619
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0946 0.0917 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0005 0.0109
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.0157 0.1789
Schistosoma mansoni hypothetical protein 0.0263 0.023 0.5924
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0008 0.0069
Loa Loa (eye worm) hypothetical protein 0.0186 0.0152 0.1736
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0675 0.0644 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0675 0.0644 0.7025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0252 0.0219 0.0214
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Brugia malayi Disintegrin family protein 0.0042 0.0008 0.0181
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0199 0.0165 0.4252
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0073 0.0039 0.1002
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.9982 1 1
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0421 0.0388 1
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.0065 0.0172
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0045 0.001 0.0264
Brugia malayi Peptidase family M13 containing protein 0.0183 0.015 0.3588
Brugia malayi glutathione reductase 0.0099 0.0065 0.1566
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0004 0.0004
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Schistosoma mansoni inositol monophosphatase 0.0043 0.0009 0.0225
Brugia malayi Inositol-1 0.0043 0.0009 0.021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0252 0.0219 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0008 0.0021
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0005 0.0109
Schistosoma mansoni lipoxygenase 0.0096 0.0062 0.16
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0186 0.0152 0.3916
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0005 0.004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0008 0.0036
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Echinococcus granulosus pyruvate kinase 0.0039 0.0005 0.007
Toxoplasma gondii thioredoxin reductase 0.0099 0.0065 0.0065
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0026 0.0026
Onchocerca volvulus Matrix metalloproteinase homolog 0.0412 0.0379 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Trypanosoma brucei trypanothione reductase 0.0099 0.0065 0.0172
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0008 0.0021
Brugia malayi Thioredoxin reductase 0.0099 0.0065 0.1566
Onchocerca volvulus 0.0091 0.0057 0.139
Toxoplasma gondii hypothetical protein 0.9982 1 1
Plasmodium vivax peptide deformylase, putative 0.9982 1 1
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.9982 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.0157 0.1708
Trypanosoma brucei glucosidase, putative 0.0042 0.0008 0.0021
Mycobacterium tuberculosis Possible exported protein 0.1491 0.1464 0.1464
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0008 0.0069
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0013 0.0346
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0058 0.1501
Leishmania major trypanothione reductase 0.0099 0.0065 0.0172
Leishmania major pyruvate kinase 0.0039 0.0005 0.0012
Trypanosoma brucei Polypeptide deformylase 1 0.3809 0.3794 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0005 0.0005
Loa Loa (eye worm) inositol-1 0.0043 0.0009 0.0049
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0005 0.0012
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0138 0.0104 0.1611
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.0157 0.2431
Mycobacterium ulcerans peptide deformylase 0.9982 1 1
Brugia malayi follicle stimulating hormone receptor 0.0273 0.024 0.5758
Mycobacterium tuberculosis Probable oxidoreductase 0.0252 0.0219 0.0219
Echinococcus multilocularis endothelin converting enzyme 1 0.0183 0.015 0.1631
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.9982 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0542 0.051 0.5561
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0273 0.024 0.2771
Mycobacterium leprae probable zinc metalloprotease 0.0183 0.015 0.0145
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0252 0.0219 0.0219
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0026 0.0397
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0199 0.0165 0.3962
Echinococcus multilocularis adam 17 protease 0.0421 0.0388 0.4235
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Loa Loa (eye worm) hypothetical protein 0.0183 0.015 0.1707
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0227 0.0193 0.0193
Echinococcus granulosus endothelin converting enzyme 1 0.0183 0.015 0.2322
Schistosoma mansoni neprilysin-2 (M13 family) 0.0092 0.0058 0.1501
Schistosoma mansoni alpha-glucosidase 0.0164 0.013 0.3346
Echinococcus multilocularis adam 0.0073 0.0039 0.0424
Loa Loa (eye worm) hypothetical protein 0.0884 0.0854 1
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0005 0.0012
Entamoeba histolytica dual specificity protein phosphatase, putative 0.1161 0.1133 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Leishmania major polypeptide deformylase-like protein, putative 0.3809 0.3794 1
Brugia malayi Matrixin family protein 0.0449 0.0417 1
Schistosoma mansoni pyruvate kinase 0.0039 0.0005 0.0117
Giardia lamblia Pyruvate kinase 0.0039 0.0005 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Schistosoma mansoni inositol monophosphatase 0.0043 0.0009 0.0225
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0005 0.0005
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0008 0.0008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0227 0.0193 0.0189
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0026 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0026 0.0026
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0009 0.0077
Echinococcus granulosus neuropeptide receptor A26 0.0542 0.051 0.7916
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.001 0.0264
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.0065 0.0065
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0063 0.0687
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0009 0.0009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0008 0.0039
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0042 0.0008 0.0195
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0042 0.0008 0.0082

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 100 ug ml-1 Cytotoxicity against human HuH7 cells by XTT assay ChEMBL. 22178557
CC50 (ADMET) > 100 ug ml-1 Cytotoxicity against human HuH7 cells by [3H]thymidine incorporation assay ChEMBL. 22178557
GI (functional) Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as growth inhibition at 0.5 to 100 ug/ml by microplate alamar blue assay ChEMBL. 22178557

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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