Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Streptococcus pyogenes serotype M1 | Streptokinase A | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0851 | 0.0721 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3194 | 0.3753 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7956 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.7511 | 0.9416 |
Brugia malayi | beta-NAC-like protein | 0.0042 | 0.3017 | 0.2007 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0518 | 0.0559 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.3017 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Brugia malayi | RNA binding protein | 0.0073 | 0.7511 | 0.7151 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.3974 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3194 | 0.2209 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3599 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4024 | 0.4348 |
Toxoplasma gondii | NAC domain-containing protein | 0.0042 | 0.3017 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0851 | 0.0679 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.7511 | 0.8116 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3194 | 0.3985 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.7511 | 0.7151 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0518 | 0.0242 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.3974 |
Schistosoma mansoni | transcription factor btf3 | 0.0042 | 0.3017 | 0.3521 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.7511 | 0.7151 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 0.975 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0042 | 0.3017 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3194 | 0.3753 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.3017 | 0.5 |
Echinococcus granulosus | transcription factor btf3 | 0.0042 | 0.3017 | 0.3739 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.7511 | 0.8116 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.7511 | 0.9416 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3017 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.7511 | 0.8116 |
Leishmania major | basic transcription factor 3a, putative | 0.0042 | 0.3017 | 0.5 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0042 | 0.3017 | 0.5 |
Loa Loa (eye worm) | ICD-1 protein | 0.0042 | 0.3017 | 0.326 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.7511 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3017 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0851 | 0.0721 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0042 | 0.3017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3611 | 0.3902 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 0.975 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3017 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.7511 | 0.9416 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4357 | 0.4709 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.7511 | 0.9416 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.7511 | 0.9416 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9254 | 1 |
Echinococcus multilocularis | transcription factor btf3 | 0.0042 | 0.3017 | 0.3739 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3194 | 0.3985 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.7511 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.374 um | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] | ChEMBL. | No reference |
EC50 (functional) | > 150 um | PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 0.0928 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.053 uM | PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.