Detailed information for compound 1253036

Basic information

Technical information
  • TDR Targets ID: 1253036
  • Name: (5-tert-butyl-4,5,6,7-tetrahydro-1,2-benzoxaz ol-3-yl)-morpholin-4-ylmethanone
  • MW: 292.373 | Formula: C16H24N2O3
  • H donors: 0 H acceptors: 2 LogP: 2.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1noc2c1CC(CC2)C(C)(C)C)N1CCOCC1
  • InChi: 1S/C16H24N2O3/c1-16(2,3)11-4-5-13-12(10-11)14(17-21-13)15(19)18-6-8-20-9-7-18/h11H,4-10H2,1-3H3
  • InChiKey: IDIKVWIULDMOTB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • (5-tert-butyl-4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)-morpholino-methanone
  • (5-tert-butyl-4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)-morpholinomethanone
  • (5-tert-butyl-4,5,6,7-tetrahydroindoxazen-3-yl)-morpholino-methanone
  • (5-tert-butyl-4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)-morpholin-4-yl-methanone
  • MLS000087412
  • SMR000023635
  • 5-tert-butyl-3-(morpholin-4-ylcarbonyl)-4,5,6,7-tetrahydro-1,2-benzisoxazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni suppressor of cytokine signaling 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Echinococcus granulosus tyrosine kinase 0.0095 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0074 0.6223 0.5873
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase shark 0.0095 1 1
Schistosoma mansoni GTPase activating protein 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase Blk 0.0095 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0074 0.6223 0.5873
Echinococcus multilocularis SH2 motif 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0095 1 1
Schistosoma mansoni tensin 0.0074 0.6223 0.5873
Schistosoma mansoni tensin 0.0074 0.6223 0.5873
Schistosoma mansoni tensin-related 0.0074 0.6223 0.5873
Echinococcus granulosus signal transduction protein lnk realted 0.0074 0.6223 0.5873
Schistosoma mansoni signal transduction protein lnk-related 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0847 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0856 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 1 1
Schistosoma mansoni adapter molecule crk 0.0074 0.6223 0.5873
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0074 0.6223 0.5873
Echinococcus granulosus expressed conserved protein 0.0074 0.6223 0.5873
Echinococcus multilocularis SHC transforming protein 3 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase Src42A 0.0074 0.6223 0.5873
Echinococcus granulosus hypothetical protein 0.0074 0.6223 0.5873
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0856 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0856 0.0011
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0095 1 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0095 1 1
Echinococcus multilocularis SH2 motif 0.0074 0.6223 0.5873
Brugia malayi SH2 domain containing protein 0.0074 0.6223 0.5873
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0856 0.0011
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0074 0.6223 0.5873
Brugia malayi hypothetical protein 0.0095 1 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0095 1 1
Echinococcus multilocularis 0.0074 0.6223 0.5873
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0856 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0856 0.0011
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Onchocerca volvulus 0.0095 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0074 0.6223 0.5873
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0074 0.6223 0.5873
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0074 0.6223 0.5873
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0856 1
Echinococcus multilocularis N chimaerin 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Schistosoma mansoni tyrosine kinase 0.0095 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0074 0.6223 0.5873
Loa Loa (eye worm) SH2 domain-containing protein 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase Src42A 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0856 0.5
Loa Loa (eye worm) STAT protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Blk 0.0095 1 1
Schistosoma mansoni tyrosine kinase 0.0095 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0095 1 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0074 0.6223 0.5873
Brugia malayi Protein kinase domain containing protein 0.0095 1 1
Brugia malayi Variant SH3 domain containing protein 0.0074 0.6223 0.5873
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0095 1 1
Brugia malayi hypothetical protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0074 0.6223 0.5873
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0095 1 1
Schistosoma mansoni hypothetical protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0074 0.6223 0.5873
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0095 1 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0856 0.0011
Echinococcus granulosus SH2 domain containing protein 7 0.0074 0.6223 0.5873
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) SH2 domain-containing protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0847 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0074 0.6223 0.5873
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0856 1
Schistosoma mansoni tensin 0.0074 0.6223 0.5873
Entamoeba histolytica SH2 domain containing protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK protein kinase 0.0095 1 1
Schistosoma mansoni tyrosine kinase 0.0095 1 1
Schistosoma mansoni SH2A 0.0074 0.6223 0.5873
Schistosoma mansoni tyrosine kinase 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0074 0.6223 0.5873
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0095 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0074 0.6223 0.5873
Brugia malayi Sex muscle abnormal protein 5 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Brugia malayi Variant SH3 domain containing protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0095 1 1
Schistosoma mansoni vav2 0.0074 0.6223 0.5873
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0074 0.6223 0.5873
Brugia malayi SH2 domain containing protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0074 0.6223 0.5873
Loa Loa (eye worm) SH2 domain-containing protein 0.0074 0.6223 0.5873
Brugia malayi protein-tyrosine kinase 0.0095 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) hypothetical protein 0.0095 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0095 1 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0856 0.0011
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 1 1
Echinococcus granulosus c src tyrosine kinase 0.0095 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0074 0.6223 0.5873
Brugia malayi SH2 domain containing protein 0.0095 1 1
Echinococcus granulosus SH2 motif 0.0074 0.6223 0.5873
Schistosoma mansoni nck2/grb4 0.0074 0.6223 0.5873
Brugia malayi SH2 domain containing protein 0.0074 0.6223 0.5873
Echinococcus granulosus tensin 0.0074 0.6223 0.5873
Onchocerca volvulus 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0095 1 1
Brugia malayi SH2 domain containing protein 0.0095 1 1
Brugia malayi SRC-1 0.0095 1 1
Brugia malayi Protein kinase domain containing protein 0.0095 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0095 1 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0095 1 1
Brugia malayi Variant SH3 domain containing protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Onchocerca volvulus 0.0095 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0095 1 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine kinase 0.0095 1 1
Echinococcus multilocularis SH2 motif 0.0074 0.6223 0.5873
Echinococcus granulosus SH2 motif 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase Src64B 0.0095 1 1
Echinococcus granulosus SHC transforming protein 3 0.0074 0.6223 0.5873
Loa Loa (eye worm) hypothetical protein 0.0045 0.0856 0.0011
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 1 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0074 0.6223 0.5873
Onchocerca volvulus 0.0095 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0095 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0095 1 1
Onchocerca volvulus 0.0095 1 1
Brugia malayi Protein kinase domain containing protein 0.0095 1 1
Onchocerca volvulus 0.0095 1 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0856 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Brugia malayi SH2 domain containing protein 0.0074 0.6223 0.5873
Brugia malayi SH2 domain containing protein 0.0074 0.6223 0.5873
Brugia malayi tRNA modification GTPase TrmE family protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine kinase 0.0095 1 1
Brugia malayi RhoGAP domain containing protein 0.0074 0.6223 0.5873
Brugia malayi STAT protein, DNA binding domain containing protein 0.0074 0.6223 0.5873
Entamoeba histolytica protein kinase, putative 0.0074 0.6223 0.5873
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0 0.5
Echinococcus granulosus NCK adaptor protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Abl 0.0095 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Echinococcus granulosus N chimaerin 0.0074 0.6223 0.5873
Brugia malayi SH2 domain containing protein 0.0074 0.6223 0.5873
Echinococcus multilocularis NCK adaptor protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0074 0.6223 0.5873
Loa Loa (eye worm) TK/FER protein kinase 0.0095 1 1
Brugia malayi Protein kinase domain containing protein 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Schistosoma mansoni tyrosine kinase 0.0095 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0095 1 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0856 0.0011
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0074 0.6223 0.5873
Echinococcus multilocularis SH2 domain containing protein 7 0.0074 0.6223 0.5873
Loa Loa (eye worm) SRC-1 0.0095 1 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0 0.5
Schistosoma mansoni tyrosine kinase 0.0095 1 1
Schistosoma mansoni shc transforming protein 0.0074 0.6223 0.5873
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0856 0.0011
Schistosoma mansoni tensin-related 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0095 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0074 0.6223 0.5873
Brugia malayi Tensin 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0074 0.6223 0.5873
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0856 0.0011
Echinococcus multilocularis tensin 0.0074 0.6223 0.5873
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0074 0.6223 0.5873
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0856 0.0011
Echinococcus multilocularis tyrosine protein kinase Srms 0.0095 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.6223 0.5873
Echinococcus multilocularis c src tyrosine kinase 0.0095 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0074 0.6223 0.5873
Brugia malayi SH2 domain containing protein 0.0074 0.6223 0.5873
Schistosoma mansoni hypothetical protein 0.0074 0.6223 0.5873
Schistosoma mansoni suppressor of cytokine signaling 0.0074 0.6223 0.5873
Brugia malayi cytokine inducible SH2-containing protein 5 0.0074 0.6223 0.5873
Brugia malayi Variant SH3 domain containing protein 0.0074 0.6223 0.5873
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0856 1
Echinococcus multilocularis tensin 0.0074 0.6223 0.5873
Schistosoma mansoni growth factor receptor-bound protein 0.0074 0.6223 0.5873
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0074 0.6223 0.5873
Echinococcus granulosus tyrosine protein kinase ABL1 0.0095 1 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0856 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0847 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0074 0.6223 0.5873

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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