TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 276.371 | Formula: C17H24O3
H donors: 0 H acceptors: 1 LogP: 4.21 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@@H]1CC[C@@](C1(C)C)(C)c1ccc(cc1)OC
InChi: 1S/C17H24O3/c1-16(2)14(15(18)20-5)10-11-17(16,3)12-6-8-13(19-4)9-7-12/h6-9,14H,10-11H2,1-5H3/t14-,17-/m0/s1
InChiKey: XXSJMTSZOJCSTM-YOEHRIQHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Rap guanine nucleotide exchange factor (GEF) 4	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	Get druggable targets OG5_131726	All targets in OG5_131726
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	N-terminal motif family protein	Get druggable targets OG5_131726	All targets in OG5_131726
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131726	All targets in OG5_131726
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0119	0.0214
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.0434	0.1353
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0365	1
Loa Loa (eye worm)	fibroinase	0.0025	0.0147	0.0459
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0662	0.2062
Echinococcus granulosus	cathepsin l1	0.002	0.0082	0.0096
Echinococcus granulosus	GPCR family 2	0.0017	0.0052	0.0003
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0701	0.2058
Brugia malayi	N-terminal motif family protein	0.0218	0.2429	0.7571
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.029	0.0905
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0052	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.029	0.024
Leishmania major	cathepsin L-like protease	0.0025	0.0147	0.0326
Schistosoma mansoni	biogenic amine receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Onchocerca volvulus		0.0037	0.029	0.0888
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.029	0.0756
Leishmania major	cathepsin L-like protease	0.0072	0.0701	0.6738
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.029	0.0756
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0365	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0119	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	glutamate receptor	0.0019	0.008	0.0249
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0365	0.3362
Brugia malayi	Dopamine receptor	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.029	0.0756
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0365	0.3362
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0365	0.0814
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0662	0.1933
Schistosoma mansoni	hypothetical protein	0.0037	0.0287	0.0745
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0489	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0287	0.0894
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0365	0.1137
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0365	0.3362
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0365	0.0992
Onchocerca volvulus		0.0037	0.029	0.0888
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0662	0.2062
Schistosoma mansoni	myosin xvIII	0.0037	0.029	0.0756
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0701	0.2058
Onchocerca volvulus		0.0037	0.029	0.0888
Echinococcus granulosus	fmrfamide receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.029	0.024
Loa Loa (eye worm)	glutamate receptor	0.0049	0.0434	0.1353
Brugia malayi	putative neuropeptide receptor	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.029	0.0756
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.029	0.0756
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0119	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0037	0.029	0.0756
Brugia malayi	neuropeptide F receptor	0.0037	0.029	0.0905
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0701	0.2058
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.029	0.024
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0147	0.0459
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0339	0.0911
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0025	0.0147	1
Echinococcus granulosus	neuropeptide receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.029	0.0905
Echinococcus multilocularis	somatostatin receptor	0.0037	0.029	0.024
Echinococcus granulosus	allatostatin A receptor	0.0037	0.029	0.0756
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0365	0.0814
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.029	0.024
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0365	1
Schistosoma mansoni	ap endonuclease	0.0023	0.0119	0.0214
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.0147	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Brugia malayi	beta-lactamase	0.0043	0.0365	0.1137
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0025	0.0147	0.0459
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0662	0.2062
Brugia malayi	Cathepsin L-like cysteine proteinase	0.002	0.0082	0.0256
Onchocerca volvulus		0.0037	0.029	0.0888
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.029	0.0756
Brugia malayi	G-protein coupled receptor	0.0037	0.029	0.0905
Leishmania major	cathepsin L-like protease	0.0072	0.0701	0.6738
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0119	0.0724
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.029	0.0756
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0025	0.0147	0.0303
Giardia lamblia	Cathepsin B precursor	0.0096	0.0983	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Onchocerca volvulus		0.0037	0.029	0.0888
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	biogenic amine receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0052	0.0001
Brugia malayi	Dopamine receptor protein 1	0.0037	0.029	0.0905
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.029	0.024
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.0147	0.0096
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0147	1
Schistosoma mansoni	opsin-like receptor	0.0037	0.029	0.0756
Brugia malayi	cathepsin L-like precursor	0.002	0.0082	0.0256
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.029	0.024
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0119	0.0724
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.029	0.024
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.029	0.024
Schistosoma mansoni	amine GPCR	0.0037	0.029	0.0756
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus granulosus	cathepsin b	0.0284	0.3208	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0365	0.0992
Leishmania major	hypothetical protein, conserved	0.0043	0.0365	0.2844
Loa Loa (eye worm)	hypothetical protein	0.0284	0.3208	1
Echinococcus granulosus	cathepsin l1	0.0025	0.0147	0.0303
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0284	0.3208	1
Schistosoma mansoni	hypothetical protein	0.0037	0.029	0.0756
Onchocerca volvulus		0.0025	0.0147	0.0278
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0052	0.0163
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.029	0.024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0256
Trichomonas vaginalis	esterase, putative	0.0043	0.0365	0.3362
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0365	0.1137
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0662	0.1933
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.029	0.0756
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	sex peptide receptor	0.0037	0.029	0.024
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.029	0.024
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0365	0.0814
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0061	0.0569	0.052
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.029	0.0756
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0082	0.0096
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0365	0.3362
Schistosoma mansoni	hypothetical protein	0.0017	0.0052	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Toxoplasma gondii	cathepsin B	0.0096	0.0983	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.0514	0.1465
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.029	0.0756
Echinococcus granulosus	neuropeptide receptor	0.0037	0.029	0.0756
Brugia malayi	RE15519p	0.0037	0.029	0.0905
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.029	0.024
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.029	0.024
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0045	0.0379	0.1182
Brugia malayi	Serotonin receptor	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0365	0.1137
Schistosoma mansoni	histamine h1 receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Echinococcus granulosus	g protein coupled receptor	0.0037	0.029	0.0756
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.029	0.0905
Onchocerca volvulus		0.0043	0.0365	0.1204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0147	0.0459
Plasmodium vivax	vivapain-2	0.0025	0.0147	0.3053
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0365	0.0814
Schistosoma mansoni	adenoreceptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.029	0.024
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0662	0.2062
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0365	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Giardia lamblia	Cathepsin B precursor	0.0096	0.0983	1
Schistosoma mansoni	hypothetical protein	0.0037	0.029	0.0756
Schistosoma mansoni	metabotropic glutamate receptor	0.0024	0.0135	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0365	0.1137
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3136	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.029	0.0756
Brugia malayi	beta-lactamase family protein	0.0043	0.0365	0.1137
Brugia malayi	AKH receptor	0.0037	0.029	0.0905
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Onchocerca volvulus		0.0025	0.0147	0.0278
Schistosoma mansoni	ap endonuclease	0.0023	0.0119	0.0214
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	cathepsin b	0.0284	0.3208	0.3172
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.029	0.0756
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	cysteine protease	0.0025	0.0147	0.0096
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0147	0.0459
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Brugia malayi	beta-lactamase family protein	0.0043	0.0365	0.1137
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0365	0.0315
Brugia malayi	TAR-binding protein	0.0069	0.0662	0.2062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0037	0.029	0.0888
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0096	0.0983	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.029	0.024
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0147	0.0459
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.029	0.024
Schistosoma mansoni	hypothetical protein	0.0017	0.0052	0.0003
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.029	0.024
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.029	0.0756
Schistosoma mansoni	amine GPCR	0.0037	0.029	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0489	0.1524
Brugia malayi	sulfakinin receptor protein	0.0037	0.029	0.0905
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0662	0.1933
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.029	0.0756
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.029	0.0756
Plasmodium vivax	vivapain-2	0.0025	0.0147	0.3053
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0365	0.1137
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Onchocerca volvulus		0.0043	0.0365	0.1204
Echinococcus multilocularis	serotonin receptor	0.0037	0.029	0.024
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.029	0.0905
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0147	0.0278
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0365	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.3208	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	cathepsin b	0.0284	0.3208	0.3172
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.029	0.024
Brugia malayi	G protein-coupled receptor	0.0037	0.029	0.0905
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.029	0.024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.029	0.024
Echinococcus granulosus	sex peptide receptor	0.0037	0.029	0.0756
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.029	0.0756
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0061	0.0569	0.1639
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.029	0.024
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0489	0.1524
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.029	0.0756
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.029	0.024
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.029	0.0905
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0096	0.0983	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.029	0.024
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.029	0.0905
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0365	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0284	0.3208	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.029	0.024
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0569	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Trypanosoma cruzi	cruzipain precursor, putative	0.0072	0.0701	0.2058
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0119	0.7057
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0365	0.1137
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0365	0.0814
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.029	0.0756
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Onchocerca volvulus		0.0025	0.0147	0.0278
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.029	0.0756
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.029	0.024
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.029	0.024
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.0636	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.029	0.0905
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.0339	0.0289
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0662	0.0613
Onchocerca volvulus		0.0037	0.029	0.0888
Giardia lamblia	Cathepsin B precursor	0.0096	0.0983	1
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.029	0.0756
Onchocerca volvulus		0.0037	0.029	0.0888
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0119	0.0214
Onchocerca volvulus		0.0037	0.029	0.0888
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0256
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.029	0.0756
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.029	0.0756
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.029	0.024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.029	0.0756
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0052	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.029	0.0756
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0365	0.0814
Onchocerca volvulus		0.0037	0.029	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.029	0.0756
Echinococcus multilocularis	cysteine protease	0.0025	0.0147	0.0096
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0119	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0052	0.0163
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0147	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.0327
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Onchocerca volvulus		0.0037	0.029	0.0888
Brugia malayi	G-protein coupled receptor	0.0037	0.029	0.0905
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0119	0.0214
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.029	0.0756
Schistosoma mansoni	neuropeptide receptor	0.0037	0.029	0.0756
Leishmania major	cathepsin L-like protease	0.0025	0.0147	0.0326
Echinococcus granulosus	g protein coupled receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Onchocerca volvulus		0.0025	0.0147	0.0278
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Brugia malayi	Dopamine receptor protein 2	0.0037	0.029	0.0905
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.029	0.024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0147	0.0303
Schistosoma mansoni	amine GPCR	0.0037	0.029	0.0756
Schistosoma mansoni	biogenic amine receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.0147	0.0096
Schistosoma mansoni	hypothetical protein	0.0017	0.0052	0.0003
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0365	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0256
Mycobacterium ulcerans	lipase LipD	0.0043	0.0365	1
Leishmania major	cathepsin L-like protease	0.0072	0.0701	0.6738
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.029	0.0756
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.029	0.0756
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0119	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Brugia malayi	ORL1-like opioid receptor	0.0037	0.029	0.0905
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.029	0.0756
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.054	0.1548
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.029	0.024
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0082	0.3182
Schistosoma mansoni	opsin-like receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0365	0.1137
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.029	0.0756
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0052	0.0003
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0662	0.1933
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0052	0.0161
Brugia malayi	larval opioid receptor	0.0037	0.029	0.0905
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.029	0.0905
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.029	0.024
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0052	0.0003
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0365	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Onchocerca volvulus		0.0025	0.0147	0.0278
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.029	0.0905
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.3208	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Echinococcus granulosus	cathepsin b	0.0284	0.3208	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.029	0.0756
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0025	0.0147	0.0303
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0096	0.0983	0.295
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0147	0.1026
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0365	0.3362
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0147	0.1026
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0365	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0662	0.1933
Schistosoma mansoni	neuropeptide receptor	0.0037	0.029	0.0756
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Onchocerca volvulus		0.0043	0.0365	0.1204
Echinococcus multilocularis	serotonin receptor	0.0037	0.029	0.024
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.029	0.0905
Echinococcus granulosus	g protein coupled receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.0147	0.0096
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0218	0.2429	0.7571
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0096	0.0983	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0147	0.0459
Onchocerca volvulus		0.0037	0.029	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.029	0.0756
Onchocerca volvulus		0.0037	0.029	0.0888
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.029	0.0756
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.029	0.0905
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0025	0.0147	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0489	0.1524
Onchocerca volvulus		0.0037	0.029	0.0888
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0147	0.0303
Echinococcus granulosus	somatostatin receptor	0.0037	0.029	0.0756
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0147	0.0459
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0365	0.0814
Echinococcus granulosus	orexin receptor type 2	0.0037	0.029	0.0756
Brugia malayi	GnHR receptor homolog	0.0037	0.029	0.0905
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0365	0.0814
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0662	0.1933
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.3208	1
Toxoplasma gondii	ABC1 family protein	0.0043	0.0365	0.2844
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.029	0.0756
Leishmania major	cysteine peptidase A (CPA)	0.0025	0.0147	0.0326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Schistosoma mansoni	amine GPCR	0.0037	0.029	0.0756
Echinococcus granulosus	hypothetical protein	0.0037	0.029	0.0756
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.029	0.024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0096	0.0983	0.295
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.029	0.0756
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.029	0.0905
Loa Loa (eye worm)	cathepsin B	0.0096	0.0983	0.3064
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.029	0.0905
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.029	0.0756
Echinococcus granulosus	serotonin receptor	0.0037	0.029	0.0756
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0147	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.029	0.024
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0119	0.7057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0147	0.1026
Schistosoma mansoni	hypothetical protein	0.0017	0.0052	0.0003
Leishmania major	cathepsin L-like protease	0.0025	0.0147	0.0326
Brugia malayi	metabotropic glutamate receptor type 2	0.0024	0.0135	0.042
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0147	0.0459
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0365	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0365	0.0992
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0119	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.029	0.0756
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0218	0.2429	1
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.0339	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0905
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.029	0.024
Schistosoma mansoni	opsin-like receptor	0.0037	0.029	0.0756
Brugia malayi	Melatonin receptor type 1A	0.0037	0.029	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0147	0.0459
Schistosoma mansoni	neuropeptide receptor	0.0037	0.029	0.0756
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.029	0.024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0256
Onchocerca volvulus		0.0037	0.029	0.0888
Schistosoma mansoni	hypothetical protein	0.0037	0.029	0.0756
Leishmania major	cathepsin L-like protease	0.0025	0.0147	0.0326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.0327
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.029	0.024
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0287	0.0894
Onchocerca volvulus		0.0037	0.029	0.0888
Schistosoma mansoni	hypothetical protein	0.0037	0.029	0.0756
Toxoplasma gondii	cathepsin CPL	0.0025	0.0147	0.0326
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.029	0.024
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.029	0.0756
Leishmania major	cathepsin L-like protease	0.0025	0.0147	0.0326
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0052	0.0163
Onchocerca volvulus		0.0037	0.029	0.0888
Brugia malayi	Serotonin receptor	0.0037	0.029	0.0905
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.029	0.0756
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0037	0.029	0.0888
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0365	0.0992
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0147	0.0459
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0025	0.0147	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0365	0.1137
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0365	0.3362
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.029	0.0905
Onchocerca volvulus	Cathepsin F homolog	0.0025	0.0147	0.0278
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0119	0.0724
Schistosoma mansoni	amine GPCR	0.0037	0.029	0.0756
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0119	0.2154
Onchocerca volvulus		0.0037	0.029	0.0888
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.029	0.0756
Onchocerca volvulus		0.0025	0.0147	0.0278
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.029	0.0756
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.029	0.0905
Brugia malayi	RNA binding protein	0.0069	0.0662	0.2062
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0147	0.0278
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.029	0.0756
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Brugia malayi	cathepsin B-like cysteine proteinase	0.0284	0.3208	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.029	0.0756
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.029	0.0756
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0365	0.0814
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.029	0.0756
Loa Loa (eye worm)	cysteine protease	0.0025	0.0147	0.0459
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0147	1
Brugia malayi	neuropeptide F receptor	0.0037	0.029	0.0905
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.029	0.0756
Loa Loa (eye worm)	ctsf protein	0.0025	0.0147	0.0459
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0701	0.6974
Brugia malayi	hypothetical protein	0.0037	0.029	0.0905
Onchocerca volvulus		0.0025	0.0147	0.0278

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.4228 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1359707

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1266074