Detailed information for compound 1266797

Basic information

Technical information
  • TDR Targets ID: 1266797
  • Name: 1-[(4-ethylphenyl)methyl]-5-oxopyrrolidine-3- carboxylic acid
  • MW: 247.29 | Formula: C14H17NO3
  • H donors: 1 H acceptors: 3 LogP: 1.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)CN1CC(CC1=O)C(=O)O
  • InChi: 1S/C14H17NO3/c1-2-10-3-5-11(6-4-10)8-15-9-12(14(17)18)7-13(15)16/h3-6,12H,2,7-9H2,1H3,(H,17,18)
  • InChiKey: YLEUWWPOJSSBGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-ethylphenyl)methyl]-5-oxo-pyrrolidine-3-carboxylic acid
  • 1-[(4-ethylphenyl)methyl]-5-oxo-3-pyrrolidinecarboxylic acid
  • 1-(4-ethylbenzyl)-5-keto-pyrrolidine-3-carboxylic acid
  • 1-(4-ethylbenzyl)-5-oxo-3-pyrrolidinecarboxylic acid
  • MLS000531231
  • SMR000136209

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3644 0.296
Echinococcus multilocularis tyrosine protein kinase shark 0.0107 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0084 0.712 0.6811
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0084 0.712 0.6811
Onchocerca volvulus 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) SRC-1 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0 0.5
Echinococcus granulosus hypothetical protein 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein kinase Src42A 0.0107 1 1
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Brugia malayi Tyrosine-protein kinase abl-1 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0107 1 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.2338 0.1514
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0084 0.712 0.6811
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.1765 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0084 0.712 0.6811
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0971 0.0971
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0107 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0107 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0107 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Echinococcus granulosus tyrosine kinase 0.0107 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.2338 0.5
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0084 0.712 0.6811
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.712 0.712
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Schistosoma mansoni shc transforming protein 0.0084 0.712 0.6811
Onchocerca volvulus 0.0107 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.3644 0.3644
Echinococcus granulosus tyrosine protein kinase Lyn 0.0107 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.2338 0.1514
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0107 1 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0084 0.712 0.6811
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Echinococcus multilocularis N chimaerin 0.0084 0.712 0.6811
Echinococcus granulosus suppressor of cytokine signaling 6 0.0084 0.712 0.6811
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0971 0.0971
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.9845 0.9845
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3644 0.296
Echinococcus granulosus expressed conserved protein 0.0084 0.712 0.6811
Schistosoma mansoni tensin 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Srms 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3644 0.296
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus multilocularis SH2 motif 0.0084 0.712 0.6811
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0084 0.712 0.712
Schistosoma mansoni tensin-related 0.0084 0.712 0.6811
Schistosoma mansoni suppressor of cytokine signaling 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus multilocularis c src tyrosine kinase 0.0107 1 1
Schistosoma mansoni tensin 0.0084 0.712 0.6811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3644 0.296
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.2338 0.5
Echinococcus multilocularis tensin 0.0084 0.712 0.6811
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0084 0.712 0.6811
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus granulosus tensin 0.0084 0.712 0.6811
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.712 0.712
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.1765 0.5
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 1 1
Onchocerca volvulus 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0107 1 1
Schistosoma mansoni adapter molecule crk 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Onchocerca volvulus 0.0107 1 1
Entamoeba histolytica SH2 domain containing protein 0.0084 0.712 0.6242
Brugia malayi STAT protein, DNA binding domain containing protein 0.0084 0.712 0.712
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.712 0.712
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Entamoeba histolytica protein kinase, putative 0.0084 0.712 0.6242
Echinococcus granulosus SH2 domain containing protein 7 0.0084 0.712 0.6811
Schistosoma mansoni SH2A 0.0084 0.712 0.6811
Schistosoma mansoni suppressor of cytokine signaling 0.0084 0.712 0.6811
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0084 0.712 0.712
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0971 0.0971
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0084 0.712 0.6811
Loa Loa (eye worm) STAT protein 0.0084 0.712 0.712
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3644 0.296
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0084 0.712 0.712
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.712 0.6811
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0084 0.712 0.6242
Echinococcus granulosus SH2 domain containing adapter protein F 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Brugia malayi SRC-1 0.0107 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3644 0.296
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Echinococcus granulosus c src tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.3644 0.3644
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.712 0.6811
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.712 0.712
Brugia malayi SH2 domain containing protein 0.0107 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.2338 0.5
Echinococcus multilocularis 0.0084 0.712 0.6811
Echinococcus granulosus signal transduction protein lnk realted 0.0084 0.712 0.6811
Schistosoma mansoni inositol monophosphatase 0.0045 0.2338 0.1514
Onchocerca volvulus 0.0107 1 1
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.2338 0.1514
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0107 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.5738 0.5738
Echinococcus multilocularis tensin 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Onchocerca volvulus 0.0107 1 1
Echinococcus granulosus SH2 motif 0.0084 0.712 0.6811
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0971 0.0971
Echinococcus multilocularis SH2 motif 0.0084 0.712 0.6811
Brugia malayi cytokine inducible SH2-containing protein 5 0.0084 0.712 0.712
Echinococcus granulosus tyrosine protein kinase Srms 0.0107 1 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.2338 0.5
Brugia malayi hypothetical protein 0.0084 0.712 0.712
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.9845 0.9845
Brugia malayi RhoGAP domain containing protein 0.0084 0.712 0.712
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.712 0.6811
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Brugia malayi SH2 domain containing protein 0.0107 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.712 0.712
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0084 0.712 0.712
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Echinococcus granulosus tyrosine protein kinase Src64B 0.0107 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Schistosoma mansoni hypothetical protein 0.0072 0.5738 0.5279
Schistosoma mansoni nck2/grb4 0.0084 0.712 0.6811
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.712 0.712
Schistosoma mansoni tensin-related 0.0084 0.712 0.6811
Schistosoma mansoni vav2 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Brugia malayi Tensin 0.0084 0.712 0.712
Loa Loa (eye worm) hypothetical protein 0.0106 0.9845 0.9845
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.9845 0.9845
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0107 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0084 0.712 0.6811
Echinococcus multilocularis signal transduction protein lnk realted 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein kinase shark 0.0107 1 1
Echinococcus multilocularis NCK adaptor protein 0.0084 0.712 0.6811
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.2338 0.5
Schistosoma mansoni hypothetical protein 0.0084 0.712 0.6811
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.712 0.6811
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) TK protein kinase 0.0107 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0084 0.712 0.6811
Echinococcus granulosus NCK adaptor protein 0.0084 0.712 0.6811
Brugia malayi hypothetical protein 0.0107 1 1
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0107 1 1
Echinococcus granulosus N chimaerin 0.0084 0.712 0.6811
Echinococcus granulosus SH2 motif 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.5738 0.5738
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus multilocularis SHC transforming protein 3 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Echinococcus granulosus SHC transforming protein 3 0.0084 0.712 0.6811
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Schistosoma mansoni hypothetical protein 0.0084 0.712 0.6811
Echinococcus multilocularis SH2 motif 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Blk 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0107 1 1
Schistosoma mansoni tensin 0.0084 0.712 0.6811
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Loa Loa (eye worm) inositol-1 0.0045 0.2338 0.2338
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3644 0.296
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0107 1 1
Schistosoma mansoni signal transduction protein lnk-related 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0107 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.712 0.6811
Schistosoma mansoni GTPase activating protein 0.0084 0.712 0.6811
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.2338 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0084 0.712 0.6811
Brugia malayi Inositol-1 0.0045 0.2338 0.2338
Echinococcus multilocularis tyrosine protein kinase Abl 0.0107 1 1
Echinococcus multilocularis tyrosine kinase 0.0107 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0084 0.712 0.6811
Brugia malayi protein-tyrosine kinase 0.0107 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0084 0.712 0.6811

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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