Detailed information for compound 1266797

Basic information

Technical information
  • TDR Targets ID: 1266797
  • Name: 1-[(4-ethylphenyl)methyl]-5-oxopyrrolidine-3- carboxylic acid
  • MW: 247.29 | Formula: C14H17NO3
  • H donors: 1 H acceptors: 3 LogP: 1.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)CN1CC(CC1=O)C(=O)O
  • InChi: 1S/C14H17NO3/c1-2-10-3-5-11(6-4-10)8-15-9-12(14(17)18)7-13(15)16/h3-6,12H,2,7-9H2,1H3,(H,17,18)
  • InChiKey: YLEUWWPOJSSBGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-ethylphenyl)methyl]-5-oxo-pyrrolidine-3-carboxylic acid
  • 1-[(4-ethylphenyl)methyl]-5-oxo-3-pyrrolidinecarboxylic acid
  • 1-(4-ethylbenzyl)-5-keto-pyrrolidine-3-carboxylic acid
  • 1-(4-ethylbenzyl)-5-oxo-3-pyrrolidinecarboxylic acid
  • MLS000531231
  • SMR000136209

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3644 0.296
Echinococcus multilocularis tyrosine protein kinase Srms 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.712 0.712
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.712 0.6811
Schistosoma mansoni hypothetical protein 0.0084 0.712 0.6811
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.712 0.712
Schistosoma mansoni shc transforming protein 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine kinase 0.0107 1 1
Echinococcus multilocularis SHC transforming protein 3 0.0084 0.712 0.6811
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.2338 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0107 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.5738 0.5738
Echinococcus granulosus suppressor of cytokine signaling 7 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein kinase shark 0.0107 1 1
Schistosoma mansoni tensin 0.0084 0.712 0.6811
Brugia malayi hypothetical protein 0.0084 0.712 0.712
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0107 1 1
Echinococcus multilocularis SH2 motif 0.0084 0.712 0.6811
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.712 0.6811
Onchocerca volvulus 0.0107 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0107 1 1
Onchocerca volvulus 0.0107 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Schistosoma mansoni nck2/grb4 0.0084 0.712 0.6811
Schistosoma mansoni suppressor of cytokine signaling 0.0084 0.712 0.6811
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Echinococcus multilocularis N chimaerin 0.0084 0.712 0.6811
Echinococcus granulosus N chimaerin 0.0084 0.712 0.6811
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.3644 0.3644
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.712 0.712
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0084 0.712 0.6811
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Echinococcus multilocularis tensin 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein kinase ABL1 0.0107 1 1
Entamoeba histolytica protein kinase, putative 0.0084 0.712 0.6242
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0084 0.712 0.6811
Echinococcus multilocularis SH2 motif 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Brugia malayi SH2 domain containing protein 0.0107 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0971 0.0971
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.712 0.6811
Onchocerca volvulus 0.0107 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0084 0.712 0.6811
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Echinococcus granulosus SH2 motif 0.0084 0.712 0.6811
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Echinococcus multilocularis tyrosine kinase 0.0107 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.712 0.6811
Brugia malayi hypothetical protein 0.0107 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus granulosus SH2 domain containing protein 7 0.0084 0.712 0.6811
Echinococcus granulosus SH2 domain containing adapter protein F 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0107 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0084 0.712 0.6811
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.712 0.6811
Loa Loa (eye worm) TK protein kinase 0.0107 1 1
Echinococcus granulosus SH2 motif 0.0084 0.712 0.6811
Schistosoma mansoni SH2A 0.0084 0.712 0.6811
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.712 0.6811
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0084 0.712 0.6811
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0084 0.712 0.6811
Echinococcus granulosus c src tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Brugia malayi SRC-1 0.0107 1 1
Entamoeba histolytica SH2 domain containing protein 0.0084 0.712 0.6242
Schistosoma mansoni tensin 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.2338 0.5
Echinococcus multilocularis 0.0084 0.712 0.6811
Schistosoma mansoni inositol monophosphatase 0.0045 0.2338 0.1514
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.1765 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0084 0.712 0.6811
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.3644 0.3644
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0107 1 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0107 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 1 1
Echinococcus granulosus expressed conserved protein 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0072 0.5738 0.5738
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Brugia malayi RhoGAP domain containing protein 0.0084 0.712 0.712
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0084 0.712 0.712
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0084 0.712 0.6811
Echinococcus multilocularis NCK adaptor protein 0.0084 0.712 0.6811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3644 0.296
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0107 1 1
Brugia malayi protein-tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) inositol-1 0.0045 0.2338 0.2338
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0084 0.712 0.6811
Schistosoma mansoni hypothetical protein 0.0072 0.5738 0.5279
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0971 0.0971
Onchocerca volvulus 0.0107 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) SRC-1 0.0107 1 1
Echinococcus multilocularis SH2 motif 0.0084 0.712 0.6811
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 1 1
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3644 0.296
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0084 0.712 0.6811
Brugia malayi cytokine inducible SH2-containing protein 5 0.0084 0.712 0.712
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3644 0.296
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0107 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Echinococcus granulosus tensin 0.0084 0.712 0.6811
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0107 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3644 0.296
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.712 0.6811
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.712 0.712
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0971 0.0971
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.9845 0.9845
Schistosoma mansoni tensin 0.0084 0.712 0.6811
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0084 0.712 0.6811
Echinococcus granulosus tyrosine protein kinase Src42A 0.0107 1 1
Echinococcus granulosus NCK adaptor protein 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0107 1 1
Schistosoma mansoni adapter molecule crk 0.0084 0.712 0.6811
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.712 0.712
Brugia malayi Inositol-1 0.0045 0.2338 0.2338
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.9845 0.9845
Schistosoma mansoni vav2 0.0084 0.712 0.6811
Schistosoma mansoni suppressor of cytokine signaling 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.2338 0.1514
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus granulosus hypothetical protein 0.0084 0.712 0.6811
Echinococcus granulosus suppressor of cytokine signaling 6 0.0084 0.712 0.6811
Schistosoma mansoni tensin-related 0.0084 0.712 0.6811
Schistosoma mansoni GTPase activating protein 0.0084 0.712 0.6811
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3644 0.296
Echinococcus granulosus tyrosine protein kinase Lyn 0.0107 1 1
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Echinococcus granulosus tyrosine protein kinase Srms 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Loa Loa (eye worm) STAT protein 0.0084 0.712 0.712
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0107 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.2338 1
Onchocerca volvulus 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0107 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) hypothetical protein 0.0033 0.0971 0.0971
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0107 1 1
Echinococcus granulosus tyrosine kinase 0.0107 1 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.9845 0.9845
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0084 0.712 0.6811
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.712 0.712
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.0084 0.712 0.6811
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Brugia malayi Protein kinase domain containing protein 0.0107 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0107 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0084 0.712 0.712
Schistosoma mansoni tensin-related 0.0084 0.712 0.6811
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3644 0.296
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Echinococcus multilocularis tensin 0.0084 0.712 0.6811
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0107 1 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0084 0.712 0.6811
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.2338 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0107 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.2338 0.1514
Brugia malayi tRNA modification GTPase TrmE family protein 0.0084 0.712 0.712
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0107 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0107 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0084 0.712 0.6811
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.9845 0.9845
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.2338 1
Schistosoma mansoni tyrosine kinase 0.0107 1 1
Brugia malayi SH2 domain containing protein 0.0084 0.712 0.712
Schistosoma mansoni hypothetical protein 0.0084 0.712 0.6811
Loa Loa (eye worm) hypothetical protein 0.0084 0.712 0.712
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0084 0.712 0.6242
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0107 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.2338 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0084 0.712 0.6811
Echinococcus granulosus SHC transforming protein 3 0.0084 0.712 0.6811
Brugia malayi Variant SH3 domain containing protein 0.0084 0.712 0.712
Onchocerca volvulus 0.0107 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0107 1 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0084 0.712 0.712
Brugia malayi Tensin 0.0084 0.712 0.712
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0084 0.712 0.712
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0107 1 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.2338 0.5
Schistosoma mansoni inositol monophosphatase 0.0045 0.2338 0.1514
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 1 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.1765 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0107 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0107 1 1
Brugia malayi SH2 domain containing protein 0.0107 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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