Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0022 | 0.0783 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0022 | 0.0783 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0022 | 0.002 |
Schistosoma mansoni | inositol transporter | 0.003 | 0.0017 | 0.0575 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.1155 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0022 | 0.0783 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0169 | 0.0154 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.002 | 0.0007 | 0.121 |
Schistosoma mansoni | high-affinity choline transporter | 0.0271 | 0.0256 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0022 | 0.002 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0032 | 0.1155 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0022 | 0.002 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0022 | 0.002 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0022 | 0.1305 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0039 | 0.2411 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0022 | 0.0872 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.0039 | 0.1447 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0032 | 0.1155 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.0039 | 0.1447 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0022 | 0.002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0032 | 0.1155 |
Mycobacterium ulcerans | TetR family transcriptional regulator | 1.0134 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0007 | 0.027 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0022 | 0.002 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0022 | 0.1305 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.0039 | 1 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0174 | 0.0159 | 0.6223 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.002 | 0.0007 | 0.121 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0022 | 0.1305 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0039 | 0.2411 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.002 | 0.0007 | 0.121 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0022 | 0.0783 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.003 | 0.0017 | 0.0575 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0022 | 0.0872 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0022 | 0.002 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.1155 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0022 | 0.5412 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0015 | 0.0002 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0.0039 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0022 | 0.002 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.002 | 0.0007 | 0.121 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0015 | 0.0002 | 0.0096 |
Onchocerca volvulus | 0.0035 | 0.0022 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.0039 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.003 | 0.0017 | 0.0575 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0022 | 0.5412 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0022 | 0.5412 |
Brugia malayi | Sodium:solute symporter family protein | 0.003 | 0.0017 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.0159 | 0.6186 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0039 | 0.2411 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.003 | 0.0017 | 0.0575 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.0039 | 0.1447 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.003 | 0.0017 | 0.0575 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.0039 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0022 | 0.1305 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0022 | 0.5412 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0007 | 0.0175 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0.0039 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.002 | 0.0007 | 0.2236 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.0039 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0022 | 0.1305 |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.0007 | 0.121 |
Brugia malayi | GH02984p | 0.0271 | 0.0256 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0039 | 0.2411 |
Schistosoma mansoni | inositol transporter | 0.003 | 0.0017 | 0.0575 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0015 | 0.0002 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0022 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.0256 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0022 | 0.002 |
Mycobacterium ulcerans | transcriptional regulator | 1.0134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0022 | 0.0783 |
Mycobacterium tuberculosis | Transcriptional regulatory repressor protein (TetR-family) EthR | 1.0134 | 1 | 1 |
Mycobacterium ulcerans | AcrR family transcriptional regulator | 1.0134 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.1155 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0022 | 0.0872 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.0039 | 0.1529 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0022 | 0.002 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0022 | 0.0872 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.002 | 0.0007 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0022 | 0.0783 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0022 | 0.002 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.0039 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0022 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0017 | 0.0575 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0032 | 0.1155 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0022 | 0.0783 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0271 | 0.0256 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.003 | 0.0017 | 0.0575 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0022 | 0.1305 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0032 | 0.1155 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0022 | 0.0783 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0022 | 0.0783 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.003 | 0.0017 | 0.0575 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.0039 | 0.1447 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.003 | 0.0017 | 0.0575 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.0039 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.021 | 0.0208 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0022 | 0.5412 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0022 | 0.002 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0022 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.003 | 0.0017 | 0.0575 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.0039 | 0.1447 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0032 | 0.124 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0015 | 0.0002 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0022 | 0.0783 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0022 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0022 | 0.0783 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.0039 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0022 | 0.002 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.002 | 0.0007 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.003 | 0.0017 | 0.0575 |
Onchocerca volvulus | 0.0035 | 0.0022 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0039 | 0.1447 |
Onchocerca volvulus | 0.0035 | 0.0022 | 1 | |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.003 | 0.0017 | 0.3976 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0.0039 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.003 | 0.0017 | 0.0575 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0271 | 0.0256 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.