Detailed information for compound 1269602

Basic information

Technical information
  • TDR Targets ID: 1269602
  • Name: 1-butyl-3-isoquinolin-5-ylthiourea
  • MW: 259.37 | Formula: C14H17N3S
  • H donors: 1 H acceptors: 1 LogP: 3.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN=C(Nc1cccc2c1ccnc2)S
  • InChi: 1S/C14H17N3S/c1-2-3-8-16-14(18)17-13-6-4-5-11-10-15-9-7-12(11)13/h4-7,9-10H,2-3,8H2,1H3,(H2,16,17,18)
  • InChiKey: HICAHGBDBXACIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-butyl-3-(5-isoquinolyl)thiourea
  • 1-butyl-3-isoquinolin-5-yl-thiourea
  • MLS000392576
  • SMR000261544
  • ZINC03261355
  • T0513-0950

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0535 0.1384 0.6526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0407 0.0859 0.4723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.1018 0.5595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0641 0.1819 0.524
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0535 0.1384 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0641 0.1819 0.1875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1031 0.3425 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1031 0.3425 0.3331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0641 0.1819 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0635 0.2202
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0535 0.1384 0.3671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0424 0.2329
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0446 0.1018 0.0979
Echinococcus granulosus sodium calcium exchanger 0.2406 0.9089 0.9076
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0635 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0424 0.2329
Loa Loa (eye worm) hypothetical protein 0.0302 0.0424 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Loa Loa (eye worm) hypothetical protein 0.0336 0.0566 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Toxoplasma gondii target of rapamycin (TOR), putative 0.0535 0.1384 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0535 0.1384 0.6526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Echinococcus multilocularis sodium calcium exchanger 0.2406 0.9089 0.9076
Loa Loa (eye worm) phosphatidylinositol 3 0.0535 0.1384 0.1388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1031 0.3425 0.3331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1031 0.3425 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0336 0.0566 0.3108
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0535 0.1384 0.6526
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0302 0.0424 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0535 0.1384 0.126
Leishmania major hypothetical protein, conserved 0.0998 0.329 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0424 0.2329
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0535 0.1384 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0535 0.1384 0.3671
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0142 0.078
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0535 0.1384 0.6526
Entamoeba histolytica hypothetical protein 0.0446 0.1018 0.6189
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0446 0.1018 0.3608
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0302 0.0424 0.0286
Brugia malayi Sodium/calcium exchanger protein 0.0962 0.3145 0.9147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0535 0.1384 0.3783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0424 0.2329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0424 0.2329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Echinococcus granulosus serine protein kinase ATM 0.0446 0.1018 0.0889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0635 0.2202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0424 0.0929 0.5108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Loa Loa (eye worm) hypothetical protein 0.0343 0.0594 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0535 0.1384 0.3671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3214 0.3116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0407 0.0859 0.4536
Echinococcus multilocularis serine protein kinase ATM 0.0446 0.1018 0.0889
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0535 0.1384 0.3831
Trypanosoma cruzi hypothetical protein, conserved 0.0895 0.2867 0.8269
Loa Loa (eye worm) solute carrier family 8 0.2406 0.9089 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Toxoplasma gondii FATC domain-containing protein 0.0446 0.1018 0.5528
Schistosoma mansoni fkbp-rapamycin associated protein 0.0302 0.0424 0.0315
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0535 0.1384 0.1388
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2627 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1031 0.3425 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0535 0.1384 0.126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0343 0.0594 0.1223
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0302 0.0424 0.0286
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0446 0.1018 0.2537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1031 0.3425 0.367
Leishmania major phosphatidylinositol 3-kinase, putative 0.0535 0.1384 0.3831
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0446 0.1018 0.2668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0424 0.2329
Schistosoma mansoni sodium/calcium exchanger 0.2406 0.9089 1
Trichomonas vaginalis conserved hypothetical protein 0.0336 0.0566 0.3108
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0424 0.0929 0.5108
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0641 0.1819 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.0424 0.0858
Giardia lamblia GTOR 0.0535 0.1384 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0635 0.3491
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0535 0.1384 0.3831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0535 0.1384 0.3831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.1384 0.7606
Loa Loa (eye worm) hypothetical protein 0.0962 0.3145 0.3356

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0032 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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