Detailed information for compound 1271564

Basic information

Technical information
  • TDR Targets ID: 1271564
  • Name: N-[2-(butyl-methylamino)ethyl]-3-(3-methoxyph enyl)-1-methylthieno[4,5-d]pyrazole-5-carboxa mide
  • MW: 400.538 | Formula: C21H28N4O2S
  • H donors: 1 H acceptors: 2 LogP: 4.12 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CCNC(=O)c1cc2c(s1)n(nc2c1cccc(c1)OC)C)C
  • InChi: 1S/C21H28N4O2S/c1-5-6-11-24(2)12-10-22-20(26)18-14-17-19(23-25(3)21(17)28-18)15-8-7-9-16(13-15)27-4/h7-9,13-14H,5-6,10-12H2,1-4H3,(H,22,26)
  • InChiKey: MBSXRUSJFAEHRG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2-(butyl-methyl-amino)ethyl]-3-(3-methoxyphenyl)-1-methyl-thieno[4,5-d]pyrazole-5-carboxamide
  • N-[2-(butyl-methylamino)ethyl]-3-(3-methoxyphenyl)-1-methyl-5-thieno[4,5-d]pyrazolecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Saccharomyces cerevisiae Rce1p Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni family U48 unassigned peptidase (U48 family) Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma brucei CAAX amino terminal protease, putative Get druggable targets OG5_129169 All targets in OG5_129169
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans ras and a-factor terminal proteolysis Get druggable targets OG5_129169 All targets in OG5_129169
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K08658 prenyl protein peptidase, putative Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi CAAX prenyl protease 2, putative Get druggable targets OG5_129169 All targets in OG5_129169
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Hypothetical protein Get druggable targets OG5_129169 All targets in OG5_129169
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus CAAX prenyl protease 2 Get druggable targets OG5_129169 All targets in OG5_129169
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense CAAX amino terminal protease, putative Get druggable targets OG5_129169 All targets in OG5_129169
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis CAAX prenyl protease 2 Get druggable targets OG5_129169 All targets in OG5_129169
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48), putative Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica CAAX prenyl protease family Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni family U48 unassigned peptidase (U48 family) Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans ras and a-factor terminal proteolysis Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi CAAX amino terminal protease family protein Get druggable targets OG5_129169 All targets in OG5_129169
Leishmania donovani CAAX prenyl protease 2, putative Get druggable targets OG5_129169 All targets in OG5_129169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0229 0.1557
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0111 0.2766 1
Schistosoma mansoni transient receptor potential channel 0.0117 0.2948 0.2948
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0111 0.2766 0.2766
Mycobacterium ulcerans integral membrane protein 0.0023 0.0333 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Leishmania major cathepsin L-like protease 0.0062 0.1408 0.4811
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0904 0.0767
Entamoeba histolytica CAAX amino terminal protease family 0.0023 0.0333 0.1203
Schistosoma mansoni hypothetical protein 0.0019 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.004 0.08 0.08
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0111 0.2766 1
Onchocerca volvulus 0.0016 0.0148 0.1447
Brugia malayi Cathepsin L-like precursor 0.0016 0.0148 0.0536
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.041 0.041
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0148 0.0536
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0023 0.0333 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0665 0.0524
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0111 0.2766 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Loa Loa (eye worm) fibroinase 0.0016 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0019 0.0228 0.0228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.2839 0.2732
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0229 0.1557
Leishmania major importin beta-1 subunit, putative 0.0028 0.0482 0.1276
Echinococcus granulosus geminin 0.0196 0.5128 0.5128
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.041 0.5069
Chlamydia trachomatis hypothetical protein 0.0023 0.0333 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0228 0.0081
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.041 0.1482
Loa Loa (eye worm) cysteine protease 0.0016 0.0148 0.0148
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0148 0.0148
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0229 0.0827
Echinococcus granulosus tumor protein p63 0.0326 0.8745 0.8745
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1231 0.1231
Schistosoma mansoni hypothetical protein 0.0196 0.5128 0.5128
Schistosoma mansoni hypothetical protein 0.0372 1 1
Leishmania major cathepsin L-like protease 0.0062 0.1408 0.4811
Echinococcus multilocularis snurportin 1 0.0372 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.1848 0.1848
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.084 0.3038
Entamoeba histolytica CAAX prenyl protease family 0.0111 0.2766 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.1848 0.1726
Brugia malayi Cathepsin L-like precursor 0.0016 0.0148 0.0536
Entamoeba histolytica hypothetical protein 0.0043 0.0904 0.3267
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1368 0.4946
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0229 0.1557
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0482 0.1744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1231 0.1231
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0041 0.084 0.084
Echinococcus multilocularis tumor protein p63 0.0326 0.8745 0.8726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Schistosoma mansoni transient receptor potential channel 0.0078 0.1848 0.1848
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0908 0.0908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0148 0.0148
Onchocerca volvulus 0.0016 0.0148 0.1447
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0665 0.1719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Entamoeba histolytica hypothetical protein 0.0043 0.0904 0.3267
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0148 0.0536
Brugia malayi RNA, U transporter 1 0.0099 0.2444 0.8835
Trichomonas vaginalis ran, putative 0.0026 0.041 0.1482
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.041 0.041
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.1848 0.1726
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.041 0.5069
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0482 0.1276
Brugia malayi Cathepsin L-like precursor 0.0016 0.0148 0.0536
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0333 1
Toxoplasma gondii CAAX amino terminal protease family protein 0.0023 0.0333 0.3571
Schistosoma mansoni hypothetical protein 0.0019 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1231 0.1099
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0908 0.3282
Loa Loa (eye worm) hypothetical protein 0.006 0.1368 0.1368
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1231 0.1231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1231 0.1099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1231 0.1231
Toxoplasma gondii hypothetical protein 0.0023 0.0333 0.3571
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0229 0.0082
Onchocerca volvulus 0.0016 0.0148 0.1447
Loa Loa (eye worm) hypothetical protein 0.0019 0.0228 0.0228
Echinococcus multilocularis geminin 0.0196 0.5128 0.5054
Plasmodium falciparum protease, putative 0.0023 0.0333 0.3571
Mycobacterium tuberculosis Probable integral membrane protein 0.0023 0.0333 1
Echinococcus multilocularis CAAX prenyl protease 2 0.0111 0.2766 0.2657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Loa Loa (eye worm) hypothetical protein 0.0111 0.2766 0.2766
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0229 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1231 0.1231
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0229 0.0082
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1368 0.4946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0111 0.2766 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0229 0.0082
Brugia malayi CAAX amino terminal protease family protein 0.0111 0.2766 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1231 0.4449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1231 0.1231
Plasmodium falciparum importin beta, putative 0.0035 0.0665 1
Schistosoma mansoni hypothetical protein 0.0019 0.0228 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0228 0.0228
Entamoeba histolytica hypothetical protein 0.0028 0.0482 0.1744
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0904 0.0904
Brugia malayi isocitrate dehydrogenase 0.0019 0.0229 0.0827
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1408 0.4811
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.1042 0.3415
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0148 0.0536
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Onchocerca volvulus 0.0048 0.1024 1
Leishmania major cathepsin L-like protease 0.0062 0.1408 0.4811
Brugia malayi Cathepsin L-like precursor 0.0016 0.0148 0.0536
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0228 0.0228
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.041 0.0715
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.1848 0.1848
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0229 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0904 0.0904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Brugia malayi Cathepsin L-like precursor 0.0016 0.0148 0.0536
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0148 0.1447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0229 0.0307
Brugia malayi Cathepsin L-like precursor 0.0016 0.0148 0.0536
Brugia malayi Importin beta-1 subunit 0.0035 0.0665 0.2403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Schistosoma mansoni hypothetical protein 0.0196 0.5128 0.5128
Giardia lamblia Hypothetical protein 0.0111 0.2766 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0665 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Trypanosoma brucei CAAX amino terminal protease, putative 0.0111 0.2766 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0148 0.0536
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Schistosoma mansoni ran 0.0026 0.041 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.041 0.1
Toxoplasma gondii hypothetical protein 0.0023 0.0333 0.3571
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0048 0.1024 0.1024
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0148 0.0148
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1408 0.4811
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0229 0.0082
Loa Loa (eye worm) hypothetical protein 0.0044 0.0908 0.0908
Onchocerca volvulus 0.0016 0.0148 0.1447
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0228 0.0823
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0482 0.1744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0023 0.0333 1
Entamoeba histolytica CAAX amino terminal protease family 0.0023 0.0333 0.1203
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.1024 0.1024
Loa Loa (eye worm) hypothetical protein 0.0074 0.174 0.174
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0229 0.0229
Entamoeba histolytica cysteine protease, putative 0.0016 0.0148 0.0536
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0665 0.1719
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1368 0.1368
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0148 0.1447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0148 0.1447
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0229 0.0307
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0908 0.0771
Onchocerca volvulus 0.0016 0.0148 0.1447
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Entamoeba histolytica Ran family GTPase 0.0026 0.041 0.1482
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0229 0.0229
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.1259 0.4245
Loa Loa (eye worm) hypothetical protein 0.0041 0.084 0.084
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.2948 0.2842
Loa Loa (eye worm) hypothetical protein 0.0035 0.0665 0.0665
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0043 0.0904 0.0904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0148 0.0536
Schistosoma mansoni importin beta-1 0.0035 0.0665 0.0665
Mycobacterium ulcerans hypothetical protein 0.0023 0.0333 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0.2948 0.2948
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0665 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0111 0.2766 0.2766
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0148 0.0536
Schistosoma mansoni transient receptor potential channel 0.0078 0.1848 0.1848
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.041 0.1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1408 0.4811
Echinococcus granulosus importin subunit beta 1 0.0035 0.0665 0.0665
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0229 0.0229
Plasmodium vivax protease, putative 0.0023 0.0333 0.3571
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.2948 0.2948
Onchocerca volvulus 0.0016 0.0148 0.1447
Echinococcus granulosus cathepsin l1 0.0016 0.0148 0.0148
Brugia malayi hypothetical protein 0.0043 0.0904 0.3267
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.041 0.5069
Echinococcus granulosus GPCR family 2 0.0019 0.0228 0.0228
Entamoeba histolytica hypothetical protein 0.0043 0.0904 0.3267
Echinococcus granulosus CAAX prenyl protease 2 0.0111 0.2766 0.2766
Echinococcus multilocularis GPCR, family 2 0.0019 0.0228 0.0081
Entamoeba histolytica hypothetical protein 0.0043 0.0904 0.3267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1408 0.4647
Loa Loa (eye worm) ctsf protein 0.0016 0.0148 0.0148
Mycobacterium ulcerans hypothetical protein 0.0023 0.0333 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1408 0.4811
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0228 0.0823
Leishmania major GTP-binding protein, putative 0.0026 0.041 0.1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0228 0.0081
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.041 0.0266
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0229 0.1557
Treponema pallidum hypothetical protein 0.0023 0.0333 0.5
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.2948 0.2948
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0482 0.1744
Onchocerca volvulus 0.0016 0.0148 0.1447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0148 0.0536
Schistosoma mansoni ran 0.0026 0.041 0.041

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 16.02 uM PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] ChEMBL. No reference
AC50 (functional) 31.45 uM PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 0.07 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2227, AID2246] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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