Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0082 | 0.0082 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.7041 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5155 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5155 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.1313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0925 | 0.0925 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.1313 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.468 | 0.9079 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.314 | 0.6092 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5155 | 0.5155 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0925 | 0.1794 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0082 | 0.0159 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5155 | 0.5155 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 0.630957344 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | = 3.548133892 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | = 11.22018454 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Potency (functional) | = 1.9953 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.