Detailed information for compound 1275302

Basic information

Technical information
  • TDR Targets ID: 1275302
  • Name: 5-[(4-ethoxyphenoxy)methyl]-N-(6-methylpyridi n-2-yl)furan-2-carboxamide
  • MW: 352.384 | Formula: C20H20N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.66 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)OCc1ccc(o1)C(=O)Nc1cccc(n1)C
  • InChi: 1S/C20H20N2O4/c1-3-24-15-7-9-16(10-8-15)25-13-17-11-12-18(26-17)20(23)22-19-6-4-5-14(2)21-19/h4-12H,3,13H2,1-2H3,(H,21,22,23)
  • InChiKey: KRYOYHDNXAUMBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(4-ethoxyphenoxy)methyl]-N-(6-methyl-2-pyridyl)furan-2-carboxamide
  • 5-[(4-ethoxyphenoxy)methyl]-N-(6-methyl-2-pyridyl)-2-furancarboxamide
  • 5-[(4-ethoxyphenoxy)methyl]-N-(6-methyl-2-pyridyl)-2-furamide
  • 5-[(4-ethoxyphenoxy)methyl]-N-(6-methyl-2-pyridinyl)-2-furamide
  • MLS000088944
  • SMR000073196
  • BAS 08303162
  • ST5285402
  • Oprea1_517147
  • ZINC02750598

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0059 0.0151
Schistosoma mansoni hypothetical protein 0.0205 0.2123 0.2123
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0348 0.3913 0.3913
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0198 0.0507
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0198 0.014
Trypanosoma cruzi GMP reductase 0.0348 0.3913 1
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0198 0.014
Echinococcus granulosus expressed conserved protein 0.0112 0.0958 0.0905
Echinococcus multilocularis geminin 0.0205 0.2123 0.2076
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3137 0.3096
Schistosoma mansoni hypothetical protein 0.0058 0.0289 0.0289
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0154 0.1483 0.3789
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0348 0.3913 1
Loa Loa (eye worm) GMP reductase 0.0154 0.1483 0.3789
Loa Loa (eye worm) RNA binding protein 0.0076 0.0518 0.1323
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0175
Echinococcus multilocularis protein patched 0.0051 0.0198 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0062 0.0342 0.0875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0251
Schistosoma mansoni ap endonuclease 0.004 0.0059 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0251 0.0193
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1049 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0059 0.5
Trypanosoma brucei GMP reductase 0.0348 0.3913 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0348 0.3913 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0518 0.0518
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0175
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0348 0.3913 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0198 0.0507
Loa Loa (eye worm) hypothetical protein 0.0286 0.3137 0.8016
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0154 0.1483 0.3789
Leishmania major guanosine monophosphate reductase 0.0348 0.3913 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0518 0.1323
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0518 0.1323
Schistosoma mansoni patched 1 0.0051 0.0198 0.0198
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0204 0.0521
Brugia malayi GMP reductase 0.0154 0.1483 0.3789
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0518 0.0518
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1049 0.0995
Brugia malayi RNA binding protein 0.0076 0.0518 0.1323
Echinococcus multilocularis protein dispatched 1 0.0058 0.0289 0.0231
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1688 0.1638
Brugia malayi TAR-binding protein 0.0076 0.0518 0.1323
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0348 0.3913 1
Brugia malayi CHE-14 protein 0.0051 0.0198 0.0507
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0194 0.199 0.5009
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1688 0.1638
Loa Loa (eye worm) IMP dehydrogenase 1 0.0348 0.3913 1
Echinococcus granulosus geminin 0.0205 0.2123 0.2076
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0289 0.0738
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0251 0.0642
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0518 0.0461
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0204 0.0521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0251 0.0193
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0348 0.3913 1
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0348 0.3913 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0348 0.3913 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0518 0.0518
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0194 0.199 0.2085
Trypanosoma cruzi GMP reductase 0.0348 0.3913 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0154 0.1483 0.3694
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0059 0.0151
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1049 0.268
Brugia malayi hypothetical protein 0.0286 0.3137 0.8016
Echinococcus granulosus tar DNA binding protein 0.0076 0.0518 0.0461
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0348 0.3913 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0348 0.3913 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0348 0.3913 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0348 0.3913 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0059 0.5
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0348 0.3913 0.3877
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0348 0.3913 0.3877
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0204 0.0521
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1049 0.0995
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0251 0.0193
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0348 0.3913 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.0958 0.0905
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0251 0.0642
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0175
Schistosoma mansoni survival motor neuron protein 0.0058 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0119 0.1049 0.268
Leishmania major inosine-5-monophosphate dehydrogenase 0.0348 0.3913 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0518 0.0518
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1072 0.1072
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3137 0.3096
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0518 0.0518
Toxoplasma gondii IMP dehydrogenas 0.0348 0.3913 1
Onchocerca volvulus Putative GMP reductase 0.0154 0.1483 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0251 0.0193
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0198 0.014
Schistosoma mansoni hypothetical protein 0.0205 0.2123 0.2123
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0518 0.1323
Schistosoma mansoni ap endonuclease 0.004 0.0059 0.0059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0204 0.0521

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4611 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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