Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0958 | 0.0958 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0158 | 0.0206 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0291 | 0.038 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0513 | 0.7658 | 0.7658 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0513 | 0.7658 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0034 | 0 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0659 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.7658 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.7658 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 1 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0659 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0158 | 0.0206 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0659 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0291 | 0.038 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Entamoeba histolytica | hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0513 | 0.7658 | 0.7658 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0513 | 0.7658 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0291 | 0.038 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0291 | 0.0291 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0513 | 0.7658 | 1 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0513 | 0.7658 | 0.7658 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0513 | 0.7658 | 1 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0513 | 0.7658 | 0.7658 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0291 | 0.038 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0158 | 0.0206 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0513 | 0.7658 | 0.7658 |
Plasmodium vivax | polyprenol reductase, putative | 0.0513 | 0.7658 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0.0958 | 0.0958 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0513 | 0.7658 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0513 | 0.7658 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.5 |
Onchocerca volvulus | 0.0513 | 0.7658 | 1 | |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0513 | 0.7658 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0659 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0513 | 0.7658 | 0.7658 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.7658 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0291 | 0.038 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0291 | 0.0291 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0659 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0513 | 0.7658 | 0.7658 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0.0958 | 0.0958 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0291 | 0.038 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0158 | 0.0206 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0513 | 0.7658 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0291 | 0.038 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0513 | 0.7658 | 0.7658 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.