Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0291 | 0.038 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.7658 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0291 | 0.0291 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0158 | 0.0206 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0513 | 0.7658 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0513 | 0.7658 | 0.7658 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0513 | 0.7658 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0513 | 0.7658 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0.0958 | 0.0958 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0659 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0659 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0291 | 0.0291 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0513 | 0.7658 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0.0958 | 0.0958 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0513 | 0.7658 | 0.7658 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0659 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.7658 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0513 | 0.7658 | 0.7658 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0158 | 0.0206 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0291 | 0.038 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0513 | 0.7658 | 0.7658 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0291 | 0.038 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0659 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Onchocerca volvulus | 0.0513 | 0.7658 | 1 | |
Plasmodium vivax | polyprenol reductase, putative | 0.0513 | 0.7658 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0513 | 0.7658 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0158 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0958 | 0.0958 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0158 | 0.0206 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0513 | 0.7658 | 0.7658 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0291 | 0.038 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0291 | 0.038 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0513 | 0.7658 | 0.7658 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0291 | 0.038 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0513 | 0.7658 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0034 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0659 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0291 | 0.038 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0158 | 0.0158 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0513 | 0.7658 | 0.7658 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0513 | 0.7658 | 0.7658 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0513 | 0.7658 | 0.7658 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0659 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0513 | 0.7658 | 0.7658 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0513 | 0.7658 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0513 | 0.7658 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.