Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0051 | 0.0055 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0457 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.3917 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3611 | 0.3902 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0061 | 0.5723 | 0.779 |
Brugia malayi | brahma associated protein 60 kDa | 0.0061 | 0.5723 | 0.5701 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1703 | 0.1661 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0457 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.5723 | 0.7175 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0457 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9254 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0061 | 0.5723 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0457 | 0.0494 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0051 | 0.0055 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.4306 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0333 | 0.0388 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0061 | 0.5723 | 0.779 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1703 | 0.209 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0061 | 0.5723 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0457 | 0.0409 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.5723 | 0.7175 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0333 | 0.0358 |
Brugia malayi | brahma associated protein 60 kDa | 0.0061 | 0.5723 | 0.5701 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0061 | 0.5723 | 1 |
Onchocerca volvulus | 0.0061 | 0.5723 | 1 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.3917 | 0.4233 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0061 | 0.5723 | 0.779 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0518 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1703 | 0.184 |
Chlamydia trachomatis | SWIB complex protein | 0.0061 | 0.5723 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0333 | 0.0388 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0851 | 0.1099 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0061 | 0.5723 | 0.779 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0061 | 0.5723 | 0.779 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.5723 | 0.7175 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0061 | 0.5723 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0051 | 0.0055 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0457 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0051 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0051 | 0.0055 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.1264 | 0.1219 |
Plasmodium vivax | hypothetical protein, conserved | 0.0061 | 0.5723 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0061 | 0.5723 | 0.6184 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0061 | 0.5723 | 0.5701 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4024 | 0.4348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.5723 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4357 | 0.4709 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0061 | 0.5723 | 0.779 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3599 | 0.3566 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0061 | 0.5723 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0851 | 0.1099 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0518 | 0.0591 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0457 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.3917 | 0.3886 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0851 | 0.1012 |
Loa Loa (eye worm) | brahma associated protein | 0.0061 | 0.5723 | 0.6184 |
Schistosoma mansoni | brg-1 associated factor | 0.0061 | 0.5723 | 0.7175 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7956 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.4306 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0457 | 0.0717 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0061 | 0.5723 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3917 | 0.4233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.