TDR Targets

Basic information

Technical information

TDR Targets ID: 1300473
Name: T5591300
MW: 377.888 | Formula: C18H20ClN3O2S
H donors: 0 H acceptors: 3 LogP: 2.93 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cccc(c1)S(=O)(=O)N1CCN(CC1c1ccccc1)C.Cl
InChi: 1S/C18H19N3O2S.ClH/c1-20-10-11-21(18(14-20)16-7-3-2-4-8-16)24(22,23)17-9-5-6-15(12-17)13-19;/h2-9,12,18H,10-11,14H2,1H3;1H
InChiKey: PESWVQOPVOLRCX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0216	0.0216
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0304	0.0304
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.006	0.0608	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0414	0.0478
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0083	0.0978	0.4543
Brugia malayi	ImpB/MucB/SamB family protein	0.006	0.0608	0.2822
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Echinococcus multilocularis	dna polymerase eta	0.0087	0.1043	0.1043
Echinococcus granulosus	GPCR family 2	0.0049	0.0429	0.0429
Leishmania major	DNA polymerase eta, putative	0.0087	0.1043	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0126	0.1682	0.0267
Loa Loa (eye worm)	glutathione reductase	0.005	0.044	0.2043
Entamoeba histolytica	deoxycytidyl transferase, putative	0.006	0.0608	0.6212
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.044	0.044
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.006	0.0608	0.0702
Mycobacterium tuberculosis	Probable reductase	0.0114	0.1476	0.1606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0414	0.0414
Plasmodium vivax	glutathione reductase, putative	0.005	0.044	0.0479
Mycobacterium ulcerans	DNA polymerase IV	0.006	0.0608	0.0661
Toxoplasma gondii	kinesin motor domain-containing protein	0.0083	0.0978	1
Plasmodium vivax	kinesin-5	0.0083	0.0978	0.1065
Plasmodium falciparum	kinesin-5	0.0083	0.0978	0.1065
Brugia malayi	Thioredoxin reductase	0.005	0.044	0.2043
Trypanosoma brucei	DNA polymerase IV, putative	0.006	0.0608	0.5825
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.044	0.0479
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0305	0.292
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0429	0.0429
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Trypanosoma cruzi	DNA polymerase eta, putative	0.0046	0.037	0.3546
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0414	0.0478
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Trypanosoma cruzi	DNA polymerase eta, putative	0.0087	0.1043	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0429	0.0429
Trypanosoma cruzi	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0046	0.037	0.3782
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.1214	0.1214
Echinococcus granulosus	dna polymerase eta	0.0087	0.1043	0.1043
Brugia malayi	Kinesin motor domain containing protein	0.0083	0.0978	0.4543
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.1214	0.1214
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.044	0.2043
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0429	0.0429
Giardia lamblia	DINP protein human, muc B family	0.006	0.0608	0.6212
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0414	0.0414
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0114	0.1476	0.1606
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0	0.5
Leishmania major	trypanothione reductase	0.005	0.044	0.4217
Loa Loa (eye worm)	hypothetical protein	0.003	0.0114	0.0532
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0114	0.0114
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0305	0.292
Trypanosoma brucei	unspecified product	0.006	0.0608	0.5825
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0629	0.292
Plasmodium falciparum	thioredoxin reductase	0.005	0.044	0.0479
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0114	0.0532
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0114	0.1476	0.1606
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0429	0.0429
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0414	0.0414
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.044	0.0479
Brugia malayi	jmjC domain containing protein	0.0097	0.1214	0.5636
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0888	0.1027
Echinococcus granulosus	peregrin	0.003	0.0114	0.0114
Schistosoma mansoni	kinesin eg-5	0.0083	0.0978	0.1131
Trypanosoma brucei	unspecified product	0.0041	0.0305	0.292
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0589	0.9189	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0114	0.0132
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0216	0.025
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0589	0.9189	1
Treponema pallidum	hypothetical protein	0.0589	0.9189	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1355	0.6294
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Brugia malayi	glutathione reductase	0.005	0.044	0.2043
Echinococcus multilocularis	kinesin family 1	0.0639	1	1
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0114	0.0125
Leishmania major	DNA polymerase eta, putative	0.0046	0.037	0.3546
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0126	0.1682	0.183
Trypanosoma brucei	DNA polymerase IV, putative	0.006	0.0608	0.5825
Schistosoma mansoni	hypothetical protein	0.0049	0.0429	0.0496
Echinococcus multilocularis	dna polymerase kappa	0.006	0.0608	0.0608
Trypanosoma brucei	trypanothione reductase	0.005	0.044	0.4217
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Loa Loa (eye worm)	hypothetical protein	0.0051	0.046	0.2134
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.044	0.4217
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0114	0.117
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0155	0.2153	1
Schistosoma mansoni	hypothetical protein	0.003	0.0114	0.0132
Trypanosoma brucei	DNA polymerase eta, putative	0.0087	0.1043	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1043	0.4845
Brugia malayi	Bromodomain containing protein	0.003	0.0114	0.0532
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.006	0.0608	0.2822
Trypanosoma brucei	unspecified product	0.0041	0.0305	0.292
Schistosoma mansoni	hypothetical protein	0.0106	0.1355	0.1566
Onchocerca volvulus	Alhambra homolog	0.003	0.0114	0.5
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0126	0.1682	0.183
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0429	0.1994
Mycobacterium ulcerans	DNA polymerase IV	0.006	0.0608	0.0661
Entamoeba histolytica	kinesin, putative	0.0083	0.0978	1
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0304	0.0304
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0414	0.0478
Brugia malayi	latrophilin 2 splice variant baaae	0.0106	0.1355	0.6294
Toxoplasma gondii	thioredoxin reductase	0.005	0.044	0.4497
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0155	0.2153	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0305	0.292
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.006	0.0608	0.5825
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.006	0.0608	0.0661
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0414	0.192
Mycobacterium tuberculosis	Probable oxidoreductase	0.0126	0.1682	0.183
Brugia malayi	jmjC domain containing protein	0.0036	0.0216	0.1004
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0114	0.117
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0429	0.1994
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0429	0.1994
Trypanosoma cruzi	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0114	0.1476	0.1606
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0155	0.2153	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.044	0.044
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0414	0.192
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.006	0.0608	0.0608
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0114	0.0114
Schistosoma mansoni	hypothetical protein	0.0049	0.0429	0.0496
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0589	0.9189	1
Trypanosoma brucei	DNA polymerase IV, putative	0.006	0.0608	0.5825
Plasmodium falciparum	glutathione reductase	0.005	0.044	0.0479
Brugia malayi	ImpB/MucB/SamB family protein	0.0087	0.1043	0.4845
Giardia lamblia	PHD finger protein 15	0.003	0.0114	0.117
Mycobacterium tuberculosis	Conserved hypothetical protein	0.006	0.0608	0.0661
Leishmania major	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Schistosoma mansoni	terminal deoxycytidyl transferase	0.006	0.0608	0.0702
Trypanosoma cruzi	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Giardia lamblia	Kinesin-5	0.0083	0.0978	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0216	0.1004
Mycobacterium tuberculosis	Probable dehydrogenase	0.0114	0.1476	0.1606
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0429	0.1994
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0429	0.0429
Brugia malayi	PHD-finger family protein	0.003	0.0114	0.0532
Trypanosoma cruzi	DNA polymerase kappa, putative	0.006	0.0608	0.5825
Schistosoma mansoni	hypothetical protein	0.0049	0.0429	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0155	0.2153	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.006	0.0608	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0429	0.0496
Schistosoma mansoni	hypothetical protein	0.0556	0.8653	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0216	0.025
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0589	0.9189	1
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0589	0.9189	1
Echinococcus multilocularis	peregrin	0.003	0.0114	0.0114
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0216	0.0216
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.006	0.0608	0.0608
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0114	0.1476	0.1606
Schistosoma mansoni	DNA polymerase eta	0.0087	0.1043	0.1206
Echinococcus granulosus	dna polymerase kappa	0.006	0.0608	0.0608
Plasmodium falciparum	phd finger protein, putative	0.003	0.0114	0.0125
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0414	0.0414

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.3778 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1414373

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1300473