Detailed information for compound 1311455

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 217.287 | Formula: C12H11NOS
  • H donors: 1 H acceptors: 1 LogP: 2.25 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1=C2Sc3ccccc3N=C2CCC1
  • InChi: 1S/C12H11NOS/c14-10-6-3-5-9-12(10)15-11-7-2-1-4-8(11)13-9/h1-2,4,7,14H,3,5-6H2
  • InChiKey: XJXYLZFUETZNSH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Simian virus 40 Large T antigen Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi DnaJ domain containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma japonicum expressed protein Get druggable targets OG5_132364 All targets in OG5_132364
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K09536 DnaJ homolog, subfamily C, member 16, putative Get druggable targets OG5_132364 All targets in OG5_132364
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis protein kinase inhibitor, putative Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) DnaJ domain-containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.0258 0.0258
Entamoeba histolytica protein kinase, putative 0.0108 0.0258 0.0258
Entamoeba histolytica protein kinase, putative 0.0108 0.0258 0.0258
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0099 0.0221 0.8573
Echinococcus multilocularis ceramide kinase 0.0099 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0107 0.0255 0.0255
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0099 0.0221 0.1919
Loa Loa (eye worm) glutaminase 2 0.033 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0099 0.0221 0.0221
Echinococcus granulosus dual specificity 0.0108 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0099 0.0221 0.0221
Plasmodium vivax diacylglycerol kinase, putative 0.0099 0.0221 0.5
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0258 1
Brugia malayi diacylglycerol kinase 0.0099 0.0221 0.1919
Brugia malayi diacylglycerol kinase 0.0099 0.0221 0.1919
Trypanosoma cruzi diacylglycerol kinase, putative 0.0099 0.0221 0.8573
Echinococcus multilocularis sphingosine kinase 1 0.2532 1 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.0122 0.0122
Trypanosoma cruzi Sphingosine kinase 0.0099 0.0221 0.8573
Trichomonas vaginalis diacylglycerol kinase, putative 0.0099 0.0221 0.1919
Brugia malayi Eye-specific diacylglycerol kinase 0.0099 0.0221 0.1919
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0615 0.0615
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3173 0.3173
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0099 0.0221 0.8573
Schistosoma mansoni sphingosine kinase A B 0.2532 1 1
Loa Loa (eye worm) glutaminase 0.033 0.1151 0.1151
Brugia malayi DnaJ domain containing protein 0.0074 0.0122 0.1058
Brugia malayi Diacylglycerol kinase protein 2 0.0099 0.0221 0.1919
Mycobacterium tuberculosis Conserved protein 0.2532 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3173 0.3173
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0099 0.0221 0.8573
Echinococcus granulosus Diacylglycerol kinase theta 0.0099 0.0221 0.0221
Trichomonas vaginalis sphingosine kinase, putative 0.0099 0.0221 0.1919
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3173 0.3173
Brugia malayi glutaminase DH11.1 0.033 0.1151 1
Trichomonas vaginalis bmru protein, putative 0.0099 0.0221 0.1919
Schistosoma mansoni alpha-glucosidase 0.0169 0.0505 0.0505
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0099 0.0221 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.0258 1
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0099 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.2532 1 1
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0099 0.0221 0.8573
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0258 0.0258
Brugia malayi Ceramide kinase 0.0099 0.0221 0.1919
Brugia malayi Protein kinase domain containing protein 0.0108 0.0258 0.2238
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.0258 0.0258
Entamoeba histolytica diacylglycerol kinase, putative 0.0099 0.0221 0.0221
Entamoeba histolytica diacylglycerol kinase, putative 0.0099 0.0221 0.0221
Entamoeba histolytica diacylglycerol kinase, putative 0.0099 0.0221 0.0221
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0615 0.5344
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0099 0.0221 0.0221
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0615 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0221 0.1919
Leishmania major diacylglycerol kinase-like protein 0.0099 0.0221 0.8573
Schistosoma mansoni hypothetical protein 0.0074 0.0122 0.0122
Schistosoma mansoni diacylglycerol kinase theta 0.0099 0.0221 0.0221
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.0122 0.0122
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0615 0.0615
Leishmania major sphingosine kinase A, B, putative 0.0099 0.0221 0.8573
Trypanosoma brucei diacylglycerol kinase, putative 0.0099 0.0221 0.8573
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.0122 0.1058
Schistosoma mansoni glutaminase 0.033 0.1151 0.1151
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.0258 1
Brugia malayi hypothetical protein 0.0099 0.0221 0.1919
Schistosoma mansoni diacylglycerol kinase theta 0.0099 0.0221 0.0221
Entamoeba histolytica hypothetical protein 0.0108 0.0258 0.0258
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.0122 0.0122
Echinococcus multilocularis Diacylglycerol kinase theta 0.0099 0.0221 0.0221
Loa Loa (eye worm) diacylglycerol kinase 2 0.0099 0.0221 0.0221
Leishmania major hypothetical protein, conserved 0.0099 0.0221 0.8573
Trichomonas vaginalis diacylglycerol kinase, putative 0.0099 0.0221 0.1919
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0221 0.8573
Plasmodium vivax diacylglycerol kinase, putative 0.0099 0.0221 0.5
Trypanosoma cruzi diacylglycerol kinase, putative 0.0099 0.0221 0.8573
Loa Loa (eye worm) hypothetical protein 0.0107 0.0255 0.0255
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0099 0.0221 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0099 0.0221 0.1919
Schistosoma mansoni alpha-glucosidase 0.0169 0.0505 0.0505
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0615 0.0615
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0258 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0099 0.0221 0.0221
Echinococcus granulosus Diacylglycerol kinase zeta 0.0099 0.0221 0.0221
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.376 0.376
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0099 0.0221 0.0221
Echinococcus granulosus ceramide kinase 0.0099 0.0221 0.0221
Trichomonas vaginalis bmru protein, putative 0.0099 0.0221 0.1919
Plasmodium falciparum diacylglycerol kinase, putative 0.0099 0.0221 0.5
Mycobacterium ulcerans hypothetical protein 0.2532 1 1
Trypanosoma cruzi Sphingosine kinase 0.0099 0.0221 0.8573
Leishmania major diacylglycerol kinase, putative 0.0099 0.0221 0.8573
Schistosoma mansoni sphingoid long chain base kinase 0.2532 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0099 0.0221 0.8573
Trichomonas vaginalis glutaminase, putative 0.033 0.1151 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0221 0.0221
Trichomonas vaginalis sphingosine kinase, putative 0.0099 0.0221 0.1919
Echinococcus multilocularis dual specificity 0.0108 0.0258 0.0258
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0099 0.0221 0.1919
Mycobacterium ulcerans glutaminase 0.033 0.1151 0.0951
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0099 0.0221 0.0221
Loa Loa (eye worm) ceramide kinase 0.0099 0.0221 0.0221
Leishmania major hypothetical protein, conserved 0.0099 0.0221 0.8573
Plasmodium falciparum diacylglycerol kinase, putative 0.0099 0.0221 0.5
Entamoeba histolytica hypothetical protein, conserved 0.2532 1 1
Trypanosoma brucei Sphingosine kinase 0.0099 0.0221 0.8573
Toxoplasma gondii diacylglycerol kinase, putative 0.0099 0.0221 1
Onchocerca volvulus 0.0114 0.0282 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0099 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0099 0.0221 0.0221
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0099 0.0221 0.0221

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 8.446 uM PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] ChEMBL. No reference
IC50 (functional) 9.55 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) = 35.2 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 59 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 11.5774 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (binding) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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