Detailed information for compound 1315007

Basic information

Technical information
  • TDR Targets ID: 1315007
  • Name: 5-[(5-acetyl-2-ethoxyphenyl)methylsulfanyl]-7 -cyclopropyl-3-methyl-1-propylpyrimido[5,6-e] pyrimidine-2,4-dione
  • MW: 468.569 | Formula: C24H28N4O4S
  • H donors: 0 H acceptors: 5 LogP: 3.26 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1CSc1nc(nc2c1c(=O)n(C)c(=O)n2CCC)C1CC1)C(=O)C
  • InChi: 1S/C24H28N4O4S/c1-5-11-28-21-19(23(30)27(4)24(28)31)22(26-20(25-21)15-7-8-15)33-13-17-12-16(14(3)29)9-10-18(17)32-6-2/h9-10,12,15H,5-8,11,13H2,1-4H3
  • InChiKey: UWTOJWYIIDRVQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(5-acetyl-2-ethoxy-phenyl)methylsulfanyl]-7-cyclopropyl-3-methyl-1-propyl-pyrimido[5,6-e]pyrimidine-2,4-dione
  • 5-[(5-acetyl-2-ethoxyphenyl)methylthio]-7-cyclopropyl-3-methyl-1-propylpyrimido[5,6-e]pyrimidine-2,4-dione
  • 5-[(5-acetyl-2-ethoxy-benzyl)thio]-7-cyclopropyl-3-methyl-1-propyl-pyrimido[5,6-e]pyrimidine-2,4-quinone
  • 7-cyclopropyl-5-[(5-ethanoyl-2-ethoxy-phenyl)methylsulfanyl]-3-methyl-1-propyl-pyrimido[5,6-e]pyrimidine-2,4-dione
  • MLS000055946
  • SMR000068343
  • T5340519
  • ZINC03430135
  • MLS001066170
  • MLS000879959

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Onchocerca volvulus Peroxidasin homolog 0.0244 0.3393 1
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1864
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.3393 0.7941
Echinococcus multilocularis peroxidasin 0.0244 0.3393 0.7936
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.027 0.0606
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1864
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1864
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.4272 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.027 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0083 0.0874 0.2026
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.3393 0.7941
Echinococcus multilocularis protein jagged 1 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Echinococcus multilocularis snurportin 1 0.0301 0.4272 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Schistosoma mansoni notch 0.0079 0.0806 0.1864
Schistosoma mansoni hypothetical protein 0.0301 0.4272 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0356 1
Brugia malayi Delta serrate ligand family protein 0.0079 0.0806 0.2375
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Echinococcus granulosus protein jagged 2 0.0079 0.0806 0.1864
Schistosoma mansoni peroxidasin 0.0244 0.3393 0.7936
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0976 0.2263
Loa Loa (eye worm) blistered cuticle protein 3 0.0244 0.3393 0.7941
Schistosoma mansoni tyrosine kinase 0.0155 0.1997 0.466
Schistosoma mansoni tyrosine kinase 0.005 0.0346 0.0786
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.005 0.0346 0.0786
Echinococcus multilocularis neurogenic locus protein delta 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Onchocerca volvulus Peroxidase homolog 0.0244 0.3393 1
Echinococcus multilocularis epidermal growth factor receptor 0.0155 0.1997 0.466
Schistosoma mansoni tyrosine kinase 0.0083 0.0874 0.2026
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0356 0.0833
Echinococcus multilocularis insulin receptor 0.005 0.0346 0.0786
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1864
Echinococcus granulosus peroxidasin 0.0244 0.3393 0.7936
Schistosoma mansoni hypothetical protein 0.0036 0.0126 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.027 0.5
Leishmania major hypothetical protein, conserved 0.005 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Echinococcus granulosus neurogenic locus protein delta 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0126 0.027
Brugia malayi EGF-like domain containing protein 0.0079 0.0806 0.2375
Echinococcus granulosus protein jagged 1 0.0079 0.0806 0.1864
Brugia malayi EGF-like domain containing protein 0.0079 0.0806 0.2375
Brugia malayi Calcium binding EGF domain containing protein 0.0079 0.0806 0.2375
Echinococcus granulosus insulin growth factor 1 receptor beta 0.005 0.0346 0.0786
Brugia malayi hypothetical protein 0.005 0.0356 0.1049
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Brugia malayi Cadherin domain containing protein 0.0079 0.0806 0.2375
Brugia malayi hypothetical protein 0.0244 0.3393 1
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.3393 0.7941
Schistosoma mansoni notch 0.0079 0.0806 0.1864
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0079 0.0806 0.2375
Onchocerca volvulus Peroxidasin homolog 0.0244 0.3393 1
Brugia malayi notch-like transmembrane receptor 0.0079 0.0806 0.2375
Brugia malayi Muscle positioning protein 4 0.0079 0.0806 0.2375
Loa Loa (eye worm) Notch2 0.0079 0.0806 0.1886
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1864
Brugia malayi Calcium binding EGF domain containing protein 0.0079 0.0806 0.2375
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Brugia malayi EGF-like domain containing protein 0.0079 0.0806 0.2375
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Loa Loa (eye worm) TK/EGFR protein kinase 0.0155 0.1997 0.4674
Schistosoma mansoni tyrosine kinase 0.0083 0.0874 0.2026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0976 0.2263
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Schistosoma mansoni laminin gamma-3 chain 0.0079 0.0806 0.1864
Echinococcus granulosus insulin receptor 0.005 0.0346 0.0786
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.027 0.7489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0976 0.2263
Echinococcus multilocularis notch 0.0079 0.0806 0.1864
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.027 0.0606
Schistosoma mansoni tyrosine kinase 0.005 0.0346 0.0786
Echinococcus granulosus notch 0.0079 0.0806 0.1864
Schistosoma mansoni tyrosine kinase 0.0082 0.0861 0.1993
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Onchocerca volvulus Chorion peroxidase homolog 0.0244 0.3393 1
Echinococcus granulosus delta-like protein 1 0.0079 0.0806 0.1864
Echinococcus multilocularis slit 2 protein 0.0079 0.0806 0.1864
Toxoplasma gondii EGF family domain-containing protein 0.0079 0.0806 1
Brugia malayi Protein kinase domain containing protein 0.005 0.0346 0.102
Schistosoma mansoni peroxidasin 0.0244 0.3393 0.7936
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Onchocerca volvulus 0.0244 0.3393 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0976 0.2263
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Onchocerca volvulus Dual oxidase homolog 0.0244 0.3393 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.027 0.0606
Schistosoma mansoni tyrosine kinase 0.0082 0.0861 0.1993
Schistosoma mansoni notch 0.0079 0.0806 0.1864
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Onchocerca volvulus 0.0244 0.3393 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Echinococcus granulosus protein jagged 2 0.0079 0.0806 0.1864
Onchocerca volvulus Peroxidase homolog 0.0244 0.3393 1
Echinococcus granulosus fibropellin Ia 0.0079 0.0806 0.1864
Schistosoma mansoni notch 0.0079 0.0806 0.1864
Brugia malayi Animal haem peroxidase family protein 0.0244 0.3393 1
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0356 0.434
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1864
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.027 0.0606
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.027 0.5
Echinococcus multilocularis 0.0048 0.0322 0.0729
Brugia malayi RNA, U transporter 1 0.008 0.0823 0.2427
Brugia malayi hypothetical protein 0.0032 0.0078 0.0229
Echinococcus multilocularis epidermal growth factor receptor 0.0083 0.0874 0.2026
Brugia malayi GCC2 and GCC3 family protein 0.0079 0.0806 0.2375
Brugia malayi Furin-like cysteine rich region family protein 0.0155 0.1997 0.5886
Brugia malayi Cadherin domain containing protein 0.0079 0.0806 0.2375
Schistosoma mansoni cell polarity protein 0.0079 0.0806 0.1864
Brugia malayi Importin beta-1 subunit 0.0028 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Loa Loa (eye worm) TK/INSR protein kinase 0.005 0.0346 0.081
Echinococcus multilocularis neurogenic locus notch protein 0.0079 0.0806 0.1864
Brugia malayi Calcium binding EGF domain containing protein 0.0079 0.0806 0.2375
Loa Loa (eye worm) hypothetical protein 0.0045 0.027 0.0631
Echinococcus granulosus neurogenic locus notch protein 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Brugia malayi EGF-like domain containing protein 0.0079 0.0806 0.2375
Brugia malayi EGF-like domain containing protein 0.0079 0.0806 0.2375
Brugia malayi EGF-like domain containing protein 0.0079 0.0806 0.2375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0027
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0079 0.0806 0.1864
Brugia malayi Animal haem peroxidase family protein 0.0244 0.3393 1
Schistosoma mansoni notch 0.0079 0.0806 0.1864
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.027 0.0606
Brugia malayi Blistered cuticle protein 3 0.0244 0.3393 1
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0356 1
Brugia malayi Peroxidasin 0.0244 0.3393 1
Giardia lamblia High cysteine protein 0.0079 0.0806 1
Echinococcus granulosus snurportin 1 0.0301 0.4272 1
Echinococcus granulosus neural cadherin 0.0079 0.0806 0.1864
Schistosoma mansoni notch 0.0079 0.0806 0.1864
Echinococcus granulosus protein jagged 1 0.0079 0.0806 0.1864
Echinococcus granulosus epidermal growth factor receptor 0.0083 0.0874 0.2026
Echinococcus multilocularis protein jagged 1 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Brugia malayi Animal haem peroxidase family protein 0.0244 0.3393 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0976 0.2263
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Schistosoma mansoni tyrosine kinase 0.0082 0.0861 0.1993
Echinococcus multilocularis neurogenic locus protein delta 0.0079 0.0806 0.1864
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0976 0.2263
Loa Loa (eye worm) notch protein 0.0079 0.0806 0.1886
Echinococcus multilocularis neural cadherin 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0244 0.3393 0.7941
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Brugia malayi hypothetical protein 0.0036 0.0126 0.0372
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.027 0.0606
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.027 0.0606
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Echinococcus multilocularis neurogenic locus notch protein 0.0079 0.0806 0.1864
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.3393 0.7941
Brugia malayi Animal haem peroxidase family protein 0.0244 0.3393 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0976 0.2876
Onchocerca volvulus 0.0244 0.3393 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0126 0.027
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.027 0.0606
Schistosoma mansoni septate junction protein 0.0079 0.0806 0.1864
Echinococcus granulosus neurogenic locus notch protein 4 0.0079 0.0806 0.1864
Echinococcus multilocularis protein jagged 2 0.0079 0.0806 0.1864
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Brugia malayi EGF-like domain containing protein 0.0079 0.0806 0.2375
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Echinococcus multilocularis neurogenic locus notch protein 4 0.0079 0.0806 0.1864
Echinococcus granulosus epidermal growth factor receptor 0.0155 0.1997 0.466
Echinococcus multilocularis fibropellin Ia 0.0079 0.0806 0.1864
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.027 0.0794
Schistosoma mansoni slit 0.0079 0.0806 0.1864
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0976 0.2284
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0356 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.027 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0976 0.2263
Echinococcus granulosus slit 2 protein 0.0079 0.0806 0.1864
Brugia malayi Animal haem peroxidase family protein 0.0244 0.3393 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0806 0.1886
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0126 0.027
Echinococcus granulosus neurogenic locus notch protein 0.0079 0.0806 0.1864

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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