Detailed information for compound 1316489

Basic information

Technical information
  • TDR Targets ID: 1316489
  • Name: N-pentyl-3-phenylpropanamide
  • MW: 219.323 | Formula: C14H21NO
  • H donors: 1 H acceptors: 1 LogP: 3.22 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCNC(=O)CCc1ccccc1
  • InChi: 1S/C14H21NO/c1-2-3-7-12-15-14(16)11-10-13-8-5-4-6-9-13/h4-6,8-9H,2-3,7,10-12H2,1H3,(H,15,16)
  • InChiKey: YOABAXQNDFFNSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-pentyl-3-phenyl-propanamide
  • N-amyl-3-phenyl-propionamide
  • MLS000550057
  • SMR000114788
  • ZINC02085861
  • AK-968/12865498
  • IVK/8172657

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0035 0.0341
Echinococcus multilocularis protoporphyrinogen oxidase 0.0776 1 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0123 0.0123
Echinococcus multilocularis snurportin 1 0.0372 0.4614 0.4614
Loa Loa (eye worm) hypothetical protein 0.0041 0.0203 0.0439
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0776 1 0.5
Plasmodium vivax hypothetical protein, conserved 0.0102 0.1019 1
Loa Loa (eye worm) glutamate receptor 0.0159 0.1782 0.3863
Brugia malayi RNA, U transporter 1 0.0099 0.0978 0.549
Brugia malayi Metabotropic glutamate receptor precursor. 0.0159 0.1782 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4614 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0102 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0266
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.0674 0.8639 1
Brugia malayi hypothetical protein 0.0102 0.1019 0.5718
Schistosoma mansoni amine oxidase 0.0102 0.1019 0.1019
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0003
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0102 0.1019 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0776 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1019 0.2209
Onchocerca volvulus 0.0102 0.1019 1
Plasmodium falciparum importin beta, putative 0.0035 0.0123 0.1203
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0035 1
Echinococcus granulosus GPCR family 3 C terminal 0.0026 0.0003 0.0004
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0102 0.1019 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0102 0.1019 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0035 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0133 0.1438 0.1664
Schistosoma mansoni metabotropic glutamate receptor 0.0133 0.1438 0.1438
Echinococcus granulosus snurportin 1 0.0372 0.4614 0.5341
Echinococcus granulosus lysine specific histone demethylase 1A 0.0102 0.1019 0.118
Brugia malayi metabotropic glutamate receptor type 2 0.0078 0.0694 0.3892
Echinococcus granulosus lysine specific histone demethylase 1A 0.0102 0.1019 0.118
Schistosoma mansoni hypothetical protein 0.0372 0.4614 0.4614
Schistosoma mansoni metabotropic glutamate receptor 0.0078 0.0694 0.0694
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0144 0.1583 0.8879
Entamoeba histolytica hypothetical protein 0.0028 0.0035 1
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0203 0.1138
Plasmodium vivax hypothetical protein, conserved 0.0102 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1019 0.2209
Echinococcus granulosus protoporphyrinogen oxidase 0.0674 0.8639 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0041 0.0203 0.0439
Trypanosoma cruzi UDP-galactopyranose mutase 0.0102 0.1019 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0123 0.0688
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0123 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.2273 0.4926
Schistosoma mansoni importin beta-1 0.0035 0.0123 0.0123
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0102 0.1019 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0133 0.1438 0.1438
Schistosoma mansoni amine oxidase 0.0102 0.1019 0.1019
Echinococcus multilocularis 0.0102 0.1019 0.1019
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0196 0.2273 0.2273
Leishmania major importin beta-1 subunit, putative 0.0028 0.0035 0.0341
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0123 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0102 0.1019 0.1019
Leishmania major UDP-galactopyranose mutase 0.0102 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0102 0.1019 0.2209
Toxoplasma gondii histone lysine-specific demethylase 0.0102 0.1019 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0102 0.1019 0.5718
Loa Loa (eye worm) glutamate receptor 0.0063 0.0494 0.107
Echinococcus granulosus importin subunit beta 1 0.0035 0.0123 0.0142
Brugia malayi SWIRM domain containing protein 0.0102 0.1019 0.5718
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0776 1 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0123 0.1203
Loa Loa (eye worm) hypothetical protein 0.0102 0.1019 0.2209
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0 0.5
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0041 0.0203 0.0439
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0102 0.1019 1
Echinococcus multilocularis GPCR, family 3, C terminal 0.0026 0.0003 0.0003
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0181 0.2073 0.2073
Loa Loa (eye worm) hypothetical protein 0.0102 0.1019 0.2209
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0035 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0102 0.1019 0.2209
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0102 0.1019 0.1019
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0123 0.1203
Echinococcus granulosus metabotropic glutamate receptor 5 0.0196 0.2273 0.2631

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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