Detailed information for compound 1317417

Basic information

Technical information
  • TDR Targets ID: 1317417
  • Name: 2-phenyl-1-(pyridin-3-ylmethyl)-5,6,7,8-tetra hydroquinazoline-4-thione
  • MW: 333.45 | Formula: C20H19N3S
  • H donors: 0 H acceptors: 1 LogP: 3.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=c1nc(c2ccccc2)n(c2c1CCCC2)Cc1cccnc1
  • InChi: 1S/C20H19N3S/c24-20-17-10-4-5-11-18(17)23(14-15-7-6-12-21-13-15)19(22-20)16-8-2-1-3-9-16/h1-3,6-9,12-13H,4-5,10-11,14H2
  • InChiKey: GVYXMJXAJRKIBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-phenyl-1-(3-pyridylmethyl)-5,6,7,8-tetrahydroquinazoline-4-thione
  • ZINC04718348
  • STOCK4S-44782
  • Oprea1_095805
  • 2-Phenyl-1-pyridin-3-ylmethyl-5,6,7,8-tetrahydro-1H-quinazoline-4-thione
  • MLS000333578
  • SMR000437763

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH1 domain-containing protein 0.0075 0.0563 0.0504
Schistosoma mansoni tar DNA-binding protein 0.0391 0.3466 0.976
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.04 0.355 1
Schistosoma mansoni hypothetical protein 0.0096 0.0752 0.1981
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.016 0.0145
Trichomonas vaginalis replication factor C large subunit, putative 0.0041 0.0254 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.016 0.0226
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.016 0.0817
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.016 0.036
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.011 0.4335
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0041 0.0254 0.0146
Schistosoma mansoni chromosome transmission fidelity factor 0.0041 0.0254 0.0556
Echinococcus multilocularis tar DNA binding protein 0.0391 0.3466 0.9756
Echinococcus multilocularis GPCR, family 2 0.0096 0.0752 0.1865
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0041 0.0254 0.1325
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0752 0.1865
Loa Loa (eye worm) RecQ helicase 0.0026 0.011 0.0048
Trypanosoma cruzi PAB1-binding protein , putative 0.0227 0.196 1
Brugia malayi hypothetical protein 0.0041 0.0254 0.0146
Loa Loa (eye worm) hypothetical protein 0.0042 0.0255 0.0194
Brugia malayi MH1 domain containing protein 0.0075 0.0563 0.0458
Brugia malayi MH2 domain containing protein 0.0034 0.0182 0.0072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.016 0.0145
Echinococcus granulosus peptidase Clp S14 family 0.0262 0.2283 0.6318
Schistosoma mansoni peptidase Clp (S14 family) 0.04 0.355 1
Loa Loa (eye worm) MH2 domain-containing protein 0.1102 1 1
Echinococcus granulosus tar DNA binding protein 0.0391 0.3466 0.9756
Schistosoma mansoni hypothetical protein 0.0096 0.0752 0.1981
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.2649 0.2567
Entamoeba histolytica hypothetical protein 0.0041 0.0254 0.1325
Loa Loa (eye worm) hypothetical protein 0.0041 0.0254 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0254 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0075 0.0563 0.1317
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0752 0.0649
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0075 0.0563 0.1441
Echinococcus multilocularis smad 0.0075 0.0563 0.1317
Schistosoma mansoni hypothetical protein 0.0096 0.0752 0.1981
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0262 0.2283 0.6156
Echinococcus multilocularis nibrin 0.0041 0.0254 0.0419
Schistosoma mansoni Smad4 0.0034 0.0182 0.0348
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0138 0.114 0.3147
Brugia malayi Isocitrate dehydrogenase 0.0031 0.016 0.005
Schistosoma mansoni tar DNA-binding protein 0.0391 0.3466 0.976
Brugia malayi MH1 domain containing protein 0.0042 0.0255 0.0146
Loa Loa (eye worm) hypothetical protein 0.0298 0.2615 0.2568
Loa Loa (eye worm) hypothetical protein 0.0041 0.0254 0.0193
Echinococcus granulosus nibrin 0.0041 0.0254 0.0419
Schistosoma mansoni smad1 5 8 and 0.0075 0.0563 0.1441
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0752 0.1865
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0752 0.0694
Entamoeba histolytica hypothetical protein 0.0223 0.1921 1
Plasmodium vivax replication factor C subunit 1, putative 0.0041 0.0254 0.0628
Schistosoma mansoni transcription factor LCR-F1 0.0223 0.1921 0.5332
Loa Loa (eye worm) hypothetical protein 0.0041 0.0254 0.0193
Entamoeba histolytica hypothetical protein 0.0223 0.1921 1
Brugia malayi MH1 domain containing protein 0.0042 0.0255 0.0146
Brugia malayi MH2 domain containing protein 0.0075 0.0563 0.0458
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0752 0.1865
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.04 0.355 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0138 0.114 0.3052
Echinococcus granulosus GPCR family 2 0.0096 0.0752 0.1865
Brugia malayi MH1 domain containing protein 0.0075 0.0563 0.0458
Plasmodium falciparum replication factor C subunit 1, putative 0.0041 0.0254 0.0499
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.2649 0.2567
Loa Loa (eye worm) TAR-binding protein 0.0391 0.3466 0.3425
Schistosoma mansoni Smad4 0.0075 0.0563 0.1441
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0254 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.016 0.0145
Entamoeba histolytica hypothetical protein 0.0223 0.1921 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0041 0.0254 0.1299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0223 0.1921 0.5265
Loa Loa (eye worm) hypothetical protein 0.0041 0.0254 0.0193
Echinococcus multilocularis Smad4 0.0075 0.0563 0.1317
Echinococcus granulosus smad 0.0075 0.0563 0.1317
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0262 0.2283 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.011 0.4335
Brugia malayi DKFZp564C0469 protein 0.0041 0.0254 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0254 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.016 0.0145
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0041 0.0254 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0102 0.0809 0.2031
Brugia malayi hypothetical protein 0.0227 0.196 0.187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.04 0.355 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0254 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.016 0.0365
Brugia malayi hypothetical protein 0.0223 0.1921 0.1831
Echinococcus multilocularis peptidase Clp (S14 family) 0.0262 0.2283 0.6318
Schistosoma mansoni hypothetical protein 0.0206 0.1771 0.4902
Echinococcus multilocularis mothers against decapentaplegic 5 0.0075 0.0563 0.1317
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0138 0.114 0.2687
Echinococcus multilocularis mothers against decapentaplegic 6 0.0034 0.0182 0.0208
Trypanosoma cruzi FHA domain containing protein, putative 0.0041 0.0254 0.1299
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.016 0.0817
Brugia malayi topoisomerase 0.0041 0.0254 0.0146
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0041 0.0254 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0391 0.3466 0.3425
Brugia malayi MH2 domain containing protein 0.0075 0.0563 0.0458
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0752 0.0649
Echinococcus granulosus mothers against decapentaplegic 2 0.0034 0.0182 0.0208
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.04 0.355 1
Entamoeba histolytica hypothetical protein 0.0223 0.1921 1
Schistosoma mansoni smad 0.0075 0.0563 0.1441
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.016 0.0365
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.04 0.355 1
Brugia malayi isocitrate dehydrogenase 0.0031 0.016 0.005
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.016 0.0145
Echinococcus granulosus mothers against decapentaplegic 6 0.0034 0.0182 0.0208
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.016 0.0098
Schistosoma mansoni smad1 5 8 and 0.0075 0.0563 0.1441
Plasmodium falciparum ataxin-2 like protein, putative 0.0227 0.196 0.5414
Brugia malayi Probable ClpP-like protease 0.04 0.355 0.3478
Plasmodium falciparum ataxin-2 like protein, putative 0.0227 0.196 0.5414
Onchocerca volvulus 0.0298 0.2615 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.04 0.355 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.016 0.0817
Schistosoma mansoni tar DNA-binding protein 0.0391 0.3466 0.976
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0138 0.114 0.2687
Loa Loa (eye worm) hypothetical protein 0.0302 0.2649 0.2603
Schistosoma mansoni hypothetical protein 0.0223 0.1921 0.5332
Loa Loa (eye worm) hypothetical protein 0.04 0.355 0.351
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0041 0.0254 1
Onchocerca volvulus 0.0041 0.0254 0.0299
Brugia malayi Pax transcription activation domain interacting protein 0.0041 0.0254 0.0146
Plasmodium vivax ataxin-2 like protein, putative 0.0227 0.196 0.5477
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0182 0.012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0254 0.0193
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.0563 0.0504
Loa Loa (eye worm) nuclear factor I 0.0042 0.0255 0.0194
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.016 0.0817
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.04 0.355 1
Schistosoma mansoni smad 0.0034 0.0182 0.0348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.2649 0.2603
Loa Loa (eye worm) hypothetical protein 0.0227 0.196 0.1909
Echinococcus granulosus Smad4 0.0075 0.0563 0.1317
Loa Loa (eye worm) hypothetical protein 0.0206 0.1771 0.1719
Schistosoma mansoni topbp1 0.0041 0.0254 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0391 0.3466 0.976
Schistosoma mansoni DNA ligase IV 0.0041 0.0254 0.0556
Brugia malayi hypothetical protein 0.0298 0.2615 0.2532
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0254 0.1299
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.04 0.355 1
Schistosoma mansoni smad1 5 8 and 0.0075 0.0563 0.1441
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0223 0.1921 0.5265
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.016 0.0817
Loa Loa (eye worm) transcription factor SMAD2 0.1102 1 1
Brugia malayi hypothetical protein 0.0041 0.0254 0.0146
Echinococcus granulosus replication factor c subunit 1 0.0041 0.0254 0.0419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.016 0.0145
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0182 0.012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0752 0.1865
Brugia malayi hypothetical protein 0.0147 0.122 0.1122
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0041 0.0254 0.1299
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.016 0.0285
Trypanosoma brucei PAB1-binding protein , putative 0.0227 0.196 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0254 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0752 0.0694
Schistosoma mansoni hypothetical protein 0.0102 0.0809 0.2145
Loa Loa (eye worm) Smad1 0.0075 0.0563 0.0504
Loa Loa (eye worm) RNA binding protein 0.0391 0.3466 0.3425
Schistosoma mansoni hypothetical protein 0.0096 0.0752 0.1981
Giardia lamblia Replication factor C, subunit 1 0.0041 0.0254 0.5
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0075 0.0563 0.1317
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0254 0.1299
Brugia malayi TAR-binding protein 0.0391 0.3466 0.3393
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.04 0.355 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0034 0.0182 0.0072
Echinococcus multilocularis mothers against decapentaplegic 2 0.0034 0.0182 0.0208
Toxoplasma gondii hypothetical protein 0.0138 0.114 0.315
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0102 0.0809 0.2031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.04 0.355 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0041 0.0254 1
Echinococcus multilocularis replication factor c subunit 1 0.0041 0.0254 0.0419
Loa Loa (eye worm) hypothetical protein 0.0041 0.0254 0.0193
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.1771 0.1679
Trypanosoma cruzi PAB1-binding protein , putative 0.0227 0.196 1
Schistosoma mansoni topbp1 0.0041 0.0254 0.0556
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.04 0.355 1
Brugia malayi RNA recognition motif domain containing protein 0.0391 0.3466 0.3393
Brugia malayi RNA binding protein 0.0391 0.3466 0.3393
Loa Loa (eye worm) hypothetical protein 0.0034 0.0182 0.012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.04 0.355 1
Schistosoma mansoni tar DNA-binding protein 0.0391 0.3466 0.976
Schistosoma mansoni Smad4 0.0034 0.0182 0.0348
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0041 0.0254 0.0633
Toxoplasma gondii ATPase, AAA family protein 0.0041 0.0254 0.0633
Brugia malayi Smad1 0.0075 0.0563 0.0458
Echinococcus granulosus mothers against decapentaplegic 5 0.0075 0.0563 0.1317
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0262 0.2283 1
Leishmania major hypothetical protein, conserved 0.0227 0.196 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.04 0.355 1
Toxoplasma gondii LsmAD domain-containing protein 0.0227 0.196 0.5479

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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