Detailed information for compound 1318683

Basic information

Technical information
  • TDR Targets ID: 1318683
  • Name: 3-(4-chlorophenyl)-6-methyl-[1,3]thiazolo[3,2 -d][1,2,4]triazole
  • MW: 249.719 | Formula: C11H8ClN3S
  • H donors: 0 H acceptors: 2 LogP: 3.97 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nnc2n1cc(s2)C
  • InChi: 1S/C11H8ClN3S/c1-7-6-15-10(13-14-11(15)16-7)8-2-4-9(12)5-3-8/h2-6H,1H3
  • InChiKey: LIQIPHVBDGBXRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-chlorophenyl)-6-methyl-thiazolo[3,2-d][1,2,4]triazole
  • 3-(4-chlorophenyl)-6-methylthiazolo[3,2-d][1,2,4]triazole
  • ZINC00112088
  • MLS000116031
  • SMR000093020
  • A3330/0141403

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.0479 0.0984
Schistosoma mansoni acetylcholine receptor subunit beta 0.019 0.0193 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0582 0.0717 0.1485
Loa Loa (eye worm) TK/INSR protein kinase 0.0061 0.0019 0.0029
Schistosoma mansoni adapter molecule crk 0.0059 0.0017 0.0017
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0304 0.0345 0.0345
Brugia malayi Trypsin-like protease protein 5 0.0219 0.0231 0.0468
Echinococcus granulosus integrin alpha ps 0.0272 0.0301 0.0285
Echinococcus granulosus allatostatin A receptor 0.0304 0.0345 0.0328
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Echinococcus multilocularis neuropeptide receptor 0.0457 0.055 0.055
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni jumonji domain containing protein 0.0076 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0404 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0304 0.0345 0.0465
Onchocerca volvulus 0.019 0.0193 0.102
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.004 0.0074
Brugia malayi SEA domain containing protein 0.0205 0.0212 0.0428
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Echinococcus granulosus tyrosine protein kinase Fyn 0.0306 0.0347 0.033
Brugia malayi CUB domain containing protein 0.007 0.0032 0.0052
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0125 0.0105 0.0088
Onchocerca volvulus 0.0304 0.0345 0.1977
Schistosoma mansoni hypothetical protein 0.013 0.0112 0.0146
Echinococcus granulosus glycine receptor subunit beta 0.0404 0.0479 0.0462
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Brugia malayi Serotonin receptor 0.0304 0.0345 0.0705
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0219 0.0231 0.0468
Echinococcus multilocularis epidermal growth factor receptor 0.0163 0.0156 0.0156
Brugia malayi GnHR receptor homolog 0.0304 0.0345 0.0705
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Echinococcus granulosus neuropeptide Y receptor 0.0304 0.0345 0.0328
Echinococcus granulosus neuropeptide receptor 0.0304 0.0345 0.0328
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0304 0.0345 0.0345
Echinococcus multilocularis glycoprotein Antigen 5 0.0219 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni nAChR subunit 0.019 0.0193 0.0257
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Toxoplasma gondii hypothetical protein 0.0217 0.0228 0.0433
Echinococcus granulosus hypothetical protein 0.0304 0.0345 0.0328
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Onchocerca volvulus 0.0304 0.0345 0.1977
Brugia malayi follicle stimulating hormone receptor 0.0582 0.0717 0.1481
Toxoplasma gondii PAN/Apple domain-containing protein 0.0217 0.0228 0.0433
Schistosoma mansoni opsin-like receptor 0.0304 0.0345 0.0465
Giardia lamblia Neurogenic locus notch-like protein 0.0123 0.0103 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1328 0.1716 0.2339
Echinococcus granulosus tar DNA binding protein 0.0076 0.004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) calcium channel 0.0125 0.0105 0.0209
Schistosoma mansoni tar DNA-binding protein 0.0076 0.004 0.0048
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Mycobacterium ulcerans hypothetical protein 0.0219 0.0231 1
Echinococcus multilocularis glycine receptor subunit beta 0.0404 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0065 0.0024 0.0007
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0304 0.0345 0.1977
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0209 0.0218 0.0444
Schistosoma mansoni amine GPCR 0.0304 0.0345 0.0465
Onchocerca volvulus 0.0217 0.0228 0.124
Giardia lamblia High cysteine protein 0.0123 0.0103 0.5
Echinococcus granulosus orexin receptor type 2 0.0304 0.0345 0.0328
Loa Loa (eye worm) hypothetical protein 0.006 0.0018 0.0026
Echinococcus granulosus Mastin 0.0219 0.0231 0.0214
Loa Loa (eye worm) neuropeptide F receptor 0.0304 0.0345 0.0709
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0125 0.0105 0.0105
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.0123 0.0103 0.0204
Echinococcus granulosus sex peptide receptor 0.0304 0.0345 0.0328
Onchocerca volvulus 0.0404 0.0479 0.2817
Brugia malayi Furin-like cysteine rich region family protein 0.0163 0.0156 0.031
Loa Loa (eye worm) hypothetical protein 0.0217 0.0228 0.0465
Onchocerca volvulus 0.0217 0.0228 0.124
Loa Loa (eye worm) hypothetical protein 0.0219 0.0231 0.0472
Echinococcus granulosus rhodopsin orphan GPCR 0.0304 0.0345 0.0328
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0214 0.0224 0.0452
Echinococcus multilocularis neuropeptide FF receptor 2 0.0304 0.0345 0.0345
Schistosoma mansoni neurotransmitter gated ion channel 0.0214 0.0224 0.0299
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.019 0.0193 0.0387
Onchocerca volvulus 0.0205 0.0212 0.1142
Echinococcus granulosus dro:myosuppressin receptor 0.0304 0.0345 0.0328
Loa Loa (eye worm) hypothetical protein 0.0984 0.1255 0.2607
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0304 0.0345 0.0345
Schistosoma mansoni opsin-like receptor 0.0304 0.0345 0.0465
Echinococcus multilocularis serotonin receptor 0.0304 0.0345 0.0345
Onchocerca volvulus 0.0304 0.0345 0.1977
Echinococcus granulosus tyrosine protein kinase HCK 0.0246 0.0268 0.0251
Toxoplasma gondii PAN domain-containing protein 0.0217 0.0228 0.0433
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Brugia malayi Trypsin family protein 0.1258 0.1622 0.3369
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Schistosoma mansoni integrin alpha 0.0272 0.0301 0.0405
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Schistosoma mansoni neurotransmitter gated ion channel 0.019 0.0193 0.0257
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0123 0.0103 0.5
Schistosoma mansoni voltage-gated potassium channel 0.054 0.0661 0.0896
Echinococcus granulosus adam 0.0123 0.0103 0.0086
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0304 0.0345 0.0705
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.7514 1 1
Loa Loa (eye worm) PAN domain-containing protein 0.0217 0.0228 0.0465
Giardia lamblia Tenascin-X 0.0123 0.0103 0.5
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0252 0.0276 0.037
Echinococcus granulosus fibrillin 1 0.0123 0.0103 0.0086
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0019 0.0029
Brugia malayi sulfakinin receptor protein 0.0304 0.0345 0.0705
Onchocerca volvulus Neuropeptide F receptor homolog 0.0304 0.0345 0.1977
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0404 0.0479 0.0984
Loa Loa (eye worm) hypothetical protein 0.013 0.0112 0.0224
Toxoplasma gondii microneme protein, putative 0.0217 0.0228 0.0433
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Echinococcus granulosus rhodopsin orphan GPCR 0.0304 0.0345 0.0328
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Brugia malayi Sex muscle abnormal protein 5 0.0059 0.0017 0.0021
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0125 0.0105 0.0105
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0306 0.0347 0.033
Brugia malayi larval opioid receptor 0.0304 0.0345 0.0705
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0219 0.0231 0.0214
Brugia malayi Protein kinase domain containing protein 0.0061 0.0019 0.0024
Brugia malayi Trypsin family protein 0.0219 0.0231 0.0468
Brugia malayi hypothetical protein 0.019 0.0193 0.0387
Onchocerca volvulus 0.0304 0.0345 0.1977
Brugia malayi hypothetical protein 0.019 0.0193 0.0387
Echinococcus multilocularis g protein coupled receptor 0.0304 0.0345 0.0345
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0304 0.0345 0.0328
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0214 0.0224 0.0299
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0306 0.0347 0.0347
Echinococcus granulosus g protein coupled receptor 0.0304 0.0345 0.0328
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0125 0.0105 0.0105
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0306 0.0347 0.0347
Echinococcus granulosus neuropeptides capa receptor 0.0304 0.0345 0.0328
Echinococcus granulosus glycoprotein Antigen 5 0.0219 0.0231 0.0214
Echinococcus multilocularis g protein coupled receptor 0.0304 0.0345 0.0345
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Schistosoma mansoni neuropeptide receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Echinococcus granulosus kelch ECH associated protein 1 like 0.0096 0.0066 0.0049
Echinococcus multilocularis integrin beta 2 0.2833 0.3731 0.3731
Loa Loa (eye worm) trypsin family protein 0.0219 0.0231 0.0472
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0404 0.0479 0.0984
Echinococcus granulosus glycine receptor subunit alpha 1 0.0404 0.0479 0.0462
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Onchocerca volvulus 0.0304 0.0345 0.1977
Toxoplasma gondii PAN domain-containing protein 0.0217 0.0228 0.0433
Onchocerca volvulus 0.0984 0.1255 0.7695
Schistosoma mansoni hypothetical protein 0.0337 0.0389 0.0525
Onchocerca volvulus 0.0123 0.0103 0.0454
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.019 0.0193 0.0392
Onchocerca volvulus 0.0304 0.0345 0.1977
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0219 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0052 0.0007 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0219 0.0231 0.0309
Echinococcus multilocularis voltage dependent calcium channel 0.0125 0.0105 0.0105
Echinococcus granulosus nAChR subunit 0.0404 0.0479 0.0462
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Onchocerca volvulus 0.0217 0.0228 0.124
Brugia malayi Integrin beta pat-3 precursor 0.3632 0.4801 1
Schistosoma mansoni integrin alpha-ps 0.0272 0.0301 0.0405
Echinococcus granulosus tm gpcr rhodopsin 0.0304 0.0345 0.0328
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0214 0.0224 0.0452
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Onchocerca volvulus 0.0219 0.0231 0.1262
Loa Loa (eye worm) hypothetical protein 0.007 0.0032 0.0057
Schistosoma mansoni growth factor receptor-bound protein 0.0059 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0141 0.0127 0.0255
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Echinococcus multilocularis sex peptide receptor 0.0304 0.0345 0.0345
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0304 0.0345 0.0465
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0304 0.0345 0.0465
Brugia malayi Receptor family ligand binding region containing protein 0.0138 0.0122 0.024
Echinococcus granulosus serotonin receptor 0.0304 0.0345 0.0328
Echinococcus granulosus receptor type guanylyl cyclase 0.0138 0.0122 0.0105
Echinococcus granulosus tm gpcr rhodopsin 0.0304 0.0345 0.0328
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0304 0.0345 0.0328
Brugia malayi G-protein coupled receptor 0.0304 0.0345 0.0705
Onchocerca volvulus 0.0304 0.0345 0.1977
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Schistosoma mansoni hypothetical protein 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0306 0.0347 0.0347
Echinococcus granulosus alpha 1A adrenergic receptor 0.0304 0.0345 0.0328
Toxoplasma gondii PAN domain-containing protein 0.2281 0.2992 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0304 0.0345 0.0705
Loa Loa (eye worm) hypothetical protein 0.0217 0.0228 0.0465
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0035 0.0018
Echinococcus multilocularis adam 0.0123 0.0103 0.0103
Brugia malayi Variant SH3 domain containing protein 0.0059 0.0017 0.0021
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Giardia lamblia Neurogenic locus Notch protein precursor 0.0123 0.0103 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.0231 0.0472
Brugia malayi Trypsin family protein 0.0219 0.0231 0.0468
Schistosoma mansoni tyrosine kinase 0.008 0.0045 0.0054
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0404 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Onchocerca volvulus 0.0304 0.0345 0.1977
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0066 0.0049
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0304 0.0345 0.0465
Brugia malayi Dopamine receptor 0.0304 0.0345 0.0705
Plasmodium falciparum cysteine repeat modular protein 1 0.0337 0.0389 0.5
Loa Loa (eye worm) hypothetical protein 0.1258 0.1622 0.3372
Brugia malayi hypothetical protein 0.019 0.0193 0.0387
Schistosoma mansoni nAChR subunit 0.0404 0.0479 0.0648
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Loa Loa (eye worm) ACC-1 protein 0.0404 0.0479 0.0988
Brugia malayi Protein kinase domain containing protein 0.035 0.0407 0.0834
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0115 0.0091 0.0091
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Echinococcus multilocularis Kelch repeat type 1 0.0096 0.0067 0.0067
Onchocerca volvulus 0.0205 0.0212 0.1142
Brugia malayi RE15519p 0.0304 0.0345 0.0705
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0404 0.0479 0.0479
Loa Loa (eye worm) GABA receptor subunit 0.0214 0.0224 0.0456
Schistosoma mansoni voltage-gated potassium channel 0.054 0.0661 0.0896
Trichomonas vaginalis hypothetical protein 0.0123 0.0103 0.5
Loa Loa (eye worm) PAN domain-containing protein 0.0217 0.0228 0.0465
Schistosoma mansoni opsin-like receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni biogenic amine receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.0219 0.0231 0.0472
Loa Loa (eye worm) RGC/RGC protein kinase 0.0138 0.0122 0.0245
Toxoplasma gondii microneme protein MIC17C 0.0217 0.0228 0.0433
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0404 0.0479 0.0984
Brugia malayi Melatonin receptor type 1A 0.0304 0.0345 0.0705
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Loa Loa (eye worm) hypothetical protein 0.1258 0.1622 0.3372
Loa Loa (eye worm) hypothetical protein 0.0217 0.0228 0.0465
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0219 0.0231 0.0309
Echinococcus granulosus transmembrane protease serine 3 0.0219 0.0231 0.0214
Loa Loa (eye worm) hypothetical protein 0.0219 0.0231 0.0472
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni histamine h1 receptor 0.0304 0.0345 0.0465
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Onchocerca volvulus 0.0219 0.0231 0.1262
Onchocerca volvulus 0.0304 0.0345 0.1977
Brugia malayi TAR-binding protein 0.0076 0.004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0059 0.0017 0.0026
Schistosoma mansoni growth hormone secretagogue receptor 0.0304 0.0345 0.0465
Onchocerca volvulus 0.0304 0.0345 0.1977
Loa Loa (eye worm) TYRA-2 protein 0.0304 0.0345 0.0709
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0304 0.0345 0.0345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Onchocerca volvulus 0.0205 0.0212 0.1142
Brugia malayi jmjC domain containing protein 0.0096 0.0066 0.0123
Echinococcus multilocularis fmrfamide receptor 0.0304 0.0345 0.0345
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0138 0.0122 0.0577
Loa Loa (eye worm) TK protein kinase 0.0276 0.0308 0.0632
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0125 0.0105 0.0136
Brugia malayi Kelch motif family protein 0.0614 0.076 0.1571
Loa Loa (eye worm) PAN domain-containing protein 0.0217 0.0228 0.0465
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1258 0.1622 0.2211
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni myosin xvIII 0.0304 0.0345 0.0465
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0304 0.0345 0.0328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0404 0.0479 0.0462
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0404 0.0479 0.0479
Echinococcus multilocularis kelch ECH associated protein 1 0.0096 0.0066 0.0066
Echinococcus multilocularis epidermal growth factor receptor 0.0093 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus tyrosine kinase 0.0276 0.0308 0.0291
Loa Loa (eye worm) hypothetical protein 0.0219 0.0231 0.0472
Echinococcus granulosus biogenic amine 5HT receptor 0.0304 0.0345 0.0328
Onchocerca volvulus 0.0304 0.0345 0.1977
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0404 0.0479 0.0988
Schistosoma mansoni amine GPCR 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.054 0.0661 0.1368
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0304 0.0345 0.0345
Brugia malayi Cation transporter family protein 0.0404 0.0479 0.0984
Echinococcus granulosus peptide allatostatin:somatostatin 0.0304 0.0345 0.0328
Loa Loa (eye worm) G-protein coupled receptor 0.0304 0.0345 0.0709
Echinococcus granulosus potassium voltage gated channel protein 0.054 0.0661 0.0645
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Toxoplasma gondii microneme protein MIC4 0.0217 0.0228 0.0433
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.0019 0.0002
Onchocerca volvulus 0.0404 0.0479 0.2817
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0059 0.0017 0.0026
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0214 0.0224 0.0452
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0304 0.0345 0.0345
Brugia malayi G-protein coupled receptor 0.0304 0.0345 0.0705
Loa Loa (eye worm) hypothetical protein 0.0217 0.0228 0.0465
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0125 0.0105 0.0136
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0404 0.0479 0.0462
Schistosoma mansoni neuropeptide receptor 0.0304 0.0345 0.0465
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0306 0.0347 0.0347
Echinococcus granulosus kelch ECH associated protein 1 like 0.0096 0.0066 0.0049
Brugia malayi Cation transporter family protein 0.0404 0.0479 0.0984
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0304 0.0345 0.0345
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0304 0.0345 0.0328
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0219 0.0231 0.0309
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus atrial natriuretic peptide receptor 0.0115 0.0091 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0304 0.0345 0.0705
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0304 0.0345 0.0705
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0404 0.0479 0.0988
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Schistosoma mansoni acetylcholine receptor-related 0.019 0.0193 0.0257
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0404 0.0479 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Loa Loa (eye worm) integrin beta-2 0.3632 0.4801 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.0479 0.0984
Brugia malayi hypothetical protein 0.019 0.0193 0.0387
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Echinococcus granulosus glycine receptor subunit beta 0.0404 0.0479 0.0462
Loa Loa (eye worm) hypothetical protein 0.0217 0.0228 0.0465
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus multilocularis g-protein coupled receptor 0.0304 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni hypothetical protein 0.0219 0.0231 0.0309
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0304 0.0345 0.0465
Schistosoma mansoni amine GPCR 0.0304 0.0345 0.0465
Echinococcus granulosus rhodopsin orphan GPCR 0.0304 0.0345 0.0328
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.0479 0.0984
Schistosoma mansoni tar DNA-binding protein 0.0076 0.004 0.0048
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus 7tm_1 domain containing protein 0.0304 0.0345 0.0328
Onchocerca volvulus 0.0304 0.0345 0.1977
Giardia lamblia Tenascin precursor 0.0123 0.0103 0.5
Brugia malayi neuropeptide F receptor 0.0304 0.0345 0.0705
Echinococcus multilocularis serotonin receptor 0.0304 0.0345 0.0345
Giardia lamblia High cysteine protein 0.0123 0.0103 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.0479 0.0984
Schistosoma mansoni tar DNA-binding protein 0.0076 0.004 0.0048
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0059 0.0017 0.0026
Echinococcus granulosus tyrosine protein kinase Src42A 0.0306 0.0347 0.033
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0217 0.0228 0.0433
Loa Loa (eye worm) TK/EGFR protein kinase 0.0163 0.0156 0.0315
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0306 0.0347 0.0347
Schistosoma mansoni tar DNA-binding protein 0.0076 0.004 0.0048
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0304 0.0345 0.0465
Loa Loa (eye worm) neuropeptide F receptor 0.0304 0.0345 0.0709
Schistosoma mansoni integrin alpha-4 0.1162 0.1493 0.2034
Onchocerca volvulus 0.0217 0.0228 0.124
Toxoplasma gondii PAN domain-containing protein 0.0217 0.0228 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0337 0.0389 1
Onchocerca volvulus 0.0304 0.0345 0.1977
Echinococcus granulosus enteropeptidase 0.0219 0.0231 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.0304 0.0345 0.0328
Echinococcus granulosus tyrosine protein kinase Src64B 0.0306 0.0347 0.033
Echinococcus multilocularis neuropeptide receptor A26 0.0304 0.0345 0.0345
Onchocerca volvulus 0.0984 0.1255 0.7695
Loa Loa (eye worm) hypothetical protein 0.0793 0.1 0.2075
Brugia malayi excitatory GABA receptor EXP-1A 0.0404 0.0479 0.0984
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0517 0.0629 0.0629
Echinococcus granulosus c src tyrosine kinase 0.0073 0.0035 0.0018
Echinococcus granulosus fibrillin 2 0.0123 0.0103 0.0086
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0404 0.0479 0.0462
Echinococcus multilocularis tyrosine protein kinase Abl 0.0073 0.0035 0.0035
Brugia malayi Kringle domain containing protein 0.0337 0.0389 0.0796
Brugia malayi putative neuropeptide receptor 0.0304 0.0345 0.0705
Brugia malayi G protein-coupled receptor 0.0304 0.0345 0.0705
Brugia malayi Integrin alpha cytoplasmic region family protein 0.013 0.0112 0.0219
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0404 0.0479 0.0648
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Schistosoma mansoni neurotransmitter gated ion channel 0.019 0.0193 0.0257
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0404 0.0479 0.0984
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0404 0.0479 0.0479
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0404 0.0479 0.0988
Loa Loa (eye worm) hypothetical protein 0.0984 0.1255 0.2607
Echinococcus granulosus rhodopsin orphan GPCR 0.0304 0.0345 0.0328
Loa Loa (eye worm) hypothetical protein 0.0123 0.0103 0.0204
Schistosoma mansoni nAChR subunit 0.019 0.0193 0.0257
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0219 0.0231 0.0309
Schistosoma mansoni neuropeptide f receptor 76f 0.0304 0.0345 0.0465
Brugia malayi Guanylyl cyclase protein 23 0.0069 0.003 0.0049
Echinococcus multilocularis allatostatin A receptor 0.0304 0.0345 0.0345
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0263 0.029 0.029
Schistosoma mansoni neuropeptide F-like receptor 0.0304 0.0345 0.0465
Schistosoma mansoni protein kinase 0.0138 0.0122 0.016
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0214 0.0224 0.0452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Echinococcus multilocularis receptor type guanylyl cyclase 0.0138 0.0122 0.0122
Onchocerca volvulus 0.019 0.0193 0.102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.019 0.0193 0.0387
Schistosoma mansoni neuropeptide F-like receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Echinococcus granulosus g protein coupled receptor 0.0304 0.0345 0.0328
Schistosoma mansoni nAChR subunit 0.0404 0.0479 0.0648
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Onchocerca volvulus 0.0219 0.0231 0.1262
Schistosoma mansoni tyrosine kinase 0.008 0.0045 0.0054
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0304 0.0345 0.0328
Echinococcus multilocularis Mastin 0.0219 0.0231 0.0231
Echinococcus multilocularis tyrosine protein kinase HCK 0.0246 0.0268 0.0268
Onchocerca volvulus 0.0209 0.0218 0.1178
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Brugia malayi EGF-like domain containing protein 0.0123 0.0103 0.0199
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0035 0.0041
Brugia malayi SRC-1 0.0306 0.0347 0.0709
Onchocerca volvulus 0.0214 0.0224 0.1215
Loa Loa (eye worm) RNA binding protein 0.0076 0.004 0.0074
Onchocerca volvulus 0.0984 0.1255 0.7695
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0306 0.0347 0.0347
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.019 0.0193 0.0387
Echinococcus multilocularis neuropeptide receptor 0.0304 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0219 0.0231 0.0309
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Schistosoma mansoni tyrosine kinase 0.0306 0.0347 0.0468
Echinococcus multilocularis tissue type plasminogen activator 0.0337 0.0389 0.0389
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0214 0.0224 0.0299
Echinococcus granulosus neuropeptide FF receptor 2 0.0304 0.0345 0.0328
Schistosoma mansoni tyrosine kinase 0.0073 0.0035 0.0041
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus multilocularis fmrfamide receptor 0.0304 0.0345 0.0345
Brugia malayi hypothetical protein 0.0581 0.0716 0.1478
Echinococcus multilocularis insulin receptor 0.0061 0.0019 0.0019
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0404 0.0479 0.0479
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Echinococcus multilocularis neuropeptide s receptor 0.0304 0.0345 0.0345
Echinococcus granulosus kelch ECH associated protein 1 0.0096 0.0066 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Schistosoma mansoni hypothetical protein 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.0123 0.0103 0.0204
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0084 0.005 0.5
Echinococcus multilocularis NCK adaptor protein 0.0059 0.0017 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0304 0.0345 0.0328
Loa Loa (eye worm) melatonin receptor type 1A 0.0304 0.0345 0.0709
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0219 0.0231 0.0214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0304 0.0345 0.0465
Schistosoma mansoni integrin beta subunit 0.2252 0.2953 0.403
Schistosoma mansoni tyrosine kinase 0.0073 0.0035 0.0041
Echinococcus multilocularis integrin alpha ps 0.013 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Onchocerca volvulus 0.0219 0.0231 0.1262
Onchocerca volvulus Putative nachr subunit 0.0404 0.0479 0.2817
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Schistosoma mansoni tyrosine kinase 0.0093 0.0063 0.0079
Echinococcus granulosus glycine receptor subunit alpha 1 0.0404 0.0479 0.0462
Loa Loa (eye worm) hypothetical protein 0.0217 0.0228 0.0465
Echinococcus multilocularis nAChR subunit 0.0214 0.0224 0.0224
Echinococcus multilocularis g protein coupled receptor 0.0304 0.0345 0.0345
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0404 0.0479 0.0462
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus multilocularis potassium voltage gated channel protein 0.054 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0581 0.0716 0.1482
Brugia malayi Trypsin family protein 0.0219 0.0231 0.0468
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Toxoplasma gondii kringle domain-containing protein 0.0337 0.0389 0.0991
Giardia lamblia hypothetical protein 0.0123 0.0103 0.5
Echinococcus granulosus fmrfamide receptor 0.0304 0.0345 0.0328
Onchocerca volvulus 0.0214 0.0224 0.1215
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0404 0.0479 0.0984
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0404 0.0479 0.0479
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0984 0.1255 0.1709
Toxoplasma gondii hypothetical protein 0.0217 0.0228 0.0433
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0125 0.0105 0.0088
Schistosoma mansoni amine GPCR 0.0304 0.0345 0.0465
Leishmania major hypothetical protein, conserved 0.0337 0.0389 0.5
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0205 0.0212 0.0432
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0404 0.0479 0.0462
Brugia malayi ORL1-like opioid receptor 0.0304 0.0345 0.0705
Giardia lamblia Tenascin-like 0.0123 0.0103 0.5
Onchocerca volvulus 0.0219 0.0231 0.1262
Loa Loa (eye worm) hypothetical protein 0.0141 0.0127 0.0255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.0479 0.0984
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0404 0.0479 0.0648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.019 0.0193 0.0176
Toxoplasma gondii subtilisin SUB12 0.0217 0.0228 0.0433
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus tyrosine protein kinase Blk 0.0276 0.0308 0.0291
Echinococcus granulosus g protein coupled receptor 0.0304 0.0345 0.0328
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0093 0.0063 0.0045
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0073 0.0035 0.0035
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0404 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0404 0.0479 0.0462
Loa Loa (eye worm) hypothetical protein 0.0337 0.0389 0.0801
Toxoplasma gondii PAN domain-containing protein 0.0217 0.0228 0.0433
Onchocerca volvulus 0.019 0.0193 0.102
Brugia malayi Cation transporter family protein 0.0984 0.1255 0.2604
Echinococcus granulosus voltage dependent calcium channel 0.0125 0.0105 0.0088
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.019 0.0193 0.0193
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Onchocerca volvulus 0.0217 0.0228 0.124
Schistosoma mansoni nAChR subunit 0.0404 0.0479 0.0648
Loa Loa (eye worm) RGC/RGC protein kinase 0.0069 0.003 0.0053
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0304 0.0345 0.0709
Onchocerca volvulus 0.0217 0.0228 0.124
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.054 0.0661 0.1363
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) PAN domain-containing protein 0.0217 0.0228 0.0465
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Schistosoma mansoni nck2/grb4 0.0059 0.0017 0.0017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0304 0.0345 0.0465
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0276 0.0308 0.0308
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.019 0.0193 0.0176
Schistosoma mansoni tyrosine kinase 0.0061 0.0019 0.0019
Brugia malayi neuropeptide F receptor 0.0304 0.0345 0.0705
Echinococcus granulosus insulin receptor 0.0061 0.0019 0.0002
Schistosoma mansoni serine-type protease inhibitor 0.5513 0.7321 1
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Echinococcus multilocularis somatostatin receptor 0.0304 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0404 0.0479 0.0984
Echinococcus multilocularis voltage dependent calcium channel 0.0125 0.0105 0.0105
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0059 0.0017 0.0017
Brugia malayi EGF-like domain containing protein 0.0123 0.0103 0.0199
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0304 0.0345 0.0709
Onchocerca volvulus 0.0404 0.0479 0.2817
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.019 0.0193 0.0387
Echinococcus granulosus tyrosine protein kinase Src42A 0.0263 0.029 0.0273
Loa Loa (eye worm) G-protein coupled receptor 0.0304 0.0345 0.0709
Echinococcus granulosus neuropeptide receptor 0.0457 0.055 0.0534
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Schistosoma mansoni nAChR subunit 0.0404 0.0479 0.0648
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0007 0.0005
Echinococcus multilocularis neuropeptide Y receptor 0.0304 0.0345 0.0345
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0306 0.0347 0.0347
Echinococcus multilocularis nAChR subunit 0.0404 0.0479 0.0479
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0337 0.0389 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0304 0.0345 0.0705
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0404 0.0479 0.0988
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Echinococcus granulosus tyrosine protein kinase Lyn 0.0306 0.0347 0.033
Loa Loa (eye worm) hypothetical protein 0.0214 0.0224 0.0456
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0306 0.0347 0.0347
Echinococcus multilocularis neuropeptides capa receptor 0.0304 0.0345 0.0345
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0125 0.0105 0.0105
Echinococcus granulosus neuropeptide s receptor 0.0304 0.0345 0.0328
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0219 0.0231 0.0309
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0404 0.0479 0.0984
Loa Loa (eye worm) integrin alpha pat-2 0.0272 0.0301 0.0618
Echinococcus multilocularis kelch ECH associated protein 1 0.0096 0.0066 0.0066
Echinococcus granulosus g-protein coupled receptor 0.0304 0.0345 0.0328
Schistosoma mansoni tyrosine kinase 0.006 0.0018 0.0017
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.0019 0.0019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0304 0.0345 0.0345
Echinococcus granulosus glycine receptor subunit alpha 1 0.0404 0.0479 0.0462
Brugia malayi solute carrier family 40, member 1 0.0193 0.0196 0.0394
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.019 0.0193 0.0387
Echinococcus granulosus neuropeptide Y receptor 0.0304 0.0345 0.0328
Echinococcus multilocularis c src tyrosine kinase 0.0073 0.0035 0.0035
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0404 0.0479 0.0988
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Echinococcus multilocularis transmembrane protease serine 3 0.0219 0.0231 0.0231
Loa Loa (eye worm) ACC-1 protein 0.0404 0.0479 0.0988
Echinococcus granulosus somatostatin receptor 0.0304 0.0345 0.0328
Schistosoma mansoni amine GPCR 0.0304 0.0345 0.0465
Schistosoma mansoni tyrosine kinase 0.0163 0.0156 0.0206
Schistosoma mansoni tyrosine kinase 0.0306 0.0347 0.0468
Schistosoma mansoni serine-type protease inhibitor 0.5513 0.7321 1
Echinococcus granulosus G protein coupled receptor 139 0.0304 0.0345 0.0328
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) hypothetical protein 0.0193 0.0196 0.0398
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0306 0.0347 0.033
Loa Loa (eye worm) LGC-31 protein 0.0404 0.0479 0.0988
Onchocerca volvulus 0.0217 0.0228 0.124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Echinococcus multilocularis integrin alpha ps 0.0272 0.0301 0.0301
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0304 0.0345 0.0345
Onchocerca volvulus 0.0304 0.0345 0.1977
Echinococcus multilocularis G-protein coupled receptor, putative 0.0304 0.0345 0.0345
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Onchocerca volvulus 0.0304 0.0345 0.1977
Schistosoma mansoni biogenic amine receptor 0.0304 0.0345 0.0465
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0304 0.0345 0.0345
Echinococcus granulosus neuropeptides capa receptor 0.0304 0.0345 0.0328
Echinococcus granulosus epidermal growth factor receptor 0.0093 0.0063 0.0045
Schistosoma mansoni alpha-1 adrenergic receptor 0.0304 0.0345 0.0465
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) DOMON domain-containing protein 0.0205 0.0212 0.0432
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0404 0.0479 0.0479
Brugia malayi G protein-coupled receptor F59B2.13 0.0304 0.0345 0.0705
Toxoplasma gondii microneme protein MIC17A 0.0217 0.0228 0.0433
Onchocerca volvulus 0.1258 0.1622 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus tissue type plasminogen activator 0.0337 0.0389 0.0372
Schistosoma mansoni biogenic amine (5HT) receptor 0.0304 0.0345 0.0465
Echinococcus multilocularis tar DNA binding protein 0.0076 0.004 0.004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0304 0.0345 0.0465
Loa Loa (eye worm) SRC-1 0.0306 0.0347 0.0714
Schistosoma mansoni tyrosine kinase 0.006 0.0018 0.0017
Brugia malayi PAN domain containing protein 0.0217 0.0228 0.046
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0984 0.1255 0.1709
Echinococcus granulosus tachykinin peptides receptor 99D 0.0304 0.0345 0.0328
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392
Brugia malayi Muscle positioning protein 4 0.0209 0.0218 0.044
Brugia malayi EGF-like domain containing protein 0.0123 0.0103 0.0199
Echinococcus multilocularis integrin alpha ps 0.0272 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0304 0.0345 0.0465
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0304 0.0345 0.0328
Schistosoma mansoni cercarial elastase (S01 family) 0.0219 0.0231 0.0309
Echinococcus multilocularis neuropeptides capa receptor 0.0304 0.0345 0.0345
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0404 0.0479 0.0648
Brugia malayi Serotonin receptor 0.0304 0.0345 0.0705
Loa Loa (eye worm) TAR-binding protein 0.0076 0.004 0.0074
Echinococcus granulosus tyrosine protein kinase Fyn 0.0306 0.0347 0.033
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0404 0.0479 0.0988
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.004 0.0069
Onchocerca volvulus 0.0217 0.0228 0.124
Schistosoma mansoni neuropeptide receptor 0.0304 0.0345 0.0465
Schistosoma mansoni hypothetical protein 0.0205 0.0212 0.0283
Toxoplasma gondii PAN domain-containing protein 0.2281 0.2992 1
Brugia malayi hypothetical protein 0.019 0.0193 0.0387
Brugia malayi Integrin alpha pat-2 precursor 0.0272 0.0301 0.0614
Echinococcus multilocularis glycine receptor subunit beta 0.0404 0.0479 0.0479
Brugia malayi Dopamine receptor protein 1 0.0304 0.0345 0.0705
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0276 0.0308 0.0291
Onchocerca volvulus 0.0193 0.0196 0.1039
Echinococcus granulosus integrin alpha ps 0.013 0.0112 0.0095
Onchocerca volvulus 0.1039 0.1328 0.8155
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus multilocularis growth factor receptor bound protein 2 0.0059 0.0017 0.0017
Brugia malayi Dopamine receptor protein 2 0.0304 0.0345 0.0705
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0304 0.0345 0.0345
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0614 0.076 0.1575
Schistosoma mansoni tar DNA-binding protein 0.0076 0.004 0.0048
Schistosoma mansoni neuropeptide receptor 0.0457 0.055 0.0745
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus multilocularis dro:myosuppressin receptor 0.0304 0.0345 0.0345
Entamoeba histolytica protein kinase, putative 0.0246 0.0268 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0404 0.0479 0.0462
Schistosoma mansoni nAChR subunit 0.0404 0.0479 0.0648
Loa Loa (eye worm) hypothetical protein 0.0123 0.0103 0.0204
Echinococcus multilocularis enteropeptidase 0.0219 0.0231 0.0231
Brugia malayi Variant SH3 domain containing protein 0.0059 0.0017 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.0479 0.0984
Echinococcus multilocularis fibrillin 2 0.0123 0.0103 0.0103
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0304 0.0345 0.0465
Brugia malayi Tyrosine-protein kinase abl-1 0.0073 0.0035 0.0058
Echinococcus multilocularis orexin receptor type 2 0.0304 0.0345 0.0345
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0306 0.0347 0.0347
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0404 0.0479 0.0984
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0304 0.0345 0.0709
Echinococcus multilocularis G protein coupled receptor 139 0.0457 0.055 0.055
Toxoplasma gondii microneme protein MIC17B 0.0217 0.0228 0.0433
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0404 0.0479 0.0462
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus multilocularis tyrosine kinase 0.006 0.0018 0.0018
Onchocerca volvulus 0.0205 0.0212 0.1142
Loa Loa (eye worm) hypothetical protein 0.0404 0.0479 0.0988
Schistosoma mansoni tyrosine kinase 0.008 0.0045 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0304 0.0345 0.0328
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.019 0.0193 0.0387
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0304 0.0345 0.0465
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.019 0.0193 0.0193
Echinococcus multilocularis neuropeptide Y receptor 0.0304 0.0345 0.0345
Echinococcus granulosus integrin alpha 3 0.013 0.0112 0.0095
Schistosoma mansoni nAChR subunit 0.0404 0.0479 0.0648
Loa Loa (eye worm) RGC/RGC protein kinase 0.0138 0.0122 0.0245
Brugia malayi EGF-like domain containing protein 0.0123 0.0103 0.0199
Onchocerca volvulus 0.0217 0.0228 0.124
Loa Loa (eye worm) acetylcholine receptor protein 0.019 0.0193 0.0392
Brugia malayi RNA binding protein 0.0076 0.004 0.0069
Schistosoma mansoni hypothetical protein 0.0304 0.0345 0.0465
Echinococcus multilocularis fibrillin 1 0.0123 0.0103 0.0103
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0304 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0217 0.0228 0.0465
Loa Loa (eye worm) hypothetical protein 0.0125 0.0105 0.0209
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0304 0.0345 0.0345
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0219 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0304 0.0345 0.0709
Echinococcus granulosus 7TM GPCR rhodopsin 0.0304 0.0345 0.0328
Schistosoma mansoni nAChR subunit 0.0404 0.0479 0.0648
Schistosoma mansoni integrin alpha-ps 0.0141 0.0127 0.0167
Schistosoma mansoni biogenic amine receptor 0.0304 0.0345 0.0465
Giardia lamblia Tenascin-37 0.0123 0.0103 0.5
Onchocerca volvulus 0.0304 0.0345 0.1977
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.019 0.0193 0.0193
Echinococcus granulosus potassium voltage gated channel subfamily A 0.054 0.0661 0.0645
Loa Loa (eye worm) PAN domain-containing protein 0.0217 0.0228 0.0465
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0404 0.0479 0.0648
Schistosoma mansoni adenoreceptor 0.0304 0.0345 0.0465
Echinococcus granulosus neuropeptide receptor A26 0.0304 0.0345 0.0328
Echinococcus multilocularis rhodopsin orphan GPCR 0.0304 0.0345 0.0345
Loa Loa (eye worm) TK/ROR protein kinase 0.035 0.0407 0.0838
Echinococcus granulosus epidermal growth factor receptor 0.0163 0.0156 0.0139
Brugia malayi protein-tyrosine kinase 0.0276 0.0308 0.0627
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0304 0.0345 0.0465
Echinococcus multilocularis sodium channel protein 0.0065 0.0024 0.0024
Onchocerca volvulus 0.0217 0.0228 0.124
Brugia malayi hypothetical protein 0.0219 0.0231 0.0468
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0125 0.0105 0.0088
Echinococcus multilocularis tyrosine protein kinase Srms 0.0276 0.0308 0.0308
Echinococcus granulosus nAChR subunit 0.0214 0.0224 0.0207
Schistosoma mansoni tyrosine kinase 0.0093 0.0063 0.0079
Echinococcus multilocularis tyrosine protein kinase Blk 0.0276 0.0308 0.0308
Schistosoma mansoni growth factor receptor-bound protein 0.0059 0.0017 0.0017
Echinococcus granulosus tyrosine protein kinase Fyn 0.0306 0.0347 0.033
Echinococcus granulosus biogenic amine 5HT receptor 0.0304 0.0345 0.0328
Loa Loa (eye worm) hypothetical protein 0.007 0.0032 0.0057
Onchocerca volvulus 0.0304 0.0345 0.1977
Echinococcus multilocularis integrin alpha 3 0.013 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.013 0.0112 0.0224
Onchocerca volvulus 0.0337 0.0389 0.2253
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0404 0.0479 0.0984
Schistosoma mansoni voltage-gated cation channel 0.0125 0.0105 0.0136
Echinococcus granulosus integrin beta 2 0.2833 0.3731 0.372
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0404 0.0479 0.0984
Brugia malayi Tachykinin-like peptides receptor 99D 0.0304 0.0345 0.0705
Schistosoma mansoni hypothetical protein 0.0096 0.0067 0.0084
Brugia malayi AKH receptor 0.0304 0.0345 0.0705
Onchocerca volvulus 0.0217 0.0228 0.124
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0125 0.0105 0.0204
Echinococcus multilocularis protein jagged 2 0.0123 0.0103 0.0103
Loa Loa (eye worm) TK protein kinase 0.0246 0.0268 0.0548
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.019 0.0193 0.0392
Brugia malayi hypothetical protein 0.0304 0.0345 0.0705
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0304 0.0345 0.0705
Schistosoma mansoni tyrosine kinase 0.0061 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.019 0.0193 0.0392

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.