Detailed information for compound 1324915

Basic information

Technical information
  • TDR Targets ID: 1324915
  • Name: [4-(2-fluorophenyl)piperazin-1-yl]-naphthalen -1-ylmethanone
  • MW: 334.387 | Formula: C21H19FN2O
  • H donors: 0 H acceptors: 1 LogP: 4.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1N1CCN(CC1)C(=O)c1cccc2c1cccc2
  • InChi: 1S/C21H19FN2O/c22-19-10-3-4-11-20(19)23-12-14-24(15-13-23)21(25)18-9-5-7-16-6-1-2-8-17(16)18/h1-11H,12-15H2
  • InChiKey: XWJLKZXSZZRPIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-(2-fluorophenyl)piperazin-1-yl]-(1-naphthyl)methanone
  • [4-(2-fluorophenyl)-1-piperazinyl]-(1-naphthyl)methanone
  • [4-(2-fluorophenyl)piperazin-1-yl]-naphthalen-1-yl-methanone
  • T5810342
  • ZINC00496780
  • MLS000075616
  • SMR000014429
  • [4-(2-Fluoro-phenyl)-piperazin-1-yl]-naphthalen-1-yl-methanone
  • BAS 07396911
  • Oprea1_243196

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0833 0.0833
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2042 0.2353
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0833 0.096
Toxoplasma gondii lactate dehydrogenase LDH2 0.0095 0.2733 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.2042 0.2353
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8681 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2042 0.7472
Leishmania major malate dehydrogenase 0.0037 0.0535 0.1959
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0037 0.0535 0.6424
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0095 0.2733 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0506 0.1853
Leishmania major glycosomal malate dehydrogenase 0.0037 0.0535 0.1959
Leishmania major mitochondrial malate dehydrogenase 0.0037 0.0535 0.1959
Brugia malayi Pre-SET motif family protein 0.0036 0.0506 0.0583
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0037 0.0535 0.1959
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2042 0.7472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0506 0.1853
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0037 0.0535 0.0617
Entamoeba histolytica malate dehydrogenase, putative 0.0037 0.0535 0.1959
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0037 0.0535 0.6424
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2042 0.7472
Toxoplasma gondii lactate dehydrogenase LDH1 0.0095 0.2733 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0833 0.3049
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0833 0.3049
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0037 0.0535 0.5
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0037 0.0535 0.1959
Leishmania major cytosolic malate dehydrogenase 0.0037 0.0535 0.1959
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0037 0.0535 0.6424
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0506 0.1853
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0095 0.2733 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0037 0.0535 0.0535
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0037 0.0535 0.0535
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0833 0.3049
Plasmodium falciparum lactate dehydrogenase, putative 0.0037 0.0535 0.1959
Plasmodium vivax lactate dehydrogenase 0.0095 0.2733 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0506 0.1853
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0833 1
Echinococcus multilocularis malate dehydrogenase 0.0037 0.0535 0.1959
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Loa Loa (eye worm) malate dehydrogenase 0.0037 0.0535 0.0617
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0833 0.3049
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2042 0.7472
Toxoplasma gondii malate dehydrogenase MDH 0.0095 0.2733 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0506 0.0583
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0833 1
Brugia malayi Pre-SET motif family protein 0.0251 0.8681 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0506 0.1853
Entamoeba histolytica malate dehydrogenase, putative 0.0095 0.2733 1
Brugia malayi RNA binding protein 0.0076 0.2042 0.2353
Chlamydia trachomatis malate dehydrogenase 0.0037 0.0535 0.5
Trypanosoma brucei cytosolic malate dehydrogenase 0.0037 0.0535 0.6424
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Schistosoma mansoni malate dehydrogenase 0.0037 0.0535 0.1959
Echinococcus granulosus malate dehydrogenase 0.0037 0.0535 0.1959
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0506 0.1853
Schistosoma mansoni L-lactate dehydrogenase 0.0037 0.0535 0.1959
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0506 0.1853
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0045 0.0833 0.096
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0833 0.0833
Schistosoma mansoni malate dehydrogenase 0.0037 0.0535 0.1959
Echinococcus granulosus cytosolic malate dehydrogenase 0.0037 0.0535 0.1959
Echinococcus granulosus lactate dehydrogenase a 0.0095 0.2733 1
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0037 0.0535 0.6424
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0833 0.3049
Plasmodium vivax malate dehydrogenase, putative 0.0095 0.2733 1
Echinococcus multilocularis malate dehydrogenase 0.0037 0.0535 0.1959
Echinococcus granulosus L lactate dehydrogenase 0.0058 0.1336 0.4886
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2042 0.2353
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Plasmodium falciparum L-lactate dehydrogenase 0.0095 0.2733 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0037 0.0535 0.6424
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Echinococcus multilocularis lactate dehydrogenase protein 0.0095 0.2733 1
Mycobacterium ulcerans malate dehydrogenase 0.0037 0.0535 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0037 0.0535 0.0535
Echinococcus multilocularis lactate dehydrogenase a 0.0095 0.2733 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0506 0.1853
Trichomonas vaginalis malate dehydrogenase, putative 0.0037 0.0535 0.0535
Echinococcus multilocularis L lactate dehydrogenase 0.0058 0.1336 0.4886
Giardia lamblia Malate dehydrogenase 0.0037 0.0535 0.6424
Echinococcus granulosus lactate dehydrogenase a 0.0095 0.2733 1
Brugia malayi TAR-binding protein 0.0076 0.2042 0.2353
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0037 0.0535 0.6424
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0833 1
Leishmania major malate dehydrogenase, putative 0.0037 0.0535 0.1959
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2042 0.7472
Trypanosoma cruzi malate dehydrogenase, putative 0.0037 0.0535 0.6424
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0833 0.3049
Brugia malayi lactate dehydrogenase. 0.0095 0.2733 0.3148
Loa Loa (eye worm) hypothetical protein 0.0095 0.2733 0.3148
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0037 0.0535 0.1959
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0833 0.3049
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0037 0.0535 0.0535
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2042 0.7472
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0037 0.0535 0.1959
Trypanosoma cruzi malate dehydrogenase, putative 0.0037 0.0535 0.6424
Plasmodium falciparum malate dehydrogenase 0.0095 0.2733 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0833 0.3049
Schistosoma mansoni malate dehydrogenase 0.0037 0.0535 0.1959
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0833 0.3049
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Loa Loa (eye worm) malate dehydrogenase 0.0037 0.0535 0.0617
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0456 0.1669
Schistosoma mansoni malate dehydrogenase 0.0095 0.2733 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0506 0.1853
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0833 0.0833
Echinococcus granulosus L lactate dehydrogenase B chain 0.0095 0.2733 1
Schistosoma mansoni L-lactate dehydrogenase 0.0095 0.2733 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0833 0.3049
Echinococcus granulosus lactate dehydrogenase protein 0.0095 0.2733 1
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0037 0.0535 0.0617
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2042 0.2353
Echinococcus granulosus tar DNA binding protein 0.0076 0.2042 0.7472
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0833 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Trypanosoma brucei glycosomal malate dehydrogenase 0.0037 0.0535 0.6424
Echinococcus multilocularis lactate dehydrogenase a 0.0095 0.2733 1
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0037 0.0535 1
Echinococcus granulosus malate dehydrogenase 0.0037 0.0535 0.1959
Trypanosoma brucei malate dehydrogenase-related 0.0037 0.0535 0.6424
Leishmania major malate dehydrogenase, putative 0.0095 0.2733 1
Echinococcus multilocularis lactate dehydrogenase a 0.0095 0.2733 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0037 0.0535 0.1959

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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