Detailed information for compound 1329833

Basic information

Technical information
  • TDR Targets ID: 1329833
  • Name: 5-bromo-2-ethoxy-N-(4-morpholin-4-ylphenyl)be nzenesulfonamide
  • MW: 441.339 | Formula: C18H21BrN2O4S
  • H donors: 1 H acceptors: 2 LogP: 3.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1S(=O)(=O)Nc1ccc(cc1)N1CCOCC1)Br
  • InChi: 1S/C18H21BrN2O4S/c1-2-25-17-8-3-14(19)13-18(17)26(22,23)20-15-4-6-16(7-5-15)21-9-11-24-12-10-21/h3-8,13,20H,2,9-12H2,1H3
  • InChiKey: TVXYCQORYFOQOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-bromo-2-ethoxy-N-(4-morpholinophenyl)benzenesulfonamide
  • T0515-6058
  • ZINC03302940
  • MLS000571117
  • SMR000150700

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0291 0.4632 0.8784
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0934 0.0909
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0005
Loa Loa (eye worm) hypothetical protein 0.0104 0.1583 0.1559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.218 0.2158
Loa Loa (eye worm) hypothetical protein 0.062 1 1
Echinococcus multilocularis protein patched 0.03 0.4778 0.4764
Echinococcus granulosus tar DNA binding protein 0.0064 0.0934 0.0909
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3999 0.3982
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0929 0.0903
Brugia malayi Pre-SET motif family protein 0.0252 0.3999 0.3982
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.062 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.218 0.2158
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0487 0.046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0958 0.0933
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.062 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0487 0.046
Onchocerca volvulus 0.0033 0.0419 0.0088
Brugia malayi CXXC zinc finger family protein 0.003 0.0382 0.0355
Loa Loa (eye worm) glutaminase 2 0.033 0.5273 0.526
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.062 1 1
Echinococcus granulosus expressed conserved protein 0.0098 0.148 0.1456
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.062 1 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.062 1 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0063 0.0035
Echinococcus multilocularis musashi 0.0033 0.0419 0.0393
Schistosoma mansoni lamin 0.0033 0.0419 0.0393
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0419 0.0393
Echinococcus granulosus Protein patched homolog 1 0.03 0.4778 0.4764
Schistosoma mansoni hypothetical protein 0.0138 0.2136 0.2114
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0032 0.0005
Schistosoma mansoni hypothetical protein 0.0043 0.0589 0.0563
Echinococcus multilocularis Niemann Pick C1 protein 0.0404 0.6473 0.6463
Trichomonas vaginalis conserved hypothetical protein 0.03 0.4778 0.9061
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0196 0.5
Schistosoma mansoni glutaminase 0.033 0.5273 0.526
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0934 0.0909
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0032 0.0005
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.03 0.4778 0.4764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.218 0.2158
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0934 0.0909
Schistosoma mansoni cpg binding protein 0.003 0.0382 0.0355
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0035
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.062 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.1583 1
Schistosoma mansoni patched 1 0.03 0.4778 0.4764
Brugia malayi CHE-14 protein 0.03 0.4778 0.4764
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.218 0.2158
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0196 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.3177 0.3158
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0929 0.0903
Loa Loa (eye worm) hypothetical protein 0.0064 0.0929 0.0903
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.218 0.2158
Echinococcus multilocularis protein dispatched 1 0.0306 0.4881 0.4867
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0107
Loa Loa (eye worm) hypothetical protein 0.03 0.4778 0.4764
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0929 0.0903
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.218 0.2158
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0934 0.0909
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0419 0.0393
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.1583 0.1559
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0929 0.0903
Echinococcus multilocularis expressed conserved protein 0.0098 0.148 0.1456
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.062 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0196 0.0169
Echinococcus granulosus cpg binding protein 0.0032 0.041 0.0384
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0196 0.0372
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0035
Echinococcus granulosus lamin 0.0033 0.0419 0.0393
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0487 0.046
Onchocerca volvulus 0.0287 0.4565 1
Echinococcus multilocularis lamin dm0 0.0033 0.0419 0.0393
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0032 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0934 0.0909
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0929 0.0903
Loa Loa (eye worm) hypothetical protein 0.0032 0.041 0.0383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.218 0.2158
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0934 0.0909
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0487 0.046
Echinococcus multilocularis lamin 0.0033 0.0419 0.0393
Brugia malayi RNA binding protein 0.0064 0.0934 0.0909
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0291 0.4632 0.8784
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0419 0.0393
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0196 0.5
Echinococcus multilocularis cpg binding protein 0.0032 0.041 0.0384
Brugia malayi TAR-binding protein 0.0064 0.0934 0.0909
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0934 0.0909
Plasmodium vivax SET domain protein, putative 0.0037 0.0487 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0196 0.0169
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0846 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.3177 0.3158
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0005
Loa Loa (eye worm) hypothetical protein 0.0138 0.2136 0.2114
Onchocerca volvulus 0.0033 0.0419 0.0088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0196 0.0169
Loa Loa (eye worm) glutaminase 0.033 0.5273 0.526
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0291 0.4632 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0487 0.046
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0173 0.0145
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.194 0.1917
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0934 0.0909
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0196 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0487 0.046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0144 0.0117
Trichomonas vaginalis set domain proteins, putative 0.0287 0.4565 0.8657
Schistosoma mansoni hypothetical protein 0.0064 0.0929 0.0903
Echinococcus granulosus GPCR family 2 0.0064 0.0929 0.0903
Brugia malayi MH2 domain containing protein 0.0126 0.194 0.1917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.218 0.2158
Onchocerca volvulus 0.0037 0.0487 0.025
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.062 1 1
Mycobacterium ulcerans glutaminase 0.033 0.5273 0.5179
Brugia malayi Pre-SET motif family protein 0.0037 0.0487 0.046
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.2136 0.2114
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0196 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0779 0.0753
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0144 0.0117
Echinococcus multilocularis GPCR, family 2 0.0064 0.0929 0.0903
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0487 0.4473
Loa Loa (eye worm) hypothetical protein 0.0202 0.3177 0.3158
Loa Loa (eye worm) RNA binding protein 0.0064 0.0934 0.0909
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0196 0.0372
Schistosoma mansoni intermediate filament proteins 0.0033 0.0419 0.0393
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0454 0.0428
Schistosoma mansoni ap endonuclease 0.0019 0.0196 0.0169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.3177 0.3158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0107
Echinococcus granulosus sterol regulatory element binding protein 0.03 0.4778 0.4764
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0934 0.0909
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0173 0.0145
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.194 0.1917
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0929 0.0903
Schistosoma mansoni lamin 0.0033 0.0419 0.0393
Echinococcus granulosus intermediate filament protein 0.0033 0.0419 0.0393
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0061 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0382 0.0355
Echinococcus granulosus Niemann Pick C1 protein 0.0404 0.6473 0.6463
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0487 0.046
Schistosoma mansoni cpg binding protein 0.0032 0.041 0.0384
Brugia malayi glutaminase DH11.1 0.033 0.5273 0.526
Schistosoma mansoni hypothetical protein 0.0043 0.0589 0.0563
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.218 0.2158
Schistosoma mansoni hypothetical protein 0.0064 0.0929 0.0903
Echinococcus granulosus lamin dm0 0.0033 0.0419 0.0393
Schistosoma mansoni hypothetical protein 0.0064 0.0929 0.0903
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0361 0.5772 0.576
Schistosoma mansoni hypothetical protein 0.0043 0.0589 0.0563
Schistosoma mansoni hypothetical protein 0.0064 0.0929 0.0903
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.1583 0.1559
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0291 0.4632 0.8784
Loa Loa (eye worm) hypothetical protein 0.0033 0.0419 0.0393
Schistosoma mansoni cpg binding protein 0.0032 0.041 0.0384
Loa Loa (eye worm) hypothetical protein 0.0037 0.0487 0.046
Schistosoma mansoni hypothetical protein 0.0043 0.0589 0.0563
Trichomonas vaginalis glutaminase, putative 0.033 0.5273 1
Echinococcus multilocularis sterol regulatory element binding protein 0.03 0.4778 0.4764
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0929 0.0903
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.1583 0.1559
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0144 0.0117
Brugia malayi intermediate filament protein 0.0033 0.0419 0.0393
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0196 0.0169

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.