Detailed information for compound 1343017

Basic information

Technical information
  • TDR Targets ID: 1343017
  • Name: 4-bromo-3-ethoxy-N-(2H-1,2,4-triazol-3-yl)ben zenesulfonamide
  • MW: 347.188 | Formula: C10H11BrN4O3S
  • H donors: 2 H acceptors: 4 LogP: 1.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1Br)S(=O)(=O)Nc1n[nH]cn1
  • InChi: 1S/C10H11BrN4O3S/c1-2-18-9-5-7(3-4-8(9)11)19(16,17)15-10-12-6-13-14-10/h3-6H,2H2,1H3,(H2,12,13,14,15)
  • InChiKey: KXXOLPCRTDYGEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC06700694

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus RUN 0.0098 0.1106 0.1106
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0111 0.1274 0.1274
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0219 0.0219
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0001
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0277 0.3381 0.2414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0289 0.0336
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Toxoplasma gondii hypothetical protein 0.0113 0.1302 0.0952
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0224 0.2712 1
Brugia malayi Uncoordinated protein 44 0.0058 0.0601 0.0699
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 0.2242
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0219 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0111 0.1274 0.1274
Echinococcus granulosus Ankyrin 0.0058 0.0601 0.0601
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.4349 0.3523
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0111 0.1274 0.1274
Brugia malayi hypothetical protein 0.0098 0.1106 0.1287
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0277 0.3381 0.7599
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1274 0.2242
Plasmodium falciparum phosphodiesterase delta, putative 0.0111 0.1274 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0111 0.1274 0.1274
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0687 0.8589 0.8589
Echinococcus multilocularis cpg binding protein 0.0037 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0798 1 1
Schistosoma mansoni cpg binding protein 0.0037 0.0329 0.0329
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0798 1 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Schistosoma mansoni netrin receptor unc5 0.0058 0.0601 0.06
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Echinococcus granulosus cpg binding protein 0.0037 0.0329 0.0329
Onchocerca volvulus Peroxidase homolog 0.0028 0.0219 0.0645
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0111 0.1274 0.1274
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2055 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Onchocerca volvulus Netrin receptor homolog 0.0058 0.0601 0.1776
Onchocerca volvulus 0.0028 0.0219 0.0645
Onchocerca volvulus 0.0277 0.3381 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0111 0.1274 0.1483
Echinococcus granulosus geminin 0.035 0.4308 0.4308
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus granulosus peroxidasin 0.0028 0.0219 0.0219
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0111 0.1274 0.1274
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4349 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0033 0.0289 0.0288
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4349 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0219 0.0219
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus multilocularis netrin receptor unc 5 0.0058 0.0601 0.0601
Brugia malayi Blistered cuticle protein 3 0.0028 0.0219 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0111 0.1274 0.1483
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0219 0.0645
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 0.2242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0219 0.0645
Echinococcus granulosus GPCR family 2 0.0033 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0072 0.0783 0.0783
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0111 0.1274 0.2242
Echinococcus granulosus Polycystic kidney disease protein 0.0098 0.1106 0.1106
Loa Loa (eye worm) hypothetical protein 0.0098 0.1106 0.1106
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0289 0.0289
Plasmodium falciparum phosphodiesterase gamma, putative 0.0111 0.1274 1
Schistosoma mansoni polycystin 1-related 0.0098 0.1106 0.1105
Plasmodium falciparum LCCL domain-containing protein 0.0098 0.1106 0.8104
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0035 0.0304 0.0303
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0304 0.0304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0001 0.0001
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0089 0.0989 0.0989
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0183 0.219 0.4553
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0277 0.3381 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0183 0.219 0.6368
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0035 0.0304 0.0897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0001
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0183 0.219 0.4553
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0289 0.0289
Loa Loa (eye worm) doublecortin family protein 0.0098 0.1106 0.1106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi hypothetical protein 0.0028 0.0219 0.0254
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0111 0.1274 0.1274
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0001 0.0001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0224 0.2712 0.5871
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0219 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0111 0.1274 0.1274
Schistosoma mansoni lipoxygenase 0.0585 0.7295 0.7295
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0277 0.3381 0.7558
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0224 0.2712 0.5871
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1302 0.2311
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0277 0.3381 0.7558
Schistosoma mansoni cpg binding protein 0.0037 0.0329 0.0329
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.1274 0.2242
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0001
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0089 0.0989 0.0989
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0152 0.1797 0.356
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0111 0.1274 0.1274
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0111 0.1274 0.1274
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1209 0.1406
Loa Loa (eye worm) hypothetical protein 0.0106 0.1209 0.1209
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0111 0.1274 0.1483
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Echinococcus multilocularis geminin 0.035 0.4308 0.4308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1209 0.1209
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0001
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0111 0.1274 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0224 0.2712 1
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1302 0.2311
Echinococcus granulosus death domain containing protein 0.0058 0.0601 0.0601
Schistosoma mansoni hypothetical protein 0.0033 0.0289 0.0288
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0111 0.1274 0.1274
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0585 0.7295 0.7295
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.035 0.4308 0.4308
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0318 0.0318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0111 0.1274 0.1483
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0089 0.0989 0.0989
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0798 1 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus multilocularis Polycystic kidney disease protein 0.0098 0.1106 0.1106
Onchocerca volvulus 0.0028 0.0219 0.0645
Schistosoma mansoni peroxidasin 0.0028 0.0219 0.0218
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.1274 0.2242
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0277 0.3381 0.7558
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0687 0.8589 0.8589
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2055 0.5572
Echinococcus multilocularis Ankyrin 0.0058 0.0601 0.0601
Onchocerca volvulus Dual oxidase homolog 0.0028 0.0219 0.0645
Echinococcus multilocularis peroxidasin 0.0028 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.035 0.4308 0.4308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0058 0.0601 0.06
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0089 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0033 0.0289 0.0289
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0111 0.1274 0.1274
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Schistosoma mansoni tumor necrosis factor receptor related 0.0089 0.0989 0.0988
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0111 0.1274 0.1274
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0219 0.0254
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0111 0.1274 0.2242
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.4349 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Onchocerca volvulus 0.0028 0.0219 0.0645
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0289 0.0336
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0219 0.0219
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0318 0.0317
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0699 0.0325
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0798 1 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0601 0.0699
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 0.2242
Schistosoma mansoni rab6-interacting 0.0098 0.1106 0.1105
Echinococcus granulosus lipoxygenase domain containing protein 0.0098 0.1106 0.1106
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Schistosoma mansoni ankyrin 23/unc44 0.0058 0.0601 0.06
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0111 0.1274 0.2242
Schistosoma mansoni loxhd1 0.0098 0.1106 0.1105
Onchocerca volvulus 0.0098 0.1106 0.3269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0289 0.0289
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0001 0.0001
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0058 0.0601 0.0601
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0277 0.3381 0.7599
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi Peroxidasin 0.0028 0.0219 0.0254
Echinococcus multilocularis lipoxygenase domain containing protein 0.0098 0.1106 0.1106
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0277 0.3381 0.7558
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0111 0.1274 0.1274
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Echinococcus multilocularis RUN 0.0098 0.1106 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1302 0.2311
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0783 0.0911
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0152 0.1797 0.2091
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2055 0.5572
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0687 0.8589 0.8589
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Plasmodium vivax multidomain scavenger receptor, putative 0.0098 0.1106 0.8104
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0277 0.3381 0.7558
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0111 0.1274 0.1274
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Schistosoma mansoni hypothetical protein 0.0033 0.0289 0.0288
Brugia malayi Death domain containing protein 0.0058 0.0601 0.0699
Echinococcus multilocularis GPCR, family 2 0.0033 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0033 0.0289 0.0288
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0001
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0152 0.1797 0.1797
Brugia malayi hypothetical protein 0.0098 0.1106 0.1287
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0224 0.2712 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0058 0.0601 0.0601
Echinococcus granulosus lipoxygenase domain containing protein 0.0098 0.1106 0.1106
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0289 0.0289
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1209 0.1406
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0289 0.0289
Brugia malayi Doublecortin family protein 0.0098 0.1106 0.1287
Loa Loa (eye worm) PDE1B protein 0.0111 0.1274 0.1274
Schistosoma mansoni rab6-interacting 0.0098 0.1106 0.1105
Brugia malayi CXXC zinc finger family protein 0.0035 0.0304 0.0353
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.1274 0.2242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0111 0.1274 0.1274
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0111 0.1274 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0001 0.0001
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0224 0.2712 1
Onchocerca volvulus Chorion peroxidase homolog 0.0028 0.0219 0.0645
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0224 0.2712 0.2712
Schistosoma mansoni hypothetical protein 0.0098 0.1106 0.1105
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0111 0.1274 0.1274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4349 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1274 0.1274
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0224 0.2712 0.2712
Schistosoma mansoni peroxidasin 0.0028 0.0219 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1274 0.2242
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni lipoxygenase 0.0409 0.5059 0.5059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.1274 0.0924
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0152 0.1797 0.356
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0318 0.0318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0798 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0058 0.0601 0.0601
Echinococcus multilocularis lipoxygenase domain containing protein 0.0098 0.1106 0.1106
Loa Loa (eye worm) hypothetical protein 0.0098 0.1106 0.1106
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0036 0.0318 0.0317
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0585 0.7295 0.7295
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0219 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.2712 0.5871
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0798 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Onchocerca volvulus 0.0098 0.1106 0.3269
Schistosoma mansoni hypothetical protein 0.0072 0.0783 0.0782
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0152 0.1797 0.1796
Loa Loa (eye worm) hypothetical protein 0.0058 0.0601 0.0601
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0224 0.2712 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0111 0.1274 0.1274
Plasmodium vivax phosphodiesterase gamma, putative 0.0111 0.1274 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0152 0.1797 0.2091
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0152 0.1797 0.1797
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0111 0.1274 0.2242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0687 0.8589 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0277 0.3381 0.7558
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0277 0.3381 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0224 0.2712 0.5871
Schistosoma mansoni hypothetical protein 0.0058 0.0601 0.06
Brugia malayi hypothetical protein 0.0036 0.0318 0.0369
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0001 0.0001
Onchocerca volvulus Peroxidase homolog 0.0028 0.0219 0.0645
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0277 0.3381 0.3381
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.2712 0.5871
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0224 0.2712 0.2712
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0219 0.0254
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.0219 0.0219
Brugia malayi Protein kinase domain containing protein 0.0058 0.0601 0.0699
Loa Loa (eye worm) hypothetical protein 0.0798 1 1
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0277 0.3381 0.3936
Loa Loa (eye worm) hypothetical protein 0.0152 0.1797 0.1797
Loa Loa (eye worm) hypothetical protein 0.0041 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0219
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0152 0.1797 0.356
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0058 0.0601 0.0601
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0001 0.0001
Echinococcus granulosus netrin receptor unc 5 0.0058 0.0601 0.0601

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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