TDR Targets

Basic information

Technical information

TDR Targets ID: 1352256
Name: ZINC02629703
MW: 345.376 | Formula: C15H15N5O3S
H donors: 1 H acceptors: 4 LogP: 1.98 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)n1cnnc1SCC(=O)Nc1noc(c1)C
InChi: 1S/C15H15N5O3S/c1-10-7-13(19-23-10)17-14(21)8-24-15-18-16-9-20(15)11-3-5-12(22-2)6-4-11/h3-7,9H,8H2,1-2H3,(H,17,19,21)
InChiKey: MLOPTOSXXJYPKZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000770537
SMR000375852
T5275450

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.0104	0.0066
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.0104	0.0066
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.0104	0.0059
Brugia malayi	Dopamine receptor protein 1	0.0037	0.0104	0.0059
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0104	0.0066
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Brugia malayi	ORL1-like opioid receptor	0.0037	0.0104	0.0059
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.0104	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.0104	0.0119
Trypanosoma cruzi	endonuclease G, putative	0.004	0.0204	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.0104	0.0119
Trypanosoma brucei	endonuclease G, putative	0.004	0.0204	0.5
Echinococcus granulosus	orexin receptor type 2	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0104	0.0066
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.004	0.0204	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.0104	0.0066
Onchocerca volvulus		0.0066	0.1258	0.1212
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0104	0.0066
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.0104	0.0133
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.0104	0.0066
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.0104	0.0119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0104	0.0133
Onchocerca volvulus		0.0037	0.0104	0.0051
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.0104	0.0059
Onchocerca volvulus		0.0037	0.0104	0.0051
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Brugia malayi	Serotonin receptor	0.0037	0.0104	0.0059
Schistosoma mansoni	hypothetical protein	0.0037	0.0104	0.0119
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0104	0.0133
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Schistosoma mansoni	myosin xvIII	0.0037	0.0104	0.0119
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.0104	0.0119
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0104	0.0133
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0066	0.1258	0.2827
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0104	0.0066
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1555
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1613
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0104	0.0059
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0104	0.0119
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.0104	0.0119
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1613
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.0104	0.0059
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.0104	0.0133
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.0104	0.0066
Echinococcus granulosus	fmrfamide receptor	0.0037	0.0104	0.0133
Brugia malayi	Serotonin receptor	0.0037	0.0104	0.0059
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0104	0.0133
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.0104	0.0119
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1555
Onchocerca volvulus		0.0037	0.0104	0.0051
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.0104	0.0066
Onchocerca volvulus		0.0047	0.0491	0.0441
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.0104	0.0066
Schistosoma mansoni	opsin-like receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Onchocerca volvulus		0.0037	0.0104	0.0051
Schistosoma mansoni	hypothetical protein	0.0143	0.4317	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.0104	0.0059
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.0104	0.0119
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.0104	0.0066
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0491	0.0512
Onchocerca volvulus		0.0037	0.0104	0.0051
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Schistosoma mansoni	amine GPCR	0.0037	0.0104	0.0119
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.0104	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1258	0.1407
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0104	0.0133
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0037	0.0104	0.0051
Leishmania major	endonuclease G, putative	0.004	0.0204	0.5
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0104	0.0119
Onchocerca volvulus		0.0037	0.0104	0.0051
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0143	0.4317	0.4978
Brugia malayi	Dopamine receptor protein 2	0.0037	0.0104	0.0059
Onchocerca volvulus		0.0066	0.1258	0.1212
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.0104	0.0066
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.0104	0.0066
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.004	0.0204	1
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	amine GPCR	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1258	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0104	0.0133
Brugia malayi	putative neuropeptide receptor	0.0037	0.0104	0.0059
Schistosoma mansoni	hypothetical protein	0.0037	0.0104	0.0119
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0104	0.0119
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.0104	0.0059
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.0104	0.0066
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0104	0.0133
Schistosoma mansoni	hypothetical protein	0.0037	0.0104	0.0119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.0104	0.0066
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.0104	0.0133
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0104	0.0133
Brugia malayi	G-protein coupled receptor	0.0037	0.0104	0.0059
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0104	0.0119
Schistosoma mansoni	amine GPCR	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0104	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0104	0.0133
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	sex peptide receptor	0.0037	0.0104	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Trypanosoma brucei	endonuclease G, putative	0.004	0.0204	0.5
Schistosoma mansoni	histamine h1 receptor	0.0037	0.0104	0.0119
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0104	0.0133
Brugia malayi	larval opioid receptor	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0104	0.0066
Onchocerca volvulus		0.0037	0.0104	0.0051
Onchocerca volvulus		0.0037	0.0104	0.0051
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0104	0.0119
Brugia malayi	AKH receptor	0.0037	0.0104	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Onchocerca volvulus		0.0037	0.0104	0.0051
Onchocerca volvulus		0.0037	0.0104	0.0051
Onchocerca volvulus		0.0037	0.0104	0.0051
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0104	0.0066
Schistosoma mansoni	adenoreceptor	0.0037	0.0104	0.0119
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0104	0.0119
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Plasmodium vivax	SET domain protein, putative	0.0036	0.0053	0.5
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Brugia malayi	G protein-coupled receptor	0.0037	0.0104	0.0059
Schistosoma mansoni	amine GPCR	0.0037	0.0104	0.0119
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1555
Echinococcus multilocularis	Endonuclease G	0.004	0.0204	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0104	0.0133
Trichomonas vaginalis	set domain proteins, putative	0.0286	1	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.0104	0.0066
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.0104	0.0133
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.0104	0.0059
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0053	0.0068
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1555
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0104	0.0133
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0491	0.1029
Schistosoma mansoni	opsin-like receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	sex peptide receptor	0.0037	0.0104	0.0133
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0104	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0104	0.0119
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0066	0.1258	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0231	0.7802	0.9046
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.0104	0.0059
Brugia malayi	Melatonin receptor type 1A	0.0037	0.0104	0.0059
Brugia malayi	G-protein coupled receptor	0.0037	0.0104	0.0059
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0104	0.0119
Echinococcus granulosus	Endonuclease G	0.004	0.0204	0.0262
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0056	0.0843	0.108
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0104	0.0066
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.0104	0.0133
Brugia malayi	endonuclease G, mitochondrial precursor	0.004	0.0204	0.0177
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.0104	0.0059
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	serotonin receptor	0.0037	0.0104	0.0066
Schistosoma mansoni	opsin-like receptor	0.0037	0.0104	0.0119
Onchocerca volvulus		0.0037	0.0104	0.0051
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0066	0.1258	0.2827
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0104	0.0059
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0056	0.0843	0.102
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Onchocerca volvulus		0.0037	0.0104	0.0051
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.0104	0.0133
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Echinococcus multilocularis	somatostatin receptor	0.0037	0.0104	0.0066
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0104	0.0066
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.0104	0.0119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0104	0.0133
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.0104	0.0066
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Onchocerca volvulus		0.0037	0.0104	0.0051
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	allatostatin A receptor	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Brugia malayi	Dopamine receptor	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.0104	0.0119
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0037	0.0104	0.0051
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.0104	0.0133
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0104	0.0066
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0104	0.0066
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0104	0.0066
Schistosoma mansoni	endonuclease related	0.004	0.0204	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Brugia malayi	RE15519p	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1258	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0104	0.0066
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.0104	0.0059
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1613
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.0104	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0104	0.0133
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.0104	0.0059
Echinococcus granulosus	serotonin receptor	0.0037	0.0104	0.0133
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0104	0.0119
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0104	0.0119
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.0104	0.0133
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0104	0.0133
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0104	0.0119
Onchocerca volvulus		0.0037	0.0104	0.0051
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.0104	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0104	0.0133
Brugia malayi	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Brugia malayi	Pre-SET motif family protein	0.0251	0.8618	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0104	0.0133
Onchocerca volvulus		0.0143	0.4317	0.4286
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0104	0.0133
Brugia malayi	hypothetical protein	0.0231	0.7802	0.9046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0104	0.0066
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.0104	0.0059
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.0104	0.0133
Onchocerca volvulus		0.0037	0.0104	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.0104	0.0133
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0143	0.4317	0.4978
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.0104	0.0133
Echinococcus granulosus	somatostatin receptor	0.0037	0.0104	0.0133
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0104	0.0066
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1613
Echinococcus granulosus	ectonucleotide	0.0056	0.0843	0.108
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.7802	1
Trypanosoma cruzi	endonuclease G, putative	0.004	0.0204	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.0104	0.0059
Brugia malayi	GnHR receptor homolog	0.0037	0.0104	0.0059
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.0104	0.0066
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0066	0.1258	0.2827
Echinococcus multilocularis	ectonucleotide	0.0056	0.0843	0.102
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0066	0.1258	0.2827
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.8618	1
Trypanosoma brucei	endonuclease G, putative	0.004	0.0204	0.5
Brugia malayi	sulfakinin receptor protein	0.0037	0.0104	0.0059
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1613
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.0104	0.0059
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.0104	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0843	0.0922
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.0104	0.0133
Schistosoma mansoni	amine GPCR	0.0037	0.0104	0.0119
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.7802	1
Brugia malayi	neuropeptide F receptor	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus multilocularis	serotonin receptor	0.0037	0.0104	0.0066
Onchocerca volvulus		0.0037	0.0104	0.0051
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0104	0.0059
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.0104	0.0059
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1555
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0104	0.0066
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.004	0.0204	0.5
Echinococcus granulosus	hypothetical protein	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0104	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0104	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0104	0.0119
Schistosoma mansoni	hypothetical protein	0.0047	0.0491	0.1029
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0104	0.0066
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0066	0.1258	0.1555
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.004	0.0204	0.5
Brugia malayi	neuropeptide F receptor	0.0037	0.0104	0.0059

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0053 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.1413 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1461957

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1352256