Detailed information for compound 1354597

Basic information

Technical information
  • TDR Targets ID: 1354597
  • Name: 7-[[2-(2,4-dimethoxybenzoyl)-6,7-dimethoxy-3, 4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-meth ylchromen-2-one
  • MW: 545.58 | Formula: C31H31NO8
  • H donors: 0 H acceptors: 2 LogP: 4.4 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(c(c1)OC)C(=O)N1CCc2c(C1COc1ccc3c(c1)oc(=O)cc3C)cc(c(c2)OC)OC
  • InChi: 1S/C31H31NO8/c1-18-12-30(33)40-27-15-21(7-8-22(18)27)39-17-25-24-16-29(38-5)28(37-4)13-19(24)10-11-32(25)31(34)23-9-6-20(35-2)14-26(23)36-3/h6-9,12-16,25H,10-11,17H2,1-5H3
  • InChiKey: SQTGZFQSPLWESV-UHFFFAOYSA-N  


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Synonyms

  • 7-[[2-(2,4-dimethoxybenzoyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-chromen-2-one
  • 7-[[2-[(2,4-dimethoxyphenyl)-oxomethyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-2-chromenone
  • 7-[[2-(2,4-dimethoxybenzoyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-coumarin
  • 7-[[2-(2,4-dimethoxyphenyl)carbonyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-chromen-2-one
  • C199-0023
  • NCGC00104893-01
  • EU-0089838

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0065 0.0022
Brugia malayi hypothetical protein 0.0036 0.0444 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0065 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0126 0.1579
Entamoeba histolytica hypothetical protein 0.0036 0.0444 0.5565
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.071 0.5622
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0762 1
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0578 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0065 0.0022
Brugia malayi nuclear hormone receptor 0.0015 0.0065 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.071 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0762 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0762 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1164 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0762 0.613
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0065 0.0266
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.071 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0162 0.2051
Schistosoma mansoni hypothetical protein 0.0036 0.0444 0.0402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Plasmodium falciparum flap endonuclease 1 0.0028 0.0292 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0444 0.0402
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.071 0.9301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0126 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0426 0.5555
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.071 0.9301
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0578 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0567 0.7408
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0126 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0567 0.4251
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0065 0.0065
Leishmania major cathepsin L-like protease 0.002 0.0162 0.0343
Brugia malayi ecdysteroid receptor 0.0015 0.0065 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0162 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0036 0.0444 0.5565
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Echinococcus granulosus tumor protein p63 0.0408 0.7005 0.6992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0321 0.4161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0065 0.0065
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0762 0.613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.071 1
Trypanosoma brucei protein kinase, putative 0.0051 0.071 0.5622
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0292 1
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0292 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0162 0.0097
Brugia malayi MAP kinase sur-1 0.0051 0.071 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0322 0.4171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0258 0.1269
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0292 0.4066
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.0118
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0065 0.0022
Onchocerca volvulus 0.002 0.0162 0.1447
Schistosoma mansoni coup transcription factor 0.0015 0.0065 0.0022
Toxoplasma gondii cathepsin CPL 0.002 0.0162 0.2205
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0065 0.0022
Brugia malayi steroid hormone receptor 0.0015 0.0065 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0065 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0444 0.5565
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0162 0.2051
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.071 0.5622
Echinococcus granulosus cathepsin l1 0.002 0.0162 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0065 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0622 0.8147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0762 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0065 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0567 0.7408
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0517 0.6753
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0162 0.0118
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0126 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0371 0.4826
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.0118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0444 0.0381
Leishmania major cathepsin L-like protease 0.0077 0.1164 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0444 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0322 0.4171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0762 0.0762
Loa Loa (eye worm) ctsf protein 0.002 0.0162 0.0162
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0162 0.0118
Schistosoma mansoni flap endonuclease-1 0.0025 0.0246 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0065 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0065 0.0022
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0762 1
Leishmania major cathepsin L-like protease 0.002 0.0162 0.0343
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0762 0.613
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0065 0.0022
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.071 0.0669
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0065 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Schistosoma mansoni hypothetical protein 0.0578 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0567 0.7408
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1641
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1641
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0203 0.0738
Onchocerca volvulus Cathepsin F homolog 0.002 0.0162 0.1447
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0065 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0162 0.0097
Onchocerca volvulus 0.002 0.0162 0.1447
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0065 0.0022
Brugia malayi nuclear receptor NHR-88 0.0015 0.0065 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0126 0.1579
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0292 0.1604
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0065 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0322 0.4171
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1164 1
Onchocerca volvulus 0.002 0.0162 0.1447
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0065 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0065 0.0022
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0126 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0322 0.4171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0065 0.0266
Onchocerca volvulus Cathepsin L homolog 0.002 0.0162 0.1447
Onchocerca volvulus 0.006 0.0859 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0762 0.613
Onchocerca volvulus 0.0015 0.0065 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0447 0.5829
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0065 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0065 0.0065
Leishmania major cathepsin L-like protease 0.002 0.0162 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0517 0.6753
Schistosoma mansoni hypothetical protein 0.0578 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0065 0.0065
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0292 0.3782
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.0118
Giardia lamblia GTOR 0.0054 0.0762 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0065 0.0022
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0162 0.0162
Loa Loa (eye worm) cysteine protease 0.002 0.0162 0.0162
Onchocerca volvulus 0.002 0.0162 0.1447
Leishmania major cathepsin L-like protease 0.0077 0.1164 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0065 0.0022
Echinococcus multilocularis cysteine protease 0.002 0.0162 0.0097
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.071 0.071
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.071 0.5622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0371 0.4826
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.0118
Echinococcus multilocularis cysteine protease 0.002 0.0162 0.0097
Leishmania major cysteine peptidase A (CPA) 0.002 0.0162 0.0343
Leishmania major cathepsin L-like protease 0.002 0.0162 0.0343
Loa Loa (eye worm) hypothetical protein 0.006 0.0859 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0126 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0377 0.4901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0517 0.6753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0762 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0377 0.4901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0567 0.7408
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0065 0.0022
Brugia malayi Flap endonuclease-1 0.0028 0.0292 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0567 0.7408
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0567 0.4251
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.071 0.5622
Leishmania major cathepsin L-like protease 0.0077 0.1164 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0762 0.0702
Onchocerca volvulus 0.002 0.0162 0.1447
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0065 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0162 0.0162
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0517 0.726
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.0118
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0292 0.3462
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0065 0.0022
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.071 0.5622
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0292 0.1604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0126 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0517 0.6753
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0762 0.613
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0517 0.6753
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0065 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0065 0.0022
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0065 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0162 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0321 0.4161
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0126 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0065 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0065 0.0022
Leishmania major cathepsin L-like protease 0.002 0.0162 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0517 0.6753
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0292 0.1604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0065 0.0065
Onchocerca volvulus Cathepsin L homolog 0.002 0.0162 0.1447
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0065 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0065 0.0022
Onchocerca volvulus 0.002 0.0162 0.1447
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1164 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0517 0.6753
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.071 0.5622
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0567 0.4251
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0065 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.049
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0873 0.7198
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1046 0.8864
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0762 0.613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0859 0.0819
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0065 0.0065
Loa Loa (eye worm) fibroinase 0.002 0.0162 0.0162
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.071 0.9301
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.071 0.0669
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Entamoeba histolytica hypothetical protein 0.0036 0.0444 0.5565
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0065 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0162 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0065 0.0022
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0126 0.0126
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.071 0.0669
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0162 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0065 0.0022
Echinococcus multilocularis tumor protein p63 0.0408 0.7005 0.6985
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0065 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0065 0.0022
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0578 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1164 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0162 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.071 0.9301
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0292 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.2051
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0762 0.0722
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.071 0.5622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Echinococcus granulosus flap endonuclease 1 0.0028 0.0292 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0321 0.4161
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0065 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0065 0.0065
Onchocerca volvulus 0.002 0.0162 0.1447
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0162 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0062 0.0729
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.071 0.8877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0377 0.4901
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1164 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0762 0.0722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.2051
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0065 0.0022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0398 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8479 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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