Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 0.1458 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0226 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.0276 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0226 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0189 | 0.1255 | 0.1458 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0273 | 0.1926 | 0.2238 |
Onchocerca volvulus | 0.1112 | 0.8606 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0189 | 0.1255 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.1112 | 0.8606 | 1 |
Brugia malayi | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0189 | 0.1255 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0189 | 0.1255 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 0.1458 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0189 | 0.1255 | 0.0076 |
Loa Loa (eye worm) | serotonin transporter b | 0.1112 | 0.8606 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0189 | 0.1255 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0189 | 0.1255 | 0.0226 |
Giardia lamblia | Kinesin-5 | 0.0167 | 0.1083 | 0.5 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0189 | 0.1255 | 0.0076 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 0.1458 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0189 | 0.1255 | 0.0226 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.1112 | 0.8606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Toxoplasma gondii | hypothetical protein | 0.0189 | 0.1255 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0273 | 0.1926 | 0.2238 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0189 | 0.1255 | 0.0076 |
Echinococcus multilocularis | serotonin transporter | 0.1112 | 0.8606 | 0.8419 |
Loa Loa (eye worm) | hypothetical protein | 0.1112 | 0.8606 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 0.1458 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.0276 | 0.0321 |
Schistosoma mansoni | hypothetical protein | 0.112 | 0.8669 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1112 | 0.8606 | 0.9918 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0189 | 0.1255 | 0.0226 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0189 | 0.1255 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.1112 | 0.8606 | 1 |
Plasmodium falciparum | transporter, putative | 0.0189 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1112 | 0.8606 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Echinococcus granulosus | serotonin transporter | 0.1112 | 0.8606 | 0.8419 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0167 | 0.1083 | 0.1258 |
Plasmodium falciparum | amino acid transporter, putative | 0.0189 | 0.1255 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0031 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0226 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 1 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0076 |
Brugia malayi | Kinesin motor domain containing protein | 0.0167 | 0.1083 | 0.1258 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0189 | 0.1255 | 0.0226 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0189 | 0.1255 | 0.0076 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0189 | 0.1255 | 0.0076 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1255 | 0.1458 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0189 | 0.1255 | 0.0076 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0226 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0076 |
Echinococcus multilocularis | kinesin family 1 | 0.1287 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 0.1458 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0189 | 0.1255 | 0.0076 |
Entamoeba histolytica | kinesin, putative | 0.0167 | 0.1083 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1112 | 0.8606 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0189 | 0.1255 | 0.0076 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0189 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1188 | 0.138 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0226 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1188 | 0.138 |
Plasmodium vivax | hypothetical protein, conserved | 0.0189 | 0.1255 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0189 | 0.1255 | 0.0226 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1112 | 0.8606 | 0.9918 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1188 | 0.138 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1112 | 0.8606 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 1.157 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation in AlphaScreen assay for MBNL1-(CUG)12 binding. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2675, AID2700] | ChEMBL. | No reference |
Potency (binding) | 8.1911 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation from the primary screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2675, AID2700] | ChEMBL. | No reference |
Potency (binding) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6092 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Counterscreen HTRF assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.