Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0071 | 0.0071 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1143 | 0.1143 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0042 | 0.1016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1412 | 0.4014 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0042 | 0.1016 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0042 | 0.1016 | 0.5 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0042 | 0.1016 | 0.5 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0042 | 0.1016 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1143 | 0.2355 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0198 | 0.0198 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0042 | 0.1016 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0042 | 0.1016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1254 | 0.3541 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0042 | 0.1016 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0042 | 0.1016 | 0.1016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0042 | 0.1016 | 0.283 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0042 | 0.1016 | 0.1016 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2677 | 0.2677 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0042 | 0.1016 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0042 | 0.1016 | 0.1016 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1143 | 0.1143 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0042 | 0.1016 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0042 | 0.1016 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1143 | 0.1143 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1143 | 0.1143 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0042 | 0.1016 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1539 | 0.4395 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2916 | 0.2916 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3698 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2677 | 0.2677 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0198 | 0.0198 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0042 | 0.1016 | 0.1016 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1091 | 0.1091 |
Toxoplasma gondii | methionine aminopeptidase | 0.0042 | 0.1016 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0042 | 0.1016 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1143 | 0.1143 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0042 | 0.1016 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0042 | 0.1016 | 0.1016 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0042 | 0.1016 | 0.1976 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0198 | 0.0198 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0042 | 0.1016 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0042 | 0.1016 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0042 | 0.1016 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1143 | 0.3209 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0042 | 0.1016 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1249 | 0.2673 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1091 | 0.1091 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0042 | 0.1016 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0042 | 0.1016 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0042 | 0.1016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3413 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 49.25 um | PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP). Inhibition of the rate of hydrolysis of fluorogenic peptide substrate (H-Leu-NHMec). Secondary screen (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.