TDR Targets

Basic information

Technical information

TDR Targets ID: 1362814
Name: 5-(2-bromophenyl)-2-(4-fluorophenyl)tetrazole
MW: 319.132 | Formula: C13H8BrFN4
H donors: 0 H acceptors: 3 LogP: 4.23 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)n1nnc(n1)c1ccccc1Br
InChi: 1S/C13H8BrFN4/c14-12-4-2-1-3-11(12)13-16-18-19(17-13)10-7-5-9(15)6-8-10/h1-8H
InChiKey: KRKGCDXFKQADCB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(2-bromophenyl)-2-(4-fluorophenyl)-1,2,3,4-tetrazole
5-(2-bromophenyl)-2-(4-fluorophenyl)-2H-tetrazole
MLS001007999
SMR000498535
ZINC04840259

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Schistosoma mansoni	hypothetical protein	0.0016	0.019	0.019
Echinococcus multilocularis	glycogen phosphorylase	0.0109	0.3133	0.3133
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0454	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0287	0.0287
Schistosoma mansoni	nAChR subunit	0.0019	0.0283	0.0283
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0283	0.0902
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0283	0.0283
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.019	0.0606
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0283	0.0902
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0283	0.0283
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0047	0.1167	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0391	0.1248
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0391	0.0357
Schistosoma mansoni	ap endonuclease	0.0023	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Schistosoma mansoni	glycogen phosphorylase	0.0109	0.3133	0.3133
Schistosoma mansoni	glycogen phosphorylase	0.0047	0.1167	0.1167
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0283	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Echinococcus multilocularis	nAChR subunit	0.0019	0.0283	0.0283
Echinococcus granulosus	nAChR subunit	0.0019	0.0283	0.0283
Schistosoma mansoni	hypothetical protein	0.0016	0.019	0.019
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0283	0.0283
Schistosoma mansoni	importin beta-1	0.003	0.0637	0.0637
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0391	0.5
Brugia malayi	Cytochrome P450 family protein	0.0049	0.1224	0.3905
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0283	0.0283
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0391	0.8581
Entamoeba histolytica	glycogenphosphorylase, putative	0.0047	0.1167	0.3725
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0283	0.0283
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.019	0.019
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0283	0.0283
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0283	0.0283
Onchocerca volvulus		0.0019	0.0283	0.0902
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0047	0.1167	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0382	0.0382
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0283	0.0902
Onchocerca volvulus		0.0019	0.0283	0.0902
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0391	0.3305
Onchocerca volvulus		0.0019	0.0283	0.0902
Echinococcus granulosus	importin subunit beta 1	0.003	0.0637	0.0637
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.019	0.019
Loa Loa (eye worm)	cytochrome P450	0.0011	0.0008	0.0008
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0391	0.8581
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0382	0.8377
Loa Loa (eye worm)	LGC-31 protein	0.0019	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.019	0.019
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0019	0.0283	0.0283
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0637	1
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0637	1
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0283	0.0283
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0391	0.0391
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0283	0.0283
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0391	0.0033
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0019	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0283	0.0283
Plasmodium falciparum	importin beta, putative	0.003	0.0637	1
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0109	0.3133	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0283	0.0902
Leishmania major	cytochrome p450-like protein	0.0019	0.0287	0.6251
Echinococcus multilocularis	GPCR, family 2	0.0016	0.019	0.019
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Schistosoma mansoni	ran	0.0022	0.0382	0.0382
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0391	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.019	0.0606
Loa Loa (eye worm)	hypothetical protein	0.003	0.0637	0.0637
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0019	0.0283	0.0902
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.1167	0.3725
Brugia malayi	excitatory GABA receptor EXP-1A	0.0019	0.0283	0.0902
Schistosoma mansoni	nAChR subunit	0.0019	0.0283	0.0283
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0019	0.0283	0.0283
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0283	0.0283
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0283	0.0283
Chlamydia trachomatis	glycogen phosphorylase	0.0109	0.3133	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1313	0.1313
Schistosoma mansoni	hypothetical protein	0.0325	1	1
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0008	0.0026
Echinococcus granulosus	GPCR family 2	0.0016	0.019	0.019
Echinococcus multilocularis	snurportin 1	0.0325	1	1
Schistosoma mansoni	ran	0.0022	0.0382	0.0382
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0283	0.0902
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0382	0.1219
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0283	0.0902
Entamoeba histolytica	glycogen phosphorylase, putative	0.0109	0.3133	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0325	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0019	0.0283	0.0283
Echinococcus multilocularis	glycogen phosphorylase	0.0109	0.3133	0.3133
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0019	0.0283	0.0902
Schistosoma mansoni	nAChR subunit	0.0019	0.0283	0.0283
Plasmodium vivax	importin-beta 2, putative	0.003	0.0637	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0637	0.0637
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0287	0.0916
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.1224	0.1224
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0019	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0637	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0454	0.0263
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0019	0.0283	0.0283
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0287	0.6251
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0283	0.0283
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0109	0.3133	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0283	0.0283
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1313	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0019	0.0283	0.0902
Echinococcus granulosus	cytochrome P450 2K1	0.0011	0.0008	0.0008
Loa Loa (eye worm)	glycogen phosphorylase	0.0109	0.3133	0.3133
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1313	0.4192
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0019	0.0283	0.0902
Schistosoma mansoni	ap endonuclease	0.0023	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0283	0.0902
Echinococcus granulosus	glycogen phosphorylase	0.0109	0.3133	0.3133
Schistosoma mansoni	nAChR subunit	0.0019	0.0283	0.0283
Schistosoma mansoni	hypothetical protein	0.0035	0.0793	0.0793
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0793	0.2532
Mycobacterium leprae	Conserved hypothetical protein	0.0011	0.0008	0.5
Onchocerca volvulus	Putative nachr subunit	0.0019	0.0283	0.0902
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0391	0.8581
Schistosoma mansoni	hypothetical protein	0.0011	0.0008	0.0008
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0382	0.5941
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0382	0.8377
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0283	0.0283
Onchocerca volvulus		0.0019	0.0283	0.0902
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0391	0.0033
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0454	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0019	0.0283	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Brugia malayi	Cation transporter family protein	0.0019	0.0283	0.0902
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0283	0.0283
Schistosoma mansoni	nAChR subunit	0.0019	0.0283	0.0283
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0454	0.0263
Brugia malayi	RNA, U transporter 1	0.0087	0.2422	0.7729
Brugia malayi	cytochrome P450	0.0011	0.0008	0.0026
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0382	0.5941
Schistosoma mansoni	hypothetical protein	0.0016	0.019	0.019
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0019	0.0283	0.0283
Brugia malayi	Cation transporter family protein	0.0019	0.0283	0.0902
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0283	0.0283
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0109	0.3133	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0283	0.0283
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0283	0.0283
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0391	0.6086
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0283	0.0283
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0283	0.0283
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0382	0.0382
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0287	0.0287
Echinococcus multilocularis		0.0011	0.0008	0.0008
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0382	0.0382
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0283	0.0283
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0019	0.0283	0.0283
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0019	0.0283	0.0902
Schistosoma mansoni	glycogen phosphorylase	0.0109	0.3133	0.3133
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0287	0.0287
Echinococcus granulosus	Glycosyl transferase family 35	0.0109	0.3133	0.3133
Schistosoma mansoni	cytochrome P450	0.0011	0.0008	0.0008
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0287	0.4433
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0019	0.0283	0.0283
Brugia malayi	Importin beta-1 subunit	0.003	0.0637	0.2035
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0287	0.0916
Toxoplasma gondii	exonuclease III APE	0.0023	0.0391	0.6086
Loa Loa (eye worm)	hypothetical protein	0.0016	0.019	0.019
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0391	0.5
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0019	0.0283	0.0283
Schistosoma mansoni	hypothetical protein	0.0016	0.019	0.019
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0283	0.0902
Entamoeba histolytica	hypothetical protein	0.0025	0.0454	0.1451
Leishmania major	GTP-binding protein, putative	0.0022	0.0382	0.8377
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0454	0.0263
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0391	0.0391
Mycobacterium leprae	putative cytochrome p450	0.0011	0.0008	0.5
Onchocerca volvulus		0.0019	0.0283	0.0902
Schistosoma mansoni	nAChR subunit	0.0019	0.0283	0.0283
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.1167	0.3725
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.019	0.019
Entamoeba histolytica	glycogen phosphorylase, putative	0.0109	0.3133	1
Entamoeba histolytica	Ran family GTPase	0.0022	0.0382	0.1219
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0019	0.0283	0.0283
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0391	0.3305
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.019	0.019
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0019	0.0283	0.0902
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0391	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0793	0.0793
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1313	0.4192
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0287	0.2408
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0283	0.0283
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0109	0.3133	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0391	0.0391
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0283	0.0283
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0019	0.0283	0.0283
Brugia malayi	Cation transporter family protein	0.0019	0.0283	0.0902
Echinococcus granulosus	glycogen phosphorylase	0.0109	0.3133	0.3133
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0283	0.0283
Brugia malayi	carbohydrate phosphorylase	0.0109	0.3133	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0019	0.0283	0.0283
Giardia lamblia	Glycogen phosphorylase	0.0109	0.3133	1
Onchocerca volvulus		0.0019	0.0283	0.0902
Schistosoma mansoni	nAChR subunit	0.0019	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0283	0.0283
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0287	0.6251
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0391	0.1248

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.3162 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.9728 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1517127

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1362814