Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0678 | 0.1661 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0113 | 0.2815 | 0.2962 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0113 | 0.2815 | 0.2962 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0113 | 0.2815 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0678 | 0.1661 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0177 | 0.5421 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.9504 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0678 | 0.1661 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0086 | 0.1742 | 0.1833 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.029 | 1 | 1 |
Plasmodium vivax | chorismate synthase | 0.0175 | 0.5345 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.029 | 1 | 1 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0113 | 0.2815 | 0.2815 |
Mycobacterium ulcerans | chorismate synthase | 0.0175 | 0.5345 | 0.5345 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0177 | 0.5421 | 0.3627 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4084 | 1 |
Plasmodium falciparum | chorismate synthase | 0.0175 | 0.5345 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | chorismate synthase, putative | 0.0175 | 0.5345 | 0.5345 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0177 | 0.5421 | 0.5421 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0678 | 0.1661 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.029 | 1 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0177 | 0.5421 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.0086 | 0.1742 | 0.1742 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4084 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0113 | 0.2815 | 0.2815 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0 | 0.5 |
Chlamydia trachomatis | chorismate synthase | 0.0175 | 0.5345 | 0.3521 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.