Detailed information for compound 1369047

Basic information

Technical information
  • TDR Targets ID: 1369047
  • Name: (E)-3-[4-[bis(2-hydroxyethyl)sulfamoyl]phenyl ]prop-2-enoic acid
  • MW: 315.342 | Formula: C13H17NO6S
  • H donors: 3 H acceptors: 6 LogP: -0.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(S(=O)(=O)c1ccc(cc1)/C=C/C(=O)O)CCO
  • InChi: 1S/C13H17NO6S/c15-9-7-14(8-10-16)21(19,20)12-4-1-11(2-5-12)3-6-13(17)18/h1-6,15-16H,7-10H2,(H,17,18)/b6-3+
  • InChiKey: PXRHVZSLYVYUQM-ZZXKWVIFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-[bis(2-hydroxyethyl)sulfamoyl]phenyl]prop-2-enoic acid
  • (E)-3-[4-[bis(2-hydroxyethyl)sulfamoyl]phenyl]acrylic acid
  • 3-[4-[bis(2-hydroxyethyl)sulfamoyl]phenyl]acrylic acid
  • MLS000713258
  • SMR000272739
  • 3-{4-[Bis-(2-hydroxy-ethyl)-sulfamoyl]-phenyl}-acrylic acid
  • BAS 01259570
  • T0502-3482

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0013 0.0015
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0323 0.0339 0.1838
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Onchocerca volvulus 0.0323 0.0339 0.0422
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0323 0.0339 0.0334
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0155 0.0151
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0018 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Entamoeba histolytica protein tyrosine phosphatase, putative 0.5075 0.6019 1
Echinococcus multilocularis protein patched 0.0051 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Onchocerca volvulus 0.0323 0.0339 0.0422
Brugia malayi Protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Onchocerca volvulus 0.0323 0.0339 0.0422
Loa Loa (eye worm) hypothetical protein 0.0051 0.0013 0.0013
Onchocerca volvulus 0.0323 0.0339 0.0422
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Brugia malayi CHE-14 protein 0.0051 0.0013 0.0013
Schistosoma mansoni alpha-glucosidase 0.0169 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0049 0.0011 0.0011
Onchocerca volvulus 4.1 G protein, putative homolog 0.0323 0.0339 0.0422
Schistosoma mansoni hypothetical protein 0.0049 0.0011 0.0011
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Schistosoma mansoni alpha-glucosidase 0.0169 0.0155 0.0155
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Trypanosoma cruzi hypothetical protein, conserved 0.1564 0.1823 1
Trypanosoma brucei protein tyrosine phosphatase 1 0.0323 0.0339 0.1838
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0323 0.0339 0.0339
Brugia malayi hypothetical protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Echinococcus granulosus geminin 0.0198 0.0189 0.0185
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Entamoeba histolytica protein tyrosine phosphatase, putative 0.5075 0.6019 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.5075 0.6019 1
Onchocerca volvulus 0.0323 0.0339 0.0422
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0323 0.0339 0.0339
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Onchocerca volvulus 0.0323 0.0339 0.0422
Leishmania major tyrosine specific protein phosphatase, putative 0.0323 0.0339 0.1838
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0094 0.015
Echinococcus multilocularis geminin 0.0198 0.0189 0.0185
Schistosoma mansoni protein tyrosine phosphatase 0.0323 0.0339 0.0339
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0323 0.0339 0.0339
Onchocerca volvulus 0.0323 0.0339 0.0422
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0323 0.0339 0.0339
Echinococcus multilocularis protein dispatched 1 0.0058 0.0022 0.0017
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0097 0.0097
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0013 0.0009
Schistosoma mansoni protein tyrosine phosphatase 0.0323 0.0339 0.0339
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0323 0.0339 0.0339
Onchocerca volvulus 0.0323 0.0339 0.0422
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0323 0.0339 0.0334
Leishmania major hypothetical protein, conserved 0.1564 0.1823 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0155 0.0151
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0323 0.0339 0.0556
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0323 0.0339 0.0339
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0094 0.009
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.8405 1 1
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.5075 0.6019 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0323 0.0339 0.0334
Brugia malayi hypothetical protein 0.0323 0.0339 0.0339
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0323 0.0339 0.0339
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0323 0.0339 0.0339
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0022 0.0022
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.5075 0.6019 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.8405 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0119 0.0094 0.0094
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0323 0.0339 0.0334
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1564 0.1823 0.3023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0323 0.0339 0.0334
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0323 0.0339 0.0334
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0323 0.0339 0.0339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0018 0.0014
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0188 0.0183
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein tyrosine phosphatase 0.0323 0.0339 0.0339
Schistosoma mansoni pcd6 interacting protein-related 0.0323 0.0339 0.0339
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0005 0.5
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1564 0.1823 0.3023
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0094 0.0094
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0323 0.0339 0.0334
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0323 0.0339 0.0334
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.1564 0.1823 1
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0013 0.0009
Brugia malayi hypothetical protein 0.0177 0.0164 0.0164
Onchocerca volvulus 0.0323 0.0339 0.0422
Echinococcus granulosus protein tyrosine phosphatase n9 0.0323 0.0339 0.0334
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0323 0.0339 0.0339
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0948 0.1086 0.1082
Onchocerca volvulus 0.0177 0.0164 0.0127
Echinococcus multilocularis expressed conserved protein 0.0112 0.0086 0.0081
Onchocerca volvulus 0.0323 0.0339 0.0422
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.5075 0.6019 0.6019
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0323 0.0339 0.0334
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Brugia malayi hypothetical protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0323 0.0339 0.0334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0018 0.0018
Onchocerca volvulus 0.0323 0.0339 0.0422
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0022 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0323 0.0339 0.0556
Onchocerca volvulus 0.0323 0.0339 0.0422
Echinococcus granulosus expressed conserved protein 0.0112 0.0086 0.0081
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.5075 0.6019 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.0164 0.0164
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0018 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Schistosoma mansoni patched 1 0.0051 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.5075 0.6019 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0323 0.0339 0.0339
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0323 0.0339 0.0339
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0188 0.0183
Loa Loa (eye worm) protein-tyrosine phosphatase 0.8405 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0323 0.0339 0.0339
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0323 0.0339 0.0334
Onchocerca volvulus 0.0323 0.0339 0.0422
Brugia malayi Protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.5075 0.6019 1
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0094 0.009
Onchocerca volvulus 0.0323 0.0339 0.0422
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0188 0.0183
Schistosoma mansoni hypothetical protein 0.0198 0.0189 0.0189
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0323 0.0339 0.0334
Echinococcus multilocularis hypothetical protein 0.0323 0.0339 0.0334
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0323 0.0339 0.0339
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0323 0.0339 0.1838
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0323 0.0339 0.1838
Trichomonas vaginalis pten, drome, putative 0.0323 0.0339 0.0556
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Onchocerca volvulus 0.0323 0.0339 0.0422
Onchocerca volvulus 0.0323 0.0339 0.0422
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Onchocerca volvulus 0.5075 0.6019 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0323 0.0339 0.0339
Onchocerca volvulus 0.0323 0.0339 0.0422
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.8405 1 1
Schistosoma mansoni protein tyrosine phosphatase 0.0323 0.0339 0.0339
Trypanosoma cruzi hypothetical protein, conserved 0.1564 0.1823 1
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0188 0.0188
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0323 0.0339 0.0334
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Onchocerca volvulus 0.0323 0.0339 0.0422
Onchocerca volvulus 0.0323 0.0339 0.0422
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0018 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus multilocularis 0.0323 0.0339 0.0334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0018 0.0018
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.5075 0.6019 0.6019
Onchocerca volvulus 0.0323 0.0339 0.0422
Onchocerca volvulus 0.0323 0.0339 0.0422
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.5075 0.6019 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0018 0.0014
Schistosoma mansoni hypothetical protein 0.0049 0.0011 0.0011
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0323 0.0339 0.0334
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0062 0.0027 0.0027
Onchocerca volvulus 0.0323 0.0339 0.0422
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0323 0.0339 0.0556
Schistosoma mansoni alpha glucosidase 0.0044 0.0005 0.0005
Brugia malayi Protein-tyrosine phosphatase 1 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.3511 0.4149 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Brugia malayi hypothetical protein 0.0323 0.0339 0.0339
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0323 0.0339 0.0339
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0018 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0018 0.0014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.5075 0.6019 1
Brugia malayi hypothetical protein 0.0323 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0323 0.0339 0.0339
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0323 0.0339 0.0334
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0323 0.0339 0.0334
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0198 0.0189 0.0189
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0323 0.0339 0.0334
Loa Loa (eye worm) hypothetical protein 0.0323 0.0339 0.0339
Schistosoma mansoni hypothetical protein 0.0049 0.0011 0.0011
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0323 0.0339 0.0339
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0323 0.0339 0.1838
Onchocerca volvulus 0.0323 0.0339 0.0422

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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